Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
11043
Gene name Gene Name - the full gene name approved by the HGNC.
Midline 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MID2
Synonyms (NCBI Gene) Gene synonyms aliases
FXY2, MRX101, RNF60, TRIM1, XLID101
Chromosome Chromosome number
X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
Xq22.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures i
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT021934 hsa-miR-128-3p Microarray 17612493
MIRT043130 hsa-miR-324-5p CLASH 23622248
MIRT1148576 hsa-miR-147 CLIP-seq
MIRT1148577 hsa-miR-155 CLIP-seq
MIRT1148578 hsa-miR-300 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003713 Function Transcription coactivator activity IDA 23077300
GO:0005515 Function Protein binding IPI 25416956, 25910212, 26871637, 28514442, 30886144, 32296183
GO:0005737 Component Cytoplasm IEA
GO:0005856 Component Cytoskeleton IEA
GO:0005874 Component Microtubule IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
300204 7096 ENSG00000080561
Protein
UniProt ID Q9UJV3
Protein name Probable E3 ubiquitin-protein ligase MID2 (EC 2.3.2.27) (Midin-2) (Midline defect 2) (Midline-2) (RING finger protein 60) (RING-type E3 ubiquitin transferase MID2) (Tripartite motif-containing protein 1)
Protein function E3 ubiquitin ligase that plays a role in microtubule stabilization. Mediates the 'Lys-48'-linked polyubiquitination of LRRK2 to drive its localization to microtubules and its proteasomal degradation in neurons. This ubiquitination inhibits LRRK2
PDB 2DJA , 2DMK , 7QRZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13445 zf-RING_UBOX 30 77 RING-type zinc-finger Domain
PF00643 zf-B_box 191 232 B-box zinc finger Domain
PF18568 COS 343 394 TRIM C-terminal subgroup One Signature domain Domain
PF00622 SPRY 590 705 SPRY domain Family
Tissue specificity TISSUE SPECIFICITY: Low level in fetal kidney and lung, and in adult prostate, ovary and small intestine.
Sequence
MGESPASVVLNASGGLFSLKMETLESELTCPICLELFEDPLLLPCAHSLCFSCAHRILVS
SCSSGESIEPITAFQCP
TCRYVISLNHRGLDGLKRNVTLQNIIDRFQKASVSGPNSPSES
RRERTYRPTTAMSSERIACQFCEQDPPRDAVKTCITCEVSYCDRCLRATHPNKKPFTSHR
LVEPVPDTHLRGITCLDHENEKVNMYCVSDDQLICALCKLVGRHRDHQVASLNDRFEKLK
QTLEMNLTNLVKRNSELENQMAKLIQICQQVEVNTAMHEAKLMEECDELVEIIQQRKQMI
AVKIKETKVMKLRKLAQQVANCRQCLERSTVLINQAEHILKENDQARFLQSAKNIAERVA
MATASSQVLIPDINFNDAFENFALDFSREKKLLE
GLDYLTAPNPPSIREELCTASHDTIT
VHWISDDEFSISSYELQYTIFTGQANFISKSWCSWGLWPEIRKCKEAVSCSRLAGAPRGL
YNSVDSWMIVPNIKQNHYTVHGLQSGTRYIFIVKAINQAGSRNSEPTRLKTNSQPFKLDP
KMTHKKLKISNDGLQMEKDESSLKKSHTPERFSGTGCYGAAGNIFIDSGCHYWEVVMGSS
TWYAIGIAYKSAPKNEWIGKNASSWVFSRCNSNFVVRHNNKEMLVDVPPHLKRLGVLLDY
DNNMLSFYDPANSLHLHTFDVTFILPVCPTFTIWNKSLMILSGLP
APDFIDYPERQECNC
RPQESPYVSGMKTCH
Sequence length 735
Interactions View interactions
<
Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Disease merge term Disease name dbSNP ID References
Mental Retardation, X-Linked Intellectual disability, X-linked 101 rs587777605 N/A
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Asthma Associate 29794786
Carcinogenesis Associate 39245738
Chromosome Duplication Associate 31951325
COVID 19 Associate 34824360
Developmental Disabilities Associate 11806752
Drug Related Side Effects and Adverse Reactions Associate 35266954
Intellectual Disability Associate 26748699
Mental Retardation X Linked 2 Associate 26748699
Mouth Neoplasms Associate 39245738
Neoplasms Associate 23791107