INSL6 (insulin like 6)

Gene
Gene Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
11172
Gene name Gene Name - the full gene name approved by the HGNC.
Insulin like 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
INSL6
Synonyms (NCBI Gene) Gene synonyms aliases
RIF1
Chromosome Chromosome number
9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9p24.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene contains a classical signature of the insulin superfamily and is significantly similar to relaxin and relaxin-like factor. This gene is preferentially expressed in testis. Its expression in testis is restricted to intersti
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide all(4)
GO ID Ontology Definition Evidence Reference
GO:0005179 Function Hormone activity IEA
GO:0005179 Function Hormone activity NAS 10598589
GO:0005576 Component Extracellular region IEA
GO:0007165 Process Signal transduction IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
606414 6089 ENSG00000120210
Protein
Gene Gene ontology Other IDs Protein Associated diseases
UniProt ID Q9Y581
Protein name Insulin-like peptide INSL6 (Insulin-like peptide 6) (Relaxin/insulin-like factor 1) [Cleaved into: Insulin-like peptide INSL6 B chain; Insulin-like peptide INSL6 A chain]
Protein function May have a role in sperm development and fertilization.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00049 Insulin 30 → 192 Insulin/IGF/Relaxin family Domain
Tissue specificity TISSUE SPECIFICITY: Testis specific.
Sequence
Sequence length 213
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Inflammatory Bowel Disease Inflammatory bowel disease (MTAG) N/A N/A GWAS
Ulcerative colitis Ulcerative colitis N/A N/A GWAS
Show/Hide Text Mining Associations (5)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 36798786
Colorectal Neoplasms Associate 22600741
Myocardial Infarction Inhibit 36798786
Neoplasms Inhibit 22600741
Neoplasms Associate 36798786