Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
11051
Gene name Gene Name - the full gene name approved by the HGNC.
Nudix hydrolase 21
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NUDT21
Synonyms (NCBI Gene) Gene synonyms aliases
CFIM25, CPSF5
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16q13
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is one subunit of a cleavage factor required for 3` RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3` end processing complex and
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT020022 hsa-miR-375 Microarray 20215506
MIRT051764 hsa-let-7c-5p CLASH 23622248
MIRT050609 hsa-miR-20a-5p CLASH 23622248
MIRT044405 hsa-miR-320a CLASH 23622248
MIRT036074 hsa-miR-1296-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003682 Function Chromatin binding IEA
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003723 Function RNA binding IDA 8626397
GO:0003723 Function RNA binding IEA
GO:0003729 Function MRNA binding IDA 21295486
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604978 13870 ENSG00000167005
Protein
UniProt ID O43809
Protein name Cleavage and polyadenylation specificity factor subunit 5 (Cleavage and polyadenylation specificity factor 25 kDa subunit) (CPSF 25 kDa subunit) (Cleavage factor Im complex 25 kDa subunit) (CFIm25) (Nucleoside diphosphate-linked moiety X motif 21) (Nudix
Protein function Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:14690600, PubMed:15937220, Pub
PDB 2CL3 , 2J8Q , 3BAP , 3BHO , 3MDG , 3MDI , 3N9U , 3P5T , 3P6Y , 3Q2S , 3Q2T , 5R4P , 5R4Q , 5R4R , 5R4S , 5R4T , 5R4U , 5R64 , 5R65 , 5R66 , 5R67
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13869 NUDIX_2 35 222 Nucleotide hydrolase Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:17098938}.
Sequence
Sequence length 227
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  mRNA surveillance pathway   mRNA Splicing - Major Pathway
mRNA 3'-end processing
RNA Polymerase II Transcription Termination
Processing of Intronless Pre-mRNAs
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Diabetes Type 2 diabetes N/A N/A GWAS
Metabolic Syndrome Metabolic syndrome N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Inhibit 32665581
Breast Neoplasms Associate 32844230
Carcinogenesis Associate 30053266, 37737260
Carcinoma Renal Cell Associate 37737260
Colorectal Neoplasms Associate 30881993
Disease Associate 26312503
Glioblastoma Associate 30053266
Glioblastoma Inhibit 30705404
Glioma Inhibit 30705404
Intellectual Disability Associate 26312503