Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
11118
Gene name Gene Name - the full gene name approved by the HGNC.
Butyrophilin subfamily 3 member A2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
BTN3A2
Synonyms (NCBI Gene) Gene synonyms aliases
BT3.2, BTF4, BTN3.2, CD277
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p22.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the immunoglobulin superfamily, which resides in the juxta-telomeric region of the major histocompatability class 1 locus and is clustered with the other family members on chromosome 6. The encoded protein may be involved in
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT039803 hsa-miR-615-3p CLASH 23622248
MIRT721482 hsa-miR-3614-3p HITS-CLIP 19536157
MIRT721481 hsa-miR-6865-3p HITS-CLIP 19536157
MIRT721480 hsa-miR-6849-3p HITS-CLIP 19536157
MIRT716896 hsa-miR-877-3p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001817 Process Regulation of cytokine production IBA
GO:0002250 Process Adaptive immune response IEA
GO:0002376 Process Immune system process IEA
GO:0002456 Process T cell mediated immunity IMP 22767497
GO:0005102 Function Signaling receptor binding IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
613594 1139 ENSG00000186470
Protein
UniProt ID P78410
Protein name Butyrophilin subfamily 3 member A2
Protein function Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells.
PDB 4F8Q
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07686 V-set 35 144 Immunoglobulin V-set domain Domain
Tissue specificity TISSUE SPECIFICITY: Detected in T-cells and natural killer cells. {ECO:0000269|PubMed:21918970}.
Sequence
MKMASSLAFLLLNFHVSLLLVQLLTPCSAQFSVLGPSGPILAMVGEDADLPCHLFPTMSA
ETMELKWVSSSLRQVVNVYADGKEVEDRQSAPYRGRTSILRDGITAGKAALRIHNVTASD
SGKYLCYFQDGDFYEKALVELKVA
ALGSNLHVEVKGYEDGGIHLECRSTGWYPQPQIQWS
NAKGENIPAVEAPVVADGVGLYEVAASVIMRGGSGEGVSCIIRNSLLGLEKTASISIADP
FFRSAQPWIAALAGTLPILLLLLAGASYFLWRQQKEITALSSEIESEQEMKEMGYAATER
EISLRESLQEELKRKKIQYLTRGEESSSDTNKSA
Sequence length 334
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Butyrophilin (BTN) family interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Asthma Age of onset of adult onset asthma N/A N/A GWAS
Diabetes Type 2 diabetes N/A N/A GWAS
Insomnia Insomnia N/A N/A GWAS
Mental Depression Major depressive disorder N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Arthritis Rheumatoid Associate 36911710
Breast Neoplasms Associate 28409241
Carcinoma Ovarian Epithelial Associate 22685580
Depressive Disorder Major Associate 36911710
Glomerulonephritis IGA Associate 36709307
Hypertension Associate 37451613
Mental Disorders Associate 34637873
Neoplasm Metastasis Associate 28409241
Neoplasms Associate 22685580
Prostatic Hyperplasia Associate 39367121