Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
11080
Gene name Gene Name - the full gene name approved by the HGNC.
DnaJ heat shock protein family (Hsp40) member B4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DNAJB4
Synonyms (NCBI Gene) Gene synonyms aliases
CMYO21, CMYP21, DNAJW, DjB4, HLJ1
Disease Acronyms (UniProt) Disease acronyms from UniProt database
CMYO21
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p31.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds inco
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001471 hsa-miR-16-5p pSILAC 18668040
MIRT019300 hsa-miR-148b-3p Microarray 17612493
MIRT021629 hsa-miR-142-3p Microarray 17612493
MIRT024618 hsa-miR-215-5p Microarray 19074876
MIRT026002 hsa-miR-148a-3p Sequencing 20371350
Transcription factors
Transcription factor Regulation Reference
YY1 Activation 15782117;21345358
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001671 Function ATPase activator activity IDA 24318877
GO:0005515 Function Protein binding IPI 21255413, 32296183, 32814053
GO:0005654 Component Nucleoplasm IDA
GO:0005829 Component Cytosol IBA 21873635
GO:0005829 Component Cytosol IDA 21231916
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
611327 14886 ENSG00000162616
Protein
UniProt ID Q9UDY4
Protein name DnaJ homolog subfamily B member 4 (Heat shock 40 kDa protein 1 homolog) (HSP40 homolog) (Heat shock protein 40 homolog) (Human liver DnaJ-like protein)
Protein function Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00226 DnaJ 4 65 DnaJ domain Domain
PF01556 DnaJ_C 160 319 DnaJ C terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in heart, pancreas and skeletal muscle, and to a lesser extent in brain, placenta and liver. {ECO:0000269|PubMed:9546042}.
Sequence
Sequence length 337
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Lung adenocarcinoma Adenocarcinoma of lung (disorder) rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370
View all (5 more)
28604730
Lung carcinoma Carcinoma of lung rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355
View all (44 more)
28604730
Psoriasis Psoriasis rs281875215, rs587777763, rs281875213, rs281875212 28537254
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
31374203
Unknown
Disease term Disease name Evidence References Source
Respiratory Failure congenital myopathy 21 with early respiratory failure GenCC
Myopathy congenital myopathy GenCC
Insomnia Insomnia GWAS
Pulmonary Fibrosis Pulmonary Fibrosis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 22529897, 36147635
Breast Neoplasms Associate 28481734
Carcinogenesis Inhibit 22529897
Carcinoma Non Small Cell Lung Associate 20494979
Colorectal Neoplasms Associate 24450541
Colorectal Neoplasms Inhibit 24696714
Endometrial Neoplasms Associate 36965898
Head and Neck Neoplasms Associate 39468638
HIV Infections Associate 33405054
Kidney Neoplasms Associate 40694159