Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
11240
Gene name Gene Name - the full gene name approved by the HGNC.
Peptidyl arginine deiminase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PADI2
Synonyms (NCBI Gene) Gene synonyms aliases
PAD-H19, PAD2, PDI2
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p36.13
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distin
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT655549 hsa-miR-5088-3p HITS-CLIP 19536157
MIRT655548 hsa-miR-6734-3p HITS-CLIP 19536157
MIRT655547 hsa-miR-3667-3p HITS-CLIP 19536157
MIRT655544 hsa-miR-623 HITS-CLIP 19536157
MIRT655543 hsa-miR-204-5p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004668 Function Protein-arginine deiminase activity IBA 21873635
GO:0004668 Function Protein-arginine deiminase activity IDA 12392711, 15629448, 18645041, 22853951, 25621824
GO:0005509 Function Calcium ion binding IDA 25621824
GO:0005576 Component Extracellular region TAS
GO:0005634 Component Nucleus IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
607935 18341 ENSG00000117115
Protein
UniProt ID Q9Y2J8
Protein name Protein-arginine deiminase type-2 (EC 3.5.3.15) (PAD-H19) (Peptidylarginine deiminase II) (Protein-arginine deiminase type II)
Protein function Catalyzes the deimination of arginine residues of proteins.
PDB 4N20 , 4N22 , 4N24 , 4N25 , 4N26 , 4N28 , 4N2A , 4N2B , 4N2C , 4N2D , 4N2E , 4N2F , 4N2G , 4N2H , 4N2I , 4N2K , 4N2L , 4N2M , 4N2N , 9B96 , 9B97 , 9B98
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08526 PAD_N 1 114 Protein-arginine deiminase (PAD) N-terminal domain Domain
PF08527 PAD_M 116 274 Protein-arginine deiminase (PAD) middle domain Domain
PF03068 PAD 284 662 Protein-arginine deiminase (PAD) Family
Tissue specificity TISSUE SPECIFICITY: Detected in keratinocytes in epidermis (at protein level). {ECO:0000269|PubMed:12392711}.
Sequence
Sequence length 665
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Chromatin modifying enzymes
Neutrophil degranulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Rheumatoid arthritis Rheumatoid Arthritis rs587776843 30423114
Unknown
Disease term Disease name Evidence References Source
Alzheimer disease Alzheimer disease GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 32629995
Arthritis Rheumatoid Associate 15020330, 17968929, 21859690, 22614825, 24339914, 26245941, 26927695, 27765067, 30161253, 30515171, 31876120, 32255561, 34421923, 34453079, 36076933
View all (3 more)
Breast Neoplasms Associate 22911765, 25211228, 26067809, 34112737, 35737372, 37778380
Carcinogenesis Inhibit 27280713, 28403548
Cardiomyopathy Dilated Associate 39442233
Cognition Disorders Associate 29084334
Colitis Ulcerative Inhibit 27280713
Colitis Ulcerative Associate 38274809
Colorectal Neoplasms Inhibit 27280713, 28403548
Colorectal Neoplasms Associate 31268166