Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID	11144
Gene name	DNA meiotic recombinase 1
Gene symbol	DMC1
Synonyms (NCBI Gene)	DMC1HLIM15dJ199H16.1
Chromosome	22
Chromosome location	22q13.1
Summary	This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is rep

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Show/Hide all (262)

miRTarBase ID	miRNA	Experiments
MIRT939068	hsa-miR-106a	CLIP-seq
MIRT939069	hsa-miR-106b	CLIP-seq
MIRT939070	hsa-miR-1234	CLIP-seq
MIRT939071	hsa-miR-1245	CLIP-seq
MIRT939072	hsa-miR-1267	CLIP-seq
MIRT939073	hsa-miR-142-5p	CLIP-seq
MIRT939074	hsa-miR-150	CLIP-seq
MIRT939075	hsa-miR-17	CLIP-seq
MIRT939076	hsa-miR-20a	CLIP-seq
MIRT939077	hsa-miR-20b	CLIP-seq
MIRT939078	hsa-miR-302a	CLIP-seq
MIRT939079	hsa-miR-302b	CLIP-seq
MIRT939080	hsa-miR-302c	CLIP-seq
MIRT939081	hsa-miR-302d	CLIP-seq
MIRT939082	hsa-miR-302e	CLIP-seq
MIRT939083	hsa-miR-3145-3p	CLIP-seq
MIRT939084	hsa-miR-331-5p	CLIP-seq
MIRT939085	hsa-miR-340	CLIP-seq
MIRT939086	hsa-miR-3545-3p	CLIP-seq
MIRT939087	hsa-miR-3663-5p	CLIP-seq
MIRT939088	hsa-miR-372	CLIP-seq
MIRT939089	hsa-miR-373	CLIP-seq
MIRT939090	hsa-miR-4635	CLIP-seq
MIRT939091	hsa-miR-4652-3p	CLIP-seq
MIRT939092	hsa-miR-4678	CLIP-seq
MIRT939093	hsa-miR-4680-5p	CLIP-seq
MIRT939094	hsa-miR-4731-5p	CLIP-seq
MIRT939095	hsa-miR-512-3p	CLIP-seq
MIRT939096	hsa-miR-519d	CLIP-seq
MIRT939097	hsa-miR-520a-3p	CLIP-seq
MIRT939098	hsa-miR-520b	CLIP-seq
MIRT939099	hsa-miR-520c-3p	CLIP-seq
MIRT939100	hsa-miR-520d-3p	CLIP-seq
MIRT939101	hsa-miR-520e	CLIP-seq
MIRT939102	hsa-miR-520g	CLIP-seq
MIRT939103	hsa-miR-520h	CLIP-seq
MIRT939104	hsa-miR-548m	CLIP-seq
MIRT939105	hsa-miR-587	CLIP-seq
MIRT939106	hsa-miR-640	CLIP-seq
MIRT939107	hsa-miR-656	CLIP-seq
MIRT939108	hsa-miR-93	CLIP-seq
MIRT939068	hsa-miR-106a	CLIP-seq
MIRT939069	hsa-miR-106b	CLIP-seq
MIRT1977817	hsa-miR-122	CLIP-seq
MIRT939070	hsa-miR-1234	CLIP-seq
MIRT939071	hsa-miR-1245	CLIP-seq
MIRT939074	hsa-miR-150	CLIP-seq
MIRT939075	hsa-miR-17	CLIP-seq
MIRT939076	hsa-miR-20a	CLIP-seq
MIRT939077	hsa-miR-20b	CLIP-seq
MIRT939078	hsa-miR-302a	CLIP-seq
MIRT939079	hsa-miR-302b	CLIP-seq
MIRT939080	hsa-miR-302c	CLIP-seq
MIRT939081	hsa-miR-302d	CLIP-seq
MIRT939082	hsa-miR-302e	CLIP-seq
MIRT1977818	hsa-miR-3135b	CLIP-seq
MIRT1977819	hsa-miR-3614-5p	CLIP-seq
MIRT1977820	hsa-miR-3652	CLIP-seq
MIRT939088	hsa-miR-372	CLIP-seq
MIRT939089	hsa-miR-373	CLIP-seq
MIRT1977821	hsa-miR-3929	CLIP-seq
MIRT1977822	hsa-miR-3934	CLIP-seq
MIRT1977823	hsa-miR-4252	CLIP-seq
MIRT1977824	hsa-miR-4325	CLIP-seq
MIRT1977825	hsa-miR-4419b	CLIP-seq
MIRT1977826	hsa-miR-4430	CLIP-seq
MIRT1977827	hsa-miR-4478	CLIP-seq
MIRT939094	hsa-miR-4731-5p	CLIP-seq
MIRT1977828	hsa-miR-4753-3p	CLIP-seq
MIRT1977829	hsa-miR-4775	CLIP-seq
MIRT1977830	hsa-miR-4793-3p	CLIP-seq
MIRT1977831	hsa-miR-5095	CLIP-seq
MIRT939095	hsa-miR-512-3p	CLIP-seq
MIRT939096	hsa-miR-519d	CLIP-seq
MIRT939097	hsa-miR-520a-3p	CLIP-seq
MIRT939098	hsa-miR-520b	CLIP-seq
MIRT939099	hsa-miR-520c-3p	CLIP-seq
MIRT939100	hsa-miR-520d-3p	CLIP-seq
MIRT939101	hsa-miR-520e	CLIP-seq
MIRT939102	hsa-miR-520g	CLIP-seq
MIRT939103	hsa-miR-520h	CLIP-seq
MIRT1977832	hsa-miR-552	CLIP-seq
MIRT1977833	hsa-miR-628-5p	CLIP-seq
MIRT939106	hsa-miR-640	CLIP-seq
MIRT1977834	hsa-miR-645	CLIP-seq
MIRT939108	hsa-miR-93	CLIP-seq
MIRT939068	hsa-miR-106a	CLIP-seq
MIRT939069	hsa-miR-106b	CLIP-seq
MIRT1977817	hsa-miR-122	CLIP-seq
MIRT939070	hsa-miR-1234	CLIP-seq
MIRT939071	hsa-miR-1245	CLIP-seq
MIRT2213151	hsa-miR-1343	CLIP-seq
MIRT939074	hsa-miR-150	CLIP-seq
MIRT939075	hsa-miR-17	CLIP-seq
MIRT2213152	hsa-miR-1976	CLIP-seq
MIRT939076	hsa-miR-20a	CLIP-seq
MIRT939077	hsa-miR-20b	CLIP-seq
MIRT2213153	hsa-miR-216b	CLIP-seq
MIRT939078	hsa-miR-302a	CLIP-seq
MIRT939079	hsa-miR-302b	CLIP-seq
MIRT939080	hsa-miR-302c	CLIP-seq
MIRT939081	hsa-miR-302d	CLIP-seq
MIRT939082	hsa-miR-302e	CLIP-seq
MIRT1977818	hsa-miR-3135b	CLIP-seq
MIRT2213154	hsa-miR-3187-3p	CLIP-seq
MIRT939086	hsa-miR-3545-3p	CLIP-seq
MIRT1977820	hsa-miR-3652	CLIP-seq
MIRT939087	hsa-miR-3663-5p	CLIP-seq
MIRT2213155	hsa-miR-3664-5p	CLIP-seq
MIRT939088	hsa-miR-372	CLIP-seq
MIRT939089	hsa-miR-373	CLIP-seq
MIRT1977821	hsa-miR-3929	CLIP-seq
MIRT2213156	hsa-miR-4279	CLIP-seq
MIRT1977825	hsa-miR-4419b	CLIP-seq
MIRT1977826	hsa-miR-4430	CLIP-seq
MIRT2213157	hsa-miR-4435	CLIP-seq
MIRT1977827	hsa-miR-4478	CLIP-seq
MIRT939090	hsa-miR-4635	CLIP-seq
MIRT2213158	hsa-miR-4639-3p	CLIP-seq
MIRT939093	hsa-miR-4680-5p	CLIP-seq
MIRT2213159	hsa-miR-4701-5p	CLIP-seq
MIRT2213160	hsa-miR-4716-5p	CLIP-seq
MIRT2213161	hsa-miR-4722-3p	CLIP-seq
MIRT939094	hsa-miR-4731-5p	CLIP-seq
MIRT2213162	hsa-miR-4755-3p	CLIP-seq
MIRT2213163	hsa-miR-4781-3p	CLIP-seq
MIRT2213164	hsa-miR-498	CLIP-seq
MIRT1977831	hsa-miR-5095	CLIP-seq
MIRT939095	hsa-miR-512-3p	CLIP-seq
MIRT939096	hsa-miR-519d	CLIP-seq
MIRT939097	hsa-miR-520a-3p	CLIP-seq
MIRT2213165	hsa-miR-520a-5p	CLIP-seq
MIRT939098	hsa-miR-520b	CLIP-seq
MIRT939099	hsa-miR-520c-3p	CLIP-seq
MIRT939100	hsa-miR-520d-3p	CLIP-seq
MIRT939101	hsa-miR-520e	CLIP-seq
MIRT939102	hsa-miR-520g	CLIP-seq
MIRT939103	hsa-miR-520h	CLIP-seq
MIRT2213166	hsa-miR-525-5p	CLIP-seq
MIRT2213167	hsa-miR-548s	CLIP-seq
MIRT1977832	hsa-miR-552	CLIP-seq
MIRT2213168	hsa-miR-588	CLIP-seq
MIRT939106	hsa-miR-640	CLIP-seq
MIRT1977834	hsa-miR-645	CLIP-seq
MIRT939108	hsa-miR-93	CLIP-seq
MIRT1977817	hsa-miR-122	CLIP-seq
MIRT939070	hsa-miR-1234	CLIP-seq
MIRT939071	hsa-miR-1245	CLIP-seq
MIRT1977818	hsa-miR-3135b	CLIP-seq
MIRT1977820	hsa-miR-3652	CLIP-seq
MIRT1977821	hsa-miR-3929	CLIP-seq
MIRT1977825	hsa-miR-4419b	CLIP-seq
MIRT1977826	hsa-miR-4430	CLIP-seq
MIRT1977827	hsa-miR-4478	CLIP-seq
MIRT1977831	hsa-miR-5095	CLIP-seq
MIRT1977832	hsa-miR-552	CLIP-seq
MIRT939106	hsa-miR-640	CLIP-seq
MIRT1977834	hsa-miR-645	CLIP-seq
MIRT1977817	hsa-miR-122	CLIP-seq
MIRT2213151	hsa-miR-1343	CLIP-seq
MIRT2213152	hsa-miR-1976	CLIP-seq
MIRT2213153	hsa-miR-216b	CLIP-seq
MIRT1977818	hsa-miR-3135b	CLIP-seq
MIRT2448379	hsa-miR-329	CLIP-seq
MIRT2448380	hsa-miR-362-3p	CLIP-seq
MIRT1977820	hsa-miR-3652	CLIP-seq
MIRT2213155	hsa-miR-3664-5p	CLIP-seq
MIRT1977821	hsa-miR-3929	CLIP-seq
MIRT2448381	hsa-miR-3941	CLIP-seq
MIRT2213156	hsa-miR-4279	CLIP-seq
MIRT2448382	hsa-miR-4294	CLIP-seq
MIRT1977825	hsa-miR-4419b	CLIP-seq
MIRT1977826	hsa-miR-4430	CLIP-seq
MIRT1977827	hsa-miR-4478	CLIP-seq
MIRT2213158	hsa-miR-4639-3p	CLIP-seq
MIRT2213161	hsa-miR-4722-3p	CLIP-seq
MIRT2448383	hsa-miR-4789-5p	CLIP-seq
MIRT2213164	hsa-miR-498	CLIP-seq
MIRT2213165	hsa-miR-520a-5p	CLIP-seq
MIRT2213166	hsa-miR-525-5p	CLIP-seq
MIRT2448384	hsa-miR-603	CLIP-seq
MIRT1977834	hsa-miR-645	CLIP-seq
MIRT2213151	hsa-miR-1343	CLIP-seq
MIRT2213152	hsa-miR-1976	CLIP-seq
MIRT2213153	hsa-miR-216b	CLIP-seq
MIRT2213156	hsa-miR-4279	CLIP-seq
MIRT2213161	hsa-miR-4722-3p	CLIP-seq
MIRT2213164	hsa-miR-498	CLIP-seq
MIRT939068	hsa-miR-106a	CLIP-seq
MIRT939069	hsa-miR-106b	CLIP-seq
MIRT939070	hsa-miR-1234	CLIP-seq
MIRT939071	hsa-miR-1245	CLIP-seq
MIRT2213151	hsa-miR-1343	CLIP-seq
MIRT939074	hsa-miR-150	CLIP-seq
MIRT939075	hsa-miR-17	CLIP-seq
MIRT2213152	hsa-miR-1976	CLIP-seq
MIRT939076	hsa-miR-20a	CLIP-seq
MIRT939077	hsa-miR-20b	CLIP-seq
MIRT2213153	hsa-miR-216b	CLIP-seq
MIRT939078	hsa-miR-302a	CLIP-seq
MIRT939079	hsa-miR-302b	CLIP-seq
MIRT939080	hsa-miR-302c	CLIP-seq
MIRT939081	hsa-miR-302d	CLIP-seq
MIRT939082	hsa-miR-302e	CLIP-seq
MIRT939088	hsa-miR-372	CLIP-seq
MIRT939089	hsa-miR-373	CLIP-seq
MIRT2213156	hsa-miR-4279	CLIP-seq
MIRT2213161	hsa-miR-4722-3p	CLIP-seq
MIRT939094	hsa-miR-4731-5p	CLIP-seq
MIRT2213164	hsa-miR-498	CLIP-seq
MIRT1977831	hsa-miR-5095	CLIP-seq
MIRT939095	hsa-miR-512-3p	CLIP-seq
MIRT939096	hsa-miR-519d	CLIP-seq
MIRT939097	hsa-miR-520a-3p	CLIP-seq
MIRT2213165	hsa-miR-520a-5p	CLIP-seq
MIRT939098	hsa-miR-520b	CLIP-seq
MIRT939099	hsa-miR-520c-3p	CLIP-seq
MIRT939100	hsa-miR-520d-3p	CLIP-seq
MIRT939101	hsa-miR-520e	CLIP-seq
MIRT939102	hsa-miR-520g	CLIP-seq
MIRT939103	hsa-miR-520h	CLIP-seq
MIRT2213166	hsa-miR-525-5p	CLIP-seq
MIRT939106	hsa-miR-640	CLIP-seq
MIRT939108	hsa-miR-93	CLIP-seq
MIRT939068	hsa-miR-106a	CLIP-seq
MIRT939069	hsa-miR-106b	CLIP-seq
MIRT939070	hsa-miR-1234	CLIP-seq
MIRT939071	hsa-miR-1245	CLIP-seq
MIRT2213151	hsa-miR-1343	CLIP-seq
MIRT939074	hsa-miR-150	CLIP-seq
MIRT939075	hsa-miR-17	CLIP-seq
MIRT2213152	hsa-miR-1976	CLIP-seq
MIRT939076	hsa-miR-20a	CLIP-seq
MIRT939077	hsa-miR-20b	CLIP-seq
MIRT2213153	hsa-miR-216b	CLIP-seq
MIRT939078	hsa-miR-302a	CLIP-seq
MIRT939079	hsa-miR-302b	CLIP-seq
MIRT939080	hsa-miR-302c	CLIP-seq
MIRT939081	hsa-miR-302d	CLIP-seq
MIRT939082	hsa-miR-302e	CLIP-seq
MIRT939088	hsa-miR-372	CLIP-seq
MIRT939089	hsa-miR-373	CLIP-seq
MIRT1977822	hsa-miR-3934	CLIP-seq
MIRT2213156	hsa-miR-4279	CLIP-seq
MIRT2213161	hsa-miR-4722-3p	CLIP-seq
MIRT939094	hsa-miR-4731-5p	CLIP-seq
MIRT2213164	hsa-miR-498	CLIP-seq
MIRT1977831	hsa-miR-5095	CLIP-seq
MIRT939095	hsa-miR-512-3p	CLIP-seq
MIRT939096	hsa-miR-519d	CLIP-seq
MIRT939097	hsa-miR-520a-3p	CLIP-seq
MIRT2213165	hsa-miR-520a-5p	CLIP-seq
MIRT939098	hsa-miR-520b	CLIP-seq
MIRT939099	hsa-miR-520c-3p	CLIP-seq
MIRT939100	hsa-miR-520d-3p	CLIP-seq
MIRT939101	hsa-miR-520e	CLIP-seq
MIRT939102	hsa-miR-520g	CLIP-seq
MIRT939103	hsa-miR-520h	CLIP-seq
MIRT2213166	hsa-miR-525-5p	CLIP-seq
MIRT1977832	hsa-miR-552	CLIP-seq
MIRT939106	hsa-miR-640	CLIP-seq
MIRT939108	hsa-miR-93	CLIP-seq

Show/Hide all (1)

Transcription factor	Regulation	Reference
BRCA2	Unknown	17541404

Show/Hide all (54)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000150	Function	DNA strand exchange activity	IBA
GO:0000150	Function	DNA strand exchange activity	IEA
GO:0000166	Function	Nucleotide binding	IEA
GO:0000724	Process	Double-strand break repair via homologous recombination	IEA
GO:0000730	Process	DNA recombinase assembly	IBA
GO:0000781	Component	Chromosome, telomeric region	IEA
GO:0000794	Component	Condensed nuclear chromosome	IBA
GO:0000794	Component	Condensed nuclear chromosome	IEA
GO:0000794	Component	Condensed nuclear chromosome	TAS	8602360
GO:0000800	Component	Lateral element	IEA
GO:0001541	Process	Ovarian follicle development	IEA
GO:0001556	Process	Oocyte maturation	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003677	Function	DNA binding	TAS	8602360
GO:0003690	Function	Double-stranded DNA binding	IBA
GO:0003697	Function	Single-stranded DNA binding	IBA
GO:0005515	Function	Protein binding	IPI	17541404, 17996711, 20729832, 21307306, 21903585, 25416956, 25910212, 31515488, 32296183
GO:0005524	Function	ATP binding	IEA
GO:0005524	Function	ATP binding	TAS	8602360
GO:0005634	Component	Nucleus	IDA	22899867, 31429579
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0005694	Component	Chromosome	ISS
GO:0006259	Process	DNA metabolic process	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006312	Process	Mitotic recombination	IBA
GO:0007129	Process	Homologous chromosome pairing at meiosis	IEA
GO:0007131	Process	Reciprocal meiotic recombination	IBA
GO:0007131	Process	Reciprocal meiotic recombination	IDA	21307306
GO:0007131	Process	Reciprocal meiotic recombination	IEA
GO:0007131	Process	Reciprocal meiotic recombination	TAS	8602360
GO:0007141	Process	Male meiosis I	IEA
GO:0007276	Process	Gamete generation	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	TAS	8590282
GO:0007286	Process	Spermatid development	IEA
GO:0007292	Process	Female gamete generation	IEA
GO:0007292	Process	Female gamete generation	TAS	8602360
GO:0008094	Function	ATP-dependent activity, acting on DNA	IBA
GO:0008094	Function	ATP-dependent activity, acting on DNA	IDA	15899844
GO:0008094	Function	ATP-dependent activity, acting on DNA	IEA
GO:0035861	Component	Site of double-strand break	IEA
GO:0042148	Process	DNA strand invasion	IBA
GO:0042802	Function	Identical protein binding	IPI	25416956, 25502805, 31515488
GO:0048477	Process	Oogenesis	IEA
GO:0051321	Process	Meiotic cell cycle	IEA
GO:0051321	Process	Meiotic cell cycle	TAS	8602360
GO:0070192	Process	Chromosome organization involved in meiotic cell cycle	IBA
GO:0140097	Function	Catalytic activity, acting on DNA	IEA
GO:0140664	Function	ATP-dependent DNA damage sensor activity	IEA
GO:1990918	Process	Double-strand break repair involved in meiotic recombination	IEA

MIM	HGNC	e!Ensembl
602721	2927	ENSG00000100206

Q14565

Protein name

Meiotic recombination protein DMC1/LIM15 homolog

Protein function

Participates in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.

PDB

1V5W , 2ZJB , 4HYY , 6R3P , 7C98 , 7C99 , 7C9C , 7CGY , 8QQE , 8R2G

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08423	Rad51	83 → 338	Rad51	Domain

Sequence

MKEDQVVAEEPGFQDEEESLFQDIDLLQKHGINVADIKKLKSVGICTIKGIQMTTRRALC
NVKGLSEAKVDKIKEAANKLIEPGFLTAFEYSEKRKMVFHITTGSQEFDKLLGGGIESMA
ITEAFGEFRTGKTQLSHTLCVTAQLPGAGGYPGGKIIFIDTENTFRPDRLRDIADRFNVD
HDAVLDNVLYARAYTSEHQMELLDYVAAKFHEEAGIFKLLIIDSIMALFRVDFSGRGELA
ERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTR
ISLRKGRGELRIAKIYDSPEMPENEATFAITAGGIGDAKE

Sequence length

340

Interactions

View interactions

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Azoospermia	Pathogenic	rs2145963298, rs2145771075	RCV001797567 RCV001797568

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign	rs2227914	RCV005909257
Cervical cancer	Benign	rs2227914	RCV005909258
Clear cell carcinoma of kidney	Benign	rs2227914	RCV005909259
Premature ovarian failure	Benign	rs2227914	RCV001258296

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Azoospermia	Associate	35172124
Infections	Associate	20084279
Neoplasms	Associate	25971253
Urethral Neoplasms	Associate	25971253
Uterine Cervical Dysplasia	Associate	20084279

DMC1 (DNA meiotic recombinase 1)