NUDT6 (nudix hydrolase 6)

Gene Gene information from NCBI Gene database.
Gene Gene ontology Other IDs Protein Associated diseases
Entrez ID 11162
Gene name Nudix hydrolase 6
Gene symbol NUDT6
Synonyms (NCBI Gene)
ASFGF2FGF-ASFGF2ASGFG-1GFG1
Chromosome 4
Chromosome location 4q28.1
Summary This gene overlaps and lies on the opposite strand from FGF2 gene, and is thought to be the FGF2 antisense gene. The two genes are independently transcribed, and their expression shows an inverse relationship, suggesting that this antisense transcript may
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide all (15)
GO ID Ontology Definition Evidence Reference
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IDA 11266510
GO:0005737 Component Cytoplasm IEA
GO:0005739 Component Mitochondrion HTP 34800366
GO:0005739 Component Mitochondrion IDA 37343711
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
606261 8053 ENSG00000170917
Protein Protein information from UniProt database.
Gene Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P53370
Protein name Nucleoside diphosphate-linked moiety X motif 6 (Nudix motif 6) (EC 3.6.1.-) (Antisense basic fibroblast growth factor) (Protein GFG)
Protein function May contribute to the regulation of cell proliferation.
PDB 3FXT , 3H95
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF18290 Nudix_hydro 46 → 129 Nudix hydrolase domain Domain
PF00293 NUDIX 141 → 270 NUDIX domain Domain
Tissue specificity TISSUE SPECIFICITY: Detected in liver, kidney and esophagus (at protein level). Ubiquitous. {ECO:0000269|PubMed:11266510, ECO:0000269|PubMed:17569023}.
Sequence
Sequence length 316
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
18
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (14)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Benign rs45625032 RCV005935519
Cervical cancer Benign rs45625032 RCV005935522
Colon adenocarcinoma Benign rs45625032 RCV005935518
Gastric cancer Benign rs45625032 RCV005935524
Show/Hide Text Mining Associations (5)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Colorectal Neoplasms Associate 19157820, 29182684, 33034614
Coronary Disease Associate 36060667
Macular Degeneration Associate 21106043
Neoplasms Associate 20197313
Stomach Neoplasms Associate 33316777