Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
11171
Gene name Gene Name - the full gene name approved by the HGNC.
Serine/threonine kinase receptor associated protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
STRAP
Synonyms (NCBI Gene) Gene synonyms aliases
MAWD, PT-WD, UNRIP
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12p12.3
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT025462 hsa-miR-34a-5p Proteomics 21566225
MIRT025462 hsa-miR-34a-5p Proteomics 21566225
MIRT025462 hsa-miR-34a-5p Proteomics 21566225
MIRT031678 hsa-miR-16-5p Proteomics 18668040
MIRT036801 hsa-miR-374b-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000387 Process Spliceosomal snRNP assembly IBA 21873635
GO:0000387 Process Spliceosomal snRNP assembly IDA 18984161
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003723 Function RNA binding IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605986 30796 ENSG00000023734
Protein
UniProt ID Q9Y3F4
Protein name Serine-threonine kinase receptor-associated protein (MAP activator with WD repeats) (UNR-interacting protein) (WD-40 repeat protein PT-WD)
Protein function The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00400 WD40 49 87 WD domain, G-beta repeat Repeat
PF00400 WD40 91 128 WD domain, G-beta repeat Repeat
PF00400 WD40 134 170 WD domain, G-beta repeat Repeat
PF00400 WD40 255 293 WD domain, G-beta repeat Repeat
Sequence
MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKG
AVWGATLNKDATKAATAAADFTAKVWD
AVSGDELMTLAHKHIVKTVDFTQDSNYLLTGGQ
DKLLRIYD
LNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMTEVKSL
NFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHPEKEFLVA
GGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKTY
GLWKCVLPEEDSGELAKPKIGFPETTEEELEEIASENSDCIFPSAPDVKA
Sequence length 350
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Downregulation of TGF-beta receptor signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
15720808
Colorectal neoplasms Colorectal Neoplasms rs28929483, rs63751108, rs28929484, rs63749831, rs63750047, rs63751207, rs63749811, rs1553350126, rs63750875, rs63750955, rs587776706, rs63750871, rs587776715, rs63751466, rs63750049
View all (1682 more)
15720808
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Hepatocellular Associate 36581319
Carcinoma Non Small Cell Lung Associate 21502811, 36551208
Colorectal Neoplasms Associate 15720808
Death Associate 15720808
Hypertension Associate 32664164
Myelodysplastic Syndromes Associate 28436936
Necrosis Associate 29046333
Neoplasms Associate 15720808, 17309779, 35272839
Neuroblastoma Associate 35272839
Smoke Inhalation Injury Associate 32564237