Gene Gene information from NCBI Gene database.
Entrez ID 11118
Gene name Butyrophilin subfamily 3 member A2
Gene symbol BTN3A2
Synonyms (NCBI Gene)
BT3.2BTF4BTN3.2CD277
Chromosome 6
Chromosome location 6p22.2
Summary This gene encodes a member of the immunoglobulin superfamily, which resides in the juxta-telomeric region of the major histocompatability class 1 locus and is clustered with the other family members on chromosome 6. The encoded protein may be involved in
miRNA miRNA information provided by mirtarbase database.
587
miRTarBase ID miRNA Experiments Reference
MIRT039803 hsa-miR-615-3p CLASH 23622248
MIRT721482 hsa-miR-3614-3p HITS-CLIP 19536157
MIRT721481 hsa-miR-6865-3p HITS-CLIP 19536157
MIRT721480 hsa-miR-6849-3p HITS-CLIP 19536157
MIRT716896 hsa-miR-877-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
14
GO ID Ontology Definition Evidence Reference
GO:0001817 Process Regulation of cytokine production IBA
GO:0002250 Process Adaptive immune response IEA
GO:0002376 Process Immune system process IEA
GO:0002456 Process T cell mediated immunity IMP 22767497
GO:0005102 Function Signaling receptor binding IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
613594 1139 ENSG00000186470
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P78410
Protein name Butyrophilin subfamily 3 member A2
Protein function Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells.
PDB 4F8Q
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07686 V-set 35 144 Immunoglobulin V-set domain Domain
Tissue specificity TISSUE SPECIFICITY: Detected in T-cells and natural killer cells. {ECO:0000269|PubMed:21918970}.
Sequence
MKMASSLAFLLLNFHVSLLLVQLLTPCSAQFSVLGPSGPILAMVGEDADLPCHLFPTMSA
ETMELKWVSSSLRQVVNVYADGKEVEDRQSAPYRGRTSILRDGITAGKAALRIHNVTASD
SGKYLCYFQDGDFYEKALVELKVA
ALGSNLHVEVKGYEDGGIHLECRSTGWYPQPQIQWS
NAKGENIPAVEAPVVADGVGLYEVAASVIMRGGSGEGVSCIIRNSLLGLEKTASISIADP
FFRSAQPWIAALAGTLPILLLLLAGASYFLWRQQKEITALSSEIESEQEMKEMGYAATER
EISLRESLQEELKRKKIQYLTRGEESSSDTNKSA
Sequence length 334
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Butyrophilin (BTN) family interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
16
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Benign rs58367598 RCV005919707
Adrenocortical carcinoma, hereditary Benign rs58367598 RCV005919710
Cholangiocarcinoma Benign rs58367598 RCV005919720
Chronic lymphocytic leukemia/small lymphocytic lymphoma Benign rs58367598 RCV005919721
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Arthritis Rheumatoid Associate 36911710
Breast Neoplasms Associate 28409241
Carcinoma Ovarian Epithelial Associate 22685580
Depressive Disorder Major Associate 36911710
Glomerulonephritis IGA Associate 36709307
Hypertension Associate 37451613
Mental Disorders Associate 34637873
Neoplasm Metastasis Associate 28409241
Neoplasms Associate 22685580
Prostatic Hyperplasia Associate 39367121