Gene Gene information from NCBI Gene database.
Entrez ID 11034
Gene name Destrin, actin depolymerizing factor
Gene symbol DSTN
Synonyms (NCBI Gene)
ACTDPADFHEL32bA462D18.2
Chromosome 20
Chromosome location 20p12.1
Summary The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) an
miRNA miRNA information provided by mirtarbase database.
430
miRTarBase ID miRNA Experiments Reference
MIRT041745 hsa-miR-484 CLASH 23622248
MIRT507530 hsa-miR-5571-5p PAR-CLIP 21572407
MIRT507529 hsa-miR-942-3p PAR-CLIP 21572407
MIRT545615 hsa-miR-4728-3p PAR-CLIP 21572407
MIRT329006 hsa-miR-380-3p PAR-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
25
GO ID Ontology Definition Evidence Reference
GO:0003779 Function Actin binding IEA
GO:0005515 Function Protein binding IPI 16189514, 25416956, 26618866, 29892012, 29924966, 31324722, 31515488, 32296183, 35156780, 35271311
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IEA
GO:0008154 Process Actin polymerization or depolymerization IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609114 15750 ENSG00000125868
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P60981
Protein name Destrin (Actin-depolymerizing factor) (ADF)
Protein function Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00241 Cofilin_ADF 23 151 Cofilin/tropomyosin-type actin-binding protein Domain
Tissue specificity TISSUE SPECIFICITY: Widely distributed in various tissues.
Sequence
Sequence length 165
Interactions View interactions