RASSF1 (Ras association domain family member 1)

Gene

• Entrez ID: 11186
• Gene name: Ras association domain family member 1
• Gene symbol: RASSF1
• Synonyms (NCBI Gene): 123F2, NORE2A, RASSF1A, RDA32, REH3P21
• Chromosome: 3
• Chromosome location: 3p21.31
• Summary: This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of thi

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT006022	hsa-miR-373-3p	Luciferase reporter assay, qRT-PCR, Western blot	21086164
MIRT006022	hsa-miR-373-3p	Luciferase reporter assay, qRT-PCR, Western blot	21086164
MIRT006022	hsa-miR-373-3p	Luciferase reporter assay, qRT-PCR, Western blot	21086164
MIRT006022	hsa-miR-373-3p	Luciferase reporter assay, qRT-PCR, Western blot	21086164
MIRT006022	hsa-miR-373-3p	Luciferase reporter assay, qRT-PCR, Western blot	21086164
MIRT006022	hsa-miR-373-3p	Luciferase reporter assay, qRT-PCR, Western blot	21086164
MIRT016088	hsa-miR-744-5p	Sequencing	20371350
MIRT020199	hsa-miR-130b-3p	Sequencing	20371350
MIRT022310	hsa-miR-124-3p	Microarray	18668037
MIRT023590	hsa-miR-1-3p	Microarray	18668037
MIRT031097	hsa-miR-19b-3p	Sequencing	20371350
MIRT045120	hsa-miR-186-5p	CLASH	23622248
MIRT1292630	hsa-miR-1285	CLIP-seq
MIRT1292631	hsa-miR-2117	CLIP-seq
MIRT1292632	hsa-miR-3138	CLIP-seq
MIRT1292633	hsa-miR-3187-5p	CLIP-seq
MIRT1292634	hsa-miR-326	CLIP-seq
MIRT1292635	hsa-miR-330-5p	CLIP-seq
MIRT1292636	hsa-miR-378g	CLIP-seq
MIRT1292637	hsa-miR-4270	CLIP-seq
MIRT1292638	hsa-miR-4273	CLIP-seq
MIRT1292639	hsa-miR-4437	CLIP-seq
MIRT1292640	hsa-miR-4441	CLIP-seq
MIRT1292641	hsa-miR-4486	CLIP-seq
MIRT1292642	hsa-miR-4674	CLIP-seq
MIRT1292643	hsa-miR-4794	CLIP-seq
MIRT1292644	hsa-miR-552	CLIP-seq
MIRT1292645	hsa-miR-612	CLIP-seq
MIRT1292646	hsa-miR-619	CLIP-seq
MIRT1292647	hsa-miR-639	CLIP-seq
MIRT1292648	hsa-miR-10a	CLIP-seq
MIRT1292649	hsa-miR-10b	CLIP-seq
MIRT1292650	hsa-miR-1182	CLIP-seq
MIRT1292651	hsa-miR-1207-3p	CLIP-seq
MIRT1292652	hsa-miR-1224-5p	CLIP-seq
MIRT1292653	hsa-miR-1291	CLIP-seq
MIRT1292654	hsa-miR-146b-3p	CLIP-seq
MIRT1292655	hsa-miR-1825	CLIP-seq
MIRT1292656	hsa-miR-1909	CLIP-seq
MIRT1292657	hsa-miR-2355-5p	CLIP-seq
MIRT1292658	hsa-miR-3120-5p	CLIP-seq
MIRT1292659	hsa-miR-3150b-3p	CLIP-seq
MIRT1292660	hsa-miR-3182	CLIP-seq
MIRT1292661	hsa-miR-328	CLIP-seq
MIRT1292662	hsa-miR-339-5p	CLIP-seq
MIRT1292663	hsa-miR-342-3p	CLIP-seq
MIRT1292664	hsa-miR-346	CLIP-seq
MIRT1292665	hsa-miR-3612	CLIP-seq
MIRT1292666	hsa-miR-3679-3p	CLIP-seq
MIRT1292667	hsa-miR-371b-3p	CLIP-seq
MIRT1292668	hsa-miR-3915	CLIP-seq
MIRT1292669	hsa-miR-4251	CLIP-seq
MIRT1292670	hsa-miR-4286	CLIP-seq
MIRT1292671	hsa-miR-4288	CLIP-seq
MIRT1292672	hsa-miR-4303	CLIP-seq
MIRT1292673	hsa-miR-4329	CLIP-seq
MIRT1292674	hsa-miR-4459	CLIP-seq
MIRT1292675	hsa-miR-4640-5p	CLIP-seq
MIRT1292676	hsa-miR-4649-3p	CLIP-seq
MIRT1292677	hsa-miR-4652-3p	CLIP-seq
MIRT1292678	hsa-miR-4689	CLIP-seq
MIRT1292679	hsa-miR-4695-5p	CLIP-seq
MIRT1292680	hsa-miR-4717-5p	CLIP-seq
MIRT1292681	hsa-miR-4725-5p	CLIP-seq
MIRT1292682	hsa-miR-4726-5p	CLIP-seq
MIRT1292683	hsa-miR-4784	CLIP-seq
MIRT1292684	hsa-miR-490-3p	CLIP-seq
MIRT1292685	hsa-miR-504	CLIP-seq
MIRT1292686	hsa-miR-5096	CLIP-seq
MIRT1292687	hsa-miR-515-5p	CLIP-seq
MIRT1292688	hsa-miR-632	CLIP-seq
MIRT1292689	hsa-miR-650	CLIP-seq
MIRT1292674	hsa-miR-4459	CLIP-seq
MIRT2086928	hsa-miR-4512	CLIP-seq
MIRT2086929	hsa-miR-4779	CLIP-seq
MIRT1292663	hsa-miR-342-3p	CLIP-seq
MIRT2457790	hsa-miR-185	CLIP-seq
MIRT2457791	hsa-miR-3119	CLIP-seq
MIRT2457792	hsa-miR-3126-5p	CLIP-seq
MIRT2457793	hsa-miR-3622a-3p	CLIP-seq
MIRT2457794	hsa-miR-3622b-3p	CLIP-seq
MIRT2457795	hsa-miR-4306	CLIP-seq
MIRT2457796	hsa-miR-4419a	CLIP-seq
MIRT2457797	hsa-miR-4510	CLIP-seq
MIRT2457798	hsa-miR-4644	CLIP-seq
MIRT1292681	hsa-miR-4725-5p	CLIP-seq
MIRT1292685	hsa-miR-504	CLIP-seq
MIRT2457799	hsa-miR-544b	CLIP-seq
MIRT1292648	hsa-miR-10a	CLIP-seq
MIRT1292649	hsa-miR-10b	CLIP-seq
MIRT1292650	hsa-miR-1182	CLIP-seq
MIRT2608228	hsa-miR-1205	CLIP-seq
MIRT1292651	hsa-miR-1207-3p	CLIP-seq
MIRT1292652	hsa-miR-1224-5p	CLIP-seq
MIRT2608229	hsa-miR-1238	CLIP-seq
MIRT2608230	hsa-miR-124	CLIP-seq
MIRT2608231	hsa-miR-1254	CLIP-seq
MIRT2608232	hsa-miR-125a-5p	CLIP-seq
MIRT2608233	hsa-miR-125b	CLIP-seq
MIRT2608234	hsa-miR-1266	CLIP-seq
MIRT2608235	hsa-miR-181a	CLIP-seq
MIRT2608236	hsa-miR-181b	CLIP-seq
MIRT2608237	hsa-miR-181c	CLIP-seq
MIRT2608238	hsa-miR-181d	CLIP-seq
MIRT2457790	hsa-miR-185	CLIP-seq
MIRT1292656	hsa-miR-1909	CLIP-seq
MIRT2608239	hsa-miR-1915	CLIP-seq
MIRT2608240	hsa-miR-1976	CLIP-seq
MIRT1292657	hsa-miR-2355-5p	CLIP-seq
MIRT2608241	hsa-miR-2467-3p	CLIP-seq
MIRT2608242	hsa-miR-3116	CLIP-seq
MIRT1292658	hsa-miR-3120-5p	CLIP-seq
MIRT2608243	hsa-miR-3124-3p	CLIP-seq
MIRT2457792	hsa-miR-3126-5p	CLIP-seq
MIRT2608244	hsa-miR-3127-5p	CLIP-seq
MIRT2608245	hsa-miR-3130-3p	CLIP-seq
MIRT2608246	hsa-miR-3136-3p	CLIP-seq
MIRT1292659	hsa-miR-3150b-3p	CLIP-seq
MIRT1292660	hsa-miR-3182	CLIP-seq
MIRT2608247	hsa-miR-323-3p	CLIP-seq
MIRT2608248	hsa-miR-342-5p	CLIP-seq
MIRT1292664	hsa-miR-346	CLIP-seq
MIRT1292665	hsa-miR-3612	CLIP-seq
MIRT2608249	hsa-miR-3614-5p	CLIP-seq
MIRT2608250	hsa-miR-3616-3p	CLIP-seq
MIRT2457793	hsa-miR-3622a-3p	CLIP-seq
MIRT2457794	hsa-miR-3622b-3p	CLIP-seq
MIRT2608251	hsa-miR-3664-3p	CLIP-seq
MIRT2608252	hsa-miR-3678-3p	CLIP-seq
MIRT1292666	hsa-miR-3679-3p	CLIP-seq
MIRT2608253	hsa-miR-370	CLIP-seq
MIRT2608254	hsa-miR-3714	CLIP-seq
MIRT2608255	hsa-miR-376a	CLIP-seq
MIRT2608256	hsa-miR-376b	CLIP-seq
MIRT2608257	hsa-miR-3910	CLIP-seq
MIRT1292668	hsa-miR-3915	CLIP-seq
MIRT2608258	hsa-miR-3918	CLIP-seq
MIRT2608259	hsa-miR-4254	CLIP-seq
MIRT2608260	hsa-miR-4262	CLIP-seq
MIRT1292670	hsa-miR-4286	CLIP-seq
MIRT1292671	hsa-miR-4288	CLIP-seq
MIRT2608261	hsa-miR-4297	CLIP-seq
MIRT2608262	hsa-miR-4301	CLIP-seq
MIRT2457795	hsa-miR-4306	CLIP-seq
MIRT2608263	hsa-miR-4318	CLIP-seq
MIRT2608264	hsa-miR-4319	CLIP-seq
MIRT2457796	hsa-miR-4419a	CLIP-seq
MIRT2608265	hsa-miR-4436b-3p	CLIP-seq
MIRT1292674	hsa-miR-4459	CLIP-seq
MIRT2457797	hsa-miR-4510	CLIP-seq
MIRT2608266	hsa-miR-4518	CLIP-seq
MIRT2457798	hsa-miR-4644	CLIP-seq
MIRT1292676	hsa-miR-4649-3p	CLIP-seq
MIRT2608267	hsa-miR-4650-5p	CLIP-seq
MIRT1292677	hsa-miR-4652-3p	CLIP-seq
MIRT2608268	hsa-miR-4664-5p	CLIP-seq
MIRT2608269	hsa-miR-4677-3p	CLIP-seq
MIRT1292678	hsa-miR-4689	CLIP-seq
MIRT2608270	hsa-miR-4693-5p	CLIP-seq
MIRT1292679	hsa-miR-4695-5p	CLIP-seq
MIRT1292680	hsa-miR-4717-5p	CLIP-seq
MIRT2608271	hsa-miR-4718	CLIP-seq
MIRT2608272	hsa-miR-4721	CLIP-seq
MIRT1292681	hsa-miR-4725-5p	CLIP-seq
MIRT2608273	hsa-miR-4732-3p	CLIP-seq
MIRT2608274	hsa-miR-4753-5p	CLIP-seq
MIRT2608275	hsa-miR-4763-5p	CLIP-seq
MIRT1292683	hsa-miR-4784	CLIP-seq
MIRT2608276	hsa-miR-4786-5p	CLIP-seq
MIRT2608277	hsa-miR-4793-3p	CLIP-seq
MIRT2608278	hsa-miR-483-3p	CLIP-seq
MIRT1292685	hsa-miR-504	CLIP-seq
MIRT2608279	hsa-miR-506	CLIP-seq
MIRT1292687	hsa-miR-515-5p	CLIP-seq
MIRT2608280	hsa-miR-521	CLIP-seq
MIRT2457799	hsa-miR-544b	CLIP-seq
MIRT2608281	hsa-miR-626	CLIP-seq
MIRT1292688	hsa-miR-632	CLIP-seq
MIRT2608282	hsa-miR-637	CLIP-seq
MIRT2608283	hsa-miR-646	CLIP-seq
MIRT1292689	hsa-miR-650	CLIP-seq
MIRT2608284	hsa-miR-670	CLIP-seq
MIRT2608285	hsa-miR-767-5p	CLIP-seq
MIRT2608286	hsa-miR-769-5p	CLIP-seq
MIRT2608287	hsa-miR-892a	CLIP-seq
MIRT1292648	hsa-miR-10a	CLIP-seq
MIRT1292649	hsa-miR-10b	CLIP-seq
MIRT2608228	hsa-miR-1205	CLIP-seq
MIRT1292651	hsa-miR-1207-3p	CLIP-seq
MIRT1292652	hsa-miR-1224-5p	CLIP-seq
MIRT2608229	hsa-miR-1238	CLIP-seq
MIRT2608230	hsa-miR-124	CLIP-seq
MIRT2608231	hsa-miR-1254	CLIP-seq
MIRT2608234	hsa-miR-1266	CLIP-seq
MIRT2608235	hsa-miR-181a	CLIP-seq
MIRT2608236	hsa-miR-181b	CLIP-seq
MIRT2608237	hsa-miR-181c	CLIP-seq
MIRT2608238	hsa-miR-181d	CLIP-seq
MIRT2608239	hsa-miR-1915	CLIP-seq
MIRT2608240	hsa-miR-1976	CLIP-seq
MIRT1292657	hsa-miR-2355-5p	CLIP-seq
MIRT2608241	hsa-miR-2467-3p	CLIP-seq
MIRT2608242	hsa-miR-3116	CLIP-seq
MIRT1292658	hsa-miR-3120-5p	CLIP-seq
MIRT2608243	hsa-miR-3124-3p	CLIP-seq
MIRT2608244	hsa-miR-3127-5p	CLIP-seq
MIRT2608245	hsa-miR-3130-3p	CLIP-seq
MIRT2608246	hsa-miR-3136-3p	CLIP-seq
MIRT1292659	hsa-miR-3150b-3p	CLIP-seq
MIRT1292660	hsa-miR-3182	CLIP-seq
MIRT2608247	hsa-miR-323-3p	CLIP-seq
MIRT2608248	hsa-miR-342-5p	CLIP-seq
MIRT1292664	hsa-miR-346	CLIP-seq
MIRT1292665	hsa-miR-3612	CLIP-seq
MIRT2608249	hsa-miR-3614-5p	CLIP-seq
MIRT2608250	hsa-miR-3616-3p	CLIP-seq
MIRT2608251	hsa-miR-3664-3p	CLIP-seq
MIRT2608252	hsa-miR-3678-3p	CLIP-seq
MIRT1292666	hsa-miR-3679-3p	CLIP-seq
MIRT2608253	hsa-miR-370	CLIP-seq
MIRT2608254	hsa-miR-3714	CLIP-seq
MIRT2608255	hsa-miR-376a	CLIP-seq
MIRT2608256	hsa-miR-376b	CLIP-seq
MIRT2608257	hsa-miR-3910	CLIP-seq
MIRT1292668	hsa-miR-3915	CLIP-seq
MIRT2608258	hsa-miR-3918	CLIP-seq
MIRT2608259	hsa-miR-4254	CLIP-seq
MIRT2608260	hsa-miR-4262	CLIP-seq
MIRT1292670	hsa-miR-4286	CLIP-seq
MIRT1292671	hsa-miR-4288	CLIP-seq
MIRT2608261	hsa-miR-4297	CLIP-seq
MIRT2608262	hsa-miR-4301	CLIP-seq
MIRT2608263	hsa-miR-4318	CLIP-seq
MIRT2608265	hsa-miR-4436b-3p	CLIP-seq
MIRT1292674	hsa-miR-4459	CLIP-seq
MIRT2608266	hsa-miR-4518	CLIP-seq
MIRT1292676	hsa-miR-4649-3p	CLIP-seq
MIRT2608267	hsa-miR-4650-5p	CLIP-seq
MIRT1292677	hsa-miR-4652-3p	CLIP-seq
MIRT2608268	hsa-miR-4664-5p	CLIP-seq
MIRT2608269	hsa-miR-4677-3p	CLIP-seq
MIRT1292678	hsa-miR-4689	CLIP-seq
MIRT2608270	hsa-miR-4693-5p	CLIP-seq
MIRT1292679	hsa-miR-4695-5p	CLIP-seq
MIRT1292680	hsa-miR-4717-5p	CLIP-seq
MIRT2608271	hsa-miR-4718	CLIP-seq
MIRT2608272	hsa-miR-4721	CLIP-seq
MIRT1292681	hsa-miR-4725-5p	CLIP-seq
MIRT2608274	hsa-miR-4753-5p	CLIP-seq
MIRT2608275	hsa-miR-4763-5p	CLIP-seq
MIRT1292683	hsa-miR-4784	CLIP-seq
MIRT2608276	hsa-miR-4786-5p	CLIP-seq
MIRT2608277	hsa-miR-4793-3p	CLIP-seq
MIRT2608278	hsa-miR-483-3p	CLIP-seq
MIRT1292685	hsa-miR-504	CLIP-seq
MIRT2608279	hsa-miR-506	CLIP-seq
MIRT2608280	hsa-miR-521	CLIP-seq
MIRT2608281	hsa-miR-626	CLIP-seq
MIRT1292688	hsa-miR-632	CLIP-seq
MIRT2608282	hsa-miR-637	CLIP-seq
MIRT2608283	hsa-miR-646	CLIP-seq
MIRT1292689	hsa-miR-650	CLIP-seq
MIRT2608285	hsa-miR-767-5p	CLIP-seq
MIRT2608286	hsa-miR-769-5p	CLIP-seq
MIRT2608287	hsa-miR-892a	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
DNMT1	Unknown	24247422
SP1	Activation	19450668
SP3	Activation	19450668
TP53	Repression	21364923

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000922	Component	Spindle pole	IEA
GO:0005515	Function	Protein binding	IPI	11857081, 12762840, 14729613, 14743218, 15109305, 16810318, 18347058, 18566590, 20562859, 20920251, 21134643, 21199877, 23455924, 28514442, 32296183, 32814053, 35512704
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	14743218, 18566590
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IEA
GO:0005819	Component	Spindle	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0006974	Process	DNA damage response	IMP	18566590
GO:0007165	Process	Signal transduction	IEA
GO:0007265	Process	Ras protein signal transduction	IBA
GO:0007265	Process	Ras protein signal transduction	IDA	15109305
GO:0008270	Function	Zinc ion binding	IEA
GO:0008270	Function	Zinc ion binding	TAS	11333291
GO:0015630	Component	Microtubule cytoskeleton	IBA
GO:0015630	Component	Microtubule cytoskeleton	IDA	14743218, 18566590
GO:0031267	Function	Small GTPase binding	IEA
GO:0031398	Process	Positive regulation of protein ubiquitination	IDA	18566590
GO:0042802	Function	Identical protein binding	IPI	11857081, 20920251
GO:0046872	Function	Metal ion binding	IEA
GO:0050821	Process	Protein stabilization	IDA	18566590
GO:0051726	Process	Regulation of cell cycle	IDA	18566590
GO:1902806	Process	Regulation of cell cycle G1/S phase transition	IMP	12024041

Other IDs

• MIM: 605082
• HGNC: 9882
• e!Ensembl: ENSG00000068028

Protein

• UniProt ID: Q9NS23
• Protein name: Ras association domain-containing protein 1
• Protein function: Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformation
• PDB: 2KZU
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00788	RA	202 → 292	Ras association (RalGDS/AF-6) domain	Domain
  PF16517	Nore1-SARAH	299 → 338	Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Isoform A and isoform C are ubiquitously expressed in all tissues tested, however isoform A is absent in many corresponding cancer cell lines. Isoform B is mainly expressed in hematopoietic cells. {ECO:0000269|PubMed:10888881, ECO:0000
• Sequence:

  MSGEPELIELRELAPAGRAGKGRTRLERANALRIARGTACNPTRQLVPGRGHRFQPAGPA
  THTWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLDCCGPRDLGWEPAVERD
  TNVDEPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSV
  PSSKKPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKHLHVLSRTRAREVIEALLRKFLVV
  DDPRKFALFERAERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDAF
  SMPELHNFLRILQREEEEHLRQILQKYSYCRQKIQEALHACPLG

• Sequence length: 344

Pathways

KEGG:

Ras signaling pathway
Hippo signaling pathway
Hippo signaling pathway - multiple species
Pathways in cancer
MicroRNAs in cancer
Bladder cancer
Non-small cell lung cancer