MAP4K1 (mitogen-activated protein kinase kinase kinase kinase 1)

Gene

• Entrez ID: 11184
• Gene name: Mitogen-activated protein kinase kinase kinase kinase 1
• Gene symbol: MAP4K1
• Synonyms (NCBI Gene): HPK1
• Chromosome: 19
• Chromosome location: 19q13.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT2036897	hsa-miR-1275	CLIP-seq
MIRT2036898	hsa-miR-143	CLIP-seq
MIRT2036899	hsa-miR-342-5p	CLIP-seq
MIRT2036900	hsa-miR-3675-5p	CLIP-seq
MIRT2036901	hsa-miR-3689a-3p	CLIP-seq
MIRT2036902	hsa-miR-3689c	CLIP-seq
MIRT2036903	hsa-miR-4525	CLIP-seq
MIRT2036904	hsa-miR-4664-5p	CLIP-seq
MIRT2036905	hsa-miR-4665-5p	CLIP-seq
MIRT2036906	hsa-miR-4708-3p	CLIP-seq
MIRT2036907	hsa-miR-4723-5p	CLIP-seq
MIRT2036908	hsa-miR-4728-5p	CLIP-seq
MIRT2036909	hsa-miR-4770	CLIP-seq
MIRT2036910	hsa-miR-4796-5p	CLIP-seq
MIRT2036911	hsa-miR-625	CLIP-seq
MIRT2266969	hsa-miR-1224-5p	CLIP-seq
MIRT2036898	hsa-miR-143	CLIP-seq
MIRT2036901	hsa-miR-3689a-3p	CLIP-seq
MIRT2036902	hsa-miR-3689c	CLIP-seq
MIRT2266970	hsa-miR-4751	CLIP-seq
MIRT2036909	hsa-miR-4770	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	8824585
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	9346925, 9788432, 17474147, 20231852, 22939624, 24362026, 31980649, 32707033, 36931259
GO:0005524	Function	ATP binding	IDA	8824585
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0006468	Process	Protein phosphorylation	IDA	8824585
GO:0007254	Process	JNK cascade	IDA	8824585
GO:0008283	Process	Cell population proliferation	IMP	24362026
GO:0008349	Function	MAP kinase kinase kinase kinase activity	IBA
GO:0008349	Function	MAP kinase kinase kinase kinase activity	IDA	11053428
GO:0008349	Function	MAP kinase kinase kinase kinase activity	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0018105	Process	Peptidyl-serine phosphorylation	IDA	11053428, 24362026
GO:0035556	Process	Intracellular signal transduction	IBA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0043410	Process	Positive regulation of MAPK cascade	IDA	11053428
GO:0046777	Process	Protein autophosphorylation	IDA	8824585, 24362026
GO:0106310	Function	Protein serine kinase activity	IEA
GO:1904628	Process	Cellular response to phorbol 13-acetate 12-myristate	IDA	8824585

Other IDs

• MIM: 601983
• HGNC: 6863
• e!Ensembl: ENSG00000104814

Protein

• UniProt ID: Q92918
• Protein name: Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1)
• Protein function: Serine/threonine-protein kinase, which plays a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). Activator of the Hippo signaling pathway which plays a pivotal
• PDB: 6CQD, 6CQE, 6CQF, 6NFY, 6NFZ, 6NG0, 7KAC, 7L24, 7L25, 7L26, 7M0K, 7M0L, 7M0M, 7R9L, 7R9N, 7R9P, 7R9T, 7SIU, 8CDW, 8CIJ, 8EEC, 8FH4, 8FJZ, 8FKO, 8PAR, 8PAS, 8PAU, 8XN7, 9BI8, 9BIK, 9BJ1, 9CZT, 9CZU, 9CZW, 9CZX, 9D00, 9H8D, 9H8E, 9H8F
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	17 → 274	Protein kinase domain	Domain
  PF00780	CNH	505 → 797	CNH domain	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine. {ECO:0000269|PubMed:8824585}.
• Sequence:

  MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ
  KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE
  VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA
  PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK
  GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI
  GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP
  PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL
  SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK
  RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS
  RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK
  IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF
  ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM
  VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ
  LLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL

• Sequence length: 833

Pathways

KEGG:

MAPK signaling pathway