PTPN21 (protein tyrosine phosphatase non-receptor type 21)

Gene

• Entrez ID: 11099
• Gene name: Protein tyrosine phosphatase non-receptor type 21
• Gene symbol: PTPN21
• Synonyms (NCBI Gene): PTPD1, PTPRL10
• Chromosome: 14
• Chromosome location: 14q31.3
• Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic tran

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT040133	hsa-miR-615-3p	CLASH	23622248
MIRT1275329	hsa-miR-1202	CLIP-seq
MIRT1275330	hsa-miR-1207-5p	CLIP-seq
MIRT1275331	hsa-miR-124	CLIP-seq
MIRT1275332	hsa-miR-1271	CLIP-seq
MIRT1275333	hsa-miR-138	CLIP-seq
MIRT1275334	hsa-miR-142-3p	CLIP-seq
MIRT1275335	hsa-miR-182	CLIP-seq
MIRT1275336	hsa-miR-1914	CLIP-seq
MIRT1275337	hsa-miR-1915	CLIP-seq
MIRT1275338	hsa-miR-2116	CLIP-seq
MIRT1275339	hsa-miR-218	CLIP-seq
MIRT1275340	hsa-miR-2964a-3p	CLIP-seq
MIRT1275341	hsa-miR-3120-5p	CLIP-seq
MIRT1275342	hsa-miR-3151	CLIP-seq
MIRT1275343	hsa-miR-3157-5p	CLIP-seq
MIRT1275344	hsa-miR-3174	CLIP-seq
MIRT1275345	hsa-miR-331-3p	CLIP-seq
MIRT1275346	hsa-miR-338-3p	CLIP-seq
MIRT1275347	hsa-miR-338-5p	CLIP-seq
MIRT1275348	hsa-miR-3653	CLIP-seq
MIRT1275349	hsa-miR-3655	CLIP-seq
MIRT1275350	hsa-miR-3658	CLIP-seq
MIRT1275351	hsa-miR-3663-3p	CLIP-seq
MIRT1275352	hsa-miR-3691-3p	CLIP-seq
MIRT1275353	hsa-miR-3714	CLIP-seq
MIRT1275354	hsa-miR-3910	CLIP-seq
MIRT1275355	hsa-miR-3922-5p	CLIP-seq
MIRT1275356	hsa-miR-3929	CLIP-seq
MIRT1275357	hsa-miR-3972	CLIP-seq
MIRT1275358	hsa-miR-4325	CLIP-seq
MIRT1275359	hsa-miR-4328	CLIP-seq
MIRT1275360	hsa-miR-4419b	CLIP-seq
MIRT1275361	hsa-miR-4424	CLIP-seq
MIRT1275362	hsa-miR-4447	CLIP-seq
MIRT1275363	hsa-miR-4472	CLIP-seq
MIRT1275364	hsa-miR-4473	CLIP-seq
MIRT1275365	hsa-miR-4477a	CLIP-seq
MIRT1275366	hsa-miR-4478	CLIP-seq
MIRT1275367	hsa-miR-450b-3p	CLIP-seq
MIRT1275368	hsa-miR-452	CLIP-seq
MIRT1275369	hsa-miR-455-5p	CLIP-seq
MIRT1275370	hsa-miR-4655-5p	CLIP-seq
MIRT1275371	hsa-miR-4662a-3p	CLIP-seq
MIRT1275372	hsa-miR-4666-5p	CLIP-seq
MIRT1275373	hsa-miR-4676-3p	CLIP-seq
MIRT1275374	hsa-miR-4677-5p	CLIP-seq
MIRT1275375	hsa-miR-4700-3p	CLIP-seq
MIRT1275376	hsa-miR-4708-3p	CLIP-seq
MIRT1275377	hsa-miR-4726-3p	CLIP-seq
MIRT1275378	hsa-miR-4753-3p	CLIP-seq
MIRT1275379	hsa-miR-4760-5p	CLIP-seq
MIRT1275380	hsa-miR-4763-3p	CLIP-seq
MIRT1275381	hsa-miR-4764-5p	CLIP-seq
MIRT1275382	hsa-miR-4780	CLIP-seq
MIRT1275383	hsa-miR-4796-5p	CLIP-seq
MIRT1275384	hsa-miR-486-3p	CLIP-seq
MIRT1275385	hsa-miR-491-5p	CLIP-seq
MIRT1275386	hsa-miR-500a	CLIP-seq
MIRT1275387	hsa-miR-501-3p	CLIP-seq
MIRT1275388	hsa-miR-501-5p	CLIP-seq
MIRT1275389	hsa-miR-502-3p	CLIP-seq
MIRT1275390	hsa-miR-505	CLIP-seq
MIRT1275391	hsa-miR-506	CLIP-seq
MIRT1275392	hsa-miR-512-3p	CLIP-seq
MIRT1275393	hsa-miR-520f	CLIP-seq
MIRT1275394	hsa-miR-548g	CLIP-seq
MIRT1275395	hsa-miR-548q	CLIP-seq
MIRT1275396	hsa-miR-549	CLIP-seq
MIRT1275397	hsa-miR-550a	CLIP-seq
MIRT1275398	hsa-miR-578	CLIP-seq
MIRT1275399	hsa-miR-600	CLIP-seq
MIRT1275400	hsa-miR-615-5p	CLIP-seq
MIRT1275401	hsa-miR-636	CLIP-seq
MIRT1275402	hsa-miR-769-3p	CLIP-seq
MIRT1275403	hsa-miR-96	CLIP-seq
MIRT2081055	hsa-miR-1227	CLIP-seq
MIRT1275331	hsa-miR-124	CLIP-seq
MIRT2081056	hsa-miR-1262	CLIP-seq
MIRT2081057	hsa-miR-1283	CLIP-seq
MIRT2081058	hsa-miR-149	CLIP-seq
MIRT2081059	hsa-miR-1825	CLIP-seq
MIRT1275337	hsa-miR-1915	CLIP-seq
MIRT2081060	hsa-miR-200b	CLIP-seq
MIRT2081061	hsa-miR-200c	CLIP-seq
MIRT2081062	hsa-miR-204	CLIP-seq
MIRT2081063	hsa-miR-205	CLIP-seq
MIRT2081064	hsa-miR-211	CLIP-seq
MIRT1275338	hsa-miR-2116	CLIP-seq
MIRT2081065	hsa-miR-217	CLIP-seq
MIRT2081066	hsa-miR-219-2-3p	CLIP-seq
MIRT2081067	hsa-miR-28-5p	CLIP-seq
MIRT1275340	hsa-miR-2964a-3p	CLIP-seq
MIRT1275341	hsa-miR-3120-5p	CLIP-seq
MIRT2081068	hsa-miR-3139	CLIP-seq
MIRT2081069	hsa-miR-3168	CLIP-seq
MIRT2081070	hsa-miR-3173-3p	CLIP-seq
MIRT2081071	hsa-miR-3184	CLIP-seq
MIRT1275349	hsa-miR-3655	CLIP-seq
MIRT2081072	hsa-miR-3662	CLIP-seq
MIRT1275351	hsa-miR-3663-3p	CLIP-seq
MIRT2081073	hsa-miR-3667-3p	CLIP-seq
MIRT1275352	hsa-miR-3691-3p	CLIP-seq
MIRT2081074	hsa-miR-369-3p	CLIP-seq
MIRT1275353	hsa-miR-3714	CLIP-seq
MIRT1275354	hsa-miR-3910	CLIP-seq
MIRT1275355	hsa-miR-3922-5p	CLIP-seq
MIRT1275356	hsa-miR-3929	CLIP-seq
MIRT2081075	hsa-miR-3938	CLIP-seq
MIRT2081076	hsa-miR-423-5p	CLIP-seq
MIRT2081077	hsa-miR-4282	CLIP-seq
MIRT2081078	hsa-miR-429	CLIP-seq
MIRT2081079	hsa-miR-4314	CLIP-seq
MIRT2081080	hsa-miR-4418	CLIP-seq
MIRT1275360	hsa-miR-4419b	CLIP-seq
MIRT2081081	hsa-miR-4428	CLIP-seq
MIRT1275366	hsa-miR-4478	CLIP-seq
MIRT2081082	hsa-miR-4520a-5p	CLIP-seq
MIRT2081083	hsa-miR-4520b-5p	CLIP-seq
MIRT2081084	hsa-miR-4639-3p	CLIP-seq
MIRT1275372	hsa-miR-4666-5p	CLIP-seq
MIRT1275374	hsa-miR-4677-5p	CLIP-seq
MIRT2081085	hsa-miR-4681	CLIP-seq
MIRT2081086	hsa-miR-4698	CLIP-seq
MIRT1275375	hsa-miR-4700-3p	CLIP-seq
MIRT2081087	hsa-miR-4701-3p	CLIP-seq
MIRT1275376	hsa-miR-4708-3p	CLIP-seq
MIRT2081088	hsa-miR-4710	CLIP-seq
MIRT1275377	hsa-miR-4726-3p	CLIP-seq
MIRT2081089	hsa-miR-4755-5p	CLIP-seq
MIRT1275382	hsa-miR-4780	CLIP-seq
MIRT2081090	hsa-miR-4793-5p	CLIP-seq
MIRT1275383	hsa-miR-4796-5p	CLIP-seq
MIRT1275390	hsa-miR-505	CLIP-seq
MIRT1275391	hsa-miR-506	CLIP-seq
MIRT2081091	hsa-miR-509-3-5p	CLIP-seq
MIRT2081092	hsa-miR-509-5p	CLIP-seq
MIRT2081093	hsa-miR-5096	CLIP-seq
MIRT1275392	hsa-miR-512-3p	CLIP-seq
MIRT2081094	hsa-miR-512-5p	CLIP-seq
MIRT2081095	hsa-miR-548u	CLIP-seq
MIRT2081096	hsa-miR-555	CLIP-seq
MIRT2081097	hsa-miR-623	CLIP-seq
MIRT2081098	hsa-miR-651	CLIP-seq
MIRT2081099	hsa-miR-708	CLIP-seq
MIRT2081100	hsa-miR-760	CLIP-seq
MIRT2081101	hsa-miR-95	CLIP-seq
MIRT1275332	hsa-miR-1271	CLIP-seq
MIRT2081057	hsa-miR-1283	CLIP-seq
MIRT1275335	hsa-miR-182	CLIP-seq
MIRT2081062	hsa-miR-204	CLIP-seq
MIRT2081063	hsa-miR-205	CLIP-seq
MIRT2081064	hsa-miR-211	CLIP-seq
MIRT2081066	hsa-miR-219-2-3p	CLIP-seq
MIRT1275340	hsa-miR-2964a-3p	CLIP-seq
MIRT2306984	hsa-miR-3121-3p	CLIP-seq
MIRT2306985	hsa-miR-3123	CLIP-seq
MIRT1275346	hsa-miR-338-3p	CLIP-seq
MIRT2081073	hsa-miR-3667-3p	CLIP-seq
MIRT2306986	hsa-miR-3925-5p	CLIP-seq
MIRT2081075	hsa-miR-3938	CLIP-seq
MIRT2306987	hsa-miR-3976	CLIP-seq
MIRT1275359	hsa-miR-4328	CLIP-seq
MIRT1275365	hsa-miR-4477a	CLIP-seq
MIRT2081086	hsa-miR-4698	CLIP-seq
MIRT2306988	hsa-miR-4719	CLIP-seq
MIRT2081089	hsa-miR-4755-5p	CLIP-seq
MIRT2081097	hsa-miR-623	CLIP-seq
MIRT1275403	hsa-miR-96	CLIP-seq
MIRT2081056	hsa-miR-1262	CLIP-seq
MIRT2604568	hsa-miR-1322	CLIP-seq
MIRT1275334	hsa-miR-142-3p	CLIP-seq
MIRT2081058	hsa-miR-149	CLIP-seq
MIRT2604569	hsa-miR-3117-5p	CLIP-seq
MIRT1275341	hsa-miR-3120-5p	CLIP-seq
MIRT2604570	hsa-miR-3122	CLIP-seq
MIRT2604571	hsa-miR-3135	CLIP-seq
MIRT2604572	hsa-miR-3153	CLIP-seq
MIRT2081070	hsa-miR-3173-3p	CLIP-seq
MIRT1275344	hsa-miR-3174	CLIP-seq
MIRT2081071	hsa-miR-3184	CLIP-seq
MIRT2081072	hsa-miR-3662	CLIP-seq
MIRT2604573	hsa-miR-3913-5p	CLIP-seq
MIRT2081076	hsa-miR-423-5p	CLIP-seq
MIRT2604574	hsa-miR-4261	CLIP-seq
MIRT2604575	hsa-miR-4280	CLIP-seq
MIRT1275361	hsa-miR-4424	CLIP-seq
MIRT2081081	hsa-miR-4428	CLIP-seq
MIRT1275364	hsa-miR-4473	CLIP-seq
MIRT2604576	hsa-miR-4477b	CLIP-seq
MIRT1275367	hsa-miR-450b-3p	CLIP-seq
MIRT1275369	hsa-miR-455-5p	CLIP-seq
MIRT2081084	hsa-miR-4639-3p	CLIP-seq
MIRT1275372	hsa-miR-4666-5p	CLIP-seq
MIRT2604577	hsa-miR-4668-5p	CLIP-seq
MIRT2604578	hsa-miR-4694-3p	CLIP-seq
MIRT2081086	hsa-miR-4698	CLIP-seq
MIRT2081087	hsa-miR-4701-3p	CLIP-seq
MIRT2081088	hsa-miR-4710	CLIP-seq
MIRT1275381	hsa-miR-4764-5p	CLIP-seq
MIRT1275383	hsa-miR-4796-5p	CLIP-seq
MIRT1275392	hsa-miR-512-3p	CLIP-seq
MIRT2081094	hsa-miR-512-5p	CLIP-seq
MIRT2604579	hsa-miR-514	CLIP-seq
MIRT2604580	hsa-miR-514b-3p	CLIP-seq
MIRT1275393	hsa-miR-520f	CLIP-seq
MIRT2604581	hsa-miR-522	CLIP-seq
MIRT1275396	hsa-miR-549	CLIP-seq
MIRT1275397	hsa-miR-550a	CLIP-seq
MIRT2081100	hsa-miR-760	CLIP-seq
MIRT1275402	hsa-miR-769-3p	CLIP-seq
MIRT2689084	hsa-miR-1208	CLIP-seq
MIRT2604568	hsa-miR-1322	CLIP-seq
MIRT1275334	hsa-miR-142-3p	CLIP-seq
MIRT2081058	hsa-miR-149	CLIP-seq
MIRT2604569	hsa-miR-3117-5p	CLIP-seq
MIRT1275341	hsa-miR-3120-5p	CLIP-seq
MIRT2604570	hsa-miR-3122	CLIP-seq
MIRT2604571	hsa-miR-3135	CLIP-seq
MIRT2604572	hsa-miR-3153	CLIP-seq
MIRT2081070	hsa-miR-3173-3p	CLIP-seq
MIRT1275344	hsa-miR-3174	CLIP-seq
MIRT1275348	hsa-miR-3653	CLIP-seq
MIRT2081072	hsa-miR-3662	CLIP-seq
MIRT2604573	hsa-miR-3913-5p	CLIP-seq
MIRT2604574	hsa-miR-4261	CLIP-seq
MIRT2604575	hsa-miR-4280	CLIP-seq
MIRT2689085	hsa-miR-4420	CLIP-seq
MIRT1275361	hsa-miR-4424	CLIP-seq
MIRT2081081	hsa-miR-4428	CLIP-seq
MIRT1275364	hsa-miR-4473	CLIP-seq
MIRT2604576	hsa-miR-4477b	CLIP-seq
MIRT1275367	hsa-miR-450b-3p	CLIP-seq
MIRT2081084	hsa-miR-4639-3p	CLIP-seq
MIRT1275372	hsa-miR-4666-5p	CLIP-seq
MIRT2604577	hsa-miR-4668-5p	CLIP-seq
MIRT2081086	hsa-miR-4698	CLIP-seq
MIRT1275383	hsa-miR-4796-5p	CLIP-seq
MIRT2689086	hsa-miR-489	CLIP-seq
MIRT1275392	hsa-miR-512-3p	CLIP-seq
MIRT2081094	hsa-miR-512-5p	CLIP-seq
MIRT2604579	hsa-miR-514	CLIP-seq
MIRT2604580	hsa-miR-514b-3p	CLIP-seq
MIRT1275393	hsa-miR-520f	CLIP-seq
MIRT1275396	hsa-miR-549	CLIP-seq
MIRT2081100	hsa-miR-760	CLIP-seq
MIRT1275402	hsa-miR-769-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	IBA
GO:0004725	Function	Protein tyrosine phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	TAS	7519780
GO:0005515	Function	Protein binding	IPI	15143158, 32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005856	Component	Cytoskeleton	TAS	7519780
GO:0006470	Process	Protein dephosphorylation	TAS	7519780
GO:0016787	Function	Hydrolase activity	IEA

Other IDs

• MIM: 603271
• HGNC: 9651
• e!Ensembl: ENSG00000070778

Protein

• UniProt ID: Q16825
• Protein name: Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1)
• PDB: 8GVL, 8GVV, 8GWH, 8GXE, 8Y8Y
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09379	FERM_N	27 → 90	FERM N-terminal domain	Domain
  PF00373	FERM_M	107 → 222	FERM central domain	Domain
  PF09380	FERM_C	226 → 312	FERM C-terminal PH-like domain	Domain
  PF00102	Y_phosphatase	921 → 1166	Protein-tyrosine phosphatase	Domain

• Sequence:

  MPLPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELRE
  VTYFSLWYYNKQNQRRWVDLEKPLKKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQY
  YLQLKKDILEGSIPCTLEQAIQLAGLAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKV
  LEEATQKVALLHQKYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEG
  IFVKHKNGRHPVVFRWHDIANMSHNKSFFALELANKEETIQFQTEDMETAKYIWRLCVAR
  HKFYRLNQCNLQTQTVTVNPIRRRSSSRMSLPKPQPYVMPPPPQLHYNGHYTEPYASSQD
  NLFVPNQNGYYCHSQTSLDRAQIDLNGRIRNGSVYSAHSTNSLNNPQPYLQPSPMSSNPS
  ITGSDVMRPDYLPSHRHSAVIPPSYRPTPDYETVMKQLNRGLVHAERQSHSLRNLNIGSS
  YAYSRPAALVYSQPEIREHAQLPSPAAAHCPFSLSYSFHSPSPYPYPAERRPVVGAVSVP
  ELTNAQLQAQDYPSPNIMRTQVYRPPPPYPPPRPANSTPDLSRHLYISSSNPDLITRRVH
  HSVQTFQEDSLPVAHSLQEVSEPLTAARHAQLHKRNSIEVAGLSHGLEGLRLKERTLSAS
  AAEVAPRAVSVGSQPSVFTERTQREGPEEAEGLRYGHKKSLSDATMLIHSSEEEEDEDFE
  EESGARAPPARAREPRPGLAQDPPGCPRVLLAGPLHILEPKAHVPDAEKRMMDSSPVRTT
  AEAQRPWRDGLLMPSMSESDLTTSGRYRARRDSLKKRPVSDLLSGKKNIVEGLPPLGGMK
  KTRVDAKKIGPLKLAALNGLSLSRVPLPDEGKEVATRATNDERCKILEQRLEQGMVFTEY
  ERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKENNTGYINASHIKVSV
  SGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNT
  VTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSY
  LEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVL
  DMLRQQRMMLVQTLCQYTFVYRVLIQFLKSSRLI

• Sequence length: 1174

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Myoepithelial tumor	Uncertain significance	rs2542028335	RCV002463964
Prostate cancer	Uncertain significance	rs193920899	RCV000149190

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma	Associate	36829221
Alzheimer Disease	Associate	31585107
Colorectal Neoplasms	Associate	19000305
Coronary Artery Disease	Associate	36222281
Inflammation	Associate	29065968
Neoplasm Invasiveness	Associate	24887297
Neoplasms	Associate	19000305, 25062045
Urinary Bladder Neoplasms	Associate	20923765