Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
11127
Gene name Gene Name - the full gene name approved by the HGNC.
Kinesin family member 3A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
KIF3A
Synonyms (NCBI Gene) Gene synonyms aliases
FLA10, KLP-20
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q31.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT674577 hsa-miR-1228-3p HITS-CLIP 23824327
MIRT674576 hsa-miR-342-3p HITS-CLIP 23824327
MIRT674575 hsa-miR-5008-5p HITS-CLIP 23824327
MIRT674574 hsa-miR-6089 HITS-CLIP 23824327
MIRT674573 hsa-miR-4755-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0003777 Function Microtubule motor activity IBA
GO:0003777 Function Microtubule motor activity IEA
GO:0005515 Function Protein binding IPI 16298999, 17043677, 19934039, 20643351, 22261744, 24338362, 24591568, 26496610, 27173435, 28514442, 31413325, 33961781, 35271311
GO:0005524 Function ATP binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604683 6319 ENSG00000131437
Protein
UniProt ID Q9Y496
Protein name Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A)
Protein function Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and f
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00225 Kinesin 20 345 Kinesin motor domain Domain
Sequence
MPINKSEKPESCDNVKVVVRCRPLNEREKSMCYKQAVSVDEMRGTITVHKTDSSNEPPKT
FTFDTVFGPESKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAIPELR
GIIPNSFAHIFGHIAKAEGDTRFLVRVSYLEIYNEEVRDLLGKDQTQRLEVKERPDVGVY
IKDLSAYVVNNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGIDGNMH
VRMGKLHLVDLAGSERQAKTGATGQRLKEATKINLSLSTLGNVISALVDGKSTHVPYRNS
KLTRLLQDSLGGNSKTMMCANIGPADYNYDETISTLRYANRAKNI
KNKARINEDPKDALL
RQFQKEIEELKKKLEEGEEISGSDISGSEEDDDEEGEVGEDGEKRKKRRGKKKVSPDKMI
EMQAKIDEERKALETKLDMEEEERNKARAELEKREKDLLKAQQEHQSLLEKLSALEKKVI
VGGVDLLAKAEEQEKLLEESNMELEERRKRAEQLRRELEEKEQERLDIEEKYTSLQEEAQ
GKTKKLKKVWTMLMAAKSEMADLQQEHQREIEGLLENIRQLSRELRLQMLIIDNFIPRDY
QEMIENYVHWNEDIGEWQLKCVAYTGNNMRKQTPVPDKKEKDPFEVDLSHVYLAYTEESL
RQSLMKLERPRTSKGKARPKTGRRKRSAKPETVIDSLLQ
Sequence length 699
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Hedgehog signaling pathway
Motor proteins
  MHC class II antigen presentation
Hedgehog 'off' state
Intraflagellar transport
Activation of SMO
COPI-dependent Golgi-to-ER retrograde traffic
Kinesins
<
Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Asthma Asthma in any disease, Asthma, Asthma (childhood onset), Nonatopic asthma, Atopic asthma, Asthma (age of onset) N/A N/A GWAS
Dermatitis Atopic dermatitis N/A N/A GWAS
Eczema Eczema N/A N/A GWAS
Psoriasis Psoriasis N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Asthma Associate 21912604, 30830718
Carcinoma Hepatocellular Associate 28901309
Ciliopathies Associate 35478224
Drug Hypersensitivity Associate 21912604, 30830718
Eczema Associate 30830718
Eosinophilic Esophagitis Associate 29129581
Fractures Stress Associate 30830718
Prostatic Neoplasms Associate 24413182
Prostatitis Associate 24413182