Gene Gene information from NCBI Gene database.
Entrez ID 11130
Gene name ZW10 interacting kinetochore protein
Gene symbol ZWINT
Synonyms (NCBI Gene)
HZwint-1KNTC2APSIP30ZWINT1
Chromosome 10
Chromosome location 10q21.1
Summary This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein l
miRNA miRNA information provided by mirtarbase database.
384
miRTarBase ID miRNA Experiments Reference
MIRT016569 hsa-miR-193b-3p Microarray 20304954
MIRT022987 hsa-miR-124-3p Microarray 18668037
MIRT029953 hsa-miR-26b-5p Microarray 19088304
MIRT049834 hsa-miR-92a-3p CLASH 23622248
MIRT045620 hsa-miR-149-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
27
GO ID Ontology Definition Evidence Reference
GO:0000070 Process Mitotic sister chromatid segregation IBA
GO:0000070 Process Mitotic sister chromatid segregation IDA 15485811
GO:0000775 Component Chromosome, centromeric region IEA
GO:0000776 Component Kinetochore IBA
GO:0000776 Component Kinetochore IDA 11682612, 15485811
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609177 13195 ENSG00000122952
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O95229
Protein name Outer kinetochore KNL1 complex subunit ZWINT (ZW10 interactor) (ZW10-interacting protein 1) (Zwint-1)
Protein function Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15094189, PubMed:15485811, PubMed:15824131, PubMed:1673
PDB 8PPR
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15556 Zwint 29 277 ZW10 interactor Family
Sequence
Sequence length 277
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Uterine corpus endometrial carcinoma Uncertain significance rs374821628 RCV005926922
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 32149105, 35406786, 37091844, 40650307
Breast Neoplasms Associate 39684488
Carcinoma Adenoid Cystic Associate 37861550
Carcinoma Hepatocellular Associate 30198401, 30702595, 31746405, 33784984, 37861550
Carcinoma Non Small Cell Lung Stimulate 37091844
Carcinoma Squamous Cell Associate 32685473
Colorectal Neoplasms Associate 32303675
Endometriosis Associate 35585523
Glioma Associate 30305647
Hepatitis B Associate 33102593