Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	11171
Gene name	Serine/threonine kinase receptor associated protein
Gene symbol	STRAP
Synonyms (NCBI Gene)	MAWDPT-WDUNRIP
Chromosome	12
Chromosome location	12p12.3

242

Show/Hide all (242)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025462	hsa-miR-34a-5p	Proteomics	21566225
MIRT025462	hsa-miR-34a-5p	Proteomics	21566225
MIRT025462	hsa-miR-34a-5p	Proteomics	21566225
MIRT031678	hsa-miR-16-5p	Proteomics	18668040
MIRT036801	hsa-miR-374b-5p	CLASH	23622248
MIRT1399324	hsa-miR-136	CLIP-seq
MIRT1399325	hsa-miR-1827	CLIP-seq
MIRT1399326	hsa-miR-2681	CLIP-seq
MIRT1399327	hsa-miR-2682	CLIP-seq
MIRT1399328	hsa-miR-3117-5p	CLIP-seq
MIRT1399329	hsa-miR-3157-5p	CLIP-seq
MIRT1399330	hsa-miR-3177-5p	CLIP-seq
MIRT1399331	hsa-miR-338-3p	CLIP-seq
MIRT1399332	hsa-miR-34a	CLIP-seq
MIRT1399333	hsa-miR-34c-5p	CLIP-seq
MIRT1399334	hsa-miR-3591-3p	CLIP-seq
MIRT1399335	hsa-miR-383	CLIP-seq
MIRT1399336	hsa-miR-4257	CLIP-seq
MIRT1399337	hsa-miR-449a	CLIP-seq
MIRT1399338	hsa-miR-449b	CLIP-seq
MIRT1399339	hsa-miR-449c	CLIP-seq
MIRT1399340	hsa-miR-4530	CLIP-seq
MIRT1399341	hsa-miR-4633-3p	CLIP-seq
MIRT1399342	hsa-miR-4659a-3p	CLIP-seq
MIRT1399343	hsa-miR-4659b-3p	CLIP-seq
MIRT1399344	hsa-miR-4691-3p	CLIP-seq
MIRT1399345	hsa-miR-4760-3p	CLIP-seq
MIRT1399346	hsa-miR-5095	CLIP-seq
MIRT1399347	hsa-miR-5096	CLIP-seq
MIRT1399348	hsa-miR-515-5p	CLIP-seq
MIRT1399349	hsa-miR-539	CLIP-seq
MIRT1399350	hsa-miR-548c-3p	CLIP-seq
MIRT1399351	hsa-miR-552	CLIP-seq
MIRT1399352	hsa-miR-576-3p	CLIP-seq
MIRT1399353	hsa-miR-600	CLIP-seq
MIRT1399354	hsa-miR-610	CLIP-seq
MIRT1399355	hsa-miR-664	CLIP-seq
MIRT1399356	hsa-miR-935	CLIP-seq
MIRT1399357	hsa-miR-942	CLIP-seq
MIRT2119667	hsa-miR-1238	CLIP-seq
MIRT2119668	hsa-miR-1273e	CLIP-seq
MIRT2119669	hsa-miR-1299	CLIP-seq
MIRT1399324	hsa-miR-136	CLIP-seq
MIRT1399328	hsa-miR-3117-5p	CLIP-seq
MIRT2119670	hsa-miR-3140-3p	CLIP-seq
MIRT2119671	hsa-miR-3143	CLIP-seq
MIRT1399329	hsa-miR-3157-5p	CLIP-seq
MIRT2119672	hsa-miR-3202	CLIP-seq
MIRT1399331	hsa-miR-338-3p	CLIP-seq
MIRT1399334	hsa-miR-3591-3p	CLIP-seq
MIRT2119673	hsa-miR-3660	CLIP-seq
MIRT2119674	hsa-miR-3929	CLIP-seq
MIRT2119675	hsa-miR-4327	CLIP-seq
MIRT2119676	hsa-miR-4419b	CLIP-seq
MIRT2119677	hsa-miR-4478	CLIP-seq
MIRT2119678	hsa-miR-4503	CLIP-seq
MIRT2119679	hsa-miR-4526	CLIP-seq
MIRT2119680	hsa-miR-4528	CLIP-seq
MIRT1399340	hsa-miR-4530	CLIP-seq
MIRT2119681	hsa-miR-4533	CLIP-seq
MIRT1399341	hsa-miR-4633-3p	CLIP-seq
MIRT1399342	hsa-miR-4659a-3p	CLIP-seq
MIRT1399343	hsa-miR-4659b-3p	CLIP-seq
MIRT1399344	hsa-miR-4691-3p	CLIP-seq
MIRT2119682	hsa-miR-4699-3p	CLIP-seq
MIRT2119683	hsa-miR-4727-5p	CLIP-seq
MIRT1399345	hsa-miR-4760-3p	CLIP-seq
MIRT2119684	hsa-miR-4768-5p	CLIP-seq
MIRT2119685	hsa-miR-4803	CLIP-seq
MIRT1399346	hsa-miR-5095	CLIP-seq
MIRT1399347	hsa-miR-5096	CLIP-seq
MIRT1399348	hsa-miR-515-5p	CLIP-seq
MIRT2119686	hsa-miR-544	CLIP-seq
MIRT2119687	hsa-miR-548b-3p	CLIP-seq
MIRT1399351	hsa-miR-552	CLIP-seq
MIRT2119688	hsa-miR-579	CLIP-seq
MIRT1399353	hsa-miR-600	CLIP-seq
MIRT1399354	hsa-miR-610	CLIP-seq
MIRT2119689	hsa-miR-618	CLIP-seq
MIRT1399355	hsa-miR-664	CLIP-seq
MIRT2119690	hsa-miR-875-3p	CLIP-seq
MIRT1399357	hsa-miR-942	CLIP-seq
MIRT1399325	hsa-miR-1827	CLIP-seq
MIRT2341822	hsa-miR-205	CLIP-seq
MIRT1399327	hsa-miR-2682	CLIP-seq
MIRT1399328	hsa-miR-3117-5p	CLIP-seq
MIRT2119671	hsa-miR-3143	CLIP-seq
MIRT1399330	hsa-miR-3177-5p	CLIP-seq
MIRT1399331	hsa-miR-338-3p	CLIP-seq
MIRT1399332	hsa-miR-34a	CLIP-seq
MIRT1399333	hsa-miR-34c-5p	CLIP-seq
MIRT1399334	hsa-miR-3591-3p	CLIP-seq
MIRT2119673	hsa-miR-3660	CLIP-seq
MIRT1399336	hsa-miR-4257	CLIP-seq
MIRT2341823	hsa-miR-4287	CLIP-seq
MIRT1399337	hsa-miR-449a	CLIP-seq
MIRT1399338	hsa-miR-449b	CLIP-seq
MIRT1399339	hsa-miR-449c	CLIP-seq
MIRT2119679	hsa-miR-4526	CLIP-seq
MIRT2119680	hsa-miR-4528	CLIP-seq
MIRT1399340	hsa-miR-4530	CLIP-seq
MIRT1399341	hsa-miR-4633-3p	CLIP-seq
MIRT2341824	hsa-miR-4685-3p	CLIP-seq
MIRT2119682	hsa-miR-4699-3p	CLIP-seq
MIRT1399345	hsa-miR-4760-3p	CLIP-seq
MIRT2341825	hsa-miR-4764-3p	CLIP-seq
MIRT2119685	hsa-miR-4803	CLIP-seq
MIRT1399346	hsa-miR-5095	CLIP-seq
MIRT1399347	hsa-miR-5096	CLIP-seq
MIRT1399349	hsa-miR-539	CLIP-seq
MIRT2119687	hsa-miR-548b-3p	CLIP-seq
MIRT1399351	hsa-miR-552	CLIP-seq
MIRT1399352	hsa-miR-576-3p	CLIP-seq
MIRT2119688	hsa-miR-579	CLIP-seq
MIRT1399353	hsa-miR-600	CLIP-seq
MIRT1399354	hsa-miR-610	CLIP-seq
MIRT1399355	hsa-miR-664	CLIP-seq
MIRT1399356	hsa-miR-935	CLIP-seq
MIRT2119667	hsa-miR-1238	CLIP-seq
MIRT1399331	hsa-miR-338-3p	CLIP-seq
MIRT1399334	hsa-miR-3591-3p	CLIP-seq
MIRT2119678	hsa-miR-4503	CLIP-seq
MIRT2119680	hsa-miR-4528	CLIP-seq
MIRT1399340	hsa-miR-4530	CLIP-seq
MIRT1399346	hsa-miR-5095	CLIP-seq
MIRT1399347	hsa-miR-5096	CLIP-seq
MIRT1399351	hsa-miR-552	CLIP-seq
MIRT1399353	hsa-miR-600	CLIP-seq
MIRT2119667	hsa-miR-1238	CLIP-seq
MIRT2119668	hsa-miR-1273e	CLIP-seq
MIRT2119669	hsa-miR-1299	CLIP-seq
MIRT2635700	hsa-miR-1324	CLIP-seq
MIRT1399324	hsa-miR-136	CLIP-seq
MIRT2635701	hsa-miR-2054	CLIP-seq
MIRT1399328	hsa-miR-3117-5p	CLIP-seq
MIRT2119670	hsa-miR-3140-3p	CLIP-seq
MIRT2119671	hsa-miR-3143	CLIP-seq
MIRT2635702	hsa-miR-3156-5p	CLIP-seq
MIRT1399329	hsa-miR-3157-5p	CLIP-seq
MIRT2635703	hsa-miR-3166	CLIP-seq
MIRT2119672	hsa-miR-3202	CLIP-seq
MIRT1399331	hsa-miR-338-3p	CLIP-seq
MIRT1399334	hsa-miR-3591-3p	CLIP-seq
MIRT2635704	hsa-miR-3613-3p	CLIP-seq
MIRT2635705	hsa-miR-3658	CLIP-seq
MIRT1399335	hsa-miR-383	CLIP-seq
MIRT2635706	hsa-miR-3910	CLIP-seq
MIRT2119674	hsa-miR-3929	CLIP-seq
MIRT2119675	hsa-miR-4327	CLIP-seq
MIRT2119676	hsa-miR-4419b	CLIP-seq
MIRT2119677	hsa-miR-4478	CLIP-seq
MIRT2119678	hsa-miR-4503	CLIP-seq
MIRT2119680	hsa-miR-4528	CLIP-seq
MIRT1399340	hsa-miR-4530	CLIP-seq
MIRT2119681	hsa-miR-4533	CLIP-seq
MIRT1399341	hsa-miR-4633-3p	CLIP-seq
MIRT2635707	hsa-miR-4645-3p	CLIP-seq
MIRT1399342	hsa-miR-4659a-3p	CLIP-seq
MIRT1399343	hsa-miR-4659b-3p	CLIP-seq
MIRT1399344	hsa-miR-4691-3p	CLIP-seq
MIRT2119682	hsa-miR-4699-3p	CLIP-seq
MIRT2119683	hsa-miR-4727-5p	CLIP-seq
MIRT1399345	hsa-miR-4760-3p	CLIP-seq
MIRT2635708	hsa-miR-4764-5p	CLIP-seq
MIRT2119684	hsa-miR-4768-5p	CLIP-seq
MIRT2635709	hsa-miR-4781-3p	CLIP-seq
MIRT2119685	hsa-miR-4803	CLIP-seq
MIRT1399346	hsa-miR-5095	CLIP-seq
MIRT1399347	hsa-miR-5096	CLIP-seq
MIRT1399348	hsa-miR-515-5p	CLIP-seq
MIRT2119686	hsa-miR-544	CLIP-seq
MIRT2635710	hsa-miR-548an	CLIP-seq
MIRT2119687	hsa-miR-548b-3p	CLIP-seq
MIRT1399350	hsa-miR-548c-3p	CLIP-seq
MIRT2635711	hsa-miR-548p	CLIP-seq
MIRT1399351	hsa-miR-552	CLIP-seq
MIRT2635712	hsa-miR-568	CLIP-seq
MIRT2119688	hsa-miR-579	CLIP-seq
MIRT1399353	hsa-miR-600	CLIP-seq
MIRT1399354	hsa-miR-610	CLIP-seq
MIRT2119689	hsa-miR-618	CLIP-seq
MIRT2635713	hsa-miR-643	CLIP-seq
MIRT1399355	hsa-miR-664	CLIP-seq
MIRT2119690	hsa-miR-875-3p	CLIP-seq
MIRT1399357	hsa-miR-942	CLIP-seq
MIRT2119667	hsa-miR-1238	CLIP-seq
MIRT2119668	hsa-miR-1273e	CLIP-seq
MIRT2119669	hsa-miR-1299	CLIP-seq
MIRT2635700	hsa-miR-1324	CLIP-seq
MIRT1399324	hsa-miR-136	CLIP-seq
MIRT2635701	hsa-miR-2054	CLIP-seq
MIRT1399328	hsa-miR-3117-5p	CLIP-seq
MIRT2119670	hsa-miR-3140-3p	CLIP-seq
MIRT2119671	hsa-miR-3143	CLIP-seq
MIRT2635702	hsa-miR-3156-5p	CLIP-seq
MIRT1399329	hsa-miR-3157-5p	CLIP-seq
MIRT2635703	hsa-miR-3166	CLIP-seq
MIRT2119672	hsa-miR-3202	CLIP-seq
MIRT1399331	hsa-miR-338-3p	CLIP-seq
MIRT1399334	hsa-miR-3591-3p	CLIP-seq
MIRT2635704	hsa-miR-3613-3p	CLIP-seq
MIRT2635705	hsa-miR-3658	CLIP-seq
MIRT1399335	hsa-miR-383	CLIP-seq
MIRT2635706	hsa-miR-3910	CLIP-seq
MIRT2119674	hsa-miR-3929	CLIP-seq
MIRT2119675	hsa-miR-4327	CLIP-seq
MIRT2119676	hsa-miR-4419b	CLIP-seq
MIRT2119677	hsa-miR-4478	CLIP-seq
MIRT2119678	hsa-miR-4503	CLIP-seq
MIRT2119680	hsa-miR-4528	CLIP-seq
MIRT1399340	hsa-miR-4530	CLIP-seq
MIRT2119681	hsa-miR-4533	CLIP-seq
MIRT1399341	hsa-miR-4633-3p	CLIP-seq
MIRT2635707	hsa-miR-4645-3p	CLIP-seq
MIRT1399342	hsa-miR-4659a-3p	CLIP-seq
MIRT1399343	hsa-miR-4659b-3p	CLIP-seq
MIRT1399344	hsa-miR-4691-3p	CLIP-seq
MIRT2119682	hsa-miR-4699-3p	CLIP-seq
MIRT2119683	hsa-miR-4727-5p	CLIP-seq
MIRT1399345	hsa-miR-4760-3p	CLIP-seq
MIRT2635708	hsa-miR-4764-5p	CLIP-seq
MIRT2119684	hsa-miR-4768-5p	CLIP-seq
MIRT2635709	hsa-miR-4781-3p	CLIP-seq
MIRT2119685	hsa-miR-4803	CLIP-seq
MIRT1399346	hsa-miR-5095	CLIP-seq
MIRT1399347	hsa-miR-5096	CLIP-seq
MIRT1399348	hsa-miR-515-5p	CLIP-seq
MIRT2119686	hsa-miR-544	CLIP-seq
MIRT2635710	hsa-miR-548an	CLIP-seq
MIRT2119687	hsa-miR-548b-3p	CLIP-seq
MIRT1399350	hsa-miR-548c-3p	CLIP-seq
MIRT2635711	hsa-miR-548p	CLIP-seq
MIRT1399351	hsa-miR-552	CLIP-seq
MIRT2635712	hsa-miR-568	CLIP-seq
MIRT2119688	hsa-miR-579	CLIP-seq
MIRT1399353	hsa-miR-600	CLIP-seq
MIRT1399354	hsa-miR-610	CLIP-seq
MIRT2119689	hsa-miR-618	CLIP-seq
MIRT2635713	hsa-miR-643	CLIP-seq
MIRT1399355	hsa-miR-664	CLIP-seq
MIRT2119690	hsa-miR-875-3p	CLIP-seq
MIRT1399357	hsa-miR-942	CLIP-seq

Show/Hide all (30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000380	Process	Alternative mRNA splicing, via spliceosome	IEA
GO:0000387	Process	Spliceosomal snRNP assembly	EXP	12067652
GO:0000387	Process	Spliceosomal snRNP assembly	IBA
GO:0000387	Process	Spliceosomal snRNP assembly	IDA	18984161
GO:0000398	Process	MRNA splicing, via spliceosome	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA
GO:0003729	Function	MRNA binding	IEA
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005515	Function	Protein binding	IPI	15848170, 17178713, 17314099, 17929853, 25959826, 26496610, 28514442, 32296183, 32814053, 33961781, 35271311
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IDA	17929853
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	18984161, 20513430
GO:0005829	Component	Cytosol	TAS
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0022618	Process	Protein-RNA complex assembly	IEA
GO:0030182	Process	Neuron differentiation	IEA
GO:0030277	Process	Maintenance of gastrointestinal epithelium	IMP	17929853
GO:0030512	Process	Negative regulation of transforming growth factor beta receptor signaling pathway	IEA
GO:0030512	Process	Negative regulation of transforming growth factor beta receptor signaling pathway	IEA
GO:0030512	Process	Negative regulation of transforming growth factor beta receptor signaling pathway	IMP	23687415
GO:0032797	Component	SMN complex	IBA
GO:0032797	Component	SMN complex	IDA	17178713, 18984161
GO:0032797	Component	SMN complex	IPI	17178713
GO:0034719	Component	SMN-Sm protein complex	IDA	18984161
GO:1990447	Function	U2 snRNP binding	IEA

MIM	HGNC	e!Ensembl
605986	30796	ENSG00000023734

Q9Y3F4

Protein name

Serine-threonine kinase receptor-associated protein (MAP activator with WD repeats) (UNR-interacting protein) (WD-40 repeat protein PT-WD)

Protein function

The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00400	WD40	49 → 87	WD domain, G-beta repeat	Repeat
PF00400	WD40	91 → 128	WD domain, G-beta repeat	Repeat
PF00400	WD40	134 → 170	WD domain, G-beta repeat	Repeat
PF00400	WD40	255 → 293	WD domain, G-beta repeat	Repeat

Sequence

MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKG
AVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLTGGQ
DKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMTEVKSL
NFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHPEKEFLVA
GGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKTY
GLWKCVLPEEDSGELAKPKIGFPETTEEELEEIASENSDCIFPSAPDVKA

Sequence length

350

Interactions

View interactions

	Reactome
			Downregulation of TGF-beta receptor signaling

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLORECTAL NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (11)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Carcinoma Hepatocellular	Associate	36581319	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Non Small Cell Lung	Associate	21502811, 36551208	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Associate	15720808	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Death	Associate	15720808	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertension	Associate	32664164	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myelodysplastic Syndromes	Associate	28436936	★★★★★ ★☆☆☆☆ Found in Text Mining only
Necrosis	Associate	29046333	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	15720808, 17309779, 35272839	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Associate	35272839	★★★★★ ★☆☆☆☆ Found in Text Mining only
Smoke Inhalation Injury	Associate	32564237	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ventricular Remodeling	Associate	32664164	★★★★★ ★☆☆☆☆ Found in Text Mining only

STRAP (serine/threonine kinase receptor associated protein)