INSL6 (insulin like 6)

Gene Gene information from NCBI Gene database.
Gene Gene ontology Other IDs Protein Associated diseases
Entrez ID 11172
Gene name Insulin like 6
Gene symbol INSL6
Synonyms (NCBI Gene)
RIF1
Chromosome 9
Chromosome location 9p24.1
Summary The protein encoded by this gene contains a classical signature of the insulin superfamily and is significantly similar to relaxin and relaxin-like factor. This gene is preferentially expressed in testis. Its expression in testis is restricted to intersti
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
4
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide all (4)
GO ID Ontology Definition Evidence Reference
GO:0005179 Function Hormone activity IEA
GO:0005179 Function Hormone activity NAS 10598589
GO:0005576 Component Extracellular region IEA
GO:0007165 Process Signal transduction IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
606414 6089 ENSG00000120210
Protein Protein information from UniProt database.
Gene Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9Y581
Protein name Insulin-like peptide INSL6 (Insulin-like peptide 6) (Relaxin/insulin-like factor 1) [Cleaved into: Insulin-like peptide INSL6 B chain; Insulin-like peptide INSL6 A chain]
Protein function May have a role in sperm development and fertilization.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00049 Insulin 30 → 192 Insulin/IGF/Relaxin family Domain
Tissue specificity TISSUE SPECIFICITY: Testis specific.
Sequence
Sequence length 213
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
2
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Lung cancer Likely benign rs138203591 RCV005902774
Melanoma Likely benign rs138203591 RCV005902773
Show/Hide Text Mining Associations (5)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 36798786
Colorectal Neoplasms Associate 22600741
Myocardial Infarction Inhibit 36798786
Neoplasms Inhibit 22600741
Neoplasms Associate 36798786