Gene Gene information from NCBI Gene database.
Entrez ID 11254
Gene name Solute carrier family 6 member 14
Gene symbol SLC6A14
Synonyms (NCBI Gene)
BMIQ11
Chromosome X
Chromosome location Xq23
Summary This gene encodes a member of the solute carrier family 6. Members of this family are sodium and chloride dependent neurotransmitter transporters. The encoded protein transports both neutral and cationic amino acids. This protein may also function as a be
miRNA miRNA information provided by mirtarbase database.
467
miRTarBase ID miRNA Experiments Reference
MIRT030183 hsa-miR-26b-5p Microarray 19088304
MIRT1365912 hsa-miR-1228 CLIP-seq
MIRT1365913 hsa-miR-125a-5p CLIP-seq
MIRT1365914 hsa-miR-125b CLIP-seq
MIRT1365915 hsa-miR-140-5p CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
40
GO ID Ontology Definition Evidence Reference
GO:0001761 Function Beta-alanine transmembrane transporter activity IBA
GO:0001761 Function Beta-alanine transmembrane transporter activity IDA 18599538
GO:0001762 Process Beta-alanine transport IBA
GO:0001762 Process Beta-alanine transport IDA 18599538
GO:0003333 Process Amino acid transmembrane transport TAS 10446133
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
300444 11047 ENSG00000268104
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UN76
Protein name Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (Amino acid transporter ATB0+) (Solute carrier family 6 member 14)
Protein function Amino acid transporter that plays an important role in the absorption of amino acids in the intestinal tract. Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent man
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00209 SNF 36 588 Sodium:neurotransmitter symporter family Family
Tissue specificity TISSUE SPECIFICITY: Levels are highest in adult and fetal lung, in trachea and salivary gland. Lower levels detected in mammary gland, stomach and pituitary gland, and very low levels in colon, uterus, prostate and testis. {ECO:0000269|PubMed:10446133}.
Sequence
Sequence length 642
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Amino acid transport across the plasma membrane
Na+/Cl- dependent neurotransmitter transporters
Variant SLC6A14 may confer susceptibility towards obesity
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
4
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Colon adenocarcinoma Benign rs12720085 RCV005908770
Gastric cancer Benign rs12720085 RCV005908771
Lung cancer Benign rs12720085 RCV005908772
SLC6A14-related disorder Likely benign rs373196599 RCV003959226
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Carcinoma Hepatocellular Associate 12381519, 14563674
Carcinoma Pancreatic Ductal Associate 26106611, 31731384
Cholangiocarcinoma Associate 39670859
Colitis Ulcerative Associate 18700007, 32190668, 36272033, 36419192, 38070204
Colorectal Neoplasms Associate 15905073
Colorectal Neoplasms Stimulate 35907820
Cystic Fibrosis Associate 25771386, 30807572, 33438800
Huntington Disease Associate 22466613
Inflammation Associate 38070204
Lung Diseases Associate 30807572