Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
11228
Gene name Gene Name - the full gene name approved by the HGNC.
Ras association domain family member 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RASSF8
Synonyms (NCBI Gene) Gene synonyms aliases
C12orf2, HOJ1
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12p12.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the Ras-assocation domain family (RASSF) of tumor suppressor proteins. This gene is essential for maintaining adherens junction function in epithelial cells and has a role in epithelial cell migration. It is a lung tumor supp
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT017153 hsa-miR-335-5p Microarray 18185580
MIRT019781 hsa-miR-375 Microarray 20215506
MIRT020197 hsa-miR-130b-3p Sequencing 20371350
MIRT021333 hsa-miR-9-5p Microarray 17612493
MIRT026013 hsa-miR-148a-3p Sequencing 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0007165 Process Signal transduction IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
608231 13232 ENSG00000123094
Protein
UniProt ID Q8NHQ8
Protein name Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1)
PDB 2CS4
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00788 RA 1 82 Ras association (RalGDS/AF-6) domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed as a 6.2 kb transcript. A 2.2 kb alternatively spliced transcript is expressed exclusively in testis. {ECO:0000269|PubMed:10951517}.
Sequence
MELKVWVDGVQRIVCGVTEVTTCQEVVIALAQAIGRTGRYTLIEKWRDTERHLAPHENPI
ISLNKWGQYASDVQLILRRTGP
SLSERPTSDSVARIPERTLYRQSLPPLAKLRPQIDKSI
KRREPKRKSLTFTGGAKGLMDIFGKGKETEFKQKVLNNCKTTADELKKLIRLQTEKLQSI
EKQLESNEIEIRFWEQKYNSNLEEEIVRLEQKIKRNDVEIEEEEFWENELQIEQENEKQL
KDQLQEIRQKITECENKLKDYLAQIRTMESGLEAEKLQREVQEAQVNEEEVKGKIGKVKG
EIDIQGQQSLRLENGIKAVERSLGQATKRLQDKEQELEQLTKELRQVNLQQFIQQTGTKV
TVLPAEPIEIEASHADIEREAPFQSGSLKRPGSSRQLPSNLRILQNPISSGFNPEGIYV
Sequence length 419
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Lung carcinoma Small cell carcinoma of lung rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355
View all (44 more)
22941189
Unknown
Disease term Disease name Evidence References Source
Atrial Fibrillation Atrial Fibrillation GWAS
Ankylosing Spondylitis Ankylosing Spondylitis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Inhibit 29467226
Esophageal Squamous Cell Carcinoma Associate 36266257
Goiter Nodular Associate 24516056
Lymphatic Metastasis Associate 24516056
Neoplasm Metastasis Associate 24516056
Neoplasms Associate 24516056, 34077011, 36266257
Neoplasms Inhibit 33000257
Osteosarcoma Associate 34077011
Squamous Cell Carcinoma of Head and Neck Inhibit 33000257
Thyroid cancer medullary Stimulate 24516056