Gene Gene information from NCBI Gene database.
Entrez ID 11102
Gene name Ribonuclease P/MRP subunit p14
Gene symbol RPP14
Synonyms (NCBI Gene)
P14
Chromosome 3
Chromosome location 3p14.3
Summary This gene encodes a subunit of ribonuclease P and has 3` to 5` exoribonuclease activity. Transcripts for this gene are bicistronic and include a conserved downstream open reading frame for the hydroxyacyl-thioester dehydratase type 2 (HTD2) gene. [provide
miRNA miRNA information provided by mirtarbase database.
646
miRTarBase ID miRNA Experiments Reference
MIRT028571 hsa-miR-30a-5p Proteomics 18668040
MIRT043625 hsa-miR-326 CLASH 23622248
MIRT708930 hsa-miR-6808-5p HITS-CLIP 19536157
MIRT708929 hsa-miR-6893-5p HITS-CLIP 19536157
MIRT708928 hsa-miR-940 HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
20
GO ID Ontology Definition Evidence Reference
GO:0001682 Process TRNA 5'-leader removal IBA
GO:0001682 Process TRNA 5'-leader removal IDA 16723659, 30454648
GO:0001682 Process TRNA 5'-leader removal IEA
GO:0003723 Function RNA binding IEA
GO:0004526 Function Ribonuclease P activity IDA 30454648
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606112 30327 ENSG00000163684
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O95059
Protein name Ribonuclease P protein subunit p14
Protein function Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
PDB 6AHR , 6AHU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01900 RNase_P_Rpp14 8 112 Rpp14/Pop5 family Family
Sequence
Sequence length 124
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    tRNA processing in the nucleus
Major pathway of rRNA processing in the nucleolus and cytosol
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
7
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Benign rs77012717 RCV005913263
Cervical cancer Benign rs77012717 RCV005913264
Clear cell carcinoma of kidney Benign rs77012717 RCV005913265
Colon adenocarcinoma Benign rs77012717 RCV005913262
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Arthritis Rheumatoid Stimulate 2292594
Brain Neoplasms Associate 23508638
Carcinogenesis Associate 15649253, 26291246
Carcinoma Associate 22648906
Carcinoma Endometrioid Associate 29250656
Carcinoma Hepatocellular Stimulate 24377595
Carcinoma Hepatocellular Associate 29865038
Carcinoma Non Small Cell Lung Associate 15073856, 26304549
Cholangiocarcinoma Associate 17550320, 22230750
Colorectal Neoplasms Inhibit 17848589