Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
11102
Gene name Gene Name - the full gene name approved by the HGNC.
Ribonuclease P/MRP subunit p14
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RPP14
Synonyms (NCBI Gene) Gene synonyms aliases
P14
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3p14.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a subunit of ribonuclease P and has 3` to 5` exoribonuclease activity. Transcripts for this gene are bicistronic and include a conserved downstream open reading frame for the hydroxyacyl-thioester dehydratase type 2 (HTD2) gene. [provide
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT028571 hsa-miR-30a-5p Proteomics 18668040
MIRT043625 hsa-miR-326 CLASH 23622248
MIRT708930 hsa-miR-6808-5p HITS-CLIP 19536157
MIRT708929 hsa-miR-6893-5p HITS-CLIP 19536157
MIRT708928 hsa-miR-940 HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001682 Process TRNA 5'-leader removal IBA
GO:0001682 Process TRNA 5'-leader removal IDA 16723659, 30454648
GO:0001682 Process TRNA 5'-leader removal IEA
GO:0003723 Function RNA binding IEA
GO:0004526 Function Ribonuclease P activity IDA 30454648
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606112 30327 ENSG00000163684
Protein
UniProt ID O95059
Protein name Ribonuclease P protein subunit p14
Protein function Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
PDB 6AHR , 6AHU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01900 RNase_P_Rpp14 8 112 Rpp14/Pop5 family Family
Sequence
Sequence length 124
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    tRNA processing in the nucleus
Major pathway of rRNA processing in the nucleolus and cytosol
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Diabetes Type 2 diabetes N/A N/A GWAS
Rheumatoid arthritis Rheumatoid arthritis N/A N/A GWAS
Systemic lupus erythematosus Systemic lupus erythematosus N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Arthritis Rheumatoid Stimulate 2292594
Brain Neoplasms Associate 23508638
Carcinogenesis Associate 15649253, 26291246
Carcinoma Associate 22648906
Carcinoma Endometrioid Associate 29250656
Carcinoma Hepatocellular Stimulate 24377595
Carcinoma Hepatocellular Associate 29865038
Carcinoma Non Small Cell Lung Associate 15073856, 26304549
Cholangiocarcinoma Associate 17550320, 22230750
Colorectal Neoplasms Inhibit 17848589