Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
11213
Gene name Gene Name - the full gene name approved by the HGNC.
Interleukin 1 receptor associated kinase 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
IRAK3
Synonyms (NCBI Gene) Gene synonyms aliases
ASRT5, IRAKM
Disease Acronyms (UniProt) Disease acronyms from UniProt database
ASRT5
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q14.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophag
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs121912630 G>A Risk-factor Coding sequence variant, intron variant, stop gained
rs150116809 G>A,T Risk-factor Splice donor variant
rs367600113 C>T Likely-pathogenic Stop gained, coding sequence variant
rs764674154 ->TGA Likely-pathogenic Coding sequence variant, stop gained
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005808 hsa-miR-155-3p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 20852130
MIRT023129 hsa-miR-124-3p Microarray 18668037
MIRT051159 hsa-miR-16-5p CLASH 23622248
MIRT664811 hsa-miR-4486 HITS-CLIP 23824327
MIRT670949 hsa-miR-605-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000287 Function Magnesium ion binding IDA 10383454
GO:0001960 Process Negative regulation of cytokine-mediated signaling pathway IC 12150927
GO:0002755 Process MyD88-dependent toll-like receptor signaling pathway TAS 10383454
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
GO:0004674 Function Protein serine/threonine kinase activity IDA 10383454
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604459 17020 ENSG00000090376
Protein
UniProt ID Q9Y616
Protein name Interleukin-1 receptor-associated kinase 3 (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) (Inactive IL-1 receptor-associated kinase 3)
Protein function Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors (PubMed:10383454, PubMed:29686383). Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling c
PDB 5UKE , 6RUU , 6ZIW
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00531 Death 26 106 Death domain Domain
PF00069 Pkinase 165 443 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in eosinophils, dendritic cells and/or monocytes (at protein level) (PubMed:29686383). Expressed predominantly in peripheral blood lymphocytes (PubMed:10383454). {ECO:0000269|PubMed:10383454, ECO:0000269|PubMed:29686383}.
Sequence
Sequence length 596
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Neurotrophin signaling pathway   MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Interleukin-1 signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Asthma asthma-related traits, susceptibility to, 5 GenCC
Associations from Text Mining
Disease Name Relationship Type References
Acute Lung Injury Associate 21297081, 22742663
Alzheimer Disease Associate 32755048
Aneurysm Ruptured Associate 33990177
Aortic Dissection Associate 35178459
Asthma Associate 17503328, 33156843, 37029363
Asthma Stimulate 28223794
Carcinoma Hepatocellular Associate 25852282
Cardiomyopathy Hypertrophic Associate 38277535
Cerebral Infarction Associate 35432334
Colitis Lymphocytic Stimulate 25232259