Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
11052
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Cleavage and polyadenylation specific factor 6 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
CPSF6 |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
CFIM, CFIM68, CFIM72, HPBRII-4, HPBRII-7 |
Chromosome
Chromosome number
|
12 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
12q15 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
The protein encoded by this gene is one subunit of a cleavage factor required for 3` RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3` end processing complex and |
UniProt ID |
Q16630
|
Protein name |
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPB |
Protein function |
Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:14690600, PubMed:29276085, Pub |
PDB |
3P5T
,
3P6Y
,
3Q2S
,
3Q2T
,
4B4N
,
4U0A
,
4U0B
,
4WYM
,
6AY9
,
6GX9
,
7SNQ
,
7ZUD
,
8CL1
,
8EJL
,
8GDV
,
9CNV
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00076
|
RRM_1 |
83 → 154 |
RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
Domain |
|
Sequence |
MADGVDHIDIYADVGEEFNQEAEYGGHDQIDLYDDVISPSANNGDAPEDRDYMDTLPPTV GDDVGKGAAPNVVYTYTGKRIALYIGNLTWWTTDEDLTEAVHSLGVNDILEIKFFENRAN GQSKGFALVGVGSEASSKKLMDLLPKRELHGQNPVVTPCNKQFLSQFEMQSRKTTQSGQM SGEGKAGPPGGSSRAAFPQGGRGRGRFPGAVPGGDRFPGPAGPGGPPPPFPAGQTPPRPP LGPPGPPGPPGPPPPGQVLPPPLAGPPNRGDRPPPPVLFPGQPFGQPPLGPLPPGPPPPV PGYGPPPGPPPPQQGPPPPPGPFPPRPPGPLGPPLTLAPPPHLPGPPPGAPPPAPHVNPA FFPPPTNSGMPTSDSRGPPPTDPYGRPPPYDRGDYGPPGREMDTARTPLSEAEFEEIMNR NRAISSSAISRAVSDASAGDYGSAIETLVTAISLIKQSKVSADDRCKVLISSLQDCLHGI ESKSYGSGSRRERSRERDHSRSREKSRRHKSRSRDRHDDYYRERSRERERHRDRDRDRDR ERDREREYRHR
|
|
Sequence length |
551 |
Interactions |
View interactions
|