Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	11275
Gene name	Kelch like family member 2
Gene symbol	KLHL2
Synonyms (NCBI Gene)	ABP-KELCHMAVMAYVEN
Chromosome	4
Chromosome location	4q32.3

133

Show/Hide all (133)

miRTarBase ID	miRNA	Experiments	Reference
MIRT046342	hsa-miR-23b-3p	CLASH	23622248
MIRT440354	hsa-miR-539-5p	HITS-CLIP	24374217
MIRT440354	hsa-miR-539-5p	HITS-CLIP	24374217
MIRT1097949	hsa-miR-106a	CLIP-seq
MIRT1097950	hsa-miR-106b	CLIP-seq
MIRT1097951	hsa-miR-1256	CLIP-seq
MIRT1097952	hsa-miR-1278	CLIP-seq
MIRT1097953	hsa-miR-17	CLIP-seq
MIRT1097954	hsa-miR-181a	CLIP-seq
MIRT1097955	hsa-miR-181b	CLIP-seq
MIRT1097956	hsa-miR-181c	CLIP-seq
MIRT1097957	hsa-miR-181d	CLIP-seq
MIRT1097958	hsa-miR-193a-3p	CLIP-seq
MIRT1097959	hsa-miR-193b	CLIP-seq
MIRT1097960	hsa-miR-2053	CLIP-seq
MIRT1097961	hsa-miR-20a	CLIP-seq
MIRT1097962	hsa-miR-20b	CLIP-seq
MIRT1097963	hsa-miR-3609	CLIP-seq
MIRT1097964	hsa-miR-3613-3p	CLIP-seq
MIRT1097965	hsa-miR-3973	CLIP-seq
MIRT1097966	hsa-miR-4262	CLIP-seq
MIRT1097967	hsa-miR-4318	CLIP-seq
MIRT1097968	hsa-miR-4452	CLIP-seq
MIRT1097969	hsa-miR-4503	CLIP-seq
MIRT1097970	hsa-miR-4528	CLIP-seq
MIRT1097971	hsa-miR-4693-5p	CLIP-seq
MIRT1097972	hsa-miR-4720-5p	CLIP-seq
MIRT1097973	hsa-miR-4733-3p	CLIP-seq
MIRT1097974	hsa-miR-4760-3p	CLIP-seq
MIRT1097975	hsa-miR-4795-5p	CLIP-seq
MIRT1097976	hsa-miR-4796-3p	CLIP-seq
MIRT1097977	hsa-miR-4799-3p	CLIP-seq
MIRT1097978	hsa-miR-519d	CLIP-seq
MIRT1097979	hsa-miR-520g	CLIP-seq
MIRT1097980	hsa-miR-520h	CLIP-seq
MIRT1097981	hsa-miR-548ac	CLIP-seq
MIRT1097982	hsa-miR-548ah	CLIP-seq
MIRT1097983	hsa-miR-548d-3p	CLIP-seq
MIRT1097984	hsa-miR-548k	CLIP-seq
MIRT1097985	hsa-miR-548z	CLIP-seq
MIRT1097986	hsa-miR-587	CLIP-seq
MIRT1097987	hsa-miR-664	CLIP-seq
MIRT1097988	hsa-miR-892a	CLIP-seq
MIRT1097989	hsa-miR-892b	CLIP-seq
MIRT1097990	hsa-miR-93	CLIP-seq
MIRT1097991	hsa-miR-1206	CLIP-seq
MIRT1097992	hsa-miR-298	CLIP-seq
MIRT1097964	hsa-miR-3613-3p	CLIP-seq
MIRT1097993	hsa-miR-3678-3p	CLIP-seq
MIRT1097994	hsa-miR-409-3p	CLIP-seq
MIRT1097995	hsa-miR-4317	CLIP-seq
MIRT1097981	hsa-miR-548ac	CLIP-seq
MIRT1097983	hsa-miR-548d-3p	CLIP-seq
MIRT1097985	hsa-miR-548z	CLIP-seq
MIRT1097996	hsa-miR-767-3p	CLIP-seq
MIRT1097949	hsa-miR-106a	CLIP-seq
MIRT1097950	hsa-miR-106b	CLIP-seq
MIRT1097953	hsa-miR-17	CLIP-seq
MIRT1097954	hsa-miR-181a	CLIP-seq
MIRT1097955	hsa-miR-181b	CLIP-seq
MIRT1097956	hsa-miR-181c	CLIP-seq
MIRT1097957	hsa-miR-181d	CLIP-seq
MIRT1097961	hsa-miR-20a	CLIP-seq
MIRT1097962	hsa-miR-20b	CLIP-seq
MIRT1097963	hsa-miR-3609	CLIP-seq
MIRT1097966	hsa-miR-4262	CLIP-seq
MIRT1097976	hsa-miR-4796-3p	CLIP-seq
MIRT2026612	hsa-miR-519a	CLIP-seq
MIRT2026613	hsa-miR-519b-3p	CLIP-seq
MIRT2026614	hsa-miR-519c-3p	CLIP-seq
MIRT1097978	hsa-miR-519d	CLIP-seq
MIRT1097982	hsa-miR-548ah	CLIP-seq
MIRT1097987	hsa-miR-664	CLIP-seq
MIRT1097990	hsa-miR-93	CLIP-seq
MIRT1097949	hsa-miR-106a	CLIP-seq
MIRT1097950	hsa-miR-106b	CLIP-seq
MIRT2257719	hsa-miR-1301	CLIP-seq
MIRT2257720	hsa-miR-1343	CLIP-seq
MIRT1097953	hsa-miR-17	CLIP-seq
MIRT1097954	hsa-miR-181a	CLIP-seq
MIRT1097955	hsa-miR-181b	CLIP-seq
MIRT1097956	hsa-miR-181c	CLIP-seq
MIRT1097957	hsa-miR-181d	CLIP-seq
MIRT1097961	hsa-miR-20a	CLIP-seq
MIRT1097962	hsa-miR-20b	CLIP-seq
MIRT1097963	hsa-miR-3609	CLIP-seq
MIRT2257721	hsa-miR-3672	CLIP-seq
MIRT2257722	hsa-miR-3944-5p	CLIP-seq
MIRT1097966	hsa-miR-4262	CLIP-seq
MIRT2257723	hsa-miR-4277	CLIP-seq
MIRT2257724	hsa-miR-4329	CLIP-seq
MIRT2257725	hsa-miR-455-3p	CLIP-seq
MIRT2257726	hsa-miR-4660	CLIP-seq
MIRT2257727	hsa-miR-4663	CLIP-seq
MIRT2257728	hsa-miR-4774-5p	CLIP-seq
MIRT1097976	hsa-miR-4796-3p	CLIP-seq
MIRT2257729	hsa-miR-5047	CLIP-seq
MIRT2026612	hsa-miR-519a	CLIP-seq
MIRT2026613	hsa-miR-519b-3p	CLIP-seq
MIRT2026614	hsa-miR-519c-3p	CLIP-seq
MIRT1097978	hsa-miR-519d	CLIP-seq
MIRT1097982	hsa-miR-548ah	CLIP-seq
MIRT1097987	hsa-miR-664	CLIP-seq
MIRT1097990	hsa-miR-93	CLIP-seq
MIRT1097991	hsa-miR-1206	CLIP-seq
MIRT1097994	hsa-miR-409-3p	CLIP-seq
MIRT1097981	hsa-miR-548ac	CLIP-seq
MIRT1097983	hsa-miR-548d-3p	CLIP-seq
MIRT1097985	hsa-miR-548z	CLIP-seq
MIRT1097987	hsa-miR-664	CLIP-seq
MIRT2452651	hsa-miR-1277	CLIP-seq
MIRT2452652	hsa-miR-889	CLIP-seq
MIRT2452651	hsa-miR-1277	CLIP-seq
MIRT2452652	hsa-miR-889	CLIP-seq
MIRT1097960	hsa-miR-2053	CLIP-seq
MIRT1097964	hsa-miR-3613-3p	CLIP-seq
MIRT1097969	hsa-miR-4503	CLIP-seq
MIRT1097949	hsa-miR-106a	CLIP-seq
MIRT1097950	hsa-miR-106b	CLIP-seq
MIRT1097951	hsa-miR-1256	CLIP-seq
MIRT1097953	hsa-miR-17	CLIP-seq
MIRT1097960	hsa-miR-2053	CLIP-seq
MIRT1097961	hsa-miR-20a	CLIP-seq
MIRT1097962	hsa-miR-20b	CLIP-seq
MIRT1097963	hsa-miR-3609	CLIP-seq
MIRT1097964	hsa-miR-3613-3p	CLIP-seq
MIRT1097969	hsa-miR-4503	CLIP-seq
MIRT1097973	hsa-miR-4733-3p	CLIP-seq
MIRT1097975	hsa-miR-4795-5p	CLIP-seq
MIRT1097976	hsa-miR-4796-3p	CLIP-seq
MIRT1097978	hsa-miR-519d	CLIP-seq
MIRT1097982	hsa-miR-548ah	CLIP-seq
MIRT1097990	hsa-miR-93	CLIP-seq

Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001726	Component	Ruffle	IEA
GO:0003779	Function	Actin binding	IDA	10397770
GO:0003779	Function	Actin binding	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 21145461, 21516116, 21784977, 25416956, 25910212, 30190310, 31515488, 32296183, 33961781, 34591642
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0015629	Component	Actin cytoskeleton	IDA	10397770
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016567	Process	Protein ubiquitination	ISS
GO:0030027	Component	Lamellipodium	IEA
GO:0031463	Component	Cul3-RING ubiquitin ligase complex	IBA
GO:0031463	Component	Cul3-RING ubiquitin ligase complex	IEA
GO:0031463	Component	Cul3-RING ubiquitin ligase complex	ISS
GO:0042802	Function	Identical protein binding	IPI	25416956, 31515488, 32296183
GO:0042995	Component	Cell projection	IEA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
GO:1990756	Function	Ubiquitin-like ligase-substrate adaptor activity	IBA
GO:1990756	Function	Ubiquitin-like ligase-substrate adaptor activity	IDA	23838290
GO:1990756	Function	Ubiquitin-like ligase-substrate adaptor activity	IEA

MIM	HGNC	e!Ensembl
605774	6353	ENSG00000109466

O95198

Protein name

Kelch-like protein 2 (Actin-binding protein Mayven)

Protein function

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, WNK1, WNK3 and WNK4, leading most often to their proteasomal degradation (PubMed:23838290). The B

PDB

2XN4 , 4CHB

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00651	BTB	46 → 153	BTB/POZ domain	Domain
PF07707	BACK	158 → 260	BTB And C-terminal Kelch	Domain
PF01344	Kelch_1	305 → 340	Kelch motif	Repeat
PF01344	Kelch_1	342 → 387	Kelch motif	Repeat
PF01344	Kelch_1	389 → 434	Kelch motif	Repeat
PF01344	Kelch_1	436 → 483	Kelch motif	Repeat
PF01344	Kelch_1	485 → 530	Kelch motif	Repeat
PF01344	Kelch_1	532 → 577	Kelch motif	Repeat

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. Detected throughout the brain. {ECO:0000269|PubMed:10397770}.

Sequence

METPPLPPACTKQGHQKPLDSKDDNTEKHCPVTVNPWHMKKAFKVMNELRSQNLLCDVTI
VAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQ
VTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTY
AEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMAR
LMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLR
TPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGG
FNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAY
NIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIA
EMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCA
VNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL

Sequence length

593

Interactions

View interactions

	Reactome
			Neddylation Antigen processing: Ubiquitination & Proteasome degradation

KLHL2 (kelch like family member 2)