Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	11224
Gene name Gene Name - the full gene name approved by the HGNC.	Ribosomal protein L35
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RPL35
Synonyms (NCBI Gene) Gene synonyms aliases	DBA19, L35, uL29
Chromosome Chromosome number	9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	9q33.3
Summary Summary of gene provided in NCBI Entrez Gene.	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

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miRTarBase ID	miRNA	Experiments	Reference
MIRT037236	hsa-miR-877-5p	CLASH	23622248
MIRT036416	hsa-miR-1226-3p	CLASH	23622248
MIRT035932	hsa-miR-1180-3p	CLASH	23622248
MIRT687016	hsa-miR-6856-3p	HITS-CLIP	23313552
MIRT687015	hsa-miR-4274	HITS-CLIP	23313552
MIRT687014	hsa-miR-6858-3p	HITS-CLIP	23313552
MIRT687013	hsa-miR-1245b-5p	HITS-CLIP	23313552
MIRT687012	hsa-miR-3142	HITS-CLIP	23313552
MIRT687011	hsa-miR-4787-3p	HITS-CLIP	23313552
MIRT687010	hsa-miR-4691-3p	HITS-CLIP	23313552
MIRT687009	hsa-miR-1972	HITS-CLIP	23313552
MIRT687008	hsa-miR-4650-5p	HITS-CLIP	23313552
MIRT687007	hsa-miR-6787-3p	HITS-CLIP	23313552
MIRT687006	hsa-miR-5008-3p	HITS-CLIP	23313552
MIRT687005	hsa-miR-6737-3p	HITS-CLIP	23313552
MIRT687004	hsa-miR-7157-3p	HITS-CLIP	23313552
MIRT687003	hsa-miR-4749-3p	HITS-CLIP	23313552
MIRT687002	hsa-miR-6743-3p	HITS-CLIP	23313552
MIRT687001	hsa-miR-3157-5p	HITS-CLIP	23313552
MIRT687000	hsa-miR-218-5p	HITS-CLIP	23313552
MIRT687016	hsa-miR-6856-3p	HITS-CLIP	23313552
MIRT687015	hsa-miR-4274	HITS-CLIP	23313552
MIRT687014	hsa-miR-6858-3p	HITS-CLIP	23313552
MIRT687013	hsa-miR-1245b-5p	HITS-CLIP	23313552
MIRT687012	hsa-miR-3142	HITS-CLIP	23313552
MIRT687011	hsa-miR-4787-3p	HITS-CLIP	23313552
MIRT687010	hsa-miR-4691-3p	HITS-CLIP	23313552
MIRT687009	hsa-miR-1972	HITS-CLIP	23313552
MIRT687008	hsa-miR-4650-5p	HITS-CLIP	23313552
MIRT687007	hsa-miR-6787-3p	HITS-CLIP	23313552
MIRT687006	hsa-miR-5008-3p	HITS-CLIP	23313552
MIRT687005	hsa-miR-6737-3p	HITS-CLIP	23313552
MIRT687004	hsa-miR-7157-3p	HITS-CLIP	23313552
MIRT687003	hsa-miR-4749-3p	HITS-CLIP	23313552
MIRT687002	hsa-miR-6743-3p	HITS-CLIP	23313552
MIRT687001	hsa-miR-3157-5p	HITS-CLIP	23313552
MIRT687000	hsa-miR-218-5p	HITS-CLIP	23313552
MIRT1316752	hsa-miR-218	CLIP-seq
MIRT1316753	hsa-miR-636	CLIP-seq
MIRT1316752	hsa-miR-218	CLIP-seq
MIRT1316753	hsa-miR-636	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000463	Process	Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA
GO:0000463	Process	Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IEA
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003729	Function	MRNA binding	IBA
GO:0003729	Function	MRNA binding	TAS
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399, 32669547
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0003735	Function	Structural constituent of ribosome	TAS
GO:0005730	Component	Nucleolus	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	12962325
GO:0006412	Process	Translation	TAS
GO:0015934	Component	Large ribosomal subunit	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA
GO:0022625	Component	Cytosolic large ribosomal subunit	IDA	32669547
GO:0022625	Component	Cytosolic large ribosomal subunit	IEA
GO:0022625	Component	Cytosolic large ribosomal subunit	IPI	25901680
GO:0022625	Component	Cytosolic large ribosomal subunit	TAS
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
618315	10344	ENSG00000136942

Protein

UniProt ID

P42766

Protein name

Large ribosomal subunit protein uL29 (60S ribosomal protein L35)

Protein function

Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669

PDB

4UG0 , 4V6X , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6IP6 , 6IP8 , 6LQM , 6LSR , 6LSS , 6LU8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6SXO , 6W6L , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 7BHP , 7F5S , 7OW7 , 7QVP , 7XNX , 7XNY , 8A3D , 8FKP , 8FKQ , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00831	Ribosomal_L29	7 → 63	Ribosomal L29 protein	Family

Sequence

MAKIKARDLRGKKKEELLKQLDDLKVELSQLRVAKVTGGAASKLSKIRVVRKSIARVLTV
INQTQKENLRKFYKGKKYKPLDLRPKKTRAMRRRLNKHEENLKTKKQQRKERLYPLRKYA
VKA

Sequence length

123

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Show/Hide Causal Diseases (1)

Disease merge term	Disease name	dbSNP ID	References
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Diamond-Blackfan anemia	Diamond-Blackfan anemia 19	rs1564307664	N/A

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Alzheimer Disease	Associate	38176923
Colonic Neoplasms	Associate	25107436
Hyperlipoproteinemia Type II	Associate	27173180
Lymphatic Metastasis	Associate	21319141
Uterine Cervical Neoplasms	Associate	21319141

RPL35 (ribosomal protein L35)