Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	11122
Gene name Gene Name - the full gene name approved by the HGNC.	Protein tyrosine phosphatase receptor type T
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PTPRT
Synonyms (NCBI Gene) Gene synonyms aliases	R-PTP-T, RPTP-rho, RPTPrho
Chromosome Chromosome number	20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	20q12-q13.11
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic tran

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SNP ID	Visualize variation	Clinical significance	Consequence
rs762135776	A>G	Likely-pathogenic	Coding sequence variant, missense variant
rs1060499749	G>A	Likely-pathogenic	Intron variant

Show/Hide all(295)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017080	hsa-miR-335-5p	Microarray	18185580
MIRT051085	hsa-miR-16-5p	CLASH	23622248
MIRT047550	hsa-miR-10a-5p	CLASH	23622248
MIRT047447	hsa-miR-10b-5p	CLASH	23622248
MIRT043524	hsa-miR-331-3p	CLASH	23622248
MIRT052887	hsa-miR-3928-3p	CLASH	23622248
MIRT054778	hsa-miR-215-5p	Luciferase reporter assay, qRT-PCR, Western blot	24434140
MIRT725207	hsa-miR-4524b-3p	HITS-CLIP	19536157
MIRT725206	hsa-miR-6747-3p	HITS-CLIP	19536157
MIRT725205	hsa-miR-4297	HITS-CLIP	19536157
MIRT725203	hsa-miR-5581-5p	HITS-CLIP	19536157
MIRT725204	hsa-miR-7702	HITS-CLIP	19536157
MIRT725202	hsa-miR-515-3p	HITS-CLIP	19536157
MIRT622553	hsa-miR-4311	HITS-CLIP	23824327
MIRT622551	hsa-miR-583	HITS-CLIP	23824327
MIRT654606	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT622550	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT622549	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT654605	hsa-miR-623	HITS-CLIP	23824327
MIRT654604	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT654603	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT654602	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT654601	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT654600	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT654599	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT622548	hsa-miR-5096	HITS-CLIP	23824327
MIRT622553	hsa-miR-4311	HITS-CLIP	23824327
MIRT622552	hsa-miR-1276	HITS-CLIP	23824327
MIRT622551	hsa-miR-583	HITS-CLIP	23824327
MIRT622550	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT622549	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT622548	hsa-miR-5096	HITS-CLIP	23824327
MIRT496336	hsa-miR-664a-3p	PAR-CLIP	22291592
MIRT496335	hsa-miR-186-3p	PAR-CLIP	22291592
MIRT496334	hsa-miR-29a-5p	PAR-CLIP	22291592
MIRT496333	hsa-miR-630	PAR-CLIP	22291592
MIRT496332	hsa-miR-3149	PAR-CLIP	22291592
MIRT725207	hsa-miR-4524b-3p	HITS-CLIP	19536157
MIRT725206	hsa-miR-6747-3p	HITS-CLIP	19536157
MIRT725205	hsa-miR-4297	HITS-CLIP	19536157
MIRT725203	hsa-miR-5581-5p	HITS-CLIP	19536157
MIRT725204	hsa-miR-7702	HITS-CLIP	19536157
MIRT725202	hsa-miR-515-3p	HITS-CLIP	19536157
MIRT622553	hsa-miR-4311	HITS-CLIP	23824327
MIRT622551	hsa-miR-583	HITS-CLIP	23824327
MIRT654606	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT622550	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT622549	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT654605	hsa-miR-623	HITS-CLIP	23824327
MIRT654604	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT654603	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT654602	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT654601	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT654600	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT654599	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT622548	hsa-miR-5096	HITS-CLIP	23824327
MIRT622553	hsa-miR-4311	HITS-CLIP	23824327
MIRT622552	hsa-miR-1276	HITS-CLIP	23824327
MIRT622551	hsa-miR-583	HITS-CLIP	23824327
MIRT622550	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT622549	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT622548	hsa-miR-5096	HITS-CLIP	23824327
MIRT496336	hsa-miR-664a-3p	PAR-CLIP	22291592
MIRT496335	hsa-miR-186-3p	PAR-CLIP	22291592
MIRT496334	hsa-miR-29a-5p	PAR-CLIP	22291592
MIRT496333	hsa-miR-630	PAR-CLIP	22291592
MIRT496332	hsa-miR-3149	PAR-CLIP	22291592
MIRT1276472	hsa-miR-1	CLIP-seq
MIRT1276473	hsa-miR-1299	CLIP-seq
MIRT1276474	hsa-miR-1909	CLIP-seq
MIRT1276475	hsa-miR-206	CLIP-seq
MIRT1276476	hsa-miR-2278	CLIP-seq
MIRT1276477	hsa-miR-3125	CLIP-seq
MIRT1276478	hsa-miR-3138	CLIP-seq
MIRT1276479	hsa-miR-3140-5p	CLIP-seq
MIRT1276480	hsa-miR-3157-5p	CLIP-seq
MIRT1276481	hsa-miR-3661	CLIP-seq
MIRT1276482	hsa-miR-3673	CLIP-seq
MIRT1276483	hsa-miR-3911	CLIP-seq
MIRT1276484	hsa-miR-3916	CLIP-seq
MIRT1276485	hsa-miR-4279	CLIP-seq
MIRT1276486	hsa-miR-4468	CLIP-seq
MIRT1276487	hsa-miR-4691-5p	CLIP-seq
MIRT1276488	hsa-miR-4693-3p	CLIP-seq
MIRT1276489	hsa-miR-4695-5p	CLIP-seq
MIRT1276490	hsa-miR-4802-5p	CLIP-seq
MIRT1276491	hsa-miR-483-3p	CLIP-seq
MIRT1276492	hsa-miR-485-5p	CLIP-seq
MIRT1276493	hsa-miR-486-5p	CLIP-seq
MIRT1276494	hsa-miR-518a-5p	CLIP-seq
MIRT1276495	hsa-miR-527	CLIP-seq
MIRT1276496	hsa-miR-574-5p	CLIP-seq
MIRT1276497	hsa-miR-592	CLIP-seq
MIRT1276498	hsa-miR-597	CLIP-seq
MIRT1276499	hsa-miR-613	CLIP-seq
MIRT1276500	hsa-miR-631	CLIP-seq
MIRT1276501	hsa-miR-765	CLIP-seq
MIRT1276502	hsa-miR-875-3p	CLIP-seq
MIRT1276503	hsa-miR-877	CLIP-seq
MIRT1276472	hsa-miR-1	CLIP-seq
MIRT1276504	hsa-miR-1178	CLIP-seq
MIRT1276505	hsa-miR-1185	CLIP-seq
MIRT1276506	hsa-miR-1273e	CLIP-seq
MIRT1276507	hsa-miR-127-5p	CLIP-seq
MIRT1276508	hsa-miR-1294	CLIP-seq
MIRT1276509	hsa-miR-1470	CLIP-seq
MIRT1276510	hsa-miR-153	CLIP-seq
MIRT1276511	hsa-miR-18a	CLIP-seq
MIRT1276512	hsa-miR-18b	CLIP-seq
MIRT1276513	hsa-miR-1915	CLIP-seq
MIRT1276514	hsa-miR-197	CLIP-seq
MIRT1276475	hsa-miR-206	CLIP-seq
MIRT1276515	hsa-miR-2392	CLIP-seq
MIRT1276516	hsa-miR-2467-3p	CLIP-seq
MIRT1276517	hsa-miR-3133	CLIP-seq
MIRT1276518	hsa-miR-3200-5p	CLIP-seq
MIRT1276519	hsa-miR-320e	CLIP-seq
MIRT1276520	hsa-miR-3605-5p	CLIP-seq
MIRT1276521	hsa-miR-3622b-5p	CLIP-seq
MIRT1276481	hsa-miR-3661	CLIP-seq
MIRT1276522	hsa-miR-3662	CLIP-seq
MIRT1276482	hsa-miR-3673	CLIP-seq
MIRT1276523	hsa-miR-3678-3p	CLIP-seq
MIRT1276524	hsa-miR-3679-5p	CLIP-seq
MIRT1276525	hsa-miR-3714	CLIP-seq
MIRT1276526	hsa-miR-4287	CLIP-seq
MIRT1276527	hsa-miR-4316	CLIP-seq
MIRT1276528	hsa-miR-433	CLIP-seq
MIRT1276529	hsa-miR-4438	CLIP-seq
MIRT1276530	hsa-miR-4469	CLIP-seq
MIRT1276531	hsa-miR-448	CLIP-seq
MIRT1276532	hsa-miR-4642	CLIP-seq
MIRT1276533	hsa-miR-4667-3p	CLIP-seq
MIRT1276534	hsa-miR-4682	CLIP-seq
MIRT1276535	hsa-miR-4685-3p	CLIP-seq
MIRT1276536	hsa-miR-4711-5p	CLIP-seq
MIRT1276537	hsa-miR-4720-5p	CLIP-seq
MIRT1276538	hsa-miR-4726-3p	CLIP-seq
MIRT1276539	hsa-miR-4735-3p	CLIP-seq
MIRT1276540	hsa-miR-4757-5p	CLIP-seq
MIRT1276541	hsa-miR-4768-3p	CLIP-seq
MIRT1276542	hsa-miR-4793-5p	CLIP-seq
MIRT1276543	hsa-miR-4799-3p	CLIP-seq
MIRT1276544	hsa-miR-513a-5p	CLIP-seq
MIRT1276545	hsa-miR-548an	CLIP-seq
MIRT1276546	hsa-miR-548k	CLIP-seq
MIRT1276499	hsa-miR-613	CLIP-seq
MIRT1276547	hsa-miR-617	CLIP-seq
MIRT1276548	hsa-miR-626	CLIP-seq
MIRT1276549	hsa-miR-627	CLIP-seq
MIRT1276500	hsa-miR-631	CLIP-seq
MIRT1276550	hsa-miR-636	CLIP-seq
MIRT1276551	hsa-miR-640	CLIP-seq
MIRT1276552	hsa-miR-873	CLIP-seq
MIRT1276553	hsa-miR-924	CLIP-seq
MIRT1276486	hsa-miR-4468	CLIP-seq
MIRT2081312	hsa-miR-3664-3p	CLIP-seq
MIRT1276525	hsa-miR-3714	CLIP-seq
MIRT1276485	hsa-miR-4279	CLIP-seq
MIRT1276545	hsa-miR-548an	CLIP-seq
MIRT2081313	hsa-miR-1343	CLIP-seq
MIRT1276476	hsa-miR-2278	CLIP-seq
MIRT2081314	hsa-miR-4781-3p	CLIP-seq
MIRT2081315	hsa-miR-939	CLIP-seq
MIRT1276472	hsa-miR-1	CLIP-seq
MIRT2307288	hsa-miR-1206	CLIP-seq
MIRT2307289	hsa-miR-1208	CLIP-seq
MIRT2307290	hsa-miR-1236	CLIP-seq
MIRT2307291	hsa-miR-1287	CLIP-seq
MIRT2307292	hsa-miR-1293	CLIP-seq
MIRT1276473	hsa-miR-1299	CLIP-seq
MIRT2307293	hsa-miR-1321	CLIP-seq
MIRT2081313	hsa-miR-1343	CLIP-seq
MIRT2307294	hsa-miR-138	CLIP-seq
MIRT2307295	hsa-miR-146b-3p	CLIP-seq
MIRT1276474	hsa-miR-1909	CLIP-seq
MIRT2307296	hsa-miR-1913	CLIP-seq
MIRT1276513	hsa-miR-1915	CLIP-seq
MIRT1276475	hsa-miR-206	CLIP-seq
MIRT2307297	hsa-miR-2115	CLIP-seq
MIRT1276476	hsa-miR-2278	CLIP-seq
MIRT2307298	hsa-miR-3074-5p	CLIP-seq
MIRT2307299	hsa-miR-3135b	CLIP-seq
MIRT2307300	hsa-miR-3148	CLIP-seq
MIRT2307301	hsa-miR-3152-3p	CLIP-seq
MIRT2307302	hsa-miR-3153	CLIP-seq
MIRT2307303	hsa-miR-3162-5p	CLIP-seq
MIRT2307304	hsa-miR-3173-5p	CLIP-seq
MIRT2307305	hsa-miR-3182	CLIP-seq
MIRT2307306	hsa-miR-3189-3p	CLIP-seq
MIRT2307307	hsa-miR-3189-5p	CLIP-seq
MIRT2307308	hsa-miR-320a	CLIP-seq
MIRT2307309	hsa-miR-320b	CLIP-seq
MIRT2307310	hsa-miR-320c	CLIP-seq
MIRT2307311	hsa-miR-320d	CLIP-seq
MIRT1276519	hsa-miR-320e	CLIP-seq
MIRT2307312	hsa-miR-323-5p	CLIP-seq
MIRT2307313	hsa-miR-324-3p	CLIP-seq
MIRT2307314	hsa-miR-3665	CLIP-seq
MIRT2307315	hsa-miR-3671	CLIP-seq
MIRT2307316	hsa-miR-3689d	CLIP-seq
MIRT2307317	hsa-miR-378g	CLIP-seq
MIRT2307318	hsa-miR-3907	CLIP-seq
MIRT2307319	hsa-miR-3918	CLIP-seq
MIRT2307320	hsa-miR-3940-5p	CLIP-seq
MIRT2307321	hsa-miR-4265	CLIP-seq
MIRT2307322	hsa-miR-4270	CLIP-seq
MIRT1276485	hsa-miR-4279	CLIP-seq
MIRT2307323	hsa-miR-4292	CLIP-seq
MIRT2307324	hsa-miR-4296	CLIP-seq
MIRT2307325	hsa-miR-432	CLIP-seq
MIRT2307326	hsa-miR-4322	CLIP-seq
MIRT2307327	hsa-miR-4420	CLIP-seq
MIRT2307328	hsa-miR-4429	CLIP-seq
MIRT2307329	hsa-miR-4437	CLIP-seq
MIRT2307330	hsa-miR-4441	CLIP-seq
MIRT2307331	hsa-miR-4483	CLIP-seq
MIRT2307332	hsa-miR-4507	CLIP-seq
MIRT2307333	hsa-miR-450b-3p	CLIP-seq
MIRT2307334	hsa-miR-4648	CLIP-seq
MIRT2307335	hsa-miR-4653-3p	CLIP-seq
MIRT2307336	hsa-miR-4654	CLIP-seq
MIRT2307337	hsa-miR-4667-5p	CLIP-seq
MIRT2307338	hsa-miR-4668-5p	CLIP-seq
MIRT2307339	hsa-miR-4674	CLIP-seq
MIRT2307340	hsa-miR-4690-3p	CLIP-seq
MIRT2307341	hsa-miR-4694-3p	CLIP-seq
MIRT2307342	hsa-miR-4694-5p	CLIP-seq
MIRT2307343	hsa-miR-4699-3p	CLIP-seq
MIRT2307344	hsa-miR-4700-5p	CLIP-seq
MIRT2307345	hsa-miR-4705	CLIP-seq
MIRT2307346	hsa-miR-4713-3p	CLIP-seq
MIRT2307347	hsa-miR-4715-5p	CLIP-seq
MIRT2307348	hsa-miR-4736	CLIP-seq
MIRT2307349	hsa-miR-4739	CLIP-seq
MIRT2307350	hsa-miR-4756-5p	CLIP-seq
MIRT2307351	hsa-miR-4758-3p	CLIP-seq
MIRT2307352	hsa-miR-4769-5p	CLIP-seq
MIRT2307353	hsa-miR-4782-5p	CLIP-seq
MIRT2307354	hsa-miR-4790-3p	CLIP-seq
MIRT1276491	hsa-miR-483-3p	CLIP-seq
MIRT2307355	hsa-miR-486-3p	CLIP-seq
MIRT2307356	hsa-miR-513a-3p	CLIP-seq
MIRT2307357	hsa-miR-516a-3p	CLIP-seq
MIRT2307358	hsa-miR-516b	CLIP-seq
MIRT2307359	hsa-miR-522	CLIP-seq
MIRT2307360	hsa-miR-541	CLIP-seq
MIRT2307361	hsa-miR-548q	CLIP-seq
MIRT2307362	hsa-miR-555	CLIP-seq
MIRT2307363	hsa-miR-607	CLIP-seq
MIRT1276499	hsa-miR-613	CLIP-seq
MIRT2307364	hsa-miR-635	CLIP-seq
MIRT2307365	hsa-miR-638	CLIP-seq
MIRT2307366	hsa-miR-651	CLIP-seq
MIRT2307367	hsa-miR-654-5p	CLIP-seq
MIRT2307368	hsa-miR-7	CLIP-seq
MIRT1276501	hsa-miR-765	CLIP-seq
MIRT2307369	hsa-miR-769-3p	CLIP-seq
MIRT2307370	hsa-miR-874	CLIP-seq
MIRT2307371	hsa-miR-876-3p	CLIP-seq
MIRT2307372	hsa-miR-922	CLIP-seq
MIRT2081315	hsa-miR-939	CLIP-seq
MIRT2307373	hsa-miR-942	CLIP-seq
MIRT2393257	hsa-miR-4796-3p	CLIP-seq
MIRT2393258	hsa-miR-584	CLIP-seq
MIRT2457479	hsa-miR-3613-3p	CLIP-seq
MIRT2604892	hsa-miR-1203	CLIP-seq
MIRT2307290	hsa-miR-1236	CLIP-seq
MIRT2604893	hsa-miR-1277	CLIP-seq
MIRT1276473	hsa-miR-1299	CLIP-seq
MIRT2081313	hsa-miR-1343	CLIP-seq
MIRT2604894	hsa-miR-3065-3p	CLIP-seq
MIRT2307298	hsa-miR-3074-5p	CLIP-seq
MIRT2307305	hsa-miR-3182	CLIP-seq
MIRT2604895	hsa-miR-3919	CLIP-seq
MIRT2604896	hsa-miR-4446-5p	CLIP-seq
MIRT2307347	hsa-miR-4715-5p	CLIP-seq
MIRT2604897	hsa-miR-4756-3p	CLIP-seq
MIRT2604898	hsa-miR-4757-3p	CLIP-seq
MIRT2307353	hsa-miR-4782-5p	CLIP-seq
MIRT2307358	hsa-miR-516b	CLIP-seq
MIRT2307362	hsa-miR-555	CLIP-seq
MIRT2604899	hsa-miR-587	CLIP-seq
MIRT2689129	hsa-miR-1200	CLIP-seq
MIRT2689130	hsa-miR-1225-3p	CLIP-seq
MIRT2689131	hsa-miR-1233	CLIP-seq
MIRT2689132	hsa-miR-1237	CLIP-seq
MIRT2689133	hsa-miR-3140-3p	CLIP-seq
MIRT2689134	hsa-miR-4303	CLIP-seq
MIRT2689135	hsa-miR-4324	CLIP-seq
MIRT2307343	hsa-miR-4699-3p	CLIP-seq
MIRT2689136	hsa-miR-4724-3p	CLIP-seq
MIRT2689137	hsa-miR-4762-3p	CLIP-seq
MIRT2689138	hsa-miR-544b	CLIP-seq
MIRT2689139	hsa-miR-935	CLIP-seq

Show/Hide all(40)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	IBA
GO:0004725	Function	Protein tyrosine phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	IMP	16973135, 17360477
GO:0005001	Function	Transmembrane receptor protein tyrosine phosphatase activity	IDA	24846175
GO:0005001	Function	Transmembrane receptor protein tyrosine phosphatase activity	IEA
GO:0005515	Function	Protein binding	IPI	16273344, 19816407, 21725282, 24846175
GO:0005886	Component	Plasma membrane	IDA	18644975, 24846175
GO:0006470	Process	Protein dephosphorylation	IDA	16973135
GO:0007155	Process	Cell adhesion	NAS	16973135
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IDA	18644975
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IEA
GO:0007165	Process	Signal transduction	IBA
GO:0007165	Process	Signal transduction	NAS	16973135
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IMP	16973135
GO:0008013	Function	Beta-catenin binding	IEA
GO:0008013	Function	Beta-catenin binding	IPI	16973135
GO:0009986	Component	Cell surface	IDA	18644975
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	9602027
GO:0016787	Function	Hydrolase activity	IEA
GO:0016790	Function	Thiolester hydrolase activity	IEA
GO:0019903	Function	Protein phosphatase binding	IPI	24846175
GO:0030336	Process	Negative regulation of cell migration	IEA
GO:0030336	Process	Negative regulation of cell migration	IMP	24846175
GO:0031175	Process	Neuron projection development	IBA
GO:0042803	Function	Protein homodimerization activity	IPI	24846175
GO:0045294	Function	Alpha-catenin binding	IDA	16973135
GO:0045294	Function	Alpha-catenin binding	IEA
GO:0045295	Function	Gamma-catenin binding	IDA	16973135
GO:0045295	Function	Gamma-catenin binding	IEA
GO:0045296	Function	Cadherin binding	IEA
GO:0045296	Function	Cadherin binding	IPI	16973135
GO:0051393	Function	Alpha-actinin binding	IEA
GO:0070097	Function	Delta-catenin binding	IEA
GO:0070097	Function	Delta-catenin binding	IPI	16973135
GO:0071354	Process	Cellular response to interleukin-6	IDA	17360477
GO:0097677	Function	STAT family protein binding	IPI	17360477
GO:1904893	Process	Negative regulation of receptor signaling pathway via STAT	IDA	17360477
GO:1904893	Process	Negative regulation of receptor signaling pathway via STAT	IMP	24846175

MIM	HGNC	e!Ensembl
608712	9682	ENSG00000196090

Protein

UniProt ID

O14522

Protein name

Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho)

Protein function

May be involved in both signal transduction and cellular adhesion in the CNS.

PDB

2OOQ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00629	MAM	32 → 190	MAM domain, meprin/A5/mu	Domain
PF00041	fn3	290 → 374	Fibronectin type III domain	Domain
PF00041	fn3	498 → 578	Fibronectin type III domain	Domain
PF18861	PTP_tm	614 → 772	Transmembrane domain of protein tyrosine phosphatase, receptor type J	Family
PF00102	Y_phosphatase	912 → 1142	Protein-tyrosine phosphatase	Domain
PF00102	Y_phosphatase	1202 → 1436	Protein-tyrosine phosphatase	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in colon, lung, heart and testis, as well as in fetal and adult brain. Not detected in muscle and peripheral blood leukocytes. {ECO:0000269|PubMed:15155950}.

Sequence

MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTW
EKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGAL
NVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVD
EVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVT
RVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAV
GATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRV
LLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSY
NLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQT
EEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRG
KVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPL
NETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDS
LHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCV
RLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYY
LKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQ
PTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQ
TASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIAT
QGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEP
LAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPI
VVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAI
LEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLP
RNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADF
WRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRIC
NMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLN
GGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSS
F

Sequence length

1441

Interactions

View interactions

Show/Hide Unknown Diseases (6)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Breast Cancer	Postmenopausal breast cancer	N/A	N/A	GWAS
Gastroesophageal Reflux Disease	Gastroesophageal reflux disease	N/A	N/A	GWAS
Insomnia	Insomnia	N/A	N/A	GWAS
Mental retardation	intellectual disability	N/A	N/A	ClinVar
Metabolic Syndrome	Serum bilirubin levels x Mediterranean diet adherence interaction in metabolic syndrome	N/A	N/A	GWAS
Schizophrenia	Schizophrenia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (29)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	31844068, 38216925
Arthritis Rheumatoid	Associate	18668548
Astrocytoma	Associate	27586084
Breast Neoplasms	Associate	34414233
Carcinogenesis	Associate	25967969
Carcinoma Hepatocellular	Associate	30551553
Carcinoma Non Small Cell Lung	Inhibit	31595832
Carcinoma Non Small Cell Lung	Associate	34862763, 35789644
Carcinoma Squamous Cell	Associate	28177435
Cholangiocarcinoma	Associate	34810298
Colorectal Neoplasms	Associate	17360477, 30231850, 35789644
Diarrhea	Associate	34270794
Esophageal Squamous Cell Carcinoma	Associate	25967969
Glioblastoma	Associate	27586084
Glioma	Associate	27586084
Heart Defects Congenital	Associate	26283027
Leukemia Myeloid Acute	Associate	24493670
Lung Neoplasms	Associate	31595832
Lung Neoplasms	Inhibit	38216925
Lupus Erythematosus Systemic	Associate	19440200
Melanoma	Associate	34862763, 35688970
Neoplasm Metastasis	Associate	25967969, 31570735, 36001319, 38216925
Neoplasms	Associate	17360477, 25393105, 25967969, 26949921, 35789644, 36248841, 36911742
Neoplasms	Inhibit	25982282, 34414233, 38216925
Oropharyngeal Neoplasms	Inhibit	26949921
Pituitary Neoplasms	Associate	40598468
Prostatic Hyperplasia	Associate	28380430
Prostatic Neoplasms	Associate	28380430
Squamous Cell Carcinoma of Head and Neck	Associate	24395800, 25982282

PTPRT (protein tyrosine phosphatase receptor type T)