Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	11046
Gene name	Solute carrier family 35 member D2
Gene symbol	SLC35D2
Synonyms (NCBI Gene)	HFRC1SQV7LUGTrel8hfrc
Chromosome	9
Chromosome location	9q22.32
Summary	Nucleotide sugars, which are synthesized in the cytosol or the nucleus, are high-energy donor substrates for glycosyltransferases located in the lumen of the endoplasmic reticulum and Golgi apparatus. Translocation of nucleotide sugars from the cytosol in

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016425	hsa-miR-193b-3p	Microarray	20304954
MIRT027692	hsa-miR-98-5p	Microarray	19088304
MIRT029531	hsa-miR-26b-5p	Microarray	19088304
MIRT696349	hsa-miR-34b-3p	HITS-CLIP	23313552
MIRT696348	hsa-miR-3123	HITS-CLIP	23313552
MIRT696347	hsa-miR-451b	HITS-CLIP	23313552
MIRT696346	hsa-miR-3929	HITS-CLIP	23313552
MIRT696345	hsa-miR-4419b	HITS-CLIP	23313552
MIRT696344	hsa-miR-4478	HITS-CLIP	23313552
MIRT696343	hsa-miR-3614-5p	HITS-CLIP	23313552
MIRT696342	hsa-miR-6500-3p	HITS-CLIP	23313552
MIRT696341	hsa-miR-5690	HITS-CLIP	23313552
MIRT696340	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT696339	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT696338	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT696337	hsa-miR-7977	HITS-CLIP	23313552
MIRT696336	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT696335	hsa-miR-6828-5p	HITS-CLIP	23313552
MIRT696349	hsa-miR-34b-3p	HITS-CLIP	23313552
MIRT696348	hsa-miR-3123	HITS-CLIP	23313552
MIRT696347	hsa-miR-451b	HITS-CLIP	23313552
MIRT696346	hsa-miR-3929	HITS-CLIP	23313552
MIRT696345	hsa-miR-4419b	HITS-CLIP	23313552
MIRT696344	hsa-miR-4478	HITS-CLIP	23313552
MIRT696343	hsa-miR-3614-5p	HITS-CLIP	23313552
MIRT696342	hsa-miR-6500-3p	HITS-CLIP	23313552
MIRT696341	hsa-miR-5690	HITS-CLIP	23313552
MIRT696340	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT696339	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT696338	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT696337	hsa-miR-7977	HITS-CLIP	23313552
MIRT696336	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT696335	hsa-miR-6828-5p	HITS-CLIP	23313552
MIRT1360781	hsa-let-7a	CLIP-seq
MIRT1360782	hsa-let-7b	CLIP-seq
MIRT1360783	hsa-let-7c	CLIP-seq
MIRT1360784	hsa-let-7d	CLIP-seq
MIRT1360785	hsa-let-7e	CLIP-seq
MIRT1360786	hsa-let-7f	CLIP-seq
MIRT1360787	hsa-let-7g	CLIP-seq
MIRT1360788	hsa-let-7i	CLIP-seq
MIRT1360789	hsa-miR-18a	CLIP-seq
MIRT1360790	hsa-miR-18b	CLIP-seq
MIRT1360791	hsa-miR-193a-3p	CLIP-seq
MIRT1360792	hsa-miR-193b	CLIP-seq
MIRT1360793	hsa-miR-196a	CLIP-seq
MIRT1360794	hsa-miR-196b	CLIP-seq
MIRT1360795	hsa-miR-202	CLIP-seq
MIRT1360796	hsa-miR-2117	CLIP-seq
MIRT1360797	hsa-miR-2355-5p	CLIP-seq
MIRT1360798	hsa-miR-24	CLIP-seq
MIRT1360799	hsa-miR-3129-3p	CLIP-seq
MIRT1360800	hsa-miR-3168	CLIP-seq
MIRT1360801	hsa-miR-330-3p	CLIP-seq
MIRT1360802	hsa-miR-33a	CLIP-seq
MIRT1360803	hsa-miR-33b	CLIP-seq
MIRT1360804	hsa-miR-34a	CLIP-seq
MIRT1360805	hsa-miR-34c-5p	CLIP-seq
MIRT1360806	hsa-miR-383	CLIP-seq
MIRT1360807	hsa-miR-4284	CLIP-seq
MIRT1360808	hsa-miR-4458	CLIP-seq
MIRT1360809	hsa-miR-448	CLIP-seq
MIRT1360810	hsa-miR-449a	CLIP-seq
MIRT1360811	hsa-miR-449b	CLIP-seq
MIRT1360812	hsa-miR-4500	CLIP-seq
MIRT1360813	hsa-miR-4714-3p	CLIP-seq
MIRT1360814	hsa-miR-4735-3p	CLIP-seq
MIRT1360815	hsa-miR-4735-5p	CLIP-seq
MIRT1360816	hsa-miR-4753-3p	CLIP-seq
MIRT1360817	hsa-miR-4761-5p	CLIP-seq
MIRT1360818	hsa-miR-4769-3p	CLIP-seq
MIRT1360819	hsa-miR-4772-5p	CLIP-seq
MIRT1360820	hsa-miR-4775	CLIP-seq
MIRT1360821	hsa-miR-4793-5p	CLIP-seq
MIRT1360822	hsa-miR-495	CLIP-seq
MIRT1360823	hsa-miR-499-3p	CLIP-seq
MIRT1360824	hsa-miR-499a-3p	CLIP-seq
MIRT1360825	hsa-miR-590-3p	CLIP-seq
MIRT1360826	hsa-miR-885-5p	CLIP-seq
MIRT1360827	hsa-miR-892b	CLIP-seq
MIRT1360828	hsa-miR-98	CLIP-seq
MIRT1360791	hsa-miR-193a-3p	CLIP-seq
MIRT1360792	hsa-miR-193b	CLIP-seq
MIRT2106826	hsa-miR-3189-3p	CLIP-seq
MIRT2106827	hsa-miR-3649	CLIP-seq
MIRT2106828	hsa-miR-3652	CLIP-seq
MIRT2106829	hsa-miR-4430	CLIP-seq
MIRT2106830	hsa-miR-4505	CLIP-seq
MIRT2106831	hsa-miR-494	CLIP-seq
MIRT2106832	hsa-miR-548g	CLIP-seq
MIRT2106833	hsa-miR-647	CLIP-seq
MIRT2330993	hsa-miR-1207-3p	CLIP-seq
MIRT1360789	hsa-miR-18a	CLIP-seq
MIRT1360790	hsa-miR-18b	CLIP-seq
MIRT1360796	hsa-miR-2117	CLIP-seq
MIRT2330994	hsa-miR-2278	CLIP-seq
MIRT2330995	hsa-miR-3160-5p	CLIP-seq
MIRT2106826	hsa-miR-3189-3p	CLIP-seq
MIRT1360802	hsa-miR-33a	CLIP-seq
MIRT1360803	hsa-miR-33b	CLIP-seq
MIRT2106827	hsa-miR-3649	CLIP-seq
MIRT2106828	hsa-miR-3652	CLIP-seq
MIRT2330996	hsa-miR-3678-3p	CLIP-seq
MIRT2330997	hsa-miR-3692	CLIP-seq
MIRT2330998	hsa-miR-4283	CLIP-seq
MIRT2106829	hsa-miR-4430	CLIP-seq
MIRT2330999	hsa-miR-4489	CLIP-seq
MIRT2106830	hsa-miR-4505	CLIP-seq
MIRT2331000	hsa-miR-450b-5p	CLIP-seq
MIRT2331001	hsa-miR-4523	CLIP-seq
MIRT2331002	hsa-miR-4731-5p	CLIP-seq
MIRT1360814	hsa-miR-4735-3p	CLIP-seq
MIRT1360816	hsa-miR-4753-3p	CLIP-seq
MIRT2331003	hsa-miR-507	CLIP-seq
MIRT2331004	hsa-miR-557	CLIP-seq
MIRT2331005	hsa-miR-646	CLIP-seq
MIRT2106833	hsa-miR-647	CLIP-seq
MIRT1360798	hsa-miR-24	CLIP-seq
MIRT1360807	hsa-miR-4284	CLIP-seq
MIRT1360809	hsa-miR-448	CLIP-seq
MIRT1360818	hsa-miR-4769-3p	CLIP-seq
MIRT1360821	hsa-miR-4793-5p	CLIP-seq
MIRT1360781	hsa-let-7a	CLIP-seq
MIRT1360782	hsa-let-7b	CLIP-seq
MIRT1360783	hsa-let-7c	CLIP-seq
MIRT1360784	hsa-let-7d	CLIP-seq
MIRT1360785	hsa-let-7e	CLIP-seq
MIRT1360786	hsa-let-7f	CLIP-seq
MIRT1360787	hsa-let-7g	CLIP-seq
MIRT1360788	hsa-let-7i	CLIP-seq
MIRT2330993	hsa-miR-1207-3p	CLIP-seq
MIRT1360793	hsa-miR-196a	CLIP-seq
MIRT1360794	hsa-miR-196b	CLIP-seq
MIRT1360795	hsa-miR-202	CLIP-seq
MIRT1360796	hsa-miR-2117	CLIP-seq
MIRT2330994	hsa-miR-2278	CLIP-seq
MIRT1360798	hsa-miR-24	CLIP-seq
MIRT1360800	hsa-miR-3168	CLIP-seq
MIRT2440527	hsa-miR-3189-5p	CLIP-seq
MIRT1360802	hsa-miR-33a	CLIP-seq
MIRT1360803	hsa-miR-33b	CLIP-seq
MIRT2330996	hsa-miR-3678-3p	CLIP-seq
MIRT2330998	hsa-miR-4283	CLIP-seq
MIRT1360807	hsa-miR-4284	CLIP-seq
MIRT1360808	hsa-miR-4458	CLIP-seq
MIRT1360809	hsa-miR-448	CLIP-seq
MIRT2330999	hsa-miR-4489	CLIP-seq
MIRT2440528	hsa-miR-4493	CLIP-seq
MIRT1360812	hsa-miR-4500	CLIP-seq
MIRT2331000	hsa-miR-450b-5p	CLIP-seq
MIRT2331001	hsa-miR-4523	CLIP-seq
MIRT2331002	hsa-miR-4731-5p	CLIP-seq
MIRT1360816	hsa-miR-4753-3p	CLIP-seq
MIRT1360821	hsa-miR-4793-5p	CLIP-seq
MIRT2331003	hsa-miR-507	CLIP-seq
MIRT2331004	hsa-miR-557	CLIP-seq
MIRT2331005	hsa-miR-646	CLIP-seq
MIRT1360828	hsa-miR-98	CLIP-seq

Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IDA	15082721
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0005338	Function	Nucleotide-sugar transmembrane transporter activity	EXP	15082721, 15607426
GO:0005338	Function	Nucleotide-sugar transmembrane transporter activity	NAS	9927678
GO:0005338	Function	Nucleotide-sugar transmembrane transporter activity	TAS
GO:0005461	Function	UDP-glucuronate transmembrane transporter activity	IBA
GO:0005462	Function	UDP-N-acetylglucosamine transmembrane transporter activity	IBA
GO:0005463	Function	UDP-N-acetylgalactosamine transmembrane transporter activity	IBA
GO:0005794	Component	Golgi apparatus	IBA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005794	Component	Golgi apparatus	IEA
GO:0015012	Process	Heparan sulfate proteoglycan biosynthetic process	IMP	15082721
GO:0015012	Process	Heparan sulfate proteoglycan biosynthetic process	TAS
GO:0015297	Function	Antiporter activity	IBA
GO:0015297	Function	Antiporter activity	IEA
GO:0015780	Process	Nucleotide-sugar transmembrane transport	IBA
GO:0015787	Process	UDP-glucuronate transmembrane transport	IEA
GO:0015789	Process	UDP-N-acetylgalactosamine transmembrane transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0018146	Process	Keratan sulfate proteoglycan biosynthetic process	TAS
GO:1990569	Process	UDP-N-acetylglucosamine transmembrane transport	IEA

MIM	HGNC	e!Ensembl
609182	20799	ENSG00000130958

Q76EJ3

Protein name

Nucleotide sugar transporter SLC35D2 (Homolog of Fringe connection protein 1) (HFRC1) (SQV7-like protein) (SQV7L) (Solute carrier family 35 member D2) (UDP-galactose transporter-related protein 8) (UGTrel8)

Protein function

Nucleotide sugar antiporter transporting UDP-N-acetylglucosamine (UDP-GlcNAc) and UDP-glucose (UDP-Glc) from the cytosol into the lumen of the Golgi in exchange of UMP. By supplying UDP-N-acetylglucosamine, a donor substrate to heparan sulfate s

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03151	TPT	24 → 313	Triose-phosphate Transporter family	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in heart, kidney, small intestine, placenta, lung and peripheral blood leukocyte. Weakly expressed in skeletal muscle and spleen. Not expressed in brain, colon and thymus. {ECO:0000269|PubMed:15607426}.

Sequence

MTAGGQAEAEGAGGEPGAARLPSRVARLLSALFYGTCSFLIVLVNKALLTTYGFPSPIFL
GIGQMAATIMILYVSKLNKIIHFPDFDKKIPVKLFPLPLLYVGNHISGLSSTSKLSLPMF
TVLRKFTIPLTLLLETIILGKQYSLNIILSVFAIILGAFIAAGSDLAFNLEGYIFVFLND
IFTAANGVYTKQKMDPKELGKYGVLFYNACFMIIPTLIISVSTGDLQQATEFNQWKNVVF
ILQFLLSCFLGFLLMYSTVLCSYYNSALTTAVVGAIKNVSVAYIGILIGGDYIFSLLNFV
GLNICMAGGLRYSFLTLSSQLKPKPVGEENICLDLKS

Sequence length

337

Interactions

View interactions

	Reactome
			Keratan sulfate biosynthesis HS-GAG biosynthesis Transport of nucleotide sugars

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATRIAL FIBRILLATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE WITH AURA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-SMALL CELL LUNG CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

SLC35D2 (solute carrier family 35 member D2)