Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	11025
Gene name	Leukocyte immunoglobulin like receptor B3
Gene symbol	LILRB3
Synonyms (NCBI Gene)	CD85AHL9ILT-5ILT5LILRA6LIR-3LIR3PIR-BPIRB
Chromosome	19
Chromosome location	19q13.42
Summary	This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular

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Show/Hide all (229)

miRTarBase ID	miRNA	Experiments
MIRT1109343	hsa-miR-1193	CLIP-seq
MIRT1109344	hsa-miR-1976	CLIP-seq
MIRT1109345	hsa-miR-2392	CLIP-seq
MIRT1109346	hsa-miR-3152-3p	CLIP-seq
MIRT1109347	hsa-miR-433	CLIP-seq
MIRT1109348	hsa-miR-4454	CLIP-seq
MIRT1109349	hsa-miR-4662a-5p	CLIP-seq
MIRT1109350	hsa-miR-4676-5p	CLIP-seq
MIRT1109351	hsa-miR-5096	CLIP-seq
MIRT1109352	hsa-miR-575	CLIP-seq
MIRT1109353	hsa-miR-103b	CLIP-seq
MIRT1109343	hsa-miR-1193	CLIP-seq
MIRT1109354	hsa-miR-122	CLIP-seq
MIRT1109355	hsa-miR-150	CLIP-seq
MIRT1109344	hsa-miR-1976	CLIP-seq
MIRT1109356	hsa-miR-216a	CLIP-seq
MIRT1109345	hsa-miR-2392	CLIP-seq
MIRT1109357	hsa-miR-3135b	CLIP-seq
MIRT1109346	hsa-miR-3152-3p	CLIP-seq
MIRT1109358	hsa-miR-3652	CLIP-seq
MIRT1109359	hsa-miR-3664-5p	CLIP-seq
MIRT1109347	hsa-miR-433	CLIP-seq
MIRT1109360	hsa-miR-4430	CLIP-seq
MIRT1109348	hsa-miR-4454	CLIP-seq
MIRT1109361	hsa-miR-4639-3p	CLIP-seq
MIRT1109349	hsa-miR-4662a-5p	CLIP-seq
MIRT1109350	hsa-miR-4676-5p	CLIP-seq
MIRT1109362	hsa-miR-4698	CLIP-seq
MIRT1109363	hsa-miR-4711-5p	CLIP-seq
MIRT1109351	hsa-miR-5096	CLIP-seq
MIRT1109364	hsa-miR-520g	CLIP-seq
MIRT1109365	hsa-miR-520h	CLIP-seq
MIRT1109352	hsa-miR-575	CLIP-seq
MIRT1109343	hsa-miR-1193	CLIP-seq
MIRT1921669	hsa-miR-129-5p	CLIP-seq
MIRT1109344	hsa-miR-1976	CLIP-seq
MIRT1109345	hsa-miR-2392	CLIP-seq
MIRT1921670	hsa-miR-3149	CLIP-seq
MIRT1109346	hsa-miR-3152-3p	CLIP-seq
MIRT1921671	hsa-miR-411	CLIP-seq
MIRT1109347	hsa-miR-433	CLIP-seq
MIRT1109348	hsa-miR-4454	CLIP-seq
MIRT1109349	hsa-miR-4662a-5p	CLIP-seq
MIRT1109350	hsa-miR-4676-5p	CLIP-seq
MIRT1921672	hsa-miR-483-5p	CLIP-seq
MIRT1109351	hsa-miR-5096	CLIP-seq
MIRT1109352	hsa-miR-575	CLIP-seq
MIRT1109343	hsa-miR-1193	CLIP-seq
MIRT1921669	hsa-miR-129-5p	CLIP-seq
MIRT1109344	hsa-miR-1976	CLIP-seq
MIRT1109345	hsa-miR-2392	CLIP-seq
MIRT1921670	hsa-miR-3149	CLIP-seq
MIRT1109346	hsa-miR-3152-3p	CLIP-seq
MIRT1921671	hsa-miR-411	CLIP-seq
MIRT1109347	hsa-miR-433	CLIP-seq
MIRT1109348	hsa-miR-4454	CLIP-seq
MIRT1109349	hsa-miR-4662a-5p	CLIP-seq
MIRT1109350	hsa-miR-4676-5p	CLIP-seq
MIRT1921672	hsa-miR-483-5p	CLIP-seq
MIRT1109351	hsa-miR-5096	CLIP-seq
MIRT1109352	hsa-miR-575	CLIP-seq
MIRT1109343	hsa-miR-1193	CLIP-seq
MIRT1921669	hsa-miR-129-5p	CLIP-seq
MIRT1109344	hsa-miR-1976	CLIP-seq
MIRT1109345	hsa-miR-2392	CLIP-seq
MIRT1921670	hsa-miR-3149	CLIP-seq
MIRT1109346	hsa-miR-3152-3p	CLIP-seq
MIRT1921671	hsa-miR-411	CLIP-seq
MIRT1109347	hsa-miR-433	CLIP-seq
MIRT1109348	hsa-miR-4454	CLIP-seq
MIRT1109349	hsa-miR-4662a-5p	CLIP-seq
MIRT1109350	hsa-miR-4676-5p	CLIP-seq
MIRT1921672	hsa-miR-483-5p	CLIP-seq
MIRT1109351	hsa-miR-5096	CLIP-seq
MIRT1109352	hsa-miR-575	CLIP-seq
MIRT1109343	hsa-miR-1193	CLIP-seq
MIRT1921669	hsa-miR-129-5p	CLIP-seq
MIRT1109344	hsa-miR-1976	CLIP-seq
MIRT1109345	hsa-miR-2392	CLIP-seq
MIRT1921670	hsa-miR-3149	CLIP-seq
MIRT1109346	hsa-miR-3152-3p	CLIP-seq
MIRT1921671	hsa-miR-411	CLIP-seq
MIRT1109347	hsa-miR-433	CLIP-seq
MIRT1109348	hsa-miR-4454	CLIP-seq
MIRT1109349	hsa-miR-4662a-5p	CLIP-seq
MIRT1109350	hsa-miR-4676-5p	CLIP-seq
MIRT1921672	hsa-miR-483-5p	CLIP-seq
MIRT1109351	hsa-miR-5096	CLIP-seq
MIRT1109352	hsa-miR-575	CLIP-seq
MIRT1109343	hsa-miR-1193	CLIP-seq
MIRT1109354	hsa-miR-122	CLIP-seq
MIRT1921669	hsa-miR-129-5p	CLIP-seq
MIRT1109355	hsa-miR-150	CLIP-seq
MIRT1109344	hsa-miR-1976	CLIP-seq
MIRT1109345	hsa-miR-2392	CLIP-seq
MIRT1109357	hsa-miR-3135b	CLIP-seq
MIRT1921670	hsa-miR-3149	CLIP-seq
MIRT1109346	hsa-miR-3152-3p	CLIP-seq
MIRT2030416	hsa-miR-3194-3p	CLIP-seq
MIRT1109358	hsa-miR-3652	CLIP-seq
MIRT2030417	hsa-miR-377	CLIP-seq
MIRT1921671	hsa-miR-411	CLIP-seq
MIRT1109347	hsa-miR-433	CLIP-seq
MIRT1109360	hsa-miR-4430	CLIP-seq
MIRT2030418	hsa-miR-4437	CLIP-seq
MIRT2030419	hsa-miR-4438	CLIP-seq
MIRT1109348	hsa-miR-4454	CLIP-seq
MIRT2030420	hsa-miR-4532	CLIP-seq
MIRT1109349	hsa-miR-4662a-5p	CLIP-seq
MIRT1109350	hsa-miR-4676-5p	CLIP-seq
MIRT1109363	hsa-miR-4711-5p	CLIP-seq
MIRT2030421	hsa-miR-4735-5p	CLIP-seq
MIRT2030422	hsa-miR-4775	CLIP-seq
MIRT1921672	hsa-miR-483-5p	CLIP-seq
MIRT1109351	hsa-miR-5096	CLIP-seq
MIRT1109364	hsa-miR-520g	CLIP-seq
MIRT1109365	hsa-miR-520h	CLIP-seq
MIRT1109352	hsa-miR-575	CLIP-seq
MIRT2030423	hsa-miR-590-3p	CLIP-seq
MIRT1109353	hsa-miR-103b	CLIP-seq
MIRT1109343	hsa-miR-1193	CLIP-seq
MIRT2261117	hsa-miR-1200	CLIP-seq
MIRT1109354	hsa-miR-122	CLIP-seq
MIRT1109355	hsa-miR-150	CLIP-seq
MIRT1109344	hsa-miR-1976	CLIP-seq
MIRT1109356	hsa-miR-216a	CLIP-seq
MIRT2261118	hsa-miR-2276	CLIP-seq
MIRT1109345	hsa-miR-2392	CLIP-seq
MIRT1109357	hsa-miR-3135b	CLIP-seq
MIRT1109346	hsa-miR-3152-3p	CLIP-seq
MIRT2261119	hsa-miR-3199	CLIP-seq
MIRT1109358	hsa-miR-3652	CLIP-seq
MIRT1109359	hsa-miR-3664-5p	CLIP-seq
MIRT2030417	hsa-miR-377	CLIP-seq
MIRT2261120	hsa-miR-4279	CLIP-seq
MIRT2261121	hsa-miR-4324	CLIP-seq
MIRT1109347	hsa-miR-433	CLIP-seq
MIRT1109360	hsa-miR-4430	CLIP-seq
MIRT2030418	hsa-miR-4437	CLIP-seq
MIRT2030419	hsa-miR-4438	CLIP-seq
MIRT1109348	hsa-miR-4454	CLIP-seq
MIRT2261122	hsa-miR-4466	CLIP-seq
MIRT2030420	hsa-miR-4532	CLIP-seq
MIRT1109361	hsa-miR-4639-3p	CLIP-seq
MIRT1109349	hsa-miR-4662a-5p	CLIP-seq
MIRT1109350	hsa-miR-4676-5p	CLIP-seq
MIRT2261123	hsa-miR-4695-3p	CLIP-seq
MIRT1109363	hsa-miR-4711-5p	CLIP-seq
MIRT2261124	hsa-miR-4722-3p	CLIP-seq
MIRT1109351	hsa-miR-5096	CLIP-seq
MIRT1109364	hsa-miR-520g	CLIP-seq
MIRT1109365	hsa-miR-520h	CLIP-seq
MIRT2261125	hsa-miR-544b	CLIP-seq
MIRT1109352	hsa-miR-575	CLIP-seq
MIRT2261126	hsa-miR-675	CLIP-seq
MIRT1109354	hsa-miR-122	CLIP-seq
MIRT1109355	hsa-miR-150	CLIP-seq
MIRT1109357	hsa-miR-3135b	CLIP-seq
MIRT1109358	hsa-miR-3652	CLIP-seq
MIRT2030417	hsa-miR-377	CLIP-seq
MIRT1109360	hsa-miR-4430	CLIP-seq
MIRT2030419	hsa-miR-4438	CLIP-seq
MIRT2261122	hsa-miR-4466	CLIP-seq
MIRT2261123	hsa-miR-4695-3p	CLIP-seq
MIRT1109363	hsa-miR-4711-5p	CLIP-seq
MIRT1109364	hsa-miR-520g	CLIP-seq
MIRT1109365	hsa-miR-520h	CLIP-seq
MIRT2261126	hsa-miR-675	CLIP-seq
MIRT1921669	hsa-miR-129-5p	CLIP-seq
MIRT1109356	hsa-miR-216a	CLIP-seq
MIRT1109357	hsa-miR-3135b	CLIP-seq
MIRT1921670	hsa-miR-3149	CLIP-seq
MIRT2030416	hsa-miR-3194-3p	CLIP-seq
MIRT1109358	hsa-miR-3652	CLIP-seq
MIRT1109359	hsa-miR-3664-5p	CLIP-seq
MIRT1921671	hsa-miR-411	CLIP-seq
MIRT1109360	hsa-miR-4430	CLIP-seq
MIRT2030418	hsa-miR-4437	CLIP-seq
MIRT2030420	hsa-miR-4532	CLIP-seq
MIRT1109361	hsa-miR-4639-3p	CLIP-seq
MIRT2030421	hsa-miR-4735-5p	CLIP-seq
MIRT2030422	hsa-miR-4775	CLIP-seq
MIRT1921672	hsa-miR-483-5p	CLIP-seq
MIRT2030423	hsa-miR-590-3p	CLIP-seq
MIRT1109354	hsa-miR-122	CLIP-seq
MIRT1921669	hsa-miR-129-5p	CLIP-seq
MIRT1109356	hsa-miR-216a	CLIP-seq
MIRT2261118	hsa-miR-2276	CLIP-seq
MIRT1109357	hsa-miR-3135b	CLIP-seq
MIRT1921670	hsa-miR-3149	CLIP-seq
MIRT1109346	hsa-miR-3152-3p	CLIP-seq
MIRT2030416	hsa-miR-3194-3p	CLIP-seq
MIRT1109358	hsa-miR-3652	CLIP-seq
MIRT1109359	hsa-miR-3664-5p	CLIP-seq
MIRT1921671	hsa-miR-411	CLIP-seq
MIRT1109360	hsa-miR-4430	CLIP-seq
MIRT2261122	hsa-miR-4466	CLIP-seq
MIRT2030420	hsa-miR-4532	CLIP-seq
MIRT1109361	hsa-miR-4639-3p	CLIP-seq
MIRT1109349	hsa-miR-4662a-5p	CLIP-seq
MIRT1109350	hsa-miR-4676-5p	CLIP-seq
MIRT2261123	hsa-miR-4695-3p	CLIP-seq
MIRT2030421	hsa-miR-4735-5p	CLIP-seq
MIRT2030422	hsa-miR-4775	CLIP-seq
MIRT1921672	hsa-miR-483-5p	CLIP-seq
MIRT1109351	hsa-miR-5096	CLIP-seq
MIRT1109352	hsa-miR-575	CLIP-seq
MIRT2030423	hsa-miR-590-3p	CLIP-seq
MIRT2261126	hsa-miR-675	CLIP-seq
MIRT1109354	hsa-miR-122	CLIP-seq
MIRT1921669	hsa-miR-129-5p	CLIP-seq
MIRT2261118	hsa-miR-2276	CLIP-seq
MIRT1109357	hsa-miR-3135b	CLIP-seq
MIRT1921670	hsa-miR-3149	CLIP-seq
MIRT1109346	hsa-miR-3152-3p	CLIP-seq
MIRT2030416	hsa-miR-3194-3p	CLIP-seq
MIRT1109358	hsa-miR-3652	CLIP-seq
MIRT1921671	hsa-miR-411	CLIP-seq
MIRT1109360	hsa-miR-4430	CLIP-seq
MIRT2261122	hsa-miR-4466	CLIP-seq
MIRT2030420	hsa-miR-4532	CLIP-seq
MIRT1109349	hsa-miR-4662a-5p	CLIP-seq
MIRT2261123	hsa-miR-4695-3p	CLIP-seq
MIRT2030421	hsa-miR-4735-5p	CLIP-seq
MIRT2030422	hsa-miR-4775	CLIP-seq
MIRT1921672	hsa-miR-483-5p	CLIP-seq
MIRT1109351	hsa-miR-5096	CLIP-seq
MIRT2030423	hsa-miR-590-3p	CLIP-seq
MIRT2261126	hsa-miR-675	CLIP-seq

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001540	Function	Amyloid-beta binding	IDA	24052308
GO:0002250	Process	Adaptive immune response	IEA
GO:0002376	Process	Immune system process	IEA
GO:0002764	Process	Immune response-regulating signaling pathway	IBA
GO:0004888	Function	Transmembrane signaling receptor activity	TAS	9278324
GO:0005515	Function	Protein binding	IPI	18802077, 26769854
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9278324
GO:0006952	Process	Defense response	TAS	9382880
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	9382880
GO:0016020	Component	Membrane	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	IBA
GO:0030667	Component	Secretory granule membrane	TAS
GO:0032396	Function	Inhibitory MHC class I receptor activity	IBA
GO:0038023	Function	Signaling receptor activity	TAS	9382880
GO:0045671	Process	Negative regulation of osteoclast differentiation	IDA	18802077

MIM	HGNC	e!Ensembl
604820	6607	ENSG00000204577

O75022

Protein name

Leukocyte immunoglobulin-like receptor subfamily B member 3 (LIR-3) (Leukocyte immunoglobulin-like receptor 3) (CD85 antigen-like family member A) (Immunoglobulin-like transcript 5) (ILT-5) (Monocyte inhibitory receptor HL9) (CD antigen CD85a)

Protein function

May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunorece

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13895	Ig_2	28 → 117	Immunoglobulin domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in monocytes and B-cells. {ECO:0000269|PubMed:9548455}.

Sequence

MTPALTALLCLGLSLGPRTRVQAGPFPKPTLWAEPGSVISWGSPVTIWCQGSQEAQEYRL
HKEGSPEPLDRNNPLEPKNKARFSIPSMTEHHAGRYRCHYYSSAGWSEPSDPLEMVMTGA
YSKPTLSALPSPVVASGGNMTLRCGSQKGYHHFVLMKEGEHQLPRTLDSQQLHSRGFQAL
FPVGPVTPSHRWRFTCYYYYTNTPWVWSHPSDPLEILPSGVSRKPSLLTLQGPVLAPGQS
LTLQCGSDVGYNRFVLYKEGERDFLQRPGQQPQAGLSQANFTLGPVSPSNGGQYRCYGAH
NLSSEWSAPSDPLNILMAGQIYDTVSLSAQPGPTVASGENVTLLCQSWWQFDTFLLTKEG
AAHPPLRLRSMYGAHKYQAEFPMSPVTSAHAGTYRCYGSYSSNPHLLSHPSEPLELVVSG
HSGGSSLPPTGPPSTPGLGRYLEVLIGVSVAFVLLLFLLLFLLLRRQRHSKHRTSDQRKT
DFQRPAGAAETEPKDRGLLRRSSPAADVQEENLYAAVKDTQSEDRVELDSQSPHDEDPQA
VTYAPVKHSSPRREMASPPSSLSGEFLDTKDRQVEEDRQMDTEAAASEASQDVTYAQLHS
LTLRRKATEPPPSQEGEPPAEPSIYATLAIH

Sequence length

631

Interactions

View interactions

	KEGG
	Osteoclast differentiation B cell receptor signaling pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CROHN'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (12)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	26769854	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Associate	35321724	★★★★★ ★☆☆☆☆ Found in Text Mining only
Critical Illness	Associate	38275610	★★★★★ ★☆☆☆☆ Found in Text Mining only
HIV Infections	Associate	25756195	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Associate	40054016	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma Large B Cell Diffuse	Associate	34114929	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mitochondrial Diseases	Stimulate	37335462	★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Associate	26730743	★★★★★ ★☆☆☆☆ Found in Text Mining only
Necrosis	Associate	26769854	★★★★★ ★☆☆☆☆ Found in Text Mining only
Reperfusion Injury	Associate	37335462	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stroke	Associate	37335462	★★★★★ ★☆☆☆☆ Found in Text Mining only
Takayasu Arteritis	Associate	25604533, 27769046, 28756073, 40054016	★★★★★ ★☆☆☆☆ Found in Text Mining only

LILRB3 (leukocyte immunoglobulin like receptor B3)