ERI2 (ERI1 exoribonuclease family member 2)

Gene

• Entrez ID: 112479
• Gene name: ERI1 exoribonuclease family member 2
• Gene symbol: ERI2
• Synonyms (NCBI Gene): EXOD1, ZGRF5
• Chromosome: 16
• Chromosome location: 16p12.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT021172	hsa-miR-186-5p	Sequencing	20371350
MIRT025955	hsa-miR-7-5p	Sequencing	20371350
MIRT030187	hsa-miR-26b-5p	Microarray	19088304
MIRT194695	hsa-miR-3646	PAR-CLIP	20371350
MIRT562378	hsa-miR-5680	PAR-CLIP	20371350
MIRT562377	hsa-miR-5094	PAR-CLIP	20371350
MIRT562376	hsa-miR-5693	PAR-CLIP	20371350
MIRT562375	hsa-miR-194-3p	PAR-CLIP	20371350
MIRT562374	hsa-miR-4747-5p	PAR-CLIP	20371350
MIRT562373	hsa-miR-5196-5p	PAR-CLIP	20371350
MIRT562372	hsa-miR-203b-3p	PAR-CLIP	20371350
MIRT194695	hsa-miR-3646	PAR-CLIP	20371350
MIRT562378	hsa-miR-5680	PAR-CLIP	20371350
MIRT562377	hsa-miR-5094	PAR-CLIP	20371350
MIRT562376	hsa-miR-5693	PAR-CLIP	20371350
MIRT562375	hsa-miR-194-3p	PAR-CLIP	20371350
MIRT562374	hsa-miR-4747-5p	PAR-CLIP	20371350
MIRT562373	hsa-miR-5196-5p	PAR-CLIP	20371350
MIRT562372	hsa-miR-203b-3p	PAR-CLIP	20371350
MIRT969129	hsa-miR-1271	CLIP-seq
MIRT969130	hsa-miR-182	CLIP-seq
MIRT969131	hsa-miR-300	CLIP-seq
MIRT969132	hsa-miR-3119	CLIP-seq
MIRT969133	hsa-miR-3127-3p	CLIP-seq
MIRT969134	hsa-miR-3130-3p	CLIP-seq
MIRT969135	hsa-miR-3180-5p	CLIP-seq
MIRT969136	hsa-miR-361-5p	CLIP-seq
MIRT969137	hsa-miR-377	CLIP-seq
MIRT969138	hsa-miR-380	CLIP-seq
MIRT969139	hsa-miR-381	CLIP-seq
MIRT969140	hsa-miR-3924	CLIP-seq
MIRT969141	hsa-miR-412	CLIP-seq
MIRT969142	hsa-miR-4282	CLIP-seq
MIRT969143	hsa-miR-4426	CLIP-seq
MIRT969144	hsa-miR-4470	CLIP-seq
MIRT969145	hsa-miR-4495	CLIP-seq
MIRT969146	hsa-miR-4643	CLIP-seq
MIRT969147	hsa-miR-4645-5p	CLIP-seq
MIRT969148	hsa-miR-4647	CLIP-seq
MIRT969149	hsa-miR-4659a-3p	CLIP-seq
MIRT969150	hsa-miR-4659b-3p	CLIP-seq
MIRT969151	hsa-miR-4662b	CLIP-seq
MIRT969152	hsa-miR-4666-3p	CLIP-seq
MIRT969153	hsa-miR-4673	CLIP-seq
MIRT969154	hsa-miR-4691-5p	CLIP-seq
MIRT969155	hsa-miR-4735-5p	CLIP-seq
MIRT969156	hsa-miR-4775	CLIP-seq
MIRT969157	hsa-miR-4780	CLIP-seq
MIRT969158	hsa-miR-513a-3p	CLIP-seq
MIRT969159	hsa-miR-548c-3p	CLIP-seq
MIRT969160	hsa-miR-577	CLIP-seq
MIRT969161	hsa-miR-590-3p	CLIP-seq
MIRT969162	hsa-miR-767-5p	CLIP-seq
MIRT969163	hsa-miR-96	CLIP-seq
MIRT2525312	hsa-miR-1273d	CLIP-seq
MIRT2525313	hsa-miR-4446-5p	CLIP-seq
MIRT2525314	hsa-miR-4687-3p	CLIP-seq
MIRT969155	hsa-miR-4735-5p	CLIP-seq
MIRT2525315	hsa-miR-4755-5p	CLIP-seq
MIRT2525316	hsa-miR-548u	CLIP-seq
MIRT2525317	hsa-miR-576-5p	CLIP-seq
MIRT2525318	hsa-miR-647	CLIP-seq
MIRT2525319	hsa-miR-660	CLIP-seq
MIRT2525312	hsa-miR-1273d	CLIP-seq
MIRT2525313	hsa-miR-4446-5p	CLIP-seq
MIRT2525314	hsa-miR-4687-3p	CLIP-seq
MIRT969155	hsa-miR-4735-5p	CLIP-seq
MIRT2525315	hsa-miR-4755-5p	CLIP-seq
MIRT2525316	hsa-miR-548u	CLIP-seq
MIRT2525317	hsa-miR-576-5p	CLIP-seq
MIRT2525318	hsa-miR-647	CLIP-seq
MIRT2525319	hsa-miR-660	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000175	Function	3'-5'-exoribonuclease activity	IBA	21873635
GO:0000467	Process	Exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA	21873635
GO:0000738	Process	DNA catabolic process, exonucleolytic	IBA	21873635
GO:0003676	Function	Nucleic acid binding	IEA
GO:0008270	Function	Zinc ion binding	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: A8K979
• Protein name: ERI1 exoribonuclease 2 (EC 3.1.-.-) (Exonuclease domain-containing protein 1)
• PDB: 7N8V, 7N8W
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00929	RNase_T	38 → 226	Exonuclease	Family
  PF06839	zf-GRF	595 → 643	GRF zinc finger	Domain

• Sequence:

  MATKRLARQLGLIRRKSIAPANGNLGRSKSKQLFDYLIVIDFESTCWNDGKHHHSQEIIE
  FPAVLLNTSTGQIDSEFQAYVQPQEHPILSEFCMELTGIKQAQVDEGVPLKICLSQFCKW
  IHKIQQQKNIIFATGISEPSASEVKLCAFVTWSDWDLGVCLEYECKRKQLLKPVFLNSWI
  DLRATYKLFYRRKPKGLSGALQEVGIEFSGREHSGLDDSRNTALLAWKMIRDGCVMKITR
  SLNKVPTKKNFSILARNLNTIQVEEMSACNISIQGPSIYNKEPKNIINPHEKVQMKSICA
  NSPIKAQQDQLQVKNNIKASLHNVKSSLPLFNTKSSTSVGQLQSPTLNSPIYMQKQGKNE
  HLAFNTKSKASTVGSELVLVSTTVPTVHHVSDLEMSSTLDCLPVLADWEDVVLLPASQPE
  ENVDCTVPISDSDLEISFNSGERLMVLKELEMSSHENFGDIEETPQKSETSKSIVYKSPH
  TTIYNVKEAKDPGSDISAFKLPEHKSSTFNRVNANMSHPLVLGKHPLLSGGTKRNPCSPQ
  AFPPAKKQPFTIHEEKPTSSDCSPVRSSSWRRLPSILTSTVNLQEPWKSGKMTPPLCKCG
  RRSKRLVVSNNGPNHGKVFYCCPIGKYQENRKCCGYFKWEQTLQKERANSMVPSHSTGGL
  TFSSPETSHICDRNLSISTKNSLRLRPSMRN

• Sequence length: 691

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Colorectal cancer	Colorectal Carcinoma	rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800, rs63750198, rs63751109, rs863223312, rs63750710, rs63751615, rs63750206, rs63750781, rs63750899, rs63750691, rs63750217, rs121912965, rs63749939, rs63751194, rs63750693, rs63750540, rs63751221, rs193922370, rs80359596, rs397514632, rs483352909, rs200495564, rs397514684, rs397516436, rs398122386, rs79512956, rs74953290, rs587779001, rs63750677, rs63749837, rs267607816, rs63751715, rs267607819, rs267607815, rs267607822, rs63749906, rs587778883, rs63750472, rs63751012, rs63750715, rs63750580, rs267607706, rs267607709, rs267607710, rs587778894, rs63750749, rs63750483, rs63751015, rs63751153, rs63751094, rs63751118, rs63750316, rs63749981, rs587778906, rs267607821, rs587778908, rs63750020, rs587778909, rs63750713, rs267607825, rs63751592, rs281864936, rs587778913, rs587778914, rs63749795, rs63750855, rs63749916, rs63749923, rs63751472, rs63751689, rs267607832, rs267607837, rs267607836, rs587778923, rs63750028, rs587778928, rs587778929, rs587778930, rs63751277, rs587778933, rs267607842, rs267607843, rs63750192, rs587778934, rs63750193, rs587778937, rs587778938, rs267607845, rs63751244, rs63751393, rs63751460, rs267607849, rs267607853, rs267607856, rs267607850, rs63751657, rs267607854, rs267607852, rs587778942, rs63750309, rs63750587, rs63749863, rs63751486, rs63750016, rs63749868, rs63750375, rs63750035, rs63750604, rs63750386, rs63750150, rs63750486, rs63751428, rs267607866, rs63749986, rs63751594, rs63750152, rs63750850, rs267607867, rs267607868, rs63751632, rs267607871, rs63751892, rs587778956, rs63750469, rs587778958, rs63749792, rs267607875, rs63751255, rs281864938, rs63751202, rs63750726, rs63751310, rs63749900, rs587778964, rs267607879, rs267607878, rs587778966, rs267607883, rs267607887, rs63750061, rs63750663, rs587778968, rs587778971, rs63750809, rs63749867, rs63750864, rs587778972, rs63751275, rs267607718, rs267607722, rs63750769, rs267607717, rs587778973, rs267607716, rs267607720, rs63749995, rs63750859, rs587778975, rs63750114, rs587778976, rs63750603, rs267607889, rs267607723, rs63750561, rs63750499, rs63751642, rs63751022, rs587778981, rs63750971, rs267607898, rs267607906, rs267607903, rs587778989, rs587778992, rs267607894, rs267607901, rs267607892, rs63750437, rs587778997, rs587778998, rs63750005, rs63750641, rs63751421, rs11541859, rs63750266, rs111052004, rs267607726, rs267607727, rs63750453, rs267607734, rs267607735, rs63751665, rs267607736, rs267607732, rs63749816, rs63750539, rs267607739, rs587779006, rs587779008, rs267607745, rs267607742, rs63751595, rs267607743, rs587779010, rs587779012, rs63750057, rs63749818, rs63751124, rs587779014, rs587779015, rs63749820, rs63751302, rs267607750, rs267607751, rs267607749, rs63750891, rs63749959, rs63749804, rs267607765, rs267607760, rs587779021, rs267607759, rs63750515, rs587779023, rs63751021, rs63751480, rs267607772, rs267607773, rs587779024, rs63751653, rs587779027, rs267607767, rs587779029, rs63750706, rs63750385, rs267607774, rs267607778, rs267607780, rs587779034, rs63751711, rs267607784, rs587779035, rs63750823, rs63750822, rs267607787, rs63750303, rs63749839, rs63749827, rs267607789, rs267607790, rs267607791, rs267607786, rs267607771, rs267607795, rs267607794, rs267607788, rs267607799, rs267607801, rs587779045, rs63750034, rs587779047, rs63750216, rs63751707, rs63751598, rs267607803, rs267607777, rs63750144, rs267607805, rs63750547, rs63750489, rs63750993, rs587779054, rs63751259, rs63749926, rs63750796, rs587779058, rs63750745, rs63750582, rs180177084, rs587779866, rs200389141, rs587779950, rs587780104, rs587780183, rs587778536, rs587780683, rs587781554, rs267607712, rs587777627, rs587783057, rs730881734, rs41542214, rs730881273, rs786203456, rs786201990, rs786202767, rs748005072, rs786204317, rs786204318, rs797045117, rs63750549, rs863225383, rs863225384, rs863225373, rs863225376, rs863225377, rs863225378, rs863225379, rs863225380, rs863225381, rs63750059, rs267607823, rs864622457, rs869312767, rs869312753, rs876661059, rs876658915, rs876658923, rs876660860, rs876660822, rs876660458, rs876660214, rs876658657, rs876658247, rs876659226, rs876658821, rs876660589, rs876659068, rs876659681, rs876659608, rs878853794, rs878853778, rs878853780, rs878853785, rs886039423, rs886039424, rs1057517543, rs1057517541, rs756843954, rs1057517617, rs1057517558, rs1057519256, rs1060500689, rs764085979, rs1060500707, rs1060500699, rs1060500706, rs1060500703, rs1064795341, rs1064793607, rs1064794348, rs1064795441, rs1064794373, rs1064793172, rs1064794122, rs1064795515, rs1064794331, rs63750978, rs1114167435, rs1553641362, rs63751448, rs1553648029, rs1553648058, rs587778903, rs1553653237, rs1553664353, rs267607744, rs1553647995, rs1553648047, rs1553653084, rs1553663750, rs1553664436, rs1553488015, rs1553637293, rs63750310, rs63750443, rs63751596, rs1553646681, rs550890395, rs1064796057, rs1553642079, rs1553648023, rs587782087, rs746536721, rs1553653037, rs1248251121, rs1553646602, rs1434898623, rs1553665683, rs1553648068, rs1553645331, rs1553644123, rs1553658246, rs1553651299, rs1553648149, rs1553663159, rs1302248679, rs1553664119, rs1553658009, rs1553665977, rs1416171624, rs1553663834, rs1553664617, rs1553664702, rs1553647969, rs1553648040, rs1437454428, rs1553641273, rs63751101, rs1553646764, rs1553648225, rs1554082118, rs1553648201, rs1553638868, rs1553665866, rs376736188, rs1553642707, rs1553645226, rs1553652883, rs63751435, rs1553653115, rs1553653195, rs63750300, rs1553662622, rs1553658104, rs1553648220, rs1559544064, rs63750584, rs267608083, rs1559551570, rs1559575107, rs1559553501, rs1565986506, rs1559524405, rs1559553492, rs1559554339, rs1559588540, rs1559558071, rs761329565, rs1559521039, rs1559574795, rs1567221417, rs1559578422, rs1481129490, rs1570714352, rs779783209, rs1575376830, rs1575469070, rs1575537843, rs1575620443, rs1575621506, rs587779022, rs1575414904, rs1575449093, rs1575469505, rs1575536254, rs1575537933, rs1575632112, rs1575639851, rs1575441094, rs1575449402, rs267607831, rs2081922847, rs2083403132, rs2085415927, rs2085469647, rs2043913790, rs147542208

Associations from Text Mining
Disease Name	Relationship Type	References
Hypertrophy Left Ventricular	Associate	25329069