Gene Gene information from NCBI Gene database.
Entrez ID 11076
Gene name Tubulin polymerization promoting protein
Gene symbol TPPP
Synonyms (NCBI Gene)
TPPP/p25TPPP1p24p25p25alpha
Chromosome 5
Chromosome location 5p15.33
miRNA miRNA information provided by mirtarbase database.
488
miRTarBase ID miRNA Experiments Reference
MIRT025429 hsa-miR-34a-5p Sequencing 20371350
MIRT029260 hsa-miR-26b-5p Microarray 19088304
MIRT520548 hsa-miR-204-5p HITS-CLIP 21572407
MIRT520547 hsa-miR-211-5p HITS-CLIP 21572407
MIRT510608 hsa-miR-410-3p HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
53
GO ID Ontology Definition Evidence Reference
GO:0000287 Function Magnesium ion binding IDA 21316364
GO:0001578 Process Microtubule bundle formation IBA
GO:0001578 Process Microtubule bundle formation IDA 17105200, 26289831
GO:0001578 Process Microtubule bundle formation ISS
GO:0003924 Function GTPase activity IDA 21316364
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
608773 24164 ENSG00000171368
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O94811
Protein name Tubulin polymerization-promoting protein (TPPP) (EC 3.6.5.-) (25 kDa brain-specific protein) (TPPP/p25) (p24) (p25-alpha)
Protein function Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (PubMed:31522887). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05517 p25-alpha 52 207 p25-alpha Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:10083737}.
Sequence
Sequence length 219
Interactions View interactions