Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1119
Gene name Gene Name - the full gene name approved by the HGNC.	Choline kinase alpha
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CHKA
Synonyms (NCBI Gene) Gene synonyms aliases	CHK, CK, CKI, EK, NEDMIMS
Disease Acronyms (UniProt) Disease acronyms from UniProt database	NEDMIMS
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11q13.2
Summary Summary of gene provided in NCBI Entrez Gene.	The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation

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miRTarBase ID	miRNA	Experiments
MIRT890114	hsa-miR-1272	CLIP-seq
MIRT890115	hsa-miR-1299	CLIP-seq
MIRT890116	hsa-miR-136	CLIP-seq
MIRT890117	hsa-miR-150	CLIP-seq
MIRT890118	hsa-miR-188-3p	CLIP-seq
MIRT890119	hsa-miR-199a-3p	CLIP-seq
MIRT890120	hsa-miR-199b-3p	CLIP-seq
MIRT890121	hsa-miR-2467-3p	CLIP-seq
MIRT890122	hsa-miR-2964a-5p	CLIP-seq
MIRT890123	hsa-miR-3129-5p	CLIP-seq
MIRT890124	hsa-miR-3174	CLIP-seq
MIRT890125	hsa-miR-3612	CLIP-seq
MIRT890126	hsa-miR-3682-3p	CLIP-seq
MIRT890127	hsa-miR-374c	CLIP-seq
MIRT890128	hsa-miR-3919	CLIP-seq
MIRT890129	hsa-miR-4438	CLIP-seq
MIRT890130	hsa-miR-4443	CLIP-seq
MIRT890131	hsa-miR-4514	CLIP-seq
MIRT890132	hsa-miR-4643	CLIP-seq
MIRT890133	hsa-miR-4645-5p	CLIP-seq
MIRT890134	hsa-miR-466	CLIP-seq
MIRT890135	hsa-miR-4673	CLIP-seq
MIRT890136	hsa-miR-4688	CLIP-seq
MIRT890137	hsa-miR-4692	CLIP-seq
MIRT890138	hsa-miR-4711-5p	CLIP-seq
MIRT890139	hsa-miR-4713-5p	CLIP-seq
MIRT890140	hsa-miR-4717-5p	CLIP-seq
MIRT890141	hsa-miR-4756-3p	CLIP-seq
MIRT890142	hsa-miR-4758-3p	CLIP-seq
MIRT890143	hsa-miR-4782-5p	CLIP-seq
MIRT890144	hsa-miR-4789-3p	CLIP-seq
MIRT890145	hsa-miR-485-3p	CLIP-seq
MIRT890146	hsa-miR-487a	CLIP-seq
MIRT890147	hsa-miR-5095	CLIP-seq
MIRT890148	hsa-miR-516b	CLIP-seq
MIRT890149	hsa-miR-532-3p	CLIP-seq
MIRT890150	hsa-miR-626	CLIP-seq
MIRT890151	hsa-miR-650	CLIP-seq
MIRT890152	hsa-miR-655	CLIP-seq
MIRT890153	hsa-miR-759	CLIP-seq
MIRT890154	hsa-miR-921	CLIP-seq
MIRT890155	hsa-miR-936	CLIP-seq
MIRT890156	hsa-miR-103a	CLIP-seq
MIRT890157	hsa-miR-107	CLIP-seq
MIRT890158	hsa-miR-1270	CLIP-seq
MIRT890159	hsa-miR-1273	CLIP-seq
MIRT890115	hsa-miR-1299	CLIP-seq
MIRT890160	hsa-miR-1301	CLIP-seq
MIRT890161	hsa-miR-134	CLIP-seq
MIRT890162	hsa-miR-1825	CLIP-seq
MIRT890163	hsa-miR-1915	CLIP-seq
MIRT890164	hsa-miR-199a-5p	CLIP-seq
MIRT890165	hsa-miR-199b-5p	CLIP-seq
MIRT890121	hsa-miR-2467-3p	CLIP-seq
MIRT890166	hsa-miR-3118	CLIP-seq
MIRT890125	hsa-miR-3612	CLIP-seq
MIRT890167	hsa-miR-432	CLIP-seq
MIRT890168	hsa-miR-4434	CLIP-seq
MIRT890130	hsa-miR-4443	CLIP-seq
MIRT890131	hsa-miR-4514	CLIP-seq
MIRT890169	hsa-miR-4516	CLIP-seq
MIRT890170	hsa-miR-4519	CLIP-seq
MIRT890171	hsa-miR-4531	CLIP-seq
MIRT890172	hsa-miR-455-3p	CLIP-seq
MIRT890133	hsa-miR-4645-5p	CLIP-seq
MIRT890135	hsa-miR-4673	CLIP-seq
MIRT890136	hsa-miR-4688	CLIP-seq
MIRT890137	hsa-miR-4692	CLIP-seq
MIRT890138	hsa-miR-4711-5p	CLIP-seq
MIRT890140	hsa-miR-4717-5p	CLIP-seq
MIRT890143	hsa-miR-4782-5p	CLIP-seq
MIRT890173	hsa-miR-5047	CLIP-seq
MIRT890148	hsa-miR-516b	CLIP-seq
MIRT890174	hsa-miR-548ag	CLIP-seq
MIRT890175	hsa-miR-548ai	CLIP-seq
MIRT890176	hsa-miR-548m	CLIP-seq
MIRT890177	hsa-miR-589	CLIP-seq
MIRT890178	hsa-miR-620	CLIP-seq
MIRT890151	hsa-miR-650	CLIP-seq
MIRT890179	hsa-miR-873	CLIP-seq
MIRT1922663	hsa-miR-4302	CLIP-seq
MIRT1922664	hsa-miR-4738-3p	CLIP-seq
MIRT1963731	hsa-miR-1251	CLIP-seq
MIRT890163	hsa-miR-1915	CLIP-seq
MIRT1963732	hsa-miR-203	CLIP-seq
MIRT1963733	hsa-miR-224	CLIP-seq
MIRT1963734	hsa-miR-27a	CLIP-seq
MIRT1963735	hsa-miR-27b	CLIP-seq
MIRT1963736	hsa-miR-3713	CLIP-seq
MIRT1963737	hsa-miR-4297	CLIP-seq
MIRT890168	hsa-miR-4434	CLIP-seq
MIRT1963738	hsa-miR-4467	CLIP-seq
MIRT890169	hsa-miR-4516	CLIP-seq
MIRT1963739	hsa-miR-4684-5p	CLIP-seq
MIRT1963740	hsa-miR-4717-3p	CLIP-seq
MIRT1963741	hsa-miR-4777-5p	CLIP-seq
MIRT1963742	hsa-miR-4796-5p	CLIP-seq
MIRT1963743	hsa-miR-520a-5p	CLIP-seq
MIRT1963744	hsa-miR-525-5p	CLIP-seq
MIRT1963745	hsa-miR-532-5p	CLIP-seq
MIRT1963746	hsa-miR-604	CLIP-seq
MIRT890150	hsa-miR-626	CLIP-seq
MIRT1963747	hsa-miR-647	CLIP-seq
MIRT1963748	hsa-miR-767-3p	CLIP-seq
MIRT1963749	hsa-miR-942	CLIP-seq
MIRT890156	hsa-miR-103a	CLIP-seq
MIRT890157	hsa-miR-107	CLIP-seq
MIRT890160	hsa-miR-1301	CLIP-seq
MIRT890116	hsa-miR-136	CLIP-seq
MIRT2200045	hsa-miR-1976	CLIP-seq
MIRT890119	hsa-miR-199a-3p	CLIP-seq
MIRT890120	hsa-miR-199b-3p	CLIP-seq
MIRT1963733	hsa-miR-224	CLIP-seq
MIRT2200046	hsa-miR-2278	CLIP-seq
MIRT890121	hsa-miR-2467-3p	CLIP-seq
MIRT1963734	hsa-miR-27a	CLIP-seq
MIRT1963735	hsa-miR-27b	CLIP-seq
MIRT2200047	hsa-miR-3064-3p	CLIP-seq
MIRT2200048	hsa-miR-3120-5p	CLIP-seq
MIRT890123	hsa-miR-3129-5p	CLIP-seq
MIRT2200049	hsa-miR-3130-3p	CLIP-seq
MIRT890124	hsa-miR-3174	CLIP-seq
MIRT2200050	hsa-miR-3175	CLIP-seq
MIRT2200051	hsa-miR-3200-3p	CLIP-seq
MIRT2200052	hsa-miR-346	CLIP-seq
MIRT2200053	hsa-miR-3616-3p	CLIP-seq
MIRT2200054	hsa-miR-3680	CLIP-seq
MIRT2200055	hsa-miR-3689a-3p	CLIP-seq
MIRT2200056	hsa-miR-3689c	CLIP-seq
MIRT890127	hsa-miR-374c	CLIP-seq
MIRT2200057	hsa-miR-3973	CLIP-seq
MIRT2200058	hsa-miR-4288	CLIP-seq
MIRT2200059	hsa-miR-4325	CLIP-seq
MIRT2200060	hsa-miR-4433	CLIP-seq
MIRT890168	hsa-miR-4434	CLIP-seq
MIRT2200061	hsa-miR-4436b-3p	CLIP-seq
MIRT2200062	hsa-miR-4454	CLIP-seq
MIRT2200063	hsa-miR-4459	CLIP-seq
MIRT2200064	hsa-miR-4468	CLIP-seq
MIRT890131	hsa-miR-4514	CLIP-seq
MIRT890169	hsa-miR-4516	CLIP-seq
MIRT890170	hsa-miR-4519	CLIP-seq
MIRT890132	hsa-miR-4643	CLIP-seq
MIRT890133	hsa-miR-4645-5p	CLIP-seq
MIRT890134	hsa-miR-466	CLIP-seq
MIRT2200065	hsa-miR-4661-3p	CLIP-seq
MIRT890135	hsa-miR-4673	CLIP-seq
MIRT2200066	hsa-miR-4687-3p	CLIP-seq
MIRT890137	hsa-miR-4692	CLIP-seq
MIRT1963740	hsa-miR-4717-3p	CLIP-seq
MIRT2200067	hsa-miR-4722-3p	CLIP-seq
MIRT2200068	hsa-miR-4722-5p	CLIP-seq
MIRT2200069	hsa-miR-4768-3p	CLIP-seq
MIRT890144	hsa-miR-4789-3p	CLIP-seq
MIRT2200070	hsa-miR-4793-3p	CLIP-seq
MIRT2200071	hsa-miR-4798-3p	CLIP-seq
MIRT890145	hsa-miR-485-3p	CLIP-seq
MIRT890146	hsa-miR-487a	CLIP-seq
MIRT890173	hsa-miR-5047	CLIP-seq
MIRT2200072	hsa-miR-508-5p	CLIP-seq
MIRT2200073	hsa-miR-513a-5p	CLIP-seq
MIRT2200074	hsa-miR-548k	CLIP-seq
MIRT890150	hsa-miR-626	CLIP-seq
MIRT2200075	hsa-miR-632	CLIP-seq
MIRT890152	hsa-miR-655	CLIP-seq
MIRT890154	hsa-miR-921	CLIP-seq
MIRT890155	hsa-miR-936	CLIP-seq
MIRT2386021	hsa-miR-25	CLIP-seq
MIRT2386022	hsa-miR-32	CLIP-seq
MIRT2386023	hsa-miR-363	CLIP-seq
MIRT2386024	hsa-miR-367	CLIP-seq
MIRT2200059	hsa-miR-4325	CLIP-seq
MIRT2386025	hsa-miR-4684-3p	CLIP-seq
MIRT2386026	hsa-miR-92a	CLIP-seq
MIRT2386027	hsa-miR-92b	CLIP-seq
MIRT2502812	hsa-miR-1178	CLIP-seq
MIRT2502813	hsa-miR-1204	CLIP-seq
MIRT2502814	hsa-miR-1207-5p	CLIP-seq
MIRT890159	hsa-miR-1273	CLIP-seq
MIRT2502815	hsa-miR-1283	CLIP-seq
MIRT2502816	hsa-miR-1909	CLIP-seq
MIRT2502817	hsa-miR-1913	CLIP-seq
MIRT1963733	hsa-miR-224	CLIP-seq
MIRT2200048	hsa-miR-3120-5p	CLIP-seq
MIRT2200049	hsa-miR-3130-3p	CLIP-seq
MIRT2200050	hsa-miR-3175	CLIP-seq
MIRT2502818	hsa-miR-3189-3p	CLIP-seq
MIRT2502819	hsa-miR-3202	CLIP-seq
MIRT2502820	hsa-miR-324-3p	CLIP-seq
MIRT2200052	hsa-miR-346	CLIP-seq
MIRT2502821	hsa-miR-3614-5p	CLIP-seq
MIRT2502822	hsa-miR-3663-3p	CLIP-seq
MIRT2200055	hsa-miR-3689a-3p	CLIP-seq
MIRT2200056	hsa-miR-3689c	CLIP-seq
MIRT2200058	hsa-miR-4288	CLIP-seq
MIRT2502823	hsa-miR-4313	CLIP-seq
MIRT2200060	hsa-miR-4433	CLIP-seq
MIRT890168	hsa-miR-4434	CLIP-seq
MIRT2200061	hsa-miR-4436b-3p	CLIP-seq
MIRT2200063	hsa-miR-4459	CLIP-seq
MIRT2502824	hsa-miR-4476	CLIP-seq
MIRT890169	hsa-miR-4516	CLIP-seq
MIRT2200066	hsa-miR-4687-3p	CLIP-seq
MIRT2502825	hsa-miR-4701-5p	CLIP-seq
MIRT1963740	hsa-miR-4717-3p	CLIP-seq
MIRT2502826	hsa-miR-4763-3p	CLIP-seq
MIRT2200069	hsa-miR-4768-3p	CLIP-seq
MIRT2502827	hsa-miR-4780	CLIP-seq
MIRT2200070	hsa-miR-4793-3p	CLIP-seq
MIRT1963742	hsa-miR-4796-5p	CLIP-seq
MIRT2502828	hsa-miR-588	CLIP-seq
MIRT2502829	hsa-miR-623	CLIP-seq
MIRT890150	hsa-miR-626	CLIP-seq
MIRT2200075	hsa-miR-632	CLIP-seq
MIRT1963748	hsa-miR-767-3p	CLIP-seq
MIRT2502812	hsa-miR-1178	CLIP-seq
MIRT2502813	hsa-miR-1204	CLIP-seq
MIRT2502814	hsa-miR-1207-5p	CLIP-seq
MIRT2678091	hsa-miR-1226	CLIP-seq
MIRT890159	hsa-miR-1273	CLIP-seq
MIRT2678092	hsa-miR-128	CLIP-seq
MIRT2502815	hsa-miR-1283	CLIP-seq
MIRT2678093	hsa-miR-181a	CLIP-seq
MIRT2678094	hsa-miR-181b	CLIP-seq
MIRT2678095	hsa-miR-181c	CLIP-seq
MIRT2678096	hsa-miR-181d	CLIP-seq
MIRT2502816	hsa-miR-1909	CLIP-seq
MIRT2502817	hsa-miR-1913	CLIP-seq
MIRT2678097	hsa-miR-197	CLIP-seq
MIRT890119	hsa-miR-199a-3p	CLIP-seq
MIRT890120	hsa-miR-199b-3p	CLIP-seq
MIRT1963733	hsa-miR-224	CLIP-seq
MIRT1963734	hsa-miR-27a	CLIP-seq
MIRT1963735	hsa-miR-27b	CLIP-seq
MIRT890122	hsa-miR-2964a-5p	CLIP-seq
MIRT2200047	hsa-miR-3064-3p	CLIP-seq
MIRT2200048	hsa-miR-3120-5p	CLIP-seq
MIRT890123	hsa-miR-3129-5p	CLIP-seq
MIRT2200049	hsa-miR-3130-3p	CLIP-seq
MIRT2678098	hsa-miR-3144-5p	CLIP-seq
MIRT2200050	hsa-miR-3175	CLIP-seq
MIRT2502818	hsa-miR-3189-3p	CLIP-seq
MIRT2502819	hsa-miR-3202	CLIP-seq
MIRT2502820	hsa-miR-324-3p	CLIP-seq
MIRT2200052	hsa-miR-346	CLIP-seq
MIRT2502821	hsa-miR-3614-5p	CLIP-seq
MIRT2502822	hsa-miR-3663-3p	CLIP-seq
MIRT2200055	hsa-miR-3689a-3p	CLIP-seq
MIRT2200056	hsa-miR-3689c	CLIP-seq
MIRT2678099	hsa-miR-4255	CLIP-seq
MIRT2678100	hsa-miR-4262	CLIP-seq
MIRT2200058	hsa-miR-4288	CLIP-seq
MIRT2502823	hsa-miR-4313	CLIP-seq
MIRT2200060	hsa-miR-4433	CLIP-seq
MIRT890168	hsa-miR-4434	CLIP-seq
MIRT2200061	hsa-miR-4436b-3p	CLIP-seq
MIRT2200063	hsa-miR-4459	CLIP-seq
MIRT2502824	hsa-miR-4476	CLIP-seq
MIRT890169	hsa-miR-4516	CLIP-seq
MIRT2200066	hsa-miR-4687-3p	CLIP-seq
MIRT890136	hsa-miR-4688	CLIP-seq
MIRT2502825	hsa-miR-4701-5p	CLIP-seq
MIRT890138	hsa-miR-4711-5p	CLIP-seq
MIRT1963740	hsa-miR-4717-3p	CLIP-seq
MIRT2678101	hsa-miR-4733-3p	CLIP-seq
MIRT2502826	hsa-miR-4763-3p	CLIP-seq
MIRT2200069	hsa-miR-4768-3p	CLIP-seq
MIRT2502827	hsa-miR-4780	CLIP-seq
MIRT2200070	hsa-miR-4793-3p	CLIP-seq
MIRT1963742	hsa-miR-4796-5p	CLIP-seq
MIRT890174	hsa-miR-548ag	CLIP-seq
MIRT890175	hsa-miR-548ai	CLIP-seq
MIRT890176	hsa-miR-548m	CLIP-seq
MIRT2502828	hsa-miR-588	CLIP-seq
MIRT2502829	hsa-miR-623	CLIP-seq
MIRT890150	hsa-miR-626	CLIP-seq
MIRT2200075	hsa-miR-632	CLIP-seq
MIRT2678102	hsa-miR-634	CLIP-seq
MIRT1963748	hsa-miR-767-3p	CLIP-seq
MIRT890179	hsa-miR-873	CLIP-seq

Show/Hide all(21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004103	Function	Choline kinase activity	IDA	19915674
GO:0004104	Function	Cholinesterase activity	IEA
GO:0004305	Function	Ethanolamine kinase activity	IDA	19915674
GO:0005524	Function	ATP binding	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006580	Process	Ethanolamine metabolic process	IEA
GO:0006629	Process	Lipid metabolic process	TAS	10363580
GO:0006646	Process	Phosphatidylethanolamine biosynthetic process	IDA	19915674
GO:0006646	Process	Phosphatidylethanolamine biosynthetic process	IEA
GO:0006646	Process	Phosphatidylethanolamine biosynthetic process	TAS
GO:0006656	Process	Phosphatidylcholine biosynthetic process	IDA	19915674
GO:0006656	Process	Phosphatidylcholine biosynthetic process	TAS
GO:0006657	Process	CDP-choline pathway	IEA
GO:0006869	Process	Lipid transport	TAS	10363580
GO:0008144	Function	Drug binding	IDA	19915674
GO:0009636	Process	Response to toxic substance	IEA
GO:0016310	Process	Phosphorylation	IEA
GO:0019695	Process	Choline metabolic process	IEA
GO:0033265	Function	Choline binding	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:1904681	Process	Response to 3-methylcholanthrene	IEA

MIM	HGNC	e!Ensembl
118491	1937	ENSG00000110721

Protein

UniProt ID

P35790

Protein name

Choline kinase alpha (CK) (EC 2.7.1.32) (CHETK-alpha) (Ethanolamine kinase) (EK) (EC 2.7.1.82)

Protein function

Plays a key role in phospholipid biosynthesis by catalyzing the phosphorylation of free choline to phosphocholine, the first step in phosphatidylcholine biosynthesis (PubMed:17007874, PubMed:19915674, PubMed:23416529, PubMed:34077757). Also phos

PDB

2CKO , 2CKP , 2CKQ , 2I7Q , 3F2R , 3G15 , 3ZM9 , 4BR3 , 4CG8 , 4CG9 , 4CGA , 4DA5 , 5AFV , 5EQE , 5EQP , 5EQY , 5FTG , 5FUT , 5W6O , 7A04 , 7A06 , 7NB1 , 7NB2 , 7NB3 , 8BI5 , 8BI6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01633	Choline_kinase	139 → 374		Family

Sequence

MKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGGQQPPLALPPP
PPLPLPLPLPQPPPPQPPADEQPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGL
SNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQMRSCNKEGSEQAQKENEFQGAEAMVLE
SVMFAILAERSLGPKLYGIFPQGRLEQFIPSRRLDTEELSLPDISAEIAEKMATFHGMKM
PFNKEPKWLFGTMEKYLKEVLRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPV
VFCHNDCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYP
FFRANIRKYPTKKQQLHFISSYLPAFQNDFENLSTEEKSIIKEEMLLEVNRFALASHFLW
GLWSIVQAKISSIEFGYMDYAQARFDAYFHQKRKLGV

Sequence length

457

Interactions

View interactions

	KEGG		Reactome
	Glycerophospholipid metabolism Metabolic pathways Choline metabolism in cancer		Synthesis of PC Synthesis of PE

CHKA (choline kinase alpha)