BTN2A1 (butyrophilin subfamily 2 member A1)

Gene

• Entrez ID: 11120
• Gene name: Butyrophilin subfamily 2 member A1
• Gene symbol: BTN2A1
• Synonyms (NCBI Gene): BK14H9.1, BT2.1, BTF1, BTN2.1, DJ3E1.1
• Chromosome: 6
• Chromosome location: 6p22.2
• Summary: This gene encodes a member of the immunoglobulin superfamily. The gene is located in a cluster of butyrophilin-like genes in the juxta-telomeric region of the major histocompatibility complex on chromosome 6. A pseudogene of this gene has been identified

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017744	hsa-miR-335-5p	Microarray	18185580
MIRT027591	hsa-miR-98-5p	Microarray	19088304
MIRT827313	hsa-miR-1245b-5p	CLIP-seq
MIRT827314	hsa-miR-214	CLIP-seq
MIRT827315	hsa-miR-3142	CLIP-seq
MIRT827316	hsa-miR-3619-5p	CLIP-seq
MIRT827317	hsa-miR-3620	CLIP-seq
MIRT827318	hsa-miR-3691-3p	CLIP-seq
MIRT827319	hsa-miR-4464	CLIP-seq
MIRT827320	hsa-miR-4641	CLIP-seq
MIRT827321	hsa-miR-4748	CLIP-seq
MIRT827322	hsa-miR-657	CLIP-seq
MIRT827323	hsa-miR-761	CLIP-seq
MIRT827314	hsa-miR-214	CLIP-seq
MIRT827324	hsa-miR-28-5p	CLIP-seq
MIRT827325	hsa-miR-3124-3p	CLIP-seq
MIRT827326	hsa-miR-3139	CLIP-seq
MIRT827327	hsa-miR-3157-5p	CLIP-seq
MIRT827316	hsa-miR-3619-5p	CLIP-seq
MIRT827328	hsa-miR-4277	CLIP-seq
MIRT827329	hsa-miR-4291	CLIP-seq
MIRT827330	hsa-miR-4433	CLIP-seq
MIRT827331	hsa-miR-4459	CLIP-seq
MIRT827332	hsa-miR-4768-3p	CLIP-seq
MIRT827333	hsa-miR-708	CLIP-seq
MIRT827323	hsa-miR-761	CLIP-seq
MIRT827334	hsa-miR-890	CLIP-seq
MIRT827335	hsa-miR-922	CLIP-seq
MIRT827324	hsa-miR-28-5p	CLIP-seq
MIRT827326	hsa-miR-3139	CLIP-seq
MIRT827327	hsa-miR-3157-5p	CLIP-seq
MIRT827330	hsa-miR-4433	CLIP-seq
MIRT827331	hsa-miR-4459	CLIP-seq
MIRT827332	hsa-miR-4768-3p	CLIP-seq
MIRT827333	hsa-miR-708	CLIP-seq
MIRT827324	hsa-miR-28-5p	CLIP-seq
MIRT827326	hsa-miR-3139	CLIP-seq
MIRT827327	hsa-miR-3157-5p	CLIP-seq
MIRT827330	hsa-miR-4433	CLIP-seq
MIRT827331	hsa-miR-4459	CLIP-seq
MIRT827332	hsa-miR-4768-3p	CLIP-seq
MIRT827333	hsa-miR-708	CLIP-seq
MIRT1944839	hsa-miR-513a-3p	CLIP-seq
MIRT2183250	hsa-let-7a	CLIP-seq
MIRT2183251	hsa-let-7b	CLIP-seq
MIRT2183252	hsa-let-7c	CLIP-seq
MIRT2183253	hsa-let-7d	CLIP-seq
MIRT2183254	hsa-let-7e	CLIP-seq
MIRT2183255	hsa-let-7f	CLIP-seq
MIRT2183256	hsa-let-7g	CLIP-seq
MIRT2183257	hsa-let-7i	CLIP-seq
MIRT2183258	hsa-miR-1266	CLIP-seq
MIRT2183259	hsa-miR-200b	CLIP-seq
MIRT2183260	hsa-miR-200c	CLIP-seq
MIRT2183261	hsa-miR-202	CLIP-seq
MIRT2183262	hsa-miR-3927	CLIP-seq
MIRT2183263	hsa-miR-429	CLIP-seq
MIRT2183264	hsa-miR-4458	CLIP-seq
MIRT2183265	hsa-miR-4500	CLIP-seq
MIRT2183266	hsa-miR-4518	CLIP-seq
MIRT2183267	hsa-miR-98	CLIP-seq
MIRT2486754	hsa-miR-1207-3p	CLIP-seq
MIRT2486755	hsa-miR-1268	CLIP-seq
MIRT2486756	hsa-miR-1268b	CLIP-seq
MIRT2486757	hsa-miR-1273f	CLIP-seq
MIRT2486758	hsa-miR-133a	CLIP-seq
MIRT2486759	hsa-miR-133b	CLIP-seq
MIRT2486760	hsa-miR-143	CLIP-seq
MIRT2486761	hsa-miR-147	CLIP-seq
MIRT2486762	hsa-miR-1470	CLIP-seq
MIRT2486763	hsa-miR-147b	CLIP-seq
MIRT2486764	hsa-miR-150	CLIP-seq
MIRT2486765	hsa-miR-1827	CLIP-seq
MIRT2486766	hsa-miR-187	CLIP-seq
MIRT2486767	hsa-miR-1915	CLIP-seq
MIRT2486768	hsa-miR-210	CLIP-seq
MIRT2486769	hsa-miR-2117	CLIP-seq
MIRT2486770	hsa-miR-3126-3p	CLIP-seq
MIRT2486771	hsa-miR-3127-3p	CLIP-seq
MIRT2486772	hsa-miR-3158-3p	CLIP-seq
MIRT2486773	hsa-miR-3192	CLIP-seq
MIRT2486774	hsa-miR-3199	CLIP-seq
MIRT2486775	hsa-miR-326	CLIP-seq
MIRT2486776	hsa-miR-330-5p	CLIP-seq
MIRT2486777	hsa-miR-342-3p	CLIP-seq
MIRT2486778	hsa-miR-3618	CLIP-seq
MIRT2486779	hsa-miR-3652	CLIP-seq
MIRT2486780	hsa-miR-3675-3p	CLIP-seq
MIRT2486781	hsa-miR-3921	CLIP-seq
MIRT2486782	hsa-miR-4267	CLIP-seq
MIRT2486783	hsa-miR-4273	CLIP-seq
MIRT2486784	hsa-miR-4279	CLIP-seq
MIRT2486785	hsa-miR-4281	CLIP-seq
MIRT2486786	hsa-miR-4300	CLIP-seq
MIRT2486787	hsa-miR-4430	CLIP-seq
MIRT2486788	hsa-miR-4436b-5p	CLIP-seq
MIRT2486789	hsa-miR-4455	CLIP-seq
MIRT2486790	hsa-miR-448	CLIP-seq
MIRT2486791	hsa-miR-4505	CLIP-seq
MIRT2486792	hsa-miR-4648	CLIP-seq
MIRT2486793	hsa-miR-4653-5p	CLIP-seq
MIRT2486794	hsa-miR-4659a-3p	CLIP-seq
MIRT2486795	hsa-miR-4659b-3p	CLIP-seq
MIRT2486796	hsa-miR-4662a-5p	CLIP-seq
MIRT2486797	hsa-miR-4663	CLIP-seq
MIRT2486798	hsa-miR-4667-3p	CLIP-seq
MIRT2486799	hsa-miR-4677-3p	CLIP-seq
MIRT2486800	hsa-miR-4685-5p	CLIP-seq
MIRT2486801	hsa-miR-4687-3p	CLIP-seq
MIRT2486802	hsa-miR-4708-5p	CLIP-seq
MIRT2486803	hsa-miR-4711-3p	CLIP-seq
MIRT2486804	hsa-miR-4713-5p	CLIP-seq
MIRT2486805	hsa-miR-4726-3p	CLIP-seq
MIRT2486806	hsa-miR-4733-3p	CLIP-seq
MIRT2486807	hsa-miR-4746-3p	CLIP-seq
MIRT2486808	hsa-miR-4753-3p	CLIP-seq
MIRT2486809	hsa-miR-4770	CLIP-seq
MIRT2486810	hsa-miR-4778-3p	CLIP-seq
MIRT2486811	hsa-miR-4779	CLIP-seq
MIRT2486812	hsa-miR-4786-5p	CLIP-seq
MIRT2486813	hsa-miR-4802-3p	CLIP-seq
MIRT2486814	hsa-miR-532-3p	CLIP-seq
MIRT2486815	hsa-miR-541	CLIP-seq
MIRT2486816	hsa-miR-581	CLIP-seq
MIRT2486817	hsa-miR-583	CLIP-seq
MIRT2486818	hsa-miR-584	CLIP-seq
MIRT2486819	hsa-miR-604	CLIP-seq
MIRT2486820	hsa-miR-609	CLIP-seq
MIRT2486821	hsa-miR-642a	CLIP-seq
MIRT2486822	hsa-miR-647	CLIP-seq
MIRT2486823	hsa-miR-654-5p	CLIP-seq
MIRT2486824	hsa-miR-7	CLIP-seq
MIRT2486825	hsa-miR-765	CLIP-seq
MIRT2486826	hsa-miR-769-5p	CLIP-seq
MIRT2486827	hsa-miR-920	CLIP-seq
MIRT2486828	hsa-miR-934	CLIP-seq
MIRT2486754	hsa-miR-1207-3p	CLIP-seq
MIRT2486755	hsa-miR-1268	CLIP-seq
MIRT2486756	hsa-miR-1268b	CLIP-seq
MIRT2486757	hsa-miR-1273f	CLIP-seq
MIRT2486758	hsa-miR-133a	CLIP-seq
MIRT2486759	hsa-miR-133b	CLIP-seq
MIRT2486760	hsa-miR-143	CLIP-seq
MIRT2486761	hsa-miR-147	CLIP-seq
MIRT2486762	hsa-miR-1470	CLIP-seq
MIRT2486763	hsa-miR-147b	CLIP-seq
MIRT2486764	hsa-miR-150	CLIP-seq
MIRT2486765	hsa-miR-1827	CLIP-seq
MIRT2486766	hsa-miR-187	CLIP-seq
MIRT2676109	hsa-miR-1914	CLIP-seq
MIRT2486767	hsa-miR-1915	CLIP-seq
MIRT2486768	hsa-miR-210	CLIP-seq
MIRT2486769	hsa-miR-2117	CLIP-seq
MIRT2486770	hsa-miR-3126-3p	CLIP-seq
MIRT2486771	hsa-miR-3127-3p	CLIP-seq
MIRT2486772	hsa-miR-3158-3p	CLIP-seq
MIRT2676110	hsa-miR-3183	CLIP-seq
MIRT2486773	hsa-miR-3192	CLIP-seq
MIRT2486774	hsa-miR-3199	CLIP-seq
MIRT2676111	hsa-miR-323-5p	CLIP-seq
MIRT2486775	hsa-miR-326	CLIP-seq
MIRT2486776	hsa-miR-330-5p	CLIP-seq
MIRT2486777	hsa-miR-342-3p	CLIP-seq
MIRT2486778	hsa-miR-3618	CLIP-seq
MIRT2486779	hsa-miR-3652	CLIP-seq
MIRT2486780	hsa-miR-3675-3p	CLIP-seq
MIRT2486781	hsa-miR-3921	CLIP-seq
MIRT2486782	hsa-miR-4267	CLIP-seq
MIRT2486783	hsa-miR-4273	CLIP-seq
MIRT2486784	hsa-miR-4279	CLIP-seq
MIRT2486785	hsa-miR-4281	CLIP-seq
MIRT2676112	hsa-miR-4299	CLIP-seq
MIRT2486786	hsa-miR-4300	CLIP-seq
MIRT2486787	hsa-miR-4430	CLIP-seq
MIRT2486788	hsa-miR-4436b-5p	CLIP-seq
MIRT2486789	hsa-miR-4455	CLIP-seq
MIRT2676113	hsa-miR-4456	CLIP-seq
MIRT2486790	hsa-miR-448	CLIP-seq
MIRT2486791	hsa-miR-4505	CLIP-seq
MIRT2486792	hsa-miR-4648	CLIP-seq
MIRT2486793	hsa-miR-4653-5p	CLIP-seq
MIRT2486794	hsa-miR-4659a-3p	CLIP-seq
MIRT2486795	hsa-miR-4659b-3p	CLIP-seq
MIRT2486796	hsa-miR-4662a-5p	CLIP-seq
MIRT2486797	hsa-miR-4663	CLIP-seq
MIRT2486798	hsa-miR-4667-3p	CLIP-seq
MIRT2486799	hsa-miR-4677-3p	CLIP-seq
MIRT2486800	hsa-miR-4685-5p	CLIP-seq
MIRT2486801	hsa-miR-4687-3p	CLIP-seq
MIRT2486802	hsa-miR-4708-5p	CLIP-seq
MIRT2486803	hsa-miR-4711-3p	CLIP-seq
MIRT2486804	hsa-miR-4713-5p	CLIP-seq
MIRT2676114	hsa-miR-4723-3p	CLIP-seq
MIRT2486805	hsa-miR-4726-3p	CLIP-seq
MIRT2486806	hsa-miR-4733-3p	CLIP-seq
MIRT2486807	hsa-miR-4746-3p	CLIP-seq
MIRT2486808	hsa-miR-4753-3p	CLIP-seq
MIRT2486809	hsa-miR-4770	CLIP-seq
MIRT2486810	hsa-miR-4778-3p	CLIP-seq
MIRT2486811	hsa-miR-4779	CLIP-seq
MIRT2486812	hsa-miR-4786-5p	CLIP-seq
MIRT2486813	hsa-miR-4802-3p	CLIP-seq
MIRT2486814	hsa-miR-532-3p	CLIP-seq
MIRT2486815	hsa-miR-541	CLIP-seq
MIRT2676115	hsa-miR-548q	CLIP-seq
MIRT2486816	hsa-miR-581	CLIP-seq
MIRT2486817	hsa-miR-583	CLIP-seq
MIRT2486818	hsa-miR-584	CLIP-seq
MIRT2486819	hsa-miR-604	CLIP-seq
MIRT2486820	hsa-miR-609	CLIP-seq
MIRT2486821	hsa-miR-642a	CLIP-seq
MIRT2486822	hsa-miR-647	CLIP-seq
MIRT2486823	hsa-miR-654-5p	CLIP-seq
MIRT2486824	hsa-miR-7	CLIP-seq
MIRT2486825	hsa-miR-765	CLIP-seq
MIRT2486826	hsa-miR-769-5p	CLIP-seq
MIRT2676116	hsa-miR-876-3p	CLIP-seq
MIRT2486827	hsa-miR-920	CLIP-seq
MIRT2486828	hsa-miR-934	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001817	Process	Regulation of cytokine production	IBA
GO:0005102	Function	Signaling receptor binding	IBA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	TAS	9382921
GO:0006629	Process	Lipid metabolic process	TAS	9382921
GO:0009897	Component	External side of plasma membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0050852	Process	T cell receptor signaling pathway	IBA

Other IDs

• MIM: 613590
• HGNC: 1136
• e!Ensembl: ENSG00000112763

Protein

• UniProt ID: Q7KYR7
• Protein name: Butyrophilin subfamily 2 member A1
• PDB: 8DFW, 8DFX, 8DFY, 8JYC, 8JYE, 8VC7
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07686	V-set	34 → 143	Immunoglobulin V-set domain	Domain
  PF13765	PRY	330 → 381	SPRY-associated domain	Family
  PF00622	SPRY	385 → 500	SPRY domain	Family

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in brain, bone marrow, small intestine, muscle, spleen and pancreas. Moderate expression was seen in lung, liver and kidney. {ECO:0000269|PubMed:9149941}.
• Sequence:

  MESAAALHFSRPASLLLLLLSLCALVSAQFIVVGPTDPILATVGENTTLRCHLSPEKNAE
  DMEVRWFRSQFSPAVFVYKGGRERTEEQMEEYRGRTTFVSKDISRGSVALVIHNITAQEN
  GTYRCYFQEGRSYDEAILHLVVAGLGSKPLISMRGHEDGGIRLECISRGWYPKPLTVWRD
  PYGGVAPALKEVSMPDADGLFMVTTAVIIRDKSVRNMSCSINNTLLGQKKESVIFIPESF
  MPSVSPCAVALPIIVVILMIPIAVCIYWINKLQKEKKILSGEKEFERETREIALKELEKE
  RVQKEEELQVKEKLQEELRWRRTFLHAVDVVLDPDTAHPDLFLSEDRRSVRRCPFRHLGE
  SVPDNPERFDSQPCVLGRESFASGKHYWEVEVENVIEWTVGVCRDSVERKGEVLLIPQNG
  FWTLEMHKGQYRAVSSPDRILPLKESLCRVGVFLDYEAGDVSFYNMRDRSHIYTCPRSAF
  SVPVRPFFRLGCEDSPIFICPALTGANGVTVPEEGLTLHRVGTHQSL

• Sequence length: 527

Pathways

Reactome:

Butyrophilin (BTN) family interactions