CHIT1 (chitinase 1)

Gene

• Entrez ID: 1118
• Gene name: Chitinase 1
• Gene symbol: CHIT1
• Synonyms (NCBI Gene): CHI3, CHIT, CHITD
• Chromosome: 1
• Chromosome location: 1q32.1
• Summary: Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. H

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs137852607	C>T	Likely-benign, affects	Non coding transcript variant, missense variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT890098	hsa-miR-1237	CLIP-seq
MIRT890099	hsa-miR-1248	CLIP-seq
MIRT890100	hsa-miR-197	CLIP-seq
MIRT890101	hsa-miR-224	CLIP-seq
MIRT890102	hsa-miR-4270	CLIP-seq
MIRT890103	hsa-miR-4289	CLIP-seq
MIRT890104	hsa-miR-4299	CLIP-seq
MIRT890105	hsa-miR-4326	CLIP-seq
MIRT890106	hsa-miR-4441	CLIP-seq
MIRT890107	hsa-miR-4456	CLIP-seq
MIRT890108	hsa-miR-4659a-3p	CLIP-seq
MIRT890109	hsa-miR-4659b-3p	CLIP-seq
MIRT890110	hsa-miR-4668-5p	CLIP-seq
MIRT890111	hsa-miR-4778-3p	CLIP-seq
MIRT890112	hsa-miR-548q	CLIP-seq
MIRT890113	hsa-miR-942	CLIP-seq
MIRT1963726	hsa-miR-2861	CLIP-seq
MIRT1963727	hsa-miR-3064-3p	CLIP-seq
MIRT1963728	hsa-miR-3918	CLIP-seq
MIRT1963729	hsa-miR-4512	CLIP-seq
MIRT890108	hsa-miR-4659a-3p	CLIP-seq
MIRT890109	hsa-miR-4659b-3p	CLIP-seq
MIRT1963730	hsa-miR-4769-3p	CLIP-seq
MIRT890113	hsa-miR-942	CLIP-seq
MIRT2200041	hsa-miR-1205	CLIP-seq
MIRT2200042	hsa-miR-1286	CLIP-seq
MIRT2200043	hsa-miR-140-3p	CLIP-seq
MIRT2200044	hsa-miR-4722-5p	CLIP-seq
MIRT1963730	hsa-miR-4769-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000272	Process	Polysaccharide catabolic process	IEA
GO:0004553	Function	Hydrolase activity, hydrolyzing O-glycosyl compounds	IEA
GO:0004553	Function	Hydrolase activity, hydrolyzing O-glycosyl compounds	TAS
GO:0004568	Function	Chitinase activity	IBA
GO:0004568	Function	Chitinase activity	IDA	11085997
GO:0004568	Function	Chitinase activity	IEA
GO:0004568	Function	Chitinase activity	TAS	7836450, 9748235
GO:0005515	Function	Protein binding	IPI	33961781
GO:0005576	Component	Extracellular region	IBA
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IDA	19725875
GO:0005615	Component	Extracellular space	TAS	7592832
GO:0005764	Component	Lysosome	IEA
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0006032	Process	Chitin catabolic process	IBA
GO:0006032	Process	Chitin catabolic process	IDA	19725875
GO:0006032	Process	Chitin catabolic process	IEA
GO:0006032	Process	Chitin catabolic process	TAS	9748235
GO:0006955	Process	Immune response	NAS	9748235
GO:0008061	Function	Chitin binding	IEA
GO:0008061	Function	Chitin binding	TAS	9748235
GO:0008843	Function	Endochitinase activity	IDA	19725875
GO:0008843	Function	Endochitinase activity	IEA
GO:0009617	Process	Response to bacterium	TAS	9402970
GO:0016787	Function	Hydrolase activity	IEA
GO:0016798	Function	Hydrolase activity, acting on glycosyl bonds	IEA
GO:0035580	Component	Specific granule lumen	TAS
GO:0044245	Process	Polysaccharide digestion	IEA
GO:0044245	Process	Polysaccharide digestion	TAS
GO:1904724	Component	Tertiary granule lumen	TAS

Other IDs

• MIM: 600031
• HGNC: 1936
• e!Ensembl: ENSG00000133063

Protein

• UniProt ID: Q13231
• Protein name: Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1)
• Protein function: Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.
• PDB: 1GUV, 1HKI, 1HKJ, 1HKK, 1HKM, 1LG1, 1LG2, 1LQ0, 1WAW, 1WB0, 4WJX, 4WK9, 4WKA, 4WKF, 4WKH, 5HBF, 5NR8, 5NRA, 5NRF, 6JJR, 6JK6, 6SO0, 6ZE8
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00704	Glyco_hydro_18	23 → 363	Glycosyl hydrolases family 18	Domain
  PF01607	CBM_14	420 → 466	Chitin binding Peritrophin-A domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Detected in spleen. Secreted by cultured macrophages. {ECO:0000269|PubMed:7836450}.
• Sequence:

  MVRSVAWAGFMVLLMIPWGSAAKLVCYFTNWAQYRQGEARFLPKDLDPSLCTHLIYAFAG
  MTNHQLSTTEWNDETLYQEFNGLKKMNPKLKTLLAIGGWNFGTQKFTDMVATANNRQTFV
  NSAIRFLRKYSFDGLDLDWEYPGSQGSPAVDKERFTTLVQDLANAFQQEAQTSGKERLLL
  SAAVPAGQTYVDAGYEVDKIAQNLDFVNLMAYDFHGSWEKVTGHNSPLYKRQEESGAAAS
  LNVDAAVQQWLQKGTPASKLILGMPTYGRSFTLASSSDTRVGAPATGSGTPGPFTKEGGM
  LAYYEVCSWKGATKQRIQDQKVPYIFRDNQWVGFDDVESFKTKVSYLKQKGLGGAMVWAL
  DLDDFAGFSCNQGRYPLIQTLRQELSLPYLPSGTPELEVPKPGQPSEPEHGPSPGQDTFC
  QGKADGLYPNPRERSSFYSCAAGRLFQQSCPTGLVFSNSCKCCTWN

• Sequence length: 466

Pathways

KEGG:

Amino sugar and nucleotide sugar metabolism
Metabolic pathways

Reactome:

Digestion of dietary carbohydrate
Neutrophil degranulation

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