PMF1 (polyamine modulated factor 1)

Gene

• Entrez ID: 11243
• Gene name: Polyamine modulated factor 1
• Gene symbol: PMF1
• Synonyms (NCBI Gene): -
• Chromosome: 1
• Chromosome location: 1q22

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024714	hsa-miR-215-5p	Microarray	19074876
MIRT029956	hsa-miR-26b-5p	Microarray	19088304
MIRT032379	hsa-let-7b-5p	Proteomics	18668040
MIRT2299378	hsa-let-7a	CLIP-seq
MIRT2299379	hsa-let-7b	CLIP-seq
MIRT2299380	hsa-let-7c	CLIP-seq
MIRT2299381	hsa-let-7d	CLIP-seq
MIRT2299382	hsa-let-7e	CLIP-seq
MIRT2299383	hsa-let-7f	CLIP-seq
MIRT2299384	hsa-let-7g	CLIP-seq
MIRT2299385	hsa-let-7i	CLIP-seq
MIRT2299386	hsa-miR-1269	CLIP-seq
MIRT2299387	hsa-miR-1269b	CLIP-seq
MIRT2299388	hsa-miR-1285	CLIP-seq
MIRT2299389	hsa-miR-1287	CLIP-seq
MIRT2299390	hsa-miR-1288	CLIP-seq
MIRT2299391	hsa-miR-140-3p	CLIP-seq
MIRT2299392	hsa-miR-1587	CLIP-seq
MIRT2299393	hsa-miR-185	CLIP-seq
MIRT2299394	hsa-miR-1972	CLIP-seq
MIRT2299395	hsa-miR-2110	CLIP-seq
MIRT2299396	hsa-miR-214	CLIP-seq
MIRT2299397	hsa-miR-2467-3p	CLIP-seq
MIRT2299398	hsa-miR-3125	CLIP-seq
MIRT2299399	hsa-miR-3134	CLIP-seq
MIRT2299400	hsa-miR-3135b	CLIP-seq
MIRT2299401	hsa-miR-3157-5p	CLIP-seq
MIRT2299402	hsa-miR-3180	CLIP-seq
MIRT2299403	hsa-miR-3180-3p	CLIP-seq
MIRT2299404	hsa-miR-3184	CLIP-seq
MIRT2299405	hsa-miR-3187-5p	CLIP-seq
MIRT2299406	hsa-miR-3196	CLIP-seq
MIRT2299407	hsa-miR-331-3p	CLIP-seq
MIRT2299408	hsa-miR-3619-3p	CLIP-seq
MIRT2299409	hsa-miR-3619-5p	CLIP-seq
MIRT2299410	hsa-miR-378g	CLIP-seq
MIRT2299411	hsa-miR-3916	CLIP-seq
MIRT2299412	hsa-miR-3918	CLIP-seq
MIRT2299413	hsa-miR-3925-5p	CLIP-seq
MIRT2299414	hsa-miR-423-5p	CLIP-seq
MIRT2299415	hsa-miR-4257	CLIP-seq
MIRT2299416	hsa-miR-4271	CLIP-seq
MIRT2299417	hsa-miR-4292	CLIP-seq
MIRT2299418	hsa-miR-4306	CLIP-seq
MIRT2299419	hsa-miR-4330	CLIP-seq
MIRT2299420	hsa-miR-4435	CLIP-seq
MIRT2299421	hsa-miR-4436b-3p	CLIP-seq
MIRT2299422	hsa-miR-4446-3p	CLIP-seq
MIRT2299423	hsa-miR-4458	CLIP-seq
MIRT2299424	hsa-miR-4459	CLIP-seq
MIRT2299425	hsa-miR-4484	CLIP-seq
MIRT2299426	hsa-miR-4488	CLIP-seq
MIRT2299427	hsa-miR-4491	CLIP-seq
MIRT2299428	hsa-miR-4492	CLIP-seq
MIRT2299429	hsa-miR-4498	CLIP-seq
MIRT2299430	hsa-miR-4500	CLIP-seq
MIRT2299431	hsa-miR-4505	CLIP-seq
MIRT2299432	hsa-miR-4515	CLIP-seq
MIRT2299433	hsa-miR-4530	CLIP-seq
MIRT2299434	hsa-miR-4534	CLIP-seq
MIRT2299435	hsa-miR-4640-5p	CLIP-seq
MIRT2299436	hsa-miR-4644	CLIP-seq
MIRT2299437	hsa-miR-4645-5p	CLIP-seq
MIRT2299438	hsa-miR-4656	CLIP-seq
MIRT2299439	hsa-miR-4657	CLIP-seq
MIRT2299440	hsa-miR-4667-5p	CLIP-seq
MIRT2299441	hsa-miR-4668-5p	CLIP-seq
MIRT2299442	hsa-miR-4673	CLIP-seq
MIRT2299443	hsa-miR-4675	CLIP-seq
MIRT2299444	hsa-miR-4685-5p	CLIP-seq
MIRT2299445	hsa-miR-4688	CLIP-seq
MIRT2299446	hsa-miR-4697-5p	CLIP-seq
MIRT2299447	hsa-miR-4699-3p	CLIP-seq
MIRT2299448	hsa-miR-4700-5p	CLIP-seq
MIRT2299449	hsa-miR-4722-5p	CLIP-seq
MIRT2299450	hsa-miR-4725-3p	CLIP-seq
MIRT2299451	hsa-miR-4726-5p	CLIP-seq
MIRT2299452	hsa-miR-4731-5p	CLIP-seq
MIRT2299453	hsa-miR-4740-5p	CLIP-seq
MIRT2299454	hsa-miR-4741	CLIP-seq
MIRT2299455	hsa-miR-4755-3p	CLIP-seq
MIRT2299456	hsa-miR-4764-5p	CLIP-seq
MIRT2299457	hsa-miR-4776-5p	CLIP-seq
MIRT2299458	hsa-miR-4779	CLIP-seq
MIRT2299459	hsa-miR-4788	CLIP-seq
MIRT2299460	hsa-miR-486-3p	CLIP-seq
MIRT2299461	hsa-miR-548an	CLIP-seq
MIRT2299462	hsa-miR-612	CLIP-seq
MIRT2299463	hsa-miR-634	CLIP-seq
MIRT2299464	hsa-miR-658	CLIP-seq
MIRT2299465	hsa-miR-761	CLIP-seq
MIRT2299466	hsa-miR-762	CLIP-seq
MIRT2299467	hsa-miR-767-5p	CLIP-seq
MIRT2299468	hsa-miR-98	CLIP-seq
MIRT2299398	hsa-miR-3125	CLIP-seq
MIRT2299411	hsa-miR-3916	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000444	Component	MIS12/MIND type complex	IBA
GO:0000444	Component	MIS12/MIND type complex	IDA	16585270, 20819937, 27881301
GO:0000444	Component	MIS12/MIND type complex	IEA
GO:0000444	Component	MIS12/MIND type complex	NAS	21633384
GO:0000775	Component	Chromosome, centromeric region	IEA
GO:0000776	Component	Kinetochore	IDA	15371340
GO:0000776	Component	Kinetochore	IEA
GO:0000776	Component	Kinetochore	NAS	21633384, 23418356
GO:0000922	Component	Spindle pole	NAS	21633384
GO:0000940	Component	Outer kinetochore	IDA	24530301
GO:0003713	Function	Transcription coactivator activity	IMP	11256947
GO:0003713	Function	Transcription coactivator activity	TAS	10419538
GO:0005515	Function	Protein binding	IPI	15371340, 15502821, 20360068, 24981860, 25416956, 26496610, 28514442, 32296183, 32814053, 32911434, 35271311, 37398436
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	21633384
GO:0005654	Component	Nucleoplasm	IDA
GO:0005667	Component	Transcription regulator complex	TAS	10419538
GO:0005694	Component	Chromosome	IEA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006366	Process	Transcription by RNA polymerase II	TAS	10419538
GO:0007059	Process	Chromosome segregation	IBA
GO:0007059	Process	Chromosome segregation	IEA
GO:0007059	Process	Chromosome segregation	IMP	15502821
GO:0008608	Process	Attachment of spindle microtubules to kinetochore	NAS	21633384
GO:0043522	Function	Leucine zipper domain binding	IPI	11256947
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0051301	Process	Cell division	IEA

Other IDs

• MIM: 609176
• HGNC: 9112
• e!Ensembl: ENSG00000160783

Interactions View interactions

Pathways

Reactome:

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BREAST CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CLEAR CELL RENAL CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INTRACEREBRAL HEMORRHAGE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
KIDNEY CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYELOPROLIFERATIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SMALL VESSEL STROKE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STROKE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Cerebral Hemorrhage	Associate	37787451	★☆☆☆☆ Found in Text Mining only
Cerebral Small Vessel Diseases	Associate	31430377	★☆☆☆☆ Found in Text Mining only
COVID 19	Associate	37794074	★☆☆☆☆ Found in Text Mining only
Stroke	Associate	36958462	★★☆☆☆ Found in Text Mining + Unknown/Other Associations