CHI3L1 (chitinase 3 like 1)

Gene
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1116
Gene name Gene Name - the full gene name approved by the HGNC.
Chitinase 3 like 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CHI3L1
Synonyms (NCBI Gene) Gene synonyms aliases
ASRT7, CGP-39, GP-39, GP39, HC-gp39, HCGP-3P, YK-40, YKL-40, YKL40, YYL-40, hCGP-39
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q32.1
Summary Summary of gene provided in NCBI Entrez Gene.
Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein membe
SNPs SNP information provided by dbSNP.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
SNP ID Visualize variation Clinical significance Consequence
rs4950928 G>A,C,T Risk-factor Upstream transcript variant
miRNA miRNA information provided by mirtarbase database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(81)
miRTarBase ID miRNA Experiments Reference
MIRT733139 hsa-miR-378g Immunoprecipitaion (IP), Luciferase reporter assay, qRT-PCR, Western blotting 32021459
MIRT2436230 hsa-miR-125a-3p CLIP-seq
MIRT2436231 hsa-miR-214 CLIP-seq
MIRT2436232 hsa-miR-24 CLIP-seq
MIRT2436233 hsa-miR-2467-5p CLIP-seq
Transcription factors
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(3)
Transcription factor Regulation Reference
NFIX Activation 21953450
SP1 Unknown 12933821
STAT3 Activation 21953450
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0004568 Function Chitinase activity IBA
GO:0004568 Function Chitinase activity IDA 8245017, 9492324
GO:0005201 Function Extracellular matrix structural constituent NAS 8245017
GO:0005515 Function Protein binding IPI 23972995, 27629921, 28143526, 29427412
GO:0005576 Component Extracellular region IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
601525 1932 ENSG00000133048
Protein
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P36222
Protein name Chitinase-3-like protein 1 (39 kDa synovial protein) (Cartilage glycoprotein 39) (CGP-39) (GP-39) (hCGP-39) (YKL-40)
Protein function Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2
PDB 1HJV , 1HJW , 1HJX , 1NWR , 1NWS , 1NWT , 1NWU , 7CJ2 , 8DF1 , 8R41 , 8R42 , 8R4X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00704 Glyco_hydro_18 23 → 357 Glycosyl hydrolases family 18 Domain
Tissue specificity TISSUE SPECIFICITY: Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Very low or undetectable expression in non-inflammatory colon. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibrobla
Sequence
Sequence length 383
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Neutrophil degranulation
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Asthma Asthma-related traits, susceptibility to, 7 N/A N/A ClinVar
Show/Hide Text Mining Associations (251)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
AA amyloidosis Associate 30846386
Achondrogenesis type 2 Associate 31277141
Acute Coronary Syndrome Associate 18615353
Acute Kidney Injury Associate 25128003, 38110934
Adenocarcinoma Associate 18723551, 27513329, 36447423
Adenoma Associate 23155391
Alzheimer Disease Stimulate 21035623, 31299989, 31892365
Alzheimer Disease Associate 24902845, 27845782, 28599675, 29558979, 30846386, 32066474, 32344399, 32568193, 34302786, 35173266, 36136224, 37794492, 39385222
Amyotrophic Lateral Sclerosis Stimulate 30215603, 31892365
Amyotrophic Lateral Sclerosis Associate 30572951, 31937582, 32666680