Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	11169
Gene name	WD repeat and HMG-box DNA binding protein 1
Gene symbol	WDHD1
Synonyms (NCBI Gene)	AND-1AND1CHTF4CTF4
Chromosome	14
Chromosome location	14q22.2-q22.3
Summary	The protein encoded by this gene contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG) box. WD40 domains are found in a variety of eukaryotic proteins and may function as adaptor/regulatory modules in signal transduction, pr

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miRTarBase ID	miRNA	Experiments	Reference
MIRT029637	hsa-miR-26b-5p	Microarray	19088304
MIRT439292	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439292	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1489663	hsa-miR-1283	CLIP-seq
MIRT1489664	hsa-miR-3618	CLIP-seq
MIRT1489665	hsa-miR-4666-5p	CLIP-seq
MIRT1489666	hsa-miR-548ac	CLIP-seq
MIRT1489667	hsa-miR-548ae	CLIP-seq
MIRT1489668	hsa-miR-548aj	CLIP-seq
MIRT1489669	hsa-miR-548am	CLIP-seq
MIRT1489670	hsa-miR-548d-3p	CLIP-seq
MIRT1489671	hsa-miR-548x	CLIP-seq
MIRT1489672	hsa-miR-548z	CLIP-seq
MIRT1489673	hsa-miR-605	CLIP-seq
MIRT1489674	hsa-miR-934	CLIP-seq
MIRT1489675	hsa-miR-1224-3p	CLIP-seq
MIRT1489676	hsa-miR-1260	CLIP-seq
MIRT1489677	hsa-miR-1260b	CLIP-seq
MIRT1489678	hsa-miR-1280	CLIP-seq
MIRT1489679	hsa-miR-1291	CLIP-seq
MIRT1489680	hsa-miR-1322	CLIP-seq
MIRT1489681	hsa-miR-142-5p	CLIP-seq
MIRT1489682	hsa-miR-1827	CLIP-seq
MIRT1489683	hsa-miR-2276	CLIP-seq
MIRT1489684	hsa-miR-3065-5p	CLIP-seq
MIRT1489685	hsa-miR-3163	CLIP-seq
MIRT1489686	hsa-miR-3173-5p	CLIP-seq
MIRT1489687	hsa-miR-335	CLIP-seq
MIRT1489688	hsa-miR-340	CLIP-seq
MIRT1489689	hsa-miR-3612	CLIP-seq
MIRT1489690	hsa-miR-3662	CLIP-seq
MIRT1489691	hsa-miR-3921	CLIP-seq
MIRT1489692	hsa-miR-4421	CLIP-seq
MIRT1489693	hsa-miR-4422	CLIP-seq
MIRT1489694	hsa-miR-4443	CLIP-seq
MIRT1489695	hsa-miR-4653-5p	CLIP-seq
MIRT1489696	hsa-miR-4733-5p	CLIP-seq
MIRT1489697	hsa-miR-4766-5p	CLIP-seq
MIRT1489698	hsa-miR-4772-3p	CLIP-seq
MIRT1489699	hsa-miR-4796-5p	CLIP-seq
MIRT1489700	hsa-miR-488	CLIP-seq
MIRT1489701	hsa-miR-505	CLIP-seq
MIRT1489666	hsa-miR-548ac	CLIP-seq
MIRT1489667	hsa-miR-548ae	CLIP-seq
MIRT1489668	hsa-miR-548aj	CLIP-seq
MIRT1489669	hsa-miR-548am	CLIP-seq
MIRT1489670	hsa-miR-548d-3p	CLIP-seq
MIRT1489671	hsa-miR-548x	CLIP-seq
MIRT1489672	hsa-miR-548z	CLIP-seq
MIRT1489673	hsa-miR-605	CLIP-seq
MIRT1489702	hsa-miR-650	CLIP-seq
MIRT2147639	hsa-miR-299-3p	CLIP-seq
MIRT2147640	hsa-miR-3125	CLIP-seq
MIRT2147641	hsa-miR-3149	CLIP-seq
MIRT2147642	hsa-miR-3916	CLIP-seq
MIRT2147643	hsa-miR-4476	CLIP-seq
MIRT2147644	hsa-miR-4491	CLIP-seq
MIRT2147645	hsa-miR-4533	CLIP-seq
MIRT2147646	hsa-miR-4657	CLIP-seq
MIRT2147647	hsa-miR-4795-3p	CLIP-seq
MIRT2147648	hsa-miR-548aa	CLIP-seq
MIRT2147649	hsa-miR-593	CLIP-seq
MIRT2147650	hsa-miR-598	CLIP-seq
MIRT2147651	hsa-miR-877	CLIP-seq
MIRT1489680	hsa-miR-1322	CLIP-seq
MIRT2147639	hsa-miR-299-3p	CLIP-seq
MIRT2463365	hsa-miR-4474-3p	CLIP-seq
MIRT2147644	hsa-miR-4491	CLIP-seq
MIRT2147646	hsa-miR-4657	CLIP-seq
MIRT2463366	hsa-miR-604	CLIP-seq
MIRT2463367	hsa-miR-647	CLIP-seq
MIRT2661494	hsa-miR-3160-5p	CLIP-seq
MIRT2661495	hsa-miR-3920	CLIP-seq
MIRT2661496	hsa-miR-4420	CLIP-seq
MIRT2661497	hsa-miR-4426	CLIP-seq
MIRT2661498	hsa-miR-4647	CLIP-seq
MIRT2661499	hsa-miR-4662b	CLIP-seq
MIRT2661500	hsa-miR-4704-3p	CLIP-seq
MIRT2661494	hsa-miR-3160-5p	CLIP-seq
MIRT2661495	hsa-miR-3920	CLIP-seq
MIRT2661496	hsa-miR-4420	CLIP-seq
MIRT2661497	hsa-miR-4426	CLIP-seq
MIRT2661498	hsa-miR-4647	CLIP-seq
MIRT2661499	hsa-miR-4662b	CLIP-seq
MIRT2661500	hsa-miR-4704-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000278	Process	Mitotic cell cycle	IBA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003677	Function	DNA binding	TAS	9175701
GO:0003682	Function	Chromatin binding	IBA
GO:0005515	Function	Protein binding	IPI	21725360
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS	9175701
GO:0005737	Component	Cytoplasm	TAS	9175701
GO:0006261	Process	DNA-templated DNA replication	IBA
GO:0006261	Process	DNA-templated DNA replication	IEA
GO:0006281	Process	DNA repair	IBA
GO:0043596	Component	Nuclear replication fork	IBA

MIM	HGNC	e!Ensembl
608126	23170	ENSG00000198554

O75717

Protein name

WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1)

Protein function

Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork. {ECO:0000269|PubMed:19805216, ECO:0000269|PubMed:34694004, EC

PDB

2D7L , 5GVA , 5GVB , 5OGS , 6XTY , 7PFO , 7PLO , 8B9D

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00400	WD40	7 → 41	WD domain, G-beta repeat	Repeat
PF00400	WD40	126 → 164	WD domain, G-beta repeat	Repeat
PF12894	ANAPC4_WD40	192 → 284	Anaphase-promoting complex subunit 4 WD40 domain	Repeat
PF12341	Mcl1_mid	431 → 715	Minichromosome loss protein, Mcl1, middle region	Family

Sequence

MPATRKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSC
ALKSGKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKI
VDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKC
NDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSP
CGQYLAAGSINGLIIVWNVETKDCMERVKHEKGYAICGLAWHPTCGRISYTDAEGNLGLL
ENVCDPSGKTSSSKVSSRVEKDYNDLFDGDDMSNAGDFLNDNAVEIPSFSKGIINDDEDD
EDLMMASGRPRQRSHILEDDENSVDISMLKTGSSLLKEEEEDGQEGSIHNLPLVTSQRPF
YDGPMPTPRQKPFQSGSTPLHLTHRFMVWNSIGIIRCYNDEQDNAIDVEFHDTSIHHATH
LSNTLNYTIADLSHEAILLACESTDELASKLHCLHFSSWDSSKEWIIDLPQNEDIEAICL
GQGWAAAATSALLLRLFTIGGVQKEVFSLAGPVVSMAGHGEQLFIVYHRGTGFDGDQCLG
VQLLELGKKKKQILHGDPLPLTRKSYLAWIGFSAEGTPCYVDSEGIVRMLNRGLGNTWTP
ICNTREHCKGKSDHYWVVGIHENPQQLRCIPCKGSRFPPTLPRPAVAILSFKLPYCQIAT
EKGQMEEQFWRSVIFHNHLDYLAKNGYEYEESTKNQATKEQQELLMKMLALSCKLEREFR
CVELADLMTQNAVNLAIKYASRSRKLILAQKLSELAVEKAAELTATQVEEEEEEEDFRKK
LNAGYSNTATEWSQPRFRNQVEEDAEDSGEADDEEKPEIHKPGQNSFSKSTNSSDVSAKS
GAVTFSSQGRVNPFKVSASSKEPAMSMNSARSTNILDNMGKSSKKSTALSRTTNNEKSPI
IKPLIPKPKPKQASAASYFQKRNSQTNKTEEVKEENLKNVLSETPAICPPQNTENQRPKT
GFQMWLEENRSNILSDNPDFSDEADIIKEGMIRFRVLSTEERKVWANKAKGETASEGTEA
KKRKRVVDESDETENQEEKAKENLNLSKKQKPLDFSTNQKLSAFAFKQE

Sequence length

1129

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (13)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTROCYTOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DRY EYE SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERIPHERAL NEUROPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Likely benign; Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
WDHD1-related disorder	Uncertain significance; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	25124574	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Associate	32883234	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Associate	37759234	★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Associate	37759234	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Associate	33345608	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypospadias	Associate	32728162	★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Stimulate	36345604	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	34923765, 34999279, 36345604, 37759234	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Associate	34999279	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Associate	33221821	★★★★★ ★☆☆☆☆ Found in Text Mining only

WDHD1 (WD repeat and HMG-box DNA binding protein 1)