Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	11164
Gene name	Nudix hydrolase 5
Gene symbol	NUDT5
Synonyms (NCBI Gene)	YSA1YSA1HYSAH1hNUDT5
Chromosome	10
Chromosome location	10p14
Summary	This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP.

Show/Hide all (73)

miRTarBase ID	miRNA	Experiments	Reference
MIRT052516	hsa-let-7a-5p	CLASH	23622248
MIRT047366	hsa-miR-34a-5p	CLASH	23622248
MIRT036897	hsa-miR-877-3p	CLASH	23622248
MIRT720805	hsa-miR-5193	HITS-CLIP	19536157
MIRT720804	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT617598	hsa-miR-3183	HITS-CLIP	19536157
MIRT617597	hsa-miR-4723-3p	HITS-CLIP	19536157
MIRT617596	hsa-miR-6769b-3p	HITS-CLIP	19536157
MIRT329961	hsa-miR-1237-3p	HITS-CLIP	19536157
MIRT329962	hsa-miR-1248	HITS-CLIP	19536157
MIRT617595	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT617594	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT617593	hsa-miR-7977	HITS-CLIP	19536157
MIRT617592	hsa-miR-7111-3p	HITS-CLIP	19536157
MIRT720803	hsa-miR-6868-3p	HITS-CLIP	19536157
MIRT720802	hsa-miR-4279	HITS-CLIP	19536157
MIRT720801	hsa-miR-1281	HITS-CLIP	19536157
MIRT617598	hsa-miR-3183	HITS-CLIP	23824327
MIRT617597	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT617596	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT617595	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT617593	hsa-miR-7977	HITS-CLIP	23824327
MIRT617598	hsa-miR-3183	HITS-CLIP	23824327
MIRT617597	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT617596	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT617595	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT617594	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT617593	hsa-miR-7977	HITS-CLIP	23824327
MIRT617592	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT177051	hsa-miR-1250-3p	PAR-CLIP	22012620
MIRT177047	hsa-miR-153-5p	PAR-CLIP	22012620
MIRT535592	hsa-miR-1224-3p	PAR-CLIP	22012620
MIRT535591	hsa-miR-4286	PAR-CLIP	22012620
MIRT535590	hsa-miR-4433b-5p	PAR-CLIP	22012620
MIRT440078	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440078	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT720805	hsa-miR-5193	HITS-CLIP	19536157
MIRT720804	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT617598	hsa-miR-3183	HITS-CLIP	19536157
MIRT617597	hsa-miR-4723-3p	HITS-CLIP	19536157
MIRT617596	hsa-miR-6769b-3p	HITS-CLIP	19536157
MIRT329961	hsa-miR-1237-3p	HITS-CLIP	19536157
MIRT329962	hsa-miR-1248	HITS-CLIP	19536157
MIRT617595	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT617594	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT617593	hsa-miR-7977	HITS-CLIP	19536157
MIRT617592	hsa-miR-7111-3p	HITS-CLIP	19536157
MIRT720803	hsa-miR-6868-3p	HITS-CLIP	19536157
MIRT720802	hsa-miR-4279	HITS-CLIP	19536157
MIRT720801	hsa-miR-1281	HITS-CLIP	19536157
MIRT617598	hsa-miR-3183	HITS-CLIP	23824327
MIRT617597	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT617596	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT617595	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT617593	hsa-miR-7977	HITS-CLIP	23824327
MIRT617598	hsa-miR-3183	HITS-CLIP	23824327
MIRT617597	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT617596	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT617595	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT617594	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT617593	hsa-miR-7977	HITS-CLIP	23824327
MIRT617592	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT177051	hsa-miR-1250-3p	PAR-CLIP	22012620
MIRT177047	hsa-miR-153-5p	PAR-CLIP	22012620
MIRT535592	hsa-miR-1224-3p	PAR-CLIP	22012620
MIRT535591	hsa-miR-4286	PAR-CLIP	22012620
MIRT535590	hsa-miR-4433b-5p	PAR-CLIP	22012620
MIRT1198358	hsa-miR-1279	CLIP-seq
MIRT1198359	hsa-miR-199a-5p	CLIP-seq
MIRT1198360	hsa-miR-199b-5p	CLIP-seq
MIRT1198361	hsa-miR-4435	CLIP-seq
MIRT1198362	hsa-miR-520d-5p	CLIP-seq
MIRT1198363	hsa-miR-524-5p	CLIP-seq

Show/Hide all (37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IDA	18462755
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	27257257, 28514442, 32296183, 33961781
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	27257257
GO:0005634	Component	Nucleus	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006139	Process	Nucleobase-containing compound metabolic process	IEA
GO:0006338	Process	Chromatin remodeling	IDA	27257257
GO:0006753	Process	Nucleoside phosphate metabolic process	IBA
GO:0009117	Process	Nucleotide metabolic process	NAS	10567213
GO:0009191	Process	Ribonucleoside diphosphate catabolic process	IDA	18462755, 19699693, 21389046
GO:0009191	Process	Ribonucleoside diphosphate catabolic process	TAS	10722730
GO:0016740	Function	Transferase activity	IEA
GO:0016779	Function	Nucleotidyltransferase activity	IDA	27257257
GO:0016787	Function	Hydrolase activity	IEA
GO:0017110	Function	Nucleoside diphosphate phosphatase activity	IEA
GO:0019144	Function	ADP-sugar diphosphatase activity	IDA	10567213, 18462755
GO:0019303	Process	D-ribose catabolic process	IDA	21389046
GO:0019303	Process	D-ribose catabolic process	NAS	10567213
GO:0019693	Process	Ribose phosphate metabolic process	IBA
GO:0030515	Function	SnoRNA binding	IEA
GO:0030515	Function	SnoRNA binding	ISS
GO:0042802	Function	Identical protein binding	IPI	32296183
GO:0042803	Function	Protein homodimerization activity	IDA	27257257
GO:0044715	Function	8-oxo-dGDP phosphatase activity	IDA	19699693, 21389046
GO:0044715	Function	8-oxo-dGDP phosphatase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0047631	Function	ADP-ribose diphosphatase activity	EXP	17052728, 18462755
GO:0047631	Function	ADP-ribose diphosphatase activity	IBA
GO:0047631	Function	ADP-ribose diphosphatase activity	IDA	21389046
GO:0047631	Function	ADP-ribose diphosphatase activity	IEA
GO:0055086	Process	Nucleobase-containing small molecule metabolic process	TAS
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0140933	Function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity	ISS
GO:1990966	Process	ATP generation from poly-ADP-D-ribose	IDA	27257257

MIM	HGNC	e!Ensembl
609230	8052	ENSG00000165609

Q9UKK9

Protein name

ADP-sugar pyrophosphatase (EC 3.6.1.13) (8-oxo-dGDP phosphatase) (EC 3.6.1.58) (Nuclear ATP-synthesis protein NUDIX5) (EC 2.7.7.96) (Nucleoside diphosphate-linked moiety X motif 5) (Nudix motif 5) (hNUDT5) (YSA1H)

Protein function

Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (PubMed:27257257). In absence of diphosphate, hydrolyzes with similar activities various modified nu

PDB

2DSB , 2DSC , 2DSD , 3AC9 , 3ACA , 3BM4 , 3L85 , 5NQR , 5NWH , 5QJ4 , 5QJ5 , 5QJ6 , 5QJ7 , 5QJ8 , 5QJ9 , 5QJA , 5QJB , 5QJC , 5QJD , 5QJE , 5QJF , 5QJG , 5QJH , 5QJI , 5QJJ , 5QJK , 5QJL , 5QJM , 5QJN , 5QJO , 5QJP , 5QJQ , 5QJR , 5QJS , 5QJT , 5QJU , 5QJV , 5QJW , 5QJX , 5QJY , 5QJZ , 5QK0 , 5QK1 , 5QK2 , 5QK3 , 5QK4 , 5QK5 , 5QK6 , 5QK7 , 5QK8 , 5QK9

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00293	NUDIX	58 → 196	NUDIX domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Most abundant in liver. {ECO:0000269|PubMed:10722730}.

Sequence

MESQEPTESSQNGKQYIISEELISEGKWVKLEKTTYMDPTGKTRTWESVKRTTRKEQTAD
GVAVIPVLQRTLHYECIVLVKQFRPPMGGYCIEFPAGLIDDGETPEAAALRELEEETGYK
GDIAECSPAVCMDPGLSNCTIHIVTVTINGDDAENARPKPKPGDGEFVEVISLPKNDLLQ
RLDALVAEEHLTVDARVYSYALALKHANAKPFEVPFLKF

Sequence length

219

Interactions

View interactions

	KEGG		Reactome
	Purine metabolism Metabolic pathways		Phosphate bond hydrolysis by NUDT proteins

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERIODONTITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Arthritis Psoriatic	Associate	34344401	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Associate	29343827	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Stimulate	33571243	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Non Small Cell Lung	Associate	33096144	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Stimulate	33096144	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	33096144, 33571243	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms Adipose Tissue	Associate	37676424	★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	40662362	★★★★★ ★☆☆☆☆ Found in Text Mining only

NUDT5 (nudix hydrolase 5)