Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
11076
Gene name Gene Name - the full gene name approved by the HGNC.
Tubulin polymerization promoting protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TPPP
Synonyms (NCBI Gene) Gene synonyms aliases
TPPP/p25, TPPP1, p24, p25, p25alpha
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5p15.33
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT025429 hsa-miR-34a-5p Sequencing 20371350
MIRT029260 hsa-miR-26b-5p Microarray 19088304
MIRT520548 hsa-miR-204-5p HITS-CLIP 21572407
MIRT520547 hsa-miR-211-5p HITS-CLIP 21572407
MIRT510608 hsa-miR-410-3p HITS-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000287 Function Magnesium ion binding IDA 21316364
GO:0001578 Process Microtubule bundle formation IBA 21873635
GO:0001578 Process Microtubule bundle formation IDA 17105200, 26289831
GO:0001578 Process Microtubule bundle formation ISS
GO:0003924 Function GTPase activity IDA 21316364
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
608773 24164 ENSG00000171368
Protein
UniProt ID O94811
Protein name Tubulin polymerization-promoting protein (TPPP) (EC 3.6.5.-) (25 kDa brain-specific protein) (TPPP/p25) (p24) (p25-alpha)
Protein function Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (PubMed:31522887). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05517 p25-alpha 52 207 p25-alpha Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:10083737}.
Sequence
Sequence length 219
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Barrett esophagus Barrett Esophagus 27527254 ClinVar
Mental depression Depression in children 24655651 ClinVar
Brugada Syndrome Brugada Syndrome GWAS
Associations from Text Mining
Disease Name Relationship Type References
Antiphospholipid Syndrome Associate 8706335
Breast Neoplasms Associate 10799446, 9729531
Carcinoma Hepatocellular Associate 33854155
Chronic Kidney Disease Mineral and Bone Disorder Associate 36720675
Colitis Ulcerative Associate 27575496
Cystic Disease Of Lung Associate 33253230
Depressive Disorder Associate 24655651
Drug Related Side Effects and Adverse Reactions Associate 21182589
Fatigue Syndrome Chronic Associate 35318112
Fractures Spontaneous Associate 32157568