Gene Gene information from NCBI Gene database.
Entrez ID 11051
Gene name Nudix hydrolase 21
Gene symbol NUDT21
Synonyms (NCBI Gene)
CFIM25CPSF5
Chromosome 16
Chromosome location 16q13
Summary The protein encoded by this gene is one subunit of a cleavage factor required for 3` RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3` end processing complex and
miRNA miRNA information provided by mirtarbase database.
778
miRTarBase ID miRNA Experiments Reference
MIRT020022 hsa-miR-375 Microarray 20215506
MIRT051764 hsa-let-7c-5p CLASH 23622248
MIRT050609 hsa-miR-20a-5p CLASH 23622248
MIRT044405 hsa-miR-320a CLASH 23622248
MIRT036074 hsa-miR-1296-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
43
GO ID Ontology Definition Evidence Reference
GO:0003682 Function Chromatin binding IEA
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003723 Function RNA binding IDA 8626397
GO:0003723 Function RNA binding IEA
GO:0003729 Function MRNA binding IDA 21295486
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604978 13870 ENSG00000167005
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O43809
Protein name Cleavage and polyadenylation specificity factor subunit 5 (Cleavage and polyadenylation specificity factor 25 kDa subunit) (CPSF 25 kDa subunit) (Cleavage factor Im complex 25 kDa subunit) (CFIm25) (Nucleoside diphosphate-linked moiety X motif 21) (Nudix
Protein function Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:14690600, PubMed:15937220, Pub
PDB 2CL3 , 2J8Q , 3BAP , 3BHO , 3MDG , 3MDI , 3N9U , 3P5T , 3P6Y , 3Q2S , 3Q2T , 5R4P , 5R4Q , 5R4R , 5R4S , 5R4T , 5R4U , 5R64 , 5R65 , 5R66 , 5R67
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13869 NUDIX_2 35 222 Nucleotide hydrolase Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:17098938}.
Sequence
Sequence length 227
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  mRNA surveillance pathway   mRNA Splicing - Major Pathway
mRNA 3'-end processing
RNA Polymerase II Transcription Termination
Processing of Intronless Pre-mRNAs