Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	11151
Gene name Gene Name - the full gene name approved by the HGNC.	Coronin 1A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CORO1A
Synonyms (NCBI Gene) Gene synonyms aliases	CLABP, CLIPINA, HCORO1, IMD8, TACO, p57
Disease Acronyms (UniProt) Disease acronyms from UniProt database	IMD8
Chromosome Chromosome number	16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	16p11.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein com

Show/Hide all(3)

SNP ID	Visualize variation	Clinical significance	Consequence
rs35967690	G>A,C	Conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs606231256	C>-	Pathogenic	Frameshift variant, coding sequence variant
rs1213680890	GTGC>-	Pathogenic	Coding sequence variant, frameshift variant

Show/Hide all(19)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005787	hsa-miR-221-3p	Western blot	21226887
MIRT005791	hsa-miR-222-3p	Western blot	21226887
MIRT030627	hsa-miR-24-3p	Western blot	20138800
MIRT039639	hsa-miR-615-3p	CLASH	23622248
MIRT2204107	hsa-miR-3652	CLIP-seq
MIRT2204108	hsa-miR-4430	CLIP-seq
MIRT2204109	hsa-miR-4474-3p	CLIP-seq
MIRT2204110	hsa-miR-4505	CLIP-seq
MIRT2204111	hsa-miR-4646-5p	CLIP-seq
MIRT2204107	hsa-miR-3652	CLIP-seq
MIRT2204108	hsa-miR-4430	CLIP-seq
MIRT2204109	hsa-miR-4474-3p	CLIP-seq
MIRT2204110	hsa-miR-4505	CLIP-seq
MIRT2204111	hsa-miR-4646-5p	CLIP-seq
MIRT2447466	hsa-miR-4659a-5p	CLIP-seq
MIRT2447467	hsa-miR-4659b-5p	CLIP-seq
MIRT2447468	hsa-miR-4727-5p	CLIP-seq
MIRT2447469	hsa-miR-4768-5p	CLIP-seq
MIRT2447470	hsa-miR-4769-3p	CLIP-seq

Show/Hide all(57)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001771	Process	Immunological synapse formation	IMP	24760828
GO:0001772	Component	Immunological synapse	IDA	24760828
GO:0001845	Process	Phagolysosome assembly	IMP	12132654
GO:0001891	Component	Phagocytic cup	IDA	17442961
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003779	Function	Actin binding	IPI	23100250
GO:0003785	Function	Actin monomer binding	IMP	23100250
GO:0005515	Function	Protein binding	IPI	11094157, 17652161, 21988832, 25416956, 31515488, 32296183, 32814053
GO:0005634	Component	Nucleus	IDA	17341475
GO:0005737	Component	Cytoplasm	IDA	17341475
GO:0005769	Component	Early endosome	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005884	Component	Actin filament	IDA	15800061
GO:0005886	Component	Plasma membrane	IDA	17341475, 17442961
GO:0005911	Component	Cell-cell junction	IEA
GO:0006816	Process	Calcium ion transport	IEA
GO:0006909	Process	Phagocytosis	IMP	17442961
GO:0007015	Process	Actin filament organization	IBA	21873635
GO:0008022	Function	Protein C-terminus binding	IPI	9365277
GO:0008092	Function	Cytoskeletal protein binding	ISS
GO:0008360	Process	Regulation of cell shape	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016477	Process	Cell migration	IBA	21873635
GO:0030027	Component	Lamellipodium	IDA	17442961
GO:0030036	Process	Actin cytoskeleton organization	IMP	17442961
GO:0030335	Process	Positive regulation of cell migration	IEA
GO:0030424	Component	Axon	IEA
GO:0030595	Process	Leukocyte chemotaxis	IEA
GO:0030670	Component	Phagocytic vesicle membrane	IEA
GO:0030864	Component	Cortical actin cytoskeleton	IDA	15800061
GO:0030864	Component	Cortical actin cytoskeleton	IDA	24760828
GO:0031339	Process	Negative regulation of vesicle fusion	IEA
GO:0031589	Process	Cell-substrate adhesion	IMP	17442961
GO:0032036	Function	Myosin heavy chain binding	IPI	23100250
GO:0032796	Process	Uropod organization	IEA
GO:0032956	Process	Regulation of actin cytoskeleton organization	IMP	24760828
GO:0032991	Component	Protein-containing complex	IDA	11094157
GO:0038180	Process	Nerve growth factor signaling pathway	IEA
GO:0042102	Process	Positive regulation of T cell proliferation	IEA
GO:0042803	Function	Protein homodimerization activity	IDA	15601263
GO:0043029	Process	T cell homeostasis	IEA
GO:0043320	Process	Natural killer cell degranulation	IMP	24760828
GO:0043524	Process	Negative regulation of neuron apoptotic process	IEA
GO:0043548	Function	Phosphatidylinositol 3-kinase binding	IDA	11094157
GO:0045087	Process	Innate immune response	NAS	17341475
GO:0045335	Component	Phagocytic vesicle	IDA	17442961
GO:0048873	Process	Homeostasis of number of cells within a tissue	IEA
GO:0050918	Process	Positive chemotaxis	IDA	17442961
GO:0051015	Function	Actin filament binding	IBA	21873635
GO:0051015	Function	Actin filament binding	IDA	7758584, 15601263
GO:0051015	Function	Actin filament binding	IMP	22364218, 23100250
GO:0051126	Process	Negative regulation of actin nucleation	IDA	17442961
GO:0051279	Process	Regulation of release of sequestered calcium ion into cytosol	IEA
GO:0061502	Process	Early endosome to recycling endosome transport	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337, 23533145
GO:0071353	Process	Cellular response to interleukin-4	IEA
GO:0098978	Component	Glutamatergic synapse	IEA

MIM	HGNC	e!Ensembl
605000	2252	ENSG00000102879

Protein

UniProt ID

P31146

Protein name

Coronin-1A (Coronin-like protein A) (Clipin-A) (Coronin-like protein p57) (Tryptophan aspartate-containing coat protein) (TACO)

Protein function

May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08953	DUF1899	4 → 69	Domain of unknown function (DUF1899)	Domain
PF00400	WD40	72 → 110	WD domain, G-beta repeat	Repeat
PF00400	WD40	121 → 160	WD domain, G-beta repeat	Repeat
PF00400	WD40	167 → 204	WD domain, G-beta repeat	Repeat
PF16300	WD40_4	345 → 387		Repeat
PF08954	Trimer_CC	410 → 461	Trimerisation motif	Coiled-coil

Tissue specificity

TISSUE SPECIFICITY: Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut.

Sequence

MSRQVVRSSKFRHVFGQPAKADQCYEDVRVSQTTWDSGFCAVNPKFVALICEASGGGAFL
VLPLGKTGRVDKNAPTVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLMLPL
REPVVTLEGHTKRVGIVAWHTTAQNVLLSAGCDNVIMVWDVGTGAAMLTLGPEVHPDTIY
SVDWSRDGGLICTSCRDKRVRIIEPRKGTVVAEKDRPHEGTRPVRAVFVSEGKILTTGFS
RMSERQVALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSE
APFLHYLSMFSSKESQRGMGYMPKRGLEVNKCEIARFYKLHERRCEPIAMTVPRKSDLFQ
EDLYPPTAGPDPALTAEEWLGGRDAGPLLISLKDGYVPPKSRELRVNRGLDTGRRRAAPE
ASGTPSSDAVSRLEEEMRKLQATVQELQKRLDRLEETVQAK

Sequence length

461

Interactions

View interactions

	KEGG		Reactome
	Phagosome Tuberculosis		Prevention of phagosomal-lysosomal fusion

Show/Hide Causal Diseases (4)

Disease term	Disease name	dbSNP ID	References
Causal
Carcinoma	Carcinoma, Carcinoma, Spindle-Cell, Undifferentiated carcinoma	rs121912654, rs555607708, rs786202962, rs1564055259	21489049
Developmental delay	Global developmental delay	rs28941770, rs199469464, rs281865469, rs143747297, rs398123009, rs587777428, rs786205133, rs606231459, rs797044854, rs797045027, rs864309504, rs878853160, rs886039902, rs886042046, rs886041291 View all (32 more)
Immunodeficiency	IMMUNODEFICIENCY 8	rs1565678077, rs121908002, rs1421444086, rs1565688667, rs944235493, rs121918314, rs587776713, rs137852678, rs587776714, rs128620188, rs2147483647, rs1569556522, rs137853331, rs137853332, rs179363866 View all (256 more)	23522482, 19097825, 25073507
Severe combined immunodeficiency disease	Severe Combined Immunodeficiency, Combined immunodeficiency, Severe combined immunodeficiency due to CORO1A deficiency	rs886037607, rs118203993, rs121908714, rs121908739, rs121908740, rs121908735, rs121908721, rs121908722, rs121908156, rs1564414523, rs1564418254, rs1564446526, rs786205074, rs121908157, rs121908159 View all (197 more)	19097825

Show/Hide Unknown Diseases (5)

Disease term	Disease name	Source
Unknown
Autism Spectrum Disorder	autism spectrum disorder	GenCC
Multiple Sclerosis	Multiple Sclerosis	GWAS
Dental caries	Dental caries	GWAS
Insomnia	Insomnia	GWAS
Atrial Fibrillation	Atrial Fibrillation	GWAS

Show/Hide Text Mining Associations (33)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	34337026
Attention Deficit Disorder with Hyperactivity	Associate	19097825
Autism Spectrum Disorder	Associate	19097825
Breast Neoplasms	Associate	38331350
Bronchiectasis	Associate	25073507
Carcinoma Hepatocellular	Associate	27779207
Carcinoma Pancreatic Ductal	Associate	37239355
Carcinoma Renal Cell	Associate	24548857
Chickenpox	Associate	19097825
Cystic Fibrosis	Associate	19454722
Epidermodysplasia Verruciformis	Associate	25073507
Exanthema	Associate	35526384
Griscelli syndrome type 1	Associate	21169636
Hepatitis B	Associate	25073507
Immunologic Deficiency Syndromes	Associate	25073507
Inflammation	Associate	19454722
Leishmaniasis Mucocutaneous	Associate	25073507
Leprosy Tuberculoid	Associate	25073507
Lymphatic Metastasis	Associate	34337026
Lymphoma	Associate	25073507
Lymphopenia	Associate	25073507
Mitochondrial Diseases	Associate	19454722
Molluscum Contagiosum	Associate	25073507
Multiple Myeloma	Stimulate	39231316
Multiple Sclerosis	Associate	23745754
Neoplasms	Stimulate	24548857
Neoplasms	Associate	34189853
Oral Ulcer	Associate	25073507
Osteogenesis imperfecta type 1A	Associate	25073507
Ovarian Neoplasms	Associate	21205084
Severe Combined Immunodeficiency	Associate	19097825, 25073507, 35303369
White Coat Hypertension	Associate	23745754
X Linked Combined Immunodeficiency Diseases	Associate	25073507

CORO1A (coronin 1A)