MID2 (midline 2)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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11043 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Midline 2 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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MID2 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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FXY2, MRX101, RNF60, TRIM1, XLID101 |
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Chromosome
Chromosome number
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X |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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Xq22.3 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures i |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | ||||||||||||||||||||||||||
| UniProt ID | Q9UJV3 | |||||||||||||||||||||||||
| Protein name | Probable E3 ubiquitin-protein ligase MID2 (EC 2.3.2.27) (Midin-2) (Midline defect 2) (Midline-2) (RING finger protein 60) (RING-type E3 ubiquitin transferase MID2) (Tripartite motif-containing protein 1) | |||||||||||||||||||||||||
| Protein function | E3 ubiquitin ligase that plays a role in microtubule stabilization. Mediates the 'Lys-48'-linked polyubiquitination of LRRK2 to drive its localization to microtubules and its proteasomal degradation in neurons. This ubiquitination inhibits LRRK2 | |||||||||||||||||||||||||
| PDB | 2DJA , 2DMK , 7QRZ | |||||||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Low level in fetal kidney and lung, and in adult prostate, ovary and small intestine. | |||||||||||||||||||||||||
| Sequence |
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| Sequence length | 735 | |||||||||||||||||||||||||
| Interactions | View interactions | |||||||||||||||||||||||||
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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