CMTM7 (CKLF like MARVEL transmembrane domain containing 7)

Gene

• Entrez ID: 112616
• Gene name: CKLF like MARVEL transmembrane domain containing 7
• Gene symbol: CMTM7
• Synonyms (NCBI Gene): CKLFSF7
• Chromosome: 3
• Chromosome location: 3p22.3
• Summary: This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene act

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022306	hsa-miR-124-3p	Microarray	18668037
MIRT899196	hsa-miR-1271	CLIP-seq
MIRT899197	hsa-miR-182	CLIP-seq
MIRT899198	hsa-miR-3660	CLIP-seq
MIRT899199	hsa-miR-4293	CLIP-seq
MIRT899200	hsa-miR-4526	CLIP-seq
MIRT899201	hsa-miR-4700-3p	CLIP-seq
MIRT899202	hsa-miR-873	CLIP-seq
MIRT899203	hsa-miR-96	CLIP-seq
MIRT899204	hsa-miR-139-5p	CLIP-seq
MIRT899205	hsa-miR-3622a-5p	CLIP-seq
MIRT899206	hsa-miR-3667-5p	CLIP-seq
MIRT899207	hsa-miR-3675-3p	CLIP-seq
MIRT899208	hsa-miR-4255	CLIP-seq
MIRT899209	hsa-miR-4269	CLIP-seq
MIRT899210	hsa-miR-4438	CLIP-seq
MIRT899211	hsa-miR-5095	CLIP-seq
MIRT899212	hsa-miR-583	CLIP-seq
MIRT899202	hsa-miR-873	CLIP-seq
MIRT2202494	hsa-miR-1343	CLIP-seq
MIRT2202495	hsa-miR-2278	CLIP-seq
MIRT2202496	hsa-miR-3124-3p	CLIP-seq
MIRT2202497	hsa-miR-3170	CLIP-seq
MIRT2202498	hsa-miR-3192	CLIP-seq
MIRT2202499	hsa-miR-3714	CLIP-seq
MIRT2202500	hsa-miR-4476	CLIP-seq
MIRT2202501	hsa-miR-4487	CLIP-seq
MIRT2202502	hsa-miR-4777-5p	CLIP-seq
MIRT2202503	hsa-miR-516a-3p	CLIP-seq
MIRT2202504	hsa-miR-518d-5p	CLIP-seq
MIRT2202505	hsa-miR-519b-5p	CLIP-seq
MIRT2202506	hsa-miR-519c-5p	CLIP-seq
MIRT2202507	hsa-miR-520c-5p	CLIP-seq
MIRT2202508	hsa-miR-526a	CLIP-seq
MIRT2202509	hsa-miR-544b	CLIP-seq
MIRT2202510	hsa-miR-570	CLIP-seq
MIRT2202511	hsa-miR-876-3p	CLIP-seq
MIRT2202496	hsa-miR-3124-3p	CLIP-seq
MIRT2447285	hsa-miR-3160-5p	CLIP-seq
MIRT2447286	hsa-miR-3612	CLIP-seq
MIRT2447287	hsa-miR-4443	CLIP-seq
MIRT2447288	hsa-miR-485-5p	CLIP-seq
MIRT2447289	hsa-miR-650	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002337	Process	B-1a B cell differentiation	IEA
GO:0005125	Function	Cytokine activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005615	Component	Extracellular space	IEA
GO:0006935	Process	Chemotaxis	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016021	Component	Integral component of membrane	IBA	21873635

Other IDs

• MIM: 607890
• HGNC: 19178
• e!Ensembl: ENSG00000153551

Protein

• UniProt ID: Q96FZ5
• Protein name: CKLF-like MARVEL transmembrane domain-containing protein 7 (Chemokine-like factor superfamily member 7)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01284	MARVEL	40 → 160	Membrane-associating domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in leukocytes. {ECO:0000269|PubMed:12782130}.
• Sequence:

  MSHGAGLVRTTCSSGSALGPGAGAAQPSASPLEGLLDLSYPRTHAALLKVAQMVTLLIAF
  ICVRSSLWTNYSAYSYFEVVTICDLIMILAFYLVHLFRFYRVLTCISWPLSELLHYLIGT
  LLLLIASIVAASKSYNQSGLVAGAIFGFMATFLCMASIWLSYKISCVTQSTDAAV

• Sequence length: 175

Associated diseases

Unknown
Disease term	Disease name	Evidence	References	Source
Heart failure	Heart failure		20400778	ClinVar

Associations from Text Mining
Disease Name	Relationship Type	References
Breast Neoplasms	Associate	32568178, 35575054
Breast Neoplasms	Inhibit	36829181
Carcinoma Hepatocellular	Inhibit	30903681
Carcinoma Hepatocellular	Associate	36975415
Neoplasm Metastasis	Inhibit	30903681
Neoplasms	Inhibit	30903681, 36829181
Obesity	Associate	32111069