NUDT6 (nudix hydrolase 6)

Gene
Gene Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
11162
Gene name Gene Name - the full gene name approved by the HGNC.
Nudix hydrolase 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NUDT6
Synonyms (NCBI Gene) Gene synonyms aliases
ASFGF2, FGF-AS, FGF2AS, GFG-1, GFG1
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q28.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene overlaps and lies on the opposite strand from FGF2 gene, and is thought to be the FGF2 antisense gene. The two genes are independently transcribed, and their expression shows an inverse relationship, suggesting that this antisense transcript may
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide all(15)
GO ID Ontology Definition Evidence Reference
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IDA 11266510
GO:0005737 Component Cytoplasm IEA
GO:0005739 Component Mitochondrion HTP 34800366
GO:0005739 Component Mitochondrion IDA 37343711
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
606261 8053 ENSG00000170917
Protein
Gene Gene ontology Other IDs Protein Associated diseases
UniProt ID P53370
Protein name Nucleoside diphosphate-linked moiety X motif 6 (Nudix motif 6) (EC 3.6.1.-) (Antisense basic fibroblast growth factor) (Protein GFG)
Protein function May contribute to the regulation of cell proliferation.
PDB 3FXT , 3H95
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF18290 Nudix_hydro 46 → 129 Nudix hydrolase domain Domain
PF00293 NUDIX 141 → 270 NUDIX domain Domain
Tissue specificity TISSUE SPECIFICITY: Detected in liver, kidney and esophagus (at protein level). Ubiquitous. {ECO:0000269|PubMed:11266510, ECO:0000269|PubMed:17569023}.
Sequence
Sequence length 316
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Diabetes Type 2 diabetes N/A N/A GWAS
Show/Hide Text Mining Associations (5)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Colorectal Neoplasms Associate 19157820, 29182684, 33034614
Coronary Disease Associate 36060667
Macular Degeneration Associate 21106043
Neoplasms Associate 20197313
Stomach Neoplasms Associate 33316777