Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	11064
Gene name	Centriolin
Gene symbol	CNTRL
Synonyms (NCBI Gene)	CEP1CEP110FANbA165P4.1
Chromosome	9
Chromosome location	9q33.2
Summary	This gene encodes a centrosomal protein required for the centrosome to function as a microtubule organizing center. The gene product is also associated with centrosome maturation. One version of stem cell myeloproliferative disorder is the result of a rec

155

Show/Hide all (155)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029815	hsa-miR-26b-5p	Microarray	19088304
MIRT030875	hsa-miR-21-5p	Microarray	18591254
MIRT052504	hsa-let-7a-5p	CLASH	23622248
MIRT901911	hsa-let-7a	CLIP-seq
MIRT901912	hsa-let-7b	CLIP-seq
MIRT901913	hsa-let-7c	CLIP-seq
MIRT901914	hsa-let-7d	CLIP-seq
MIRT901915	hsa-let-7e	CLIP-seq
MIRT901916	hsa-let-7f	CLIP-seq
MIRT901917	hsa-let-7g	CLIP-seq
MIRT901918	hsa-let-7i	CLIP-seq
MIRT901919	hsa-miR-1294	CLIP-seq
MIRT901920	hsa-miR-139-5p	CLIP-seq
MIRT901921	hsa-miR-144	CLIP-seq
MIRT901922	hsa-miR-181a	CLIP-seq
MIRT901923	hsa-miR-181b	CLIP-seq
MIRT901924	hsa-miR-181c	CLIP-seq
MIRT901925	hsa-miR-181d	CLIP-seq
MIRT901926	hsa-miR-196a	CLIP-seq
MIRT901927	hsa-miR-196b	CLIP-seq
MIRT901928	hsa-miR-202	CLIP-seq
MIRT901929	hsa-miR-2053	CLIP-seq
MIRT901930	hsa-miR-3681	CLIP-seq
MIRT901931	hsa-miR-3689d	CLIP-seq
MIRT901932	hsa-miR-3941	CLIP-seq
MIRT901933	hsa-miR-3973	CLIP-seq
MIRT901934	hsa-miR-4262	CLIP-seq
MIRT901935	hsa-miR-4276	CLIP-seq
MIRT901936	hsa-miR-4438	CLIP-seq
MIRT901937	hsa-miR-4458	CLIP-seq
MIRT901938	hsa-miR-4500	CLIP-seq
MIRT901939	hsa-miR-4504	CLIP-seq
MIRT901940	hsa-miR-4645-3p	CLIP-seq
MIRT901941	hsa-miR-4653-3p	CLIP-seq
MIRT901942	hsa-miR-466	CLIP-seq
MIRT901943	hsa-miR-4672	CLIP-seq
MIRT901944	hsa-miR-4697-3p	CLIP-seq
MIRT901945	hsa-miR-4699-3p	CLIP-seq
MIRT901946	hsa-miR-4731-3p	CLIP-seq
MIRT901947	hsa-miR-4742-5p	CLIP-seq
MIRT901948	hsa-miR-4801	CLIP-seq
MIRT901949	hsa-miR-502-5p	CLIP-seq
MIRT901950	hsa-miR-5095	CLIP-seq
MIRT901951	hsa-miR-542-3p	CLIP-seq
MIRT901952	hsa-miR-548a-5p	CLIP-seq
MIRT901953	hsa-miR-548ab	CLIP-seq
MIRT901954	hsa-miR-548ak	CLIP-seq
MIRT901955	hsa-miR-548b-5p	CLIP-seq
MIRT901956	hsa-miR-548c-5p	CLIP-seq
MIRT901957	hsa-miR-548d-5p	CLIP-seq
MIRT901958	hsa-miR-548h	CLIP-seq
MIRT901959	hsa-miR-548i	CLIP-seq
MIRT901960	hsa-miR-548j	CLIP-seq
MIRT901961	hsa-miR-548w	CLIP-seq
MIRT901962	hsa-miR-548y	CLIP-seq
MIRT901963	hsa-miR-559	CLIP-seq
MIRT901964	hsa-miR-569	CLIP-seq
MIRT901965	hsa-miR-98	CLIP-seq
MIRT901911	hsa-let-7a	CLIP-seq
MIRT901912	hsa-let-7b	CLIP-seq
MIRT901913	hsa-let-7c	CLIP-seq
MIRT901914	hsa-let-7d	CLIP-seq
MIRT901915	hsa-let-7e	CLIP-seq
MIRT901916	hsa-let-7f	CLIP-seq
MIRT901917	hsa-let-7g	CLIP-seq
MIRT901918	hsa-let-7i	CLIP-seq
MIRT901919	hsa-miR-1294	CLIP-seq
MIRT901922	hsa-miR-181a	CLIP-seq
MIRT901923	hsa-miR-181b	CLIP-seq
MIRT901924	hsa-miR-181c	CLIP-seq
MIRT901925	hsa-miR-181d	CLIP-seq
MIRT901926	hsa-miR-196a	CLIP-seq
MIRT901927	hsa-miR-196b	CLIP-seq
MIRT901928	hsa-miR-202	CLIP-seq
MIRT901929	hsa-miR-2053	CLIP-seq
MIRT1967535	hsa-miR-217	CLIP-seq
MIRT901930	hsa-miR-3681	CLIP-seq
MIRT901931	hsa-miR-3689d	CLIP-seq
MIRT901934	hsa-miR-4262	CLIP-seq
MIRT1967536	hsa-miR-4264	CLIP-seq
MIRT901935	hsa-miR-4276	CLIP-seq
MIRT1967537	hsa-miR-4277	CLIP-seq
MIRT1967538	hsa-miR-4420	CLIP-seq
MIRT901937	hsa-miR-4458	CLIP-seq
MIRT901938	hsa-miR-4500	CLIP-seq
MIRT901944	hsa-miR-4697-3p	CLIP-seq
MIRT1967539	hsa-miR-4797-3p	CLIP-seq
MIRT901964	hsa-miR-569	CLIP-seq
MIRT901965	hsa-miR-98	CLIP-seq
MIRT901911	hsa-let-7a	CLIP-seq
MIRT901912	hsa-let-7b	CLIP-seq
MIRT901913	hsa-let-7c	CLIP-seq
MIRT901914	hsa-let-7d	CLIP-seq
MIRT901915	hsa-let-7e	CLIP-seq
MIRT901916	hsa-let-7f	CLIP-seq
MIRT901917	hsa-let-7g	CLIP-seq
MIRT901918	hsa-let-7i	CLIP-seq
MIRT2203274	hsa-miR-1256	CLIP-seq
MIRT901919	hsa-miR-1294	CLIP-seq
MIRT901920	hsa-miR-139-5p	CLIP-seq
MIRT901926	hsa-miR-196a	CLIP-seq
MIRT901927	hsa-miR-196b	CLIP-seq
MIRT901928	hsa-miR-202	CLIP-seq
MIRT2203275	hsa-miR-216a	CLIP-seq
MIRT1967535	hsa-miR-217	CLIP-seq
MIRT2203276	hsa-miR-3163	CLIP-seq
MIRT2203277	hsa-miR-340	CLIP-seq
MIRT901930	hsa-miR-3681	CLIP-seq
MIRT901931	hsa-miR-3689d	CLIP-seq
MIRT901932	hsa-miR-3941	CLIP-seq
MIRT2203278	hsa-miR-3942-3p	CLIP-seq
MIRT1967536	hsa-miR-4264	CLIP-seq
MIRT901935	hsa-miR-4276	CLIP-seq
MIRT1967537	hsa-miR-4277	CLIP-seq
MIRT1967538	hsa-miR-4420	CLIP-seq
MIRT901937	hsa-miR-4458	CLIP-seq
MIRT901938	hsa-miR-4500	CLIP-seq
MIRT2203279	hsa-miR-4642	CLIP-seq
MIRT901940	hsa-miR-4645-3p	CLIP-seq
MIRT901941	hsa-miR-4653-3p	CLIP-seq
MIRT901942	hsa-miR-466	CLIP-seq
MIRT901943	hsa-miR-4672	CLIP-seq
MIRT901944	hsa-miR-4697-3p	CLIP-seq
MIRT901945	hsa-miR-4699-3p	CLIP-seq
MIRT901946	hsa-miR-4731-3p	CLIP-seq
MIRT1967539	hsa-miR-4797-3p	CLIP-seq
MIRT901948	hsa-miR-4801	CLIP-seq
MIRT901949	hsa-miR-502-5p	CLIP-seq
MIRT2203280	hsa-miR-548ac	CLIP-seq
MIRT2203281	hsa-miR-548ae	CLIP-seq
MIRT2203282	hsa-miR-548aj	CLIP-seq
MIRT2203283	hsa-miR-548am	CLIP-seq
MIRT2203284	hsa-miR-548d-3p	CLIP-seq
MIRT2203285	hsa-miR-548x	CLIP-seq
MIRT2203286	hsa-miR-548z	CLIP-seq
MIRT901965	hsa-miR-98	CLIP-seq
MIRT901911	hsa-let-7a	CLIP-seq
MIRT901912	hsa-let-7b	CLIP-seq
MIRT901913	hsa-let-7c	CLIP-seq
MIRT901914	hsa-let-7d	CLIP-seq
MIRT901915	hsa-let-7e	CLIP-seq
MIRT901916	hsa-let-7f	CLIP-seq
MIRT901917	hsa-let-7g	CLIP-seq
MIRT901918	hsa-let-7i	CLIP-seq
MIRT901919	hsa-miR-1294	CLIP-seq
MIRT901926	hsa-miR-196a	CLIP-seq
MIRT901927	hsa-miR-196b	CLIP-seq
MIRT901928	hsa-miR-202	CLIP-seq
MIRT901930	hsa-miR-3681	CLIP-seq
MIRT901931	hsa-miR-3689d	CLIP-seq
MIRT901935	hsa-miR-4276	CLIP-seq
MIRT901937	hsa-miR-4458	CLIP-seq
MIRT901938	hsa-miR-4500	CLIP-seq
MIRT901944	hsa-miR-4697-3p	CLIP-seq
MIRT901965	hsa-miR-98	CLIP-seq

Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001822	Process	Kidney development	IEA
GO:0003279	Process	Cardiac septum development	IEA
GO:0003281	Process	Ventricular septum development	IEA
GO:0005515	Function	Protein binding	IPI	17140400
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005813	Component	Centrosome	IDA	15337773, 21399614
GO:0005813	Component	Centrosome	IEA
GO:0005815	Component	Microtubule organizing center	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0015630	Component	Microtubule cytoskeleton	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0034451	Component	Centriolar satellite	IDA
GO:0035904	Process	Aorta development	IEA
GO:0036064	Component	Ciliary basal body	IDA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0051301	Process	Cell division	IEA
GO:0060976	Process	Coronary vasculature development	IEA
GO:0072687	Component	Meiotic spindle	IEA
GO:0090543	Component	Flemming body	IEA
GO:0090619	Component	Meiotic spindle pole	IEA
GO:0097431	Component	Mitotic spindle pole	IEA
GO:0120103	Component	Centriolar subdistal appendage	IDA	23213374

MIM	HGNC	e!Ensembl
605496	1858	ENSG00000119397

Q7Z7A1

Protein name

Centriolin (Centrosomal protein 1) (Centrosomal protein of 110 kDa) (Cep110)

Protein function

Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission. {ECO:0000269|PubMed:12732615, ECO:0000269|PubMe

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF14580	LRR_9	116 → 280		Repeat

Tissue specificity

TISSUE SPECIFICITY: Widely expressed with highest levels in testis and trachea. {ECO:0000269|PubMed:10688839}.

Sequence

MKKGSQQKIFSKAKIPSSSHSPIPSSMSNMRSRSLSPLIGSETLPFHSGGQWCEQVEIAD
ENNMLLDYQDHKGADSHAGVRYITEALIKKLTKQDNLALIKSLNLSLSKDGGKKFKYIEN
LEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNE
IEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFT
IFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEI
KNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYK
IDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDE
QLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEA
IQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAI
DSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLT
EGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQER
DQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEAN
QLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQD
DNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSL
ADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNF
DKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKL
EDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQ
EAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKL
NETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSMADPFKRR
GYWYFMPPPPSSKVSSHSSQATKDSGVGLKYSASTPVRKPRPGQQDGKEGSQPPPASGYW
VYSPIRSGLHKLFPSRDADSGGDSQEESELDDQEEPPFVPPPGYMMYTVLPDGSPVPQGM
ALYAPPPPLPNNSRPLTPGTVVYGPPPAGAPMVYGPPPPNFSIPFIPMGVLHCNVPEHHN
LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEEL
HRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADR
LLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRS
LQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERN
EDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQA
KADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKE
EENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLEL
ENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWE
KKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQ
EKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQK
EEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEK
ELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGE
LLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSC
IQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTL
KSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKL
NFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQ
VDALGELVTSTSADSASSPSLSQLESSLTEDSQLGQNQEKNASAR

Sequence length

2325

Interactions

View interactions

	Reactome
			Signaling by cytosolic FGFR1 fusion mutants Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Signaling by FGFR1 in disease AURKA Activation by TPX2

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Uncertain significance; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
URTICARIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VITREOUS BODY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Arthritis Rheumatoid	Associate	21360494, 22674012, 25990747, 27145822	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Associate	26474971	★★★★★ ★☆☆☆☆ Found in Text Mining only
Depressive Disorder	Associate	36982982	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liposarcoma	Associate	36464833	★★★★★ ★☆☆☆☆ Found in Text Mining only

CNTRL (centriolin)