NXPH2 (neurexophilin 2)

Gene

• Entrez ID: 11249
• Gene name: Neurexophilin 2
• Gene symbol: NXPH2
• Synonyms (NCBI Gene): NPH2
• Chromosome: 2
• Chromosome location: 2q22.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023595	hsa-miR-1-3p	Microarray	18668037
MIRT051108	hsa-miR-16-5p	CLASH	23622248
MIRT1200587	hsa-miR-1236	CLIP-seq
MIRT1200588	hsa-miR-3117-3p	CLIP-seq
MIRT1200589	hsa-miR-3123	CLIP-seq
MIRT1200590	hsa-miR-3169	CLIP-seq
MIRT1200591	hsa-miR-361-5p	CLIP-seq
MIRT1200592	hsa-miR-3646	CLIP-seq
MIRT1200593	hsa-miR-3692	CLIP-seq
MIRT1200594	hsa-miR-3925-5p	CLIP-seq
MIRT1200595	hsa-miR-3976	CLIP-seq
MIRT1200596	hsa-miR-4310	CLIP-seq
MIRT1200597	hsa-miR-433	CLIP-seq
MIRT1200598	hsa-miR-4452	CLIP-seq
MIRT1200599	hsa-miR-4511	CLIP-seq
MIRT1200600	hsa-miR-451b	CLIP-seq
MIRT1200601	hsa-miR-4662a-3p	CLIP-seq
MIRT1200602	hsa-miR-4699-5p	CLIP-seq
MIRT1200603	hsa-miR-4753-3p	CLIP-seq
MIRT1200604	hsa-miR-4759	CLIP-seq
MIRT1200605	hsa-miR-486-5p	CLIP-seq
MIRT1200606	hsa-miR-498	CLIP-seq
MIRT1200607	hsa-miR-548ac	CLIP-seq
MIRT1200608	hsa-miR-548ae	CLIP-seq
MIRT1200609	hsa-miR-548aj	CLIP-seq
MIRT1200610	hsa-miR-548am	CLIP-seq
MIRT1200611	hsa-miR-548d-3p	CLIP-seq
MIRT1200612	hsa-miR-548x	CLIP-seq
MIRT1200613	hsa-miR-548z	CLIP-seq
MIRT1200614	hsa-miR-578	CLIP-seq
MIRT1200615	hsa-miR-651	CLIP-seq
MIRT1200616	hsa-miR-942	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003674	Function	Molecular_function	ND
GO:0005102	Function	Signaling receptor binding	IBA	21873635
GO:0005576	Component	Extracellular region	IEA
GO:0007218	Process	Neuropeptide signaling pathway	NAS	9570794

Other IDs

• MIM: 604635
• HGNC: 8076
• e!Ensembl: ENSG00000144227

Protein

• UniProt ID: O95156
• Protein name: Neurexophilin-2
• Protein function: May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06312	Neurexophilin	52 → 264	Neurexophilin	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in brain and kidney.
• Sequence:

  MRLRPLPLVVVPGLLQLLFCDSKEVVHATEGLDWEDKDAPGTLVGNVVHSRIISPLRLFV
  KQSPVPKPGPMAYADSMENFWDWLANITEIQEPLARTKRRPIVKTGKFKKMFGWGDFHSN
  IKTVKLNLLITGKIVDHGNGTFSVYFRHNSTGLGNVSVSLVPPSKVVEFEVSPQSTLETK
  ESKSFNCRIEYEKTDRAKKTALCNFDPSKICYQEQTQSHVSWLCSKPFKVICIYIAFYSV
  DYKLVQKVCPDYNYHSETPYLSSG

• Sequence length: 264

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Nephronophthisis	NEPHRONOPHTHISIS 2	rs62635288, rs267607116, rs201893408, rs267607117, rs202149403, rs118204032, rs121918244, rs750962965, rs1474058708, rs119456959, rs119456960, rs119456961, rs119456962, rs267606916, rs137852856, rs137852918, rs137852919, rs137852920, rs28940891, rs1278089386, rs137852922, rs137852923, rs1233478832, rs121907898, rs121907899, rs74315396, rs104893698, rs28936684, rs104893701, rs104893705, rs797044441, rs104893716, rs121964994, rs267607185, rs200844390, rs753348470, rs387906983, rs786205114, rs373909351, rs387907009, rs140511594, rs387907059, rs766132877, rs201188361, rs193922432, rs1565649749, rs387907309, rs387907310, rs387907311, rs145646425, rs397514728, rs397514257, rs587777024, rs587777025, rs397514258, rs375661404, rs398123285, rs398123538, rs398124546, rs368138001, rs587777350, rs587777351, rs587777352, rs587777486, rs879255575, rs368619022, rs879255576, rs587777487, rs369483167, rs587777488, rs587783011, rs144972972, rs727503968, rs727503969, rs730880299, rs757704417, rs760040426, rs758558609, rs755549444, rs763300393, rs794727964, rs182135982, rs758498695, rs775883520, rs777686211, rs756856188, rs777668842, rs756302731, rs751527253, rs138783896, rs869312915, rs769256610, rs878855332, rs376879175, rs878855335, rs886041154, rs886041637, rs766524637, rs769739938, rs201405662, rs376974221, rs201633414, rs1057519303, rs1057519304, rs202001274, rs1057519305, rs1057519306, rs752616462, rs1060499938, rs745340459, rs771215577, rs1064794347, rs201091657, rs771742823, rs1553484094, rs747861275, rs773521620, rs1456714047, rs1553773271, rs1555564134, rs752792782, rs398124289, rs1025515771, rs747052534, rs904520404, rs1553200990, rs1553178047, rs866982675, rs1182741031, rs1556026984, rs150001738, rs780247729, rs1555564214, rs372607453, rs61893682, rs549662742, rs774456004, rs1189889920, rs370210428, rs1557580413, rs1368105372, rs1559056633, rs765263671, rs1280238814, rs1560000875, rs1560002147, rs758238787, rs201237799, rs1560017690, rs1564123602, rs1425211517, rs369437168, rs764893412, rs747914869, rs778819060, rs1207804224, rs756090222, rs1564228101, rs1565455033, rs1322951938, rs1564236717, rs1565454034, rs375753623, rs374141736, rs1349732291, rs1017750255, rs1210874691, rs1379989124, rs1565582604, rs1485445500, rs758275952, rs1276839362, rs1576682880, rs1588420907, rs375416014, rs955421639, rs1596759273, rs755288504, rs1588153872, rs780020801, rs1576660495, rs1596088812, rs1576875819, rs779696701, rs759262253, rs775612958, rs1570504754, rs754862360, rs1679148969, rs1311042980, rs1682584195, rs753517219, rs1358793834, rs1560002113, rs1939543636, rs1205325321, rs1329661241, rs140611214, rs780500128, rs2061113374, rs1652115764, rs780148543, rs749866369, rs1459158279, rs756111113

Associations from Text Mining
Disease Name	Relationship Type	References
Ovarian Neoplasms	Associate	19304784