MAP4K1 (mitogen-activated protein kinase kinase kinase kinase 1)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
11184
Gene name Gene Name - the full gene name approved by the HGNC.
Mitogen-activated protein kinase kinase kinase kinase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MAP4K1
Synonyms (NCBI Gene) Gene synonyms aliases
HPK1
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.2
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways
Show/Hide all(21)
miRTarBase ID miRNA Experiments Reference
MIRT2036897 hsa-miR-1275 CLIP-seq
MIRT2036898 hsa-miR-143 CLIP-seq
MIRT2036899 hsa-miR-342-5p CLIP-seq
MIRT2036900 hsa-miR-3675-5p CLIP-seq
MIRT2036901 hsa-miR-3689a-3p CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways
Show/Hide all(16)
GO ID Ontology Definition Evidence Reference
GO:0000185 Process Activation of MAPKKK activity IC 11053428
GO:0004672 Function Protein kinase activity TAS 8824585
GO:0004674 Function Protein serine/threonine kinase activity IDA 8824585
GO:0005515 Function Protein binding IPI 9346925, 9788432, 17474147, 20231852, 22939624, 24362026, 31980649
GO:0005524 Function ATP binding IDA 8824585
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways
MIM HGNC e!Ensembl
601983 6863 ENSG00000104814
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways
UniProt ID Q92918
Protein name Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1)
Protein function Serine/threonine-protein kinase, which plays a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). Activator of the Hippo signaling pathway which plays a pivotal
PDB 6CQD , 6CQE , 6CQF , 6NFY , 6NFZ , 6NG0 , 7KAC , 7L24 , 7L25 , 7L26 , 7M0K , 7M0L , 7M0M , 7R9L , 7R9N , 7R9P , 7R9T , 7SIU , 8CDW , 8CIJ , 8EEC , 8FH4 , 8FJZ , 8FKO , 8PAR , 8PAS , 8PAU , 8XN7 , 9BI8 , 9BIK , 9BJ1 , 9CZT , 9CZU , 9CZW , 9CZX , 9D00 , 9H8D , 9H8E , 9H8F
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 17 → 274 Protein kinase domain Domain
PF00780 CNH 505 → 797 CNH domain Family
Tissue specificity TISSUE SPECIFICITY: Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine. {ECO:0000269|PubMed:8824585}.
Sequence 
MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ
KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE
VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA
PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK
GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI
GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP
PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL
SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK
RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS
RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK
IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF
ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM
VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ
LLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
Sequence length 833
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways
  KEGG  
  MAPK signaling pathway