Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	11040
Gene name Gene Name - the full gene name approved by the HGNC.	Pim-2 proto-oncogene, serine/threonine kinase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PIM2
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	Xp11.23
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival.[provided by RefSeq, Nov 2009]

Show/Hide all(145)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030307	hsa-miR-26b-5p	Microarray	19088304
MIRT030617	hsa-miR-24-3p	Sequencing	20371350
MIRT036440	hsa-miR-1226-3p	CLASH	23622248
MIRT471073	hsa-miR-5197-3p	PAR-CLIP	23592263
MIRT471072	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT471071	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT471070	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT471069	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT471068	hsa-miR-940	PAR-CLIP	23592263
MIRT471067	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT471065	hsa-miR-4514	PAR-CLIP	23592263
MIRT471066	hsa-miR-4692	PAR-CLIP	23592263
MIRT471064	hsa-miR-4645-5p	PAR-CLIP	23592263
MIRT471063	hsa-miR-4673	PAR-CLIP	23592263
MIRT471062	hsa-miR-1253	PAR-CLIP	23592263
MIRT471061	hsa-miR-3616-3p	PAR-CLIP	23592263
MIRT471060	hsa-miR-8064	PAR-CLIP	23592263
MIRT471059	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT471058	hsa-miR-4434	PAR-CLIP	23592263
MIRT471056	hsa-miR-4516	PAR-CLIP	23592263
MIRT471057	hsa-miR-5703	PAR-CLIP	23592263
MIRT471073	hsa-miR-5197-3p	PAR-CLIP	23592263
MIRT471072	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT471071	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT471070	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT471069	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT471068	hsa-miR-940	PAR-CLIP	23592263
MIRT471067	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT471065	hsa-miR-4514	PAR-CLIP	23592263
MIRT471066	hsa-miR-4692	PAR-CLIP	23592263
MIRT471064	hsa-miR-4645-5p	PAR-CLIP	23592263
MIRT471063	hsa-miR-4673	PAR-CLIP	23592263
MIRT471062	hsa-miR-1253	PAR-CLIP	23592263
MIRT471061	hsa-miR-3616-3p	PAR-CLIP	23592263
MIRT471060	hsa-miR-8064	PAR-CLIP	23592263
MIRT471059	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT471058	hsa-miR-4434	PAR-CLIP	23592263
MIRT471056	hsa-miR-4516	PAR-CLIP	23592263
MIRT471057	hsa-miR-5703	PAR-CLIP	23592263
MIRT1235168	hsa-miR-1182	CLIP-seq
MIRT1235169	hsa-miR-1226	CLIP-seq
MIRT1235170	hsa-miR-1243	CLIP-seq
MIRT1235171	hsa-miR-1292	CLIP-seq
MIRT1235172	hsa-miR-188-5p	CLIP-seq
MIRT1235173	hsa-miR-197	CLIP-seq
MIRT1235174	hsa-miR-200b	CLIP-seq
MIRT1235175	hsa-miR-200c	CLIP-seq
MIRT1235176	hsa-miR-2276	CLIP-seq
MIRT1235177	hsa-miR-24	CLIP-seq
MIRT1235178	hsa-miR-3614-5p	CLIP-seq
MIRT1235179	hsa-miR-3654	CLIP-seq
MIRT1235180	hsa-miR-3664-3p	CLIP-seq
MIRT1235181	hsa-miR-378	CLIP-seq
MIRT1235182	hsa-miR-378b	CLIP-seq
MIRT1235183	hsa-miR-378c	CLIP-seq
MIRT1235184	hsa-miR-378d	CLIP-seq
MIRT1235185	hsa-miR-378e	CLIP-seq
MIRT1235186	hsa-miR-378f	CLIP-seq
MIRT1235187	hsa-miR-378h	CLIP-seq
MIRT1235188	hsa-miR-378i	CLIP-seq
MIRT1235189	hsa-miR-412	CLIP-seq
MIRT1235190	hsa-miR-422a	CLIP-seq
MIRT1235191	hsa-miR-4283	CLIP-seq
MIRT1235192	hsa-miR-429	CLIP-seq
MIRT1235193	hsa-miR-4433	CLIP-seq
MIRT1235194	hsa-miR-4437	CLIP-seq
MIRT1235195	hsa-miR-4449	CLIP-seq
MIRT1235196	hsa-miR-4459	CLIP-seq
MIRT1235197	hsa-miR-4471	CLIP-seq
MIRT1235198	hsa-miR-4490	CLIP-seq
MIRT1235199	hsa-miR-4508	CLIP-seq
MIRT1235200	hsa-miR-450b-3p	CLIP-seq
MIRT1235201	hsa-miR-4520a-3p	CLIP-seq
MIRT1235202	hsa-miR-4520b-3p	CLIP-seq
MIRT1235203	hsa-miR-4532	CLIP-seq
MIRT1235204	hsa-miR-4684-3p	CLIP-seq
MIRT1235205	hsa-miR-4696	CLIP-seq
MIRT1235206	hsa-miR-4724-3p	CLIP-seq
MIRT1235207	hsa-miR-4733-3p	CLIP-seq
MIRT1235208	hsa-miR-4772-3p	CLIP-seq
MIRT1235209	hsa-miR-4797-5p	CLIP-seq
MIRT1235210	hsa-miR-765	CLIP-seq
MIRT1235211	hsa-miR-769-3p	CLIP-seq
MIRT2069234	hsa-miR-3065-5p	CLIP-seq
MIRT2069235	hsa-miR-3121-5p	CLIP-seq
MIRT2069236	hsa-miR-3159	CLIP-seq
MIRT2069237	hsa-miR-3192	CLIP-seq
MIRT2069238	hsa-miR-3674	CLIP-seq
MIRT2069239	hsa-miR-3689a-3p	CLIP-seq
MIRT2069240	hsa-miR-3689c	CLIP-seq
MIRT2069241	hsa-miR-4314	CLIP-seq
MIRT2069242	hsa-miR-4448	CLIP-seq
MIRT2069243	hsa-miR-4476	CLIP-seq
MIRT2069244	hsa-miR-4646-5p	CLIP-seq
MIRT2069245	hsa-miR-4728-5p	CLIP-seq
MIRT2069246	hsa-miR-505	CLIP-seq
MIRT2069247	hsa-miR-654-3p	CLIP-seq
MIRT1235170	hsa-miR-1243	CLIP-seq
MIRT1235171	hsa-miR-1292	CLIP-seq
MIRT2296314	hsa-miR-1343	CLIP-seq
MIRT2296315	hsa-miR-140-3p	CLIP-seq
MIRT2296316	hsa-miR-1587	CLIP-seq
MIRT2296317	hsa-miR-1827	CLIP-seq
MIRT1235172	hsa-miR-188-5p	CLIP-seq
MIRT1235173	hsa-miR-197	CLIP-seq
MIRT1235174	hsa-miR-200b	CLIP-seq
MIRT1235175	hsa-miR-200c	CLIP-seq
MIRT1235177	hsa-miR-24	CLIP-seq
MIRT2069235	hsa-miR-3121-5p	CLIP-seq
MIRT2069236	hsa-miR-3159	CLIP-seq
MIRT2069237	hsa-miR-3192	CLIP-seq
MIRT1235178	hsa-miR-3614-5p	CLIP-seq
MIRT1235179	hsa-miR-3654	CLIP-seq
MIRT2069238	hsa-miR-3674	CLIP-seq
MIRT2069239	hsa-miR-3689a-3p	CLIP-seq
MIRT2069240	hsa-miR-3689c	CLIP-seq
MIRT1235181	hsa-miR-378	CLIP-seq
MIRT1235182	hsa-miR-378b	CLIP-seq
MIRT1235183	hsa-miR-378c	CLIP-seq
MIRT1235184	hsa-miR-378d	CLIP-seq
MIRT1235185	hsa-miR-378e	CLIP-seq
MIRT1235186	hsa-miR-378f	CLIP-seq
MIRT2296318	hsa-miR-378g	CLIP-seq
MIRT1235187	hsa-miR-378h	CLIP-seq
MIRT1235188	hsa-miR-378i	CLIP-seq
MIRT1235189	hsa-miR-412	CLIP-seq
MIRT1235190	hsa-miR-422a	CLIP-seq
MIRT1235192	hsa-miR-429	CLIP-seq
MIRT2069241	hsa-miR-4314	CLIP-seq
MIRT2069242	hsa-miR-4448	CLIP-seq
MIRT1235197	hsa-miR-4471	CLIP-seq
MIRT2069243	hsa-miR-4476	CLIP-seq
MIRT1235198	hsa-miR-4490	CLIP-seq
MIRT2296319	hsa-miR-4492	CLIP-seq
MIRT2296320	hsa-miR-4498	CLIP-seq
MIRT2069244	hsa-miR-4646-5p	CLIP-seq
MIRT2296321	hsa-miR-4649-3p	CLIP-seq
MIRT2296322	hsa-miR-4656	CLIP-seq
MIRT2296323	hsa-miR-4675	CLIP-seq
MIRT1235206	hsa-miR-4724-3p	CLIP-seq
MIRT2069245	hsa-miR-4728-5p	CLIP-seq
MIRT2296324	hsa-miR-4736	CLIP-seq
MIRT2296325	hsa-miR-4741	CLIP-seq
MIRT2296326	hsa-miR-646	CLIP-seq
MIRT2296327	hsa-miR-762	CLIP-seq

Show/Hide all(22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000082	Process	G1/S transition of mitotic cell cycle	IDA	20307683
GO:0004674	Function	Protein serine/threonine kinase activity	IBA	21873635
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	18593906
GO:0005515	Function	Protein binding	IPI	16713569, 25416956, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0006468	Process	Protein phosphorylation	IDA	18593906
GO:0006468	Process	Protein phosphorylation	ISS
GO:0006915	Process	Apoptotic process	IEA
GO:0007346	Process	Regulation of mitotic cell cycle	IBA	21873635
GO:0008285	Process	Negative regulation of cell population proliferation	IDA	20307683
GO:0009615	Process	Response to virus	IEP	16548883
GO:0010508	Process	Positive regulation of autophagy	ISS
GO:0043066	Process	Negative regulation of apoptotic process	IBA	21873635
GO:0043066	Process	Negative regulation of apoptotic process	IDA	18675992
GO:0043123	Process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	ISS
GO:0045893	Process	Positive regulation of transcription, DNA-templated	ISS
GO:0046777	Process	Protein autophosphorylation	IBA	21873635
GO:0050821	Process	Protein stabilization	IMP	20307683
GO:0050821	Process	Protein stabilization	ISS
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0106311	Function	Protein threonine kinase activity	IEA

MIM	HGNC	e!Ensembl
300295	8987	ENSG00000102096

Protein

UniProt ID

Q9P1W9

Protein name

Serine/threonine-protein kinase pim-2 (EC 2.7.11.1) (Pim-2h)

Protein function

Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulatio

PDB

2IWI , 4X7Q

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	32 → 286	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in hematopoietic tissues, in leukemic and lymphoma cell lines, testis, small intestine, colon and colorectal adenocarcinoma cells. Weakly expressed in normal liver, but highly expressed in hepatocellular carcinoma tiss

Sequence

MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAI
KVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPL
PAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKL
IDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFER
DQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKG
GPAPLAWSLLP

Sequence length

311

Interactions

View interactions

	KEGG
	Pathways in cancer Acute myeloid leukemia

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Leukemia	Leukemia, Myelocytic, Acute, Acute Myeloid Leukemia (AML-M2)	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	19458359

Show/Hide Text Mining Associations (38)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	38071755
Arthritis Rheumatoid	Associate	26064888
Breast Neoplasms	Associate	25854938
Carcinogenesis	Associate	32641749
Carcinoma Hepatocellular	Associate	19821157, 32641749, 35802648
Colitis Ulcerative	Associate	34718239
Colorectal Neoplasms	Associate	26078709, 28306719
Drug Related Side Effects and Adverse Reactions	Associate	24009772, 27564460
Endometriosis	Associate	36109523
Hypoxia	Stimulate	24505470
Idiopathic Pulmonary Fibrosis	Associate	35130915
Inflammation	Associate	26064888, 35802648
Leukemia	Associate	23752607, 31671637
Leukemia Lymphocytic Chronic B Cell	Associate	30525315
Leukemia Myeloid Acute	Associate	19458359, 23752607
Liver Cirrhosis	Associate	32641749
Liver Cirrhosis Biliary	Associate	33675743
Lymphoma	Associate	23752607, 31671637
Lymphoma B Cell	Associate	21937691, 25207815
Lymphoma B Cell Marginal Zone	Stimulate	21937691
Lymphoma Follicular	Stimulate	21937691
Lymphoma Large B Cell Diffuse	Stimulate	21937691
Lymphoma Large B Cell Diffuse	Associate	26643319
Lymphoma Mantle Cell	Stimulate	21937691
Lymphoma Non Hodgkin	Associate	26643319
Multiple Myeloma	Associate	12200383, 26500282, 27564460, 35108359
Neoplasm Metastasis	Stimulate	32641749
Neoplasm Metastasis	Associate	35802648
Neoplasms	Associate	22506047, 24142698, 24403608, 24505470, 24975213, 29765150, 32641749, 34718239, 35802648
Neuroblastoma	Associate	36907773
Paraplegia	Stimulate	15308563
Polyps	Associate	28306719
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	23752607
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	24975213, 26500282
Prostatic Neoplasms	Associate	24767770, 33932111
Prostatic Neoplasms Castration Resistant	Stimulate	33932111
Status Asthmaticus	Associate	30013989
Stomach Neoplasms	Associate	29879757

PIM2 (Pim-2 proto-oncogene, serine/threonine kinase)