Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	11062
Gene name Gene Name - the full gene name approved by the HGNC.	Dihydrouridine synthase 4 like
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DUS4L
Synonyms (NCBI Gene) Gene synonyms aliases	DUS4, PP35
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7q22.3

Show/Hide all(31)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023098	hsa-miR-124-3p	Microarray	18668037
MIRT947323	hsa-miR-1260	CLIP-seq
MIRT947324	hsa-miR-1260b	CLIP-seq
MIRT947325	hsa-miR-1283	CLIP-seq
MIRT947326	hsa-miR-1293	CLIP-seq
MIRT947327	hsa-miR-188-3p	CLIP-seq
MIRT947328	hsa-miR-216b	CLIP-seq
MIRT947329	hsa-miR-2278	CLIP-seq
MIRT947330	hsa-miR-3135	CLIP-seq
MIRT947331	hsa-miR-3145-5p	CLIP-seq
MIRT947332	hsa-miR-3152-5p	CLIP-seq
MIRT947333	hsa-miR-3156-3p	CLIP-seq
MIRT947334	hsa-miR-3618	CLIP-seq
MIRT947335	hsa-miR-3921	CLIP-seq
MIRT947336	hsa-miR-4301	CLIP-seq
MIRT947337	hsa-miR-4483	CLIP-seq
MIRT947338	hsa-miR-4649-3p	CLIP-seq
MIRT947339	hsa-miR-4653-5p	CLIP-seq
MIRT947340	hsa-miR-4773	CLIP-seq
MIRT947341	hsa-miR-4774-3p	CLIP-seq
MIRT947342	hsa-miR-508-5p	CLIP-seq
MIRT947343	hsa-miR-660	CLIP-seq
MIRT947344	hsa-miR-934	CLIP-seq
MIRT1980624	hsa-miR-1915	CLIP-seq
MIRT1980625	hsa-miR-193a-5p	CLIP-seq
MIRT947331	hsa-miR-3145-5p	CLIP-seq
MIRT1980626	hsa-miR-4314	CLIP-seq
MIRT1980627	hsa-miR-4726-3p	CLIP-seq
MIRT947342	hsa-miR-508-5p	CLIP-seq
MIRT1980628	hsa-miR-579	CLIP-seq
MIRT947344	hsa-miR-934	CLIP-seq

Show/Hide all(3)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002943	Process	TRNA dihydrouridine synthesis	IEA
GO:0017150	Function	TRNA dihydrouridine synthase activity	IBA	21873635
GO:0050660	Function	Flavin adenine dinucleotide binding	IEA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Protein

UniProt ID

O95620

Protein name

tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like (EC 1.3.1.90) (pp35) (tRNA-dihydrouridine synthase 4-like)

Protein function

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01207	Dus	30 → 310	Dihydrouridine synthase (Dus)	Family

Sequence

MKSDCMQTTICQERKKDPIEMFHSGQLVKVCAPMVRYSKLAFRTLVRKYSCDLCYTPMIV
AADFVKSIKARDSEFTTNQGDCPLIVQFAANDARLLSDAARIVCPYANGIDINCGCPQRW
AMAEGYGACLINKPELVQDMVKQVRNQVETPGFSVSIKIRIHDDLKRTVDLCQKAEATGV
SWITVHGRTAEERHQPVHYDSIKIIKENMSIPVIANGDIRSLKEAENVWRITGTDGVMVA
RGLLANPAMFAGYEETPLKCIWDWVDIALELGTPYMCFHQHLMYMMEKITSRQEKRVFNA
LSSTSAIIDYLTDHYGI

Sequence length

317

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Arthritis	Degenerative polyarthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470	21068099

Show/Hide Unknown Diseases (3)

Disease term	Disease name	Source
Unknown
Coronary Heart Disease	Coronary Heart Disease	GWAS
Coronary artery disease	Coronary artery disease	GWAS
Insomnia	Insomnia	GWAS

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References
Associations from Text Mining
Osteoarthritis	Associate	24825461
Osteoarthritis Knee	Associate	36089590
Stomach Neoplasms	Associate	28415823

DUS4L (dihydrouridine synthase 4 like)