Gene Gene information from NCBI Gene database.
Entrez ID 11264
Gene name Peroxisomal membrane protein 4
Gene symbol PXMP4
Synonyms (NCBI Gene)
PMP24
Chromosome 20
Chromosome location 20q11.22
miRNA miRNA information provided by mirtarbase database.
840
miRTarBase ID miRNA Experiments Reference
MIRT717974 hsa-miR-335-5p HITS-CLIP 19536157
MIRT717972 hsa-miR-1224-3p HITS-CLIP 19536157
MIRT680102 hsa-miR-4726-3p HITS-CLIP 19536157
MIRT717971 hsa-miR-150-5p HITS-CLIP 19536157
MIRT717970 hsa-miR-532-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
11
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 14709540
GO:0005777 Component Peroxisome IDA
GO:0005777 Component Peroxisome IEA
GO:0005778 Component Peroxisomal membrane IBA
GO:0005778 Component Peroxisomal membrane IDA 14709540
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
616397 15920 ENSG00000101417
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9Y6I8
Protein name Peroxisomal membrane protein 4 (24 kDa peroxisomal intrinsic membrane protein)
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02466 Tim17 19 132 Family
Tissue specificity TISSUE SPECIFICITY: Expressed in normal prostate epithelial cells, and androgen-sensitive prostate adenocarcinoma cells. Not expressed in androgen-insensitive prostate adenocarcinoma cells. {ECO:0000269|PubMed:14712230}.
Sequence
MAAPPQLRALLVVVNALLRKRRYHAALAVLKGFRNGAVYGAKIRAPHALVMTFLFRNGSL
QEKLWAILQATYIHSWNLARFVFTYKGLRALQSYIQGKTYPAHAFLAAFLGGILVFGENN
NINSQINMYLLS
RVLFALSRLAVEKGYIPEPRWDPFPLLTAVVWGLVLWLFEYHRSTLQP
SLQSSMTYLYEDSNVWHDISDFLVYNKSRPSN
Sequence length 212
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Peroxisome   Class I peroxisomal membrane protein import
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
HEART FAILURE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1 Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Carcinoma Hepatocellular Associate 38415547
★☆☆☆☆
Found in Text Mining only
Lymphatic Metastasis Stimulate 38415547
★☆☆☆☆
Found in Text Mining only
Neoplasms Associate 20054818
★☆☆☆☆
Found in Text Mining only
Prostatic Neoplasms Associate 20054818
★☆☆☆☆
Found in Text Mining only
Prostatitis Associate 20054818
★☆☆☆☆
Found in Text Mining only