Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	11138
Gene name Gene Name - the full gene name approved by the HGNC.	TBC1 domain family member 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TBC1D8
Synonyms (NCBI Gene) Gene synonyms aliases	AD3, GRAMD8, HBLP1, TBC1D8A, VRP
Disease Acronyms (UniProt) Disease acronyms from UniProt database	AD3
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2q11.2

Show/Hide all(184)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019002	hsa-miR-335-5p	Microarray	18185580
MIRT553755	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT553754	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT553753	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT553752	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT553751	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT553750	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT553749	hsa-miR-7849-3p	PAR-CLIP	21572407
MIRT445542	hsa-miR-7161-3p	PAR-CLIP	21572407
MIRT553748	hsa-miR-3681-5p	PAR-CLIP	21572407
MIRT553747	hsa-miR-6849-5p	PAR-CLIP	21572407
MIRT553746	hsa-miR-4666a-3p	PAR-CLIP	21572407
MIRT553745	hsa-miR-4287	PAR-CLIP	21572407
MIRT553744	hsa-miR-4685-3p	PAR-CLIP	21572407
MIRT445540	hsa-miR-4635	PAR-CLIP	21572407
MIRT445544	hsa-miR-3609	PAR-CLIP	22100165
MIRT445543	hsa-miR-548ah-5p	PAR-CLIP	22100165
MIRT445542	hsa-miR-7161-3p	PAR-CLIP	22100165
MIRT445540	hsa-miR-4635	PAR-CLIP	22100165
MIRT445541	hsa-miR-145-3p	PAR-CLIP	22100165
MIRT445539	hsa-miR-488-3p	PAR-CLIP	22100165
MIRT445544	hsa-miR-3609	PAR-CLIP	22100165
MIRT445543	hsa-miR-548ah-5p	PAR-CLIP	22100165
MIRT445542	hsa-miR-7161-3p	PAR-CLIP	22100165
MIRT445540	hsa-miR-4635	PAR-CLIP	22100165
MIRT445541	hsa-miR-145-3p	PAR-CLIP	22100165
MIRT445539	hsa-miR-488-3p	PAR-CLIP	22100165
MIRT553755	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT553754	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT553753	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT553752	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT553751	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT553750	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT553749	hsa-miR-7849-3p	PAR-CLIP	21572407
MIRT445542	hsa-miR-7161-3p	PAR-CLIP	21572407
MIRT553748	hsa-miR-3681-5p	PAR-CLIP	21572407
MIRT553747	hsa-miR-6849-5p	PAR-CLIP	21572407
MIRT553746	hsa-miR-4666a-3p	PAR-CLIP	21572407
MIRT553745	hsa-miR-4287	PAR-CLIP	21572407
MIRT553744	hsa-miR-4685-3p	PAR-CLIP	21572407
MIRT445540	hsa-miR-4635	PAR-CLIP	21572407
MIRT445544	hsa-miR-3609	PAR-CLIP	22100165
MIRT445543	hsa-miR-548ah-5p	PAR-CLIP	22100165
MIRT445542	hsa-miR-7161-3p	PAR-CLIP	22100165
MIRT445540	hsa-miR-4635	PAR-CLIP	22100165
MIRT445541	hsa-miR-145-3p	PAR-CLIP	22100165
MIRT445539	hsa-miR-488-3p	PAR-CLIP	22100165
MIRT445544	hsa-miR-3609	PAR-CLIP	22100165
MIRT445543	hsa-miR-548ah-5p	PAR-CLIP	22100165
MIRT445542	hsa-miR-7161-3p	PAR-CLIP	22100165
MIRT445540	hsa-miR-4635	PAR-CLIP	22100165
MIRT445541	hsa-miR-145-3p	PAR-CLIP	22100165
MIRT445539	hsa-miR-488-3p	PAR-CLIP	22100165
MIRT1413697	hsa-miR-106a	CLIP-seq
MIRT1413698	hsa-miR-106b	CLIP-seq
MIRT1413699	hsa-miR-142-5p	CLIP-seq
MIRT1413700	hsa-miR-153	CLIP-seq
MIRT1413701	hsa-miR-15a	CLIP-seq
MIRT1413702	hsa-miR-15b	CLIP-seq
MIRT1413703	hsa-miR-16	CLIP-seq
MIRT1413704	hsa-miR-17	CLIP-seq
MIRT1413705	hsa-miR-1825	CLIP-seq
MIRT1413706	hsa-miR-195	CLIP-seq
MIRT1413707	hsa-miR-199a-5p	CLIP-seq
MIRT1413708	hsa-miR-199b-5p	CLIP-seq
MIRT1413709	hsa-miR-20a	CLIP-seq
MIRT1413710	hsa-miR-20b	CLIP-seq
MIRT1413711	hsa-miR-25	CLIP-seq
MIRT1413712	hsa-miR-3165	CLIP-seq
MIRT1413713	hsa-miR-32	CLIP-seq
MIRT1413714	hsa-miR-340	CLIP-seq
MIRT1413715	hsa-miR-363	CLIP-seq
MIRT1413716	hsa-miR-367	CLIP-seq
MIRT1413717	hsa-miR-3925-3p	CLIP-seq
MIRT1413718	hsa-miR-424	CLIP-seq
MIRT1413719	hsa-miR-4302	CLIP-seq
MIRT1413720	hsa-miR-4524	CLIP-seq
MIRT1413721	hsa-miR-4666-3p	CLIP-seq
MIRT1413722	hsa-miR-4796-3p	CLIP-seq
MIRT1413723	hsa-miR-488	CLIP-seq
MIRT1413724	hsa-miR-497	CLIP-seq
MIRT1413725	hsa-miR-503	CLIP-seq
MIRT1413726	hsa-miR-508-5p	CLIP-seq
MIRT1413727	hsa-miR-517a	CLIP-seq
MIRT1413728	hsa-miR-517c	CLIP-seq
MIRT1413729	hsa-miR-519d	CLIP-seq
MIRT1413730	hsa-miR-548ah	CLIP-seq
MIRT1413731	hsa-miR-646	CLIP-seq
MIRT1413732	hsa-miR-648	CLIP-seq
MIRT1413733	hsa-miR-9	CLIP-seq
MIRT1413734	hsa-miR-92a	CLIP-seq
MIRT1413735	hsa-miR-92b	CLIP-seq
MIRT1413736	hsa-miR-93	CLIP-seq
MIRT2346481	hsa-miR-130a	CLIP-seq
MIRT2346482	hsa-miR-130b	CLIP-seq
MIRT2346483	hsa-miR-148a	CLIP-seq
MIRT2346484	hsa-miR-148b	CLIP-seq
MIRT2346485	hsa-miR-152	CLIP-seq
MIRT2346486	hsa-miR-19a	CLIP-seq
MIRT2346487	hsa-miR-19b	CLIP-seq
MIRT1413711	hsa-miR-25	CLIP-seq
MIRT2346488	hsa-miR-301a	CLIP-seq
MIRT2346489	hsa-miR-301b	CLIP-seq
MIRT1413713	hsa-miR-32	CLIP-seq
MIRT2346490	hsa-miR-3613-3p	CLIP-seq
MIRT1413715	hsa-miR-363	CLIP-seq
MIRT2346491	hsa-miR-3666	CLIP-seq
MIRT1413716	hsa-miR-367	CLIP-seq
MIRT2346492	hsa-miR-382	CLIP-seq
MIRT2346493	hsa-miR-4295	CLIP-seq
MIRT2346494	hsa-miR-454	CLIP-seq
MIRT2346495	hsa-miR-4642	CLIP-seq
MIRT1413721	hsa-miR-4666-3p	CLIP-seq
MIRT2346496	hsa-miR-4704-5p	CLIP-seq
MIRT2346497	hsa-miR-4715-5p	CLIP-seq
MIRT2346498	hsa-miR-494	CLIP-seq
MIRT1413734	hsa-miR-92a	CLIP-seq
MIRT1413735	hsa-miR-92b	CLIP-seq
MIRT2395555	hsa-miR-3977	CLIP-seq
MIRT2395556	hsa-miR-578	CLIP-seq
MIRT2461182	hsa-miR-1273e	CLIP-seq
MIRT2461183	hsa-miR-296-3p	CLIP-seq
MIRT2461184	hsa-miR-3189-5p	CLIP-seq
MIRT2461185	hsa-miR-331-3p	CLIP-seq
MIRT2461186	hsa-miR-376c	CLIP-seq
MIRT2461187	hsa-miR-4662a-5p	CLIP-seq
MIRT2461188	hsa-miR-4676-5p	CLIP-seq
MIRT2461189	hsa-miR-4701-5p	CLIP-seq
MIRT2461190	hsa-miR-4758-3p	CLIP-seq
MIRT2461191	hsa-miR-513c	CLIP-seq
MIRT2461192	hsa-miR-514b-5p	CLIP-seq
MIRT2461193	hsa-miR-575	CLIP-seq
MIRT2461194	hsa-miR-588	CLIP-seq
MIRT2461195	hsa-miR-592	CLIP-seq
MIRT2461196	hsa-miR-599	CLIP-seq
MIRT2461182	hsa-miR-1273e	CLIP-seq
MIRT2639104	hsa-miR-132	CLIP-seq
MIRT2639105	hsa-miR-151-3p	CLIP-seq
MIRT2639106	hsa-miR-212	CLIP-seq
MIRT2461183	hsa-miR-296-3p	CLIP-seq
MIRT1413712	hsa-miR-3165	CLIP-seq
MIRT2461184	hsa-miR-3189-5p	CLIP-seq
MIRT2461185	hsa-miR-331-3p	CLIP-seq
MIRT2639107	hsa-miR-3529	CLIP-seq
MIRT2461186	hsa-miR-376c	CLIP-seq
MIRT2639108	hsa-miR-379	CLIP-seq
MIRT2639109	hsa-miR-3927	CLIP-seq
MIRT2639110	hsa-miR-4463	CLIP-seq
MIRT2639111	hsa-miR-4499	CLIP-seq
MIRT2461187	hsa-miR-4662a-5p	CLIP-seq
MIRT2461188	hsa-miR-4676-5p	CLIP-seq
MIRT2461189	hsa-miR-4701-5p	CLIP-seq
MIRT2461190	hsa-miR-4758-3p	CLIP-seq
MIRT1413726	hsa-miR-508-5p	CLIP-seq
MIRT2461191	hsa-miR-513c	CLIP-seq
MIRT2461192	hsa-miR-514b-5p	CLIP-seq
MIRT1413727	hsa-miR-517a	CLIP-seq
MIRT1413728	hsa-miR-517c	CLIP-seq
MIRT2639112	hsa-miR-548ag	CLIP-seq
MIRT2639113	hsa-miR-548ai	CLIP-seq
MIRT2461193	hsa-miR-575	CLIP-seq
MIRT2461194	hsa-miR-588	CLIP-seq
MIRT2461195	hsa-miR-592	CLIP-seq
MIRT2461196	hsa-miR-599	CLIP-seq
MIRT2639114	hsa-miR-622	CLIP-seq
MIRT1413733	hsa-miR-9	CLIP-seq
MIRT2461182	hsa-miR-1273e	CLIP-seq
MIRT2461183	hsa-miR-296-3p	CLIP-seq
MIRT1413712	hsa-miR-3165	CLIP-seq
MIRT2461185	hsa-miR-331-3p	CLIP-seq
MIRT2461186	hsa-miR-376c	CLIP-seq
MIRT2461187	hsa-miR-4662a-5p	CLIP-seq
MIRT2461188	hsa-miR-4676-5p	CLIP-seq
MIRT2461189	hsa-miR-4701-5p	CLIP-seq
MIRT1413726	hsa-miR-508-5p	CLIP-seq
MIRT2461191	hsa-miR-513c	CLIP-seq
MIRT2461192	hsa-miR-514b-5p	CLIP-seq
MIRT1413727	hsa-miR-517a	CLIP-seq
MIRT1413728	hsa-miR-517c	CLIP-seq
MIRT2461193	hsa-miR-575	CLIP-seq
MIRT2461194	hsa-miR-588	CLIP-seq
MIRT2461195	hsa-miR-592	CLIP-seq
MIRT2461196	hsa-miR-599	CLIP-seq
MIRT1413733	hsa-miR-9	CLIP-seq

Show/Hide all(8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	32296183
GO:0006886	Process	Intracellular protein transport	IBA	21873635
GO:0008015	Process	Blood circulation	TAS	10373574
GO:0008284	Process	Positive regulation of cell population proliferation	TAS	10373574
GO:0016020	Component	Membrane	TAS	10373574
GO:0090630	Process	Activation of GTPase activity	IBA	21873635
GO:1902017	Process	Regulation of cilium assembly	IMP	17646400

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Protein

UniProt ID

O95759

Protein name

TBC1 domain family member 8 (AD 3) (Vascular Rab-GAP/TBC-containing protein)

Protein function

May act as a GTPase-activating protein for Rab family protein(s).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02893	GRAM	145 → 252	GRAM domain	Domain
PF02893	GRAM	285 → 396	GRAM domain	Domain
PF00566	RabGAP-TBC	508 → 712	Rab-GTPase-TBC domain	Family

Sequence

MWLKPEEVLLKNALKLWVTQKSSCYFILQRRRGHGEGGGRLTGRLVGALDAVLDSNARVA
PFRILLQVPGSQVYSPIACGATLEEINQHWDWLEQNLLHTLSVFDNKDDIASFVKGKVKA
LIAEETSSRLAEQEEEPEKFREALVKFEARFNFPEAEKLVTYYSCCCWKGRVPRQGWLYL
SINHLCFYSFFLGKELKLVVPWVDIQKLERTSNVFLTDTIRITTQNKERDFSMFLNLDEV
FKVMEQLADVTLRRLLDNEVFDLDPDLQEPSQITKRDLEARAQNEFFRAFFRLPRKEKLH
AVVDCSLWTPFSRCHTTGRMFASDSYICFASREDGCCKIILPLREVVSIEKMEDTSLLPH
PIIVSIRSKVAFQFIELRDRDSLVEALLARLKQVHANHPVHYDTSADDDMASLVFHSTSM
CSDHRFGDLEMMSSQNSEESEKEKSPLMHPDALVTAFQQSGSQSPDSRMSREQIKISLWN
DHFVEYGRTVCMFRTEKIRKLVAMGIPESLRGRLWLLFSDAVTDLASHPGYYGNLVEESL
GKCCLVTEEIERDLHRSLPEHPAFQNETGIAALRRVLTAYAHRNPKIGYCQSMNILTSVL
LLYTKEEEAFWLLVAVCERMLPDYFNHRVIGAQVDQSVFEELIKGHLPELAEHMNDLSAL
ASVSLSWFLTLFLSIMPLESAVNVVDCFFYDGIKAIFQLGLAVLEANAEDLCSSKDDGQA
LMILSRFLDHIKNEDSPGPPVGSHHAFFSDDQEPYPVTDISDLIRDSYEKFGDQSVEQIE
HLRYKHRIRVLQGHEDTTKQNVLRVVIPEVSILPEDLEELYDLFKREHMMSCYWEQPRPM
ASRHDPSRPYAEQYRIDARQFAHLFQLVSPWTCGAHTEILAERTFRLLDDNMDQLIEFKA
FVSCLDIMYNGEMNEKIKLLYRLHIPPALTENDRDSQSPLRNPLLSTSRPLVFGKPNGDA
VDYQKQLKQMIKDLAKEKDKTEKELPKMSQREFIQFCKTLYSMFHEDPEENDLYQAIATV
TTLLLQIGEVGQRGSSSGSCSQECGEELRASAPSPEDSVFADTGKTPQDSQAFPEAAERD
WTVSLEHILASLLTEQSLVNFFEKPLDMKSKLENAKINQYNLKTFEMSHQSQSELKLSNL

Sequence length

1140

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Osteoporosis	Osteoporosis	rs72658152, rs72667023, rs587776916, rs72656370, rs768615287	20548944

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Source
Unknown
Progressive Supranuclear Palsy	Progressive Supranuclear Palsy	GWAS
Rheumatoid arthritis	Rheumatoid arthritis	GWAS

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text Mining
Carcinogenesis	Associate	35918393
Colorectal Neoplasms	Stimulate	35918393
Deafness	Associate	35248088
Hearing Loss	Associate	35248088
Hypoxia	Associate	35918393
Keratoconjunctivitis	Associate	15722597
Osteoporosis	Associate	28369098
Pancreatic Neoplasms	Associate	21347333
Prostatic Neoplasms	Associate	29318656
Supranuclear Palsy Progressive	Associate	33635380

TBC1D8 (TBC1 domain family member 8)