Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	11184
Gene name Gene Name - the full gene name approved by the HGNC.	Mitogen-activated protein kinase kinase kinase kinase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MAP4K1
Synonyms (NCBI Gene) Gene synonyms aliases	HPK1
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19q13.2

Show/Hide all(21)

miRTarBase ID	miRNA	Experiments
MIRT2036897	hsa-miR-1275	CLIP-seq
MIRT2036898	hsa-miR-143	CLIP-seq
MIRT2036899	hsa-miR-342-5p	CLIP-seq
MIRT2036900	hsa-miR-3675-5p	CLIP-seq
MIRT2036901	hsa-miR-3689a-3p	CLIP-seq
MIRT2036902	hsa-miR-3689c	CLIP-seq
MIRT2036903	hsa-miR-4525	CLIP-seq
MIRT2036904	hsa-miR-4664-5p	CLIP-seq
MIRT2036905	hsa-miR-4665-5p	CLIP-seq
MIRT2036906	hsa-miR-4708-3p	CLIP-seq
MIRT2036907	hsa-miR-4723-5p	CLIP-seq
MIRT2036908	hsa-miR-4728-5p	CLIP-seq
MIRT2036909	hsa-miR-4770	CLIP-seq
MIRT2036910	hsa-miR-4796-5p	CLIP-seq
MIRT2036911	hsa-miR-625	CLIP-seq
MIRT2266969	hsa-miR-1224-5p	CLIP-seq
MIRT2036898	hsa-miR-143	CLIP-seq
MIRT2036901	hsa-miR-3689a-3p	CLIP-seq
MIRT2036902	hsa-miR-3689c	CLIP-seq
MIRT2266970	hsa-miR-4751	CLIP-seq
MIRT2036909	hsa-miR-4770	CLIP-seq

Show/Hide all(24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	8824585
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	9346925, 9788432, 17474147, 20231852, 22939624, 24362026, 31980649, 32707033, 36931259
GO:0005524	Function	ATP binding	IDA	8824585
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0006468	Process	Protein phosphorylation	IDA	8824585
GO:0007254	Process	JNK cascade	IDA	8824585
GO:0008283	Process	Cell population proliferation	IMP	24362026
GO:0008349	Function	MAP kinase kinase kinase kinase activity	IBA
GO:0008349	Function	MAP kinase kinase kinase kinase activity	IDA	11053428
GO:0008349	Function	MAP kinase kinase kinase kinase activity	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0018105	Process	Peptidyl-serine phosphorylation	IDA	11053428, 24362026
GO:0035556	Process	Intracellular signal transduction	IBA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0043410	Process	Positive regulation of MAPK cascade	IDA	11053428
GO:0046777	Process	Protein autophosphorylation	IDA	8824585, 24362026
GO:0106310	Function	Protein serine kinase activity	IEA
GO:1904628	Process	Cellular response to phorbol 13-acetate 12-myristate	IDA	8824585

MIM	HGNC	e!Ensembl
601983	6863	ENSG00000104814

Protein

UniProt ID

Q92918

Protein name

Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1)

Protein function

Serine/threonine-protein kinase, which plays a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). Activator of the Hippo signaling pathway which plays a pivotal

PDB

6CQD , 6CQE , 6CQF , 6NFY , 6NFZ , 6NG0 , 7KAC , 7L24 , 7L25 , 7L26 , 7M0K , 7M0L , 7M0M , 7R9L , 7R9N , 7R9P , 7R9T , 7SIU , 8CDW , 8CIJ , 8EEC , 8FH4 , 8FJZ , 8FKO , 8PAR , 8PAS , 8PAU , 8XN7 , 9BI8 , 9BIK , 9BJ1 , 9CZT , 9CZU , 9CZW , 9CZX , 9D00 , 9H8D , 9H8E , 9H8F

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	17 → 274	Protein kinase domain	Domain
PF00780	CNH	505 → 797	CNH domain	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine. {ECO:0000269|PubMed:8824585}.

Sequence

MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ
KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE
VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA
PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK
GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI
GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP
PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL
SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK
RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS
RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK
IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF
ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM
VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ
LLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL

Sequence length

833

Interactions

View interactions

	KEGG
	MAPK signaling pathway

MAP4K1 (mitogen-activated protein kinase kinase kinase kinase 1)