Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	11260
Gene name	Exportin for tRNA
Gene symbol	XPOT
Synonyms (NCBI Gene)	XPO3
Chromosome	12
Chromosome location	12q14.2
Summary	This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN. [provided by RefSeq,

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Show/Hide all (215)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023982	hsa-miR-1-3p	Proteomics	18668040
MIRT031897	hsa-miR-16-5p	Proteomics	18668040
MIRT049957	hsa-miR-30a-5p	CLASH	23622248
MIRT049726	hsa-miR-92a-3p	CLASH	23622248
MIRT043727	hsa-miR-342-3p	CLASH	23622248
MIRT718310	hsa-miR-449b-3p	HITS-CLIP	19536157
MIRT718309	hsa-miR-1245b-5p	HITS-CLIP	19536157
MIRT718308	hsa-miR-3142	HITS-CLIP	19536157
MIRT718307	hsa-miR-4650-5p	HITS-CLIP	19536157
MIRT718306	hsa-miR-140-3p	HITS-CLIP	19536157
MIRT718305	hsa-miR-205-5p	HITS-CLIP	19536157
MIRT718304	hsa-miR-1199-5p	HITS-CLIP	19536157
MIRT718303	hsa-miR-6751-3p	HITS-CLIP	19536157
MIRT718302	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT678930	hsa-miR-1245a	HITS-CLIP	23824327
MIRT678929	hsa-miR-8079	HITS-CLIP	23824327
MIRT678928	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT678927	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT678926	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT678925	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT678924	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT678923	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT678922	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT678921	hsa-miR-4312	HITS-CLIP	23824327
MIRT678920	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT678919	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT678918	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT678917	hsa-miR-640	HITS-CLIP	23824327
MIRT678916	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT274346	hsa-miR-548n	PAR-CLIP	20371350
MIRT274345	hsa-miR-548l	PAR-CLIP	20371350
MIRT564939	hsa-miR-141-3p	PAR-CLIP	20371350
MIRT564938	hsa-miR-200a-3p	PAR-CLIP	20371350
MIRT564937	hsa-miR-3163	PAR-CLIP	20371350
MIRT564936	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT274358	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT274336	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT564934	hsa-miR-6083	PAR-CLIP	20371350
MIRT564935	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT463808	hsa-miR-6835-3p	PAR-CLIP	23592263
MIRT463807	hsa-miR-4422	PAR-CLIP	23592263
MIRT463806	hsa-miR-1252-3p	PAR-CLIP	23592263
MIRT463805	hsa-miR-6782-3p	PAR-CLIP	23592263
MIRT463804	hsa-miR-4433b-3p	PAR-CLIP	23592263
MIRT463803	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT463802	hsa-miR-4784	PAR-CLIP	23592263
MIRT463801	hsa-miR-655-5p	PAR-CLIP	23592263
MIRT463800	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT463799	hsa-miR-6086	PAR-CLIP	23592263
MIRT463798	hsa-miR-1294	PAR-CLIP	23592263
MIRT463797	hsa-miR-9-3p	PAR-CLIP	23592263
MIRT463796	hsa-miR-4724-3p	PAR-CLIP	23592263
MIRT463795	hsa-miR-3915	PAR-CLIP	23592263
MIRT463794	hsa-miR-1224-5p	PAR-CLIP	23592263
MIRT463792	hsa-miR-4689	PAR-CLIP	23592263
MIRT463793	hsa-miR-6858-5p	PAR-CLIP	23592263
MIRT718310	hsa-miR-449b-3p	HITS-CLIP	19536157
MIRT718309	hsa-miR-1245b-5p	HITS-CLIP	19536157
MIRT718308	hsa-miR-3142	HITS-CLIP	19536157
MIRT718307	hsa-miR-4650-5p	HITS-CLIP	19536157
MIRT718306	hsa-miR-140-3p	HITS-CLIP	19536157
MIRT718305	hsa-miR-205-5p	HITS-CLIP	19536157
MIRT718304	hsa-miR-1199-5p	HITS-CLIP	19536157
MIRT718303	hsa-miR-6751-3p	HITS-CLIP	19536157
MIRT718302	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT678930	hsa-miR-1245a	HITS-CLIP	23824327
MIRT678929	hsa-miR-8079	HITS-CLIP	23824327
MIRT678928	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT678927	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT678926	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT678925	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT678924	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT678923	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT678922	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT678921	hsa-miR-4312	HITS-CLIP	23824327
MIRT678920	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT678919	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT678918	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT678917	hsa-miR-640	HITS-CLIP	23824327
MIRT678916	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT274346	hsa-miR-548n	PAR-CLIP	20371350
MIRT274345	hsa-miR-548l	PAR-CLIP	20371350
MIRT564939	hsa-miR-141-3p	PAR-CLIP	20371350
MIRT564938	hsa-miR-200a-3p	PAR-CLIP	20371350
MIRT564937	hsa-miR-3163	PAR-CLIP	20371350
MIRT564936	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT274358	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT274336	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT564934	hsa-miR-6083	PAR-CLIP	20371350
MIRT564935	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT463808	hsa-miR-6835-3p	PAR-CLIP	23592263
MIRT463807	hsa-miR-4422	PAR-CLIP	23592263
MIRT463806	hsa-miR-1252-3p	PAR-CLIP	23592263
MIRT463805	hsa-miR-6782-3p	PAR-CLIP	23592263
MIRT463804	hsa-miR-4433b-3p	PAR-CLIP	23592263
MIRT463803	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT463802	hsa-miR-4784	PAR-CLIP	23592263
MIRT463801	hsa-miR-655-5p	PAR-CLIP	23592263
MIRT463800	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT463799	hsa-miR-6086	PAR-CLIP	23592263
MIRT463798	hsa-miR-1294	PAR-CLIP	23592263
MIRT463797	hsa-miR-9-3p	PAR-CLIP	23592263
MIRT463796	hsa-miR-4724-3p	PAR-CLIP	23592263
MIRT463795	hsa-miR-3915	PAR-CLIP	23592263
MIRT463794	hsa-miR-1224-5p	PAR-CLIP	23592263
MIRT463792	hsa-miR-4689	PAR-CLIP	23592263
MIRT463793	hsa-miR-6858-5p	PAR-CLIP	23592263
MIRT1496927	hsa-miR-1208	CLIP-seq
MIRT1496928	hsa-miR-1257	CLIP-seq
MIRT1496929	hsa-miR-1279	CLIP-seq
MIRT1496930	hsa-miR-141	CLIP-seq
MIRT1496931	hsa-miR-142-5p	CLIP-seq
MIRT1496932	hsa-miR-183	CLIP-seq
MIRT1496933	hsa-miR-186	CLIP-seq
MIRT1496934	hsa-miR-199a-5p	CLIP-seq
MIRT1496935	hsa-miR-199b-5p	CLIP-seq
MIRT1496936	hsa-miR-200a	CLIP-seq
MIRT1496937	hsa-miR-2052	CLIP-seq
MIRT1496938	hsa-miR-3133	CLIP-seq
MIRT1496939	hsa-miR-340	CLIP-seq
MIRT1496940	hsa-miR-361-3p	CLIP-seq
MIRT1496941	hsa-miR-3622a-5p	CLIP-seq
MIRT1496942	hsa-miR-3647-3p	CLIP-seq
MIRT1496943	hsa-miR-3674	CLIP-seq
MIRT1496944	hsa-miR-3679-3p	CLIP-seq
MIRT1496945	hsa-miR-3692	CLIP-seq
MIRT1496946	hsa-miR-377	CLIP-seq
MIRT1496947	hsa-miR-410	CLIP-seq
MIRT1496948	hsa-miR-412	CLIP-seq
MIRT1496949	hsa-miR-4302	CLIP-seq
MIRT1496950	hsa-miR-4304	CLIP-seq
MIRT1496951	hsa-miR-433	CLIP-seq
MIRT1496952	hsa-miR-4423-3p	CLIP-seq
MIRT1496953	hsa-miR-4436b-5p	CLIP-seq
MIRT1496954	hsa-miR-4496	CLIP-seq
MIRT1496955	hsa-miR-452	CLIP-seq
MIRT1496956	hsa-miR-4676-3p	CLIP-seq
MIRT1496957	hsa-miR-4711-3p	CLIP-seq
MIRT1496958	hsa-miR-4742-3p	CLIP-seq
MIRT1496959	hsa-miR-4742-5p	CLIP-seq
MIRT1496960	hsa-miR-4753-3p	CLIP-seq
MIRT1496961	hsa-miR-4760-3p	CLIP-seq
MIRT1496962	hsa-miR-4789-3p	CLIP-seq
MIRT1496963	hsa-miR-4790-3p	CLIP-seq
MIRT1496964	hsa-miR-494	CLIP-seq
MIRT1496965	hsa-miR-548aa	CLIP-seq
MIRT1496966	hsa-miR-548c-3p	CLIP-seq
MIRT1496967	hsa-miR-548k	CLIP-seq
MIRT1496968	hsa-miR-592	CLIP-seq
MIRT1496969	hsa-miR-599	CLIP-seq
MIRT1496970	hsa-miR-626	CLIP-seq
MIRT1496971	hsa-miR-660	CLIP-seq
MIRT1496972	hsa-miR-891b	CLIP-seq
MIRT2149665	hsa-miR-1281	CLIP-seq
MIRT1496933	hsa-miR-186	CLIP-seq
MIRT1496938	hsa-miR-3133	CLIP-seq
MIRT1496939	hsa-miR-340	CLIP-seq
MIRT1496940	hsa-miR-361-3p	CLIP-seq
MIRT1496944	hsa-miR-3679-3p	CLIP-seq
MIRT1496945	hsa-miR-3692	CLIP-seq
MIRT1496946	hsa-miR-377	CLIP-seq
MIRT1496948	hsa-miR-412	CLIP-seq
MIRT1496950	hsa-miR-4304	CLIP-seq
MIRT1496951	hsa-miR-433	CLIP-seq
MIRT1496953	hsa-miR-4436b-5p	CLIP-seq
MIRT1496955	hsa-miR-452	CLIP-seq
MIRT2149666	hsa-miR-4520b-3p	CLIP-seq
MIRT2149667	hsa-miR-4529-3p	CLIP-seq
MIRT2149668	hsa-miR-4535	CLIP-seq
MIRT1496956	hsa-miR-4676-3p	CLIP-seq
MIRT1496957	hsa-miR-4711-3p	CLIP-seq
MIRT1496961	hsa-miR-4760-3p	CLIP-seq
MIRT2149669	hsa-miR-4776-5p	CLIP-seq
MIRT1496962	hsa-miR-4789-3p	CLIP-seq
MIRT2149670	hsa-miR-4789-5p	CLIP-seq
MIRT1496966	hsa-miR-548c-3p	CLIP-seq
MIRT2149671	hsa-miR-561	CLIP-seq
MIRT2149672	hsa-miR-582-3p	CLIP-seq
MIRT1496968	hsa-miR-592	CLIP-seq
MIRT1496969	hsa-miR-599	CLIP-seq
MIRT1496970	hsa-miR-626	CLIP-seq
MIRT2149665	hsa-miR-1281	CLIP-seq
MIRT2369921	hsa-miR-1283	CLIP-seq
MIRT1496930	hsa-miR-141	CLIP-seq
MIRT1496936	hsa-miR-200a	CLIP-seq
MIRT1496937	hsa-miR-2052	CLIP-seq
MIRT1496939	hsa-miR-340	CLIP-seq
MIRT1496940	hsa-miR-361-3p	CLIP-seq
MIRT1496944	hsa-miR-3679-3p	CLIP-seq
MIRT1496951	hsa-miR-433	CLIP-seq
MIRT1496957	hsa-miR-4711-3p	CLIP-seq
MIRT1496960	hsa-miR-4753-3p	CLIP-seq
MIRT1496961	hsa-miR-4760-3p	CLIP-seq
MIRT1496965	hsa-miR-548aa	CLIP-seq
MIRT1496966	hsa-miR-548c-3p	CLIP-seq
MIRT2149672	hsa-miR-582-3p	CLIP-seq
MIRT1496968	hsa-miR-592	CLIP-seq
MIRT1496969	hsa-miR-599	CLIP-seq
MIRT1496970	hsa-miR-626	CLIP-seq
MIRT2149665	hsa-miR-1281	CLIP-seq
MIRT1496939	hsa-miR-340	CLIP-seq
MIRT1496941	hsa-miR-3622a-5p	CLIP-seq
MIRT1496951	hsa-miR-433	CLIP-seq
MIRT1496952	hsa-miR-4423-3p	CLIP-seq
MIRT1496961	hsa-miR-4760-3p	CLIP-seq
MIRT1496966	hsa-miR-548c-3p	CLIP-seq
MIRT2149672	hsa-miR-582-3p	CLIP-seq
MIRT2149665	hsa-miR-1281	CLIP-seq
MIRT1496939	hsa-miR-340	CLIP-seq
MIRT1496941	hsa-miR-3622a-5p	CLIP-seq
MIRT1496951	hsa-miR-433	CLIP-seq
MIRT1496952	hsa-miR-4423-3p	CLIP-seq
MIRT1496961	hsa-miR-4760-3p	CLIP-seq
MIRT1496966	hsa-miR-548c-3p	CLIP-seq
MIRT2149672	hsa-miR-582-3p	CLIP-seq

Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000049	Function	TRNA binding	IBA
GO:0000049	Function	TRNA binding	IDA	9660920
GO:0000049	Function	TRNA binding	IEA
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IEA
GO:0005643	Component	Nuclear pore	IBA
GO:0005643	Component	Nuclear pore	IDA	9660920
GO:0005654	Component	Nucleoplasm	IDA	9660920
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	9660920
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006409	Process	TRNA export from nucleus	IDA	9660920
GO:0006409	Process	TRNA export from nucleus	IEA
GO:0006886	Process	Intracellular protein transport	IEA
GO:0006913	Process	Nucleocytoplasmic transport	IEA
GO:0016363	Component	Nuclear matrix	IBA
GO:0031267	Function	Small GTPase binding	IEA
GO:0071528	Process	TRNA re-export from nucleus	IBA
GO:0071528	Process	TRNA re-export from nucleus	IEA

MIM	HGNC	e!Ensembl
603180	12826	ENSG00000184575

O43592

Protein name

Exportin-T (Exportin(tRNA)) (tRNA exportin)

Protein function

Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03810	IBN_N	19 → 89	Importin-beta N-terminal domain	Family
PF08389	Xpo1	98 → 247	Exportin 1-like protein	Family

Sequence

MDEQALLGLNPNADSDFRQRALAYFEQLKISPDAWQVCAEALAQRTYSDDHVKFFCFQVL
EHQVKYKYSELTTVQQQLIRETLISWLQAQMLNPQPEKTFIRNKAAQVFALLFVTEYLTK
WPKFFFDILSVVDLNPRGVDLYLRILMAIDSELVDRDVVHTSEEARRNTLIKDTMREQCI
PNLVESWYQILQNYQFTNSEVTCQCLEVVGAYVSWIDLSLIANDRFINMLLGHMSIEVLR
EEACDCLFEVVNKGMDPVDKMKLVESLCQVLQSAGFFSIDQEEDVDFLARFSKLVNGMGQ
SLIVSWSKLIKNGDIKNAQEALQAIETKVALMLQLLIHEDDDISSNIIGFCYDYLHILKQ
LTVLSDQQKANVEAIMLAVMKKLTYDEEYNFENEGEDEAMFVEYRKQLKLLLDRLAQVSP
ELLLASVRRVFSSTLQNWQTTRFMEVEVAIRLLYMLAEALPVSHGAHFSGDVSKASALQD
MMRTLVTSGVSSYQHTSVTLEFFETVVRYEKFFTVEPQHIPCVLMAFLDHRGLRHSSAKV
RSRTAYLFSRFVKSLNKQMNPFIEDILNRIQDLLELSPPENGHQSLLSSDDQLFIYETAG
VLIVNSEYPAERKQALMRNLLTPLMEKFKILLEKLMLAQDEERQASLADCLNHAVGFASR
TSKAFSNKQTVKQCGCSEVYLDCLQTFLPALSCPLQKDILRSGVRTFLHRMIICLEEEVL
PFIPSASEHMLKDCEAKDLQEFIPLINQITAKFKIQVSPFLQQMFMPLLHAIFEVLLRPA
EENDQSAALEKQMLRRSYFAFLQTVTGSGMSEVIANQGAENVERVLVTVIQGAVEYPDPI
AQKTCFIILSKLVELWGGKDGPVGFADFVYKHIVPACFLAPLKQTFDLADAQTVLALSEC
AVTLKTIHLKRGPECVQYLQQEYLPSLQVAPEIIQEFCQALQQPDAKVFKNYLKVFFQRA
KP

Sequence length

962

Interactions

View interactions

	KEGG		Reactome
	Nucleocytoplasmic transport		tRNA processing in the nucleus

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	37928256	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Associate	31371628	★★★★★ ★☆☆☆☆ Found in Text Mining only
Low Tension Glaucoma	Associate	23421332	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Associate	34469238	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Associate	37928256	★★★★★ ★☆☆☆☆ Found in Text Mining only

XPOT (exportin for tRNA)