Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	11017
Gene name Gene Name - the full gene name approved by the HGNC.	Small nuclear ribonucleoprotein U4/U6.U5 subunit 27
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SNRNP27
Synonyms (NCBI Gene) Gene synonyms aliases	27K, RY1
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2p13.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a serine/arginine-rich (SR) protein. SR proteins play important roles in pre-mRNA splicing by facilitating the recognition and selection of splice sites. The encoded protein associates with the 25S U4/U6.U5 tri-snRNP, a major component o

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miRTarBase ID	miRNA	Experiments	Reference
MIRT048472	hsa-miR-100-5p	CLASH	23622248
MIRT462015	hsa-miR-548n	PAR-CLIP	23592263
MIRT462014	hsa-miR-3133	PAR-CLIP	23592263
MIRT462013	hsa-miR-186-5p	PAR-CLIP	23592263
MIRT462012	hsa-miR-548av-5p	PAR-CLIP	23592263
MIRT462011	hsa-miR-548k	PAR-CLIP	23592263
MIRT462009	hsa-miR-8054	PAR-CLIP	23592263
MIRT462010	hsa-miR-4511	PAR-CLIP	23592263
MIRT303303	hsa-miR-101-3p	PAR-CLIP	23592263
MIRT462008	hsa-miR-376c-3p	PAR-CLIP	23592263
MIRT462007	hsa-miR-217	PAR-CLIP	23592263
MIRT462006	hsa-miR-6807-3p	PAR-CLIP	23592263
MIRT462005	hsa-miR-5003-3p	PAR-CLIP	23592263
MIRT462004	hsa-miR-6888-5p	PAR-CLIP	23592263
MIRT303305	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT303311	hsa-miR-5197-5p	PAR-CLIP	23592263
MIRT462003	hsa-miR-944	PAR-CLIP	23592263
MIRT462002	hsa-miR-1244	PAR-CLIP	23592263
MIRT303308	hsa-miR-128-3p	PAR-CLIP	23592263
MIRT303307	hsa-miR-216a-3p	PAR-CLIP	23592263
MIRT303310	hsa-miR-3681-3p	PAR-CLIP	23592263
MIRT303309	hsa-miR-4328	PAR-CLIP	23592263
MIRT462001	hsa-miR-4524a-3p	PAR-CLIP	23592263
MIRT462000	hsa-miR-139-3p	PAR-CLIP	23592263
MIRT303306	hsa-miR-31-5p	PAR-CLIP	23592263
MIRT303312	hsa-miR-6809-5p	PAR-CLIP	23592263
MIRT461999	hsa-miR-374a-5p	PAR-CLIP	23592263
MIRT461998	hsa-miR-374b-5p	PAR-CLIP	23592263
MIRT303302	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT303304	hsa-miR-27b-3p	PAR-CLIP	23592263
MIRT462015	hsa-miR-548n	PAR-CLIP	23592263
MIRT462014	hsa-miR-3133	PAR-CLIP	23592263
MIRT462013	hsa-miR-186-5p	PAR-CLIP	23592263
MIRT462012	hsa-miR-548av-5p	PAR-CLIP	23592263
MIRT462011	hsa-miR-548k	PAR-CLIP	23592263
MIRT462009	hsa-miR-8054	PAR-CLIP	23592263
MIRT462010	hsa-miR-4511	PAR-CLIP	23592263
MIRT303303	hsa-miR-101-3p	PAR-CLIP	23592263
MIRT462008	hsa-miR-376c-3p	PAR-CLIP	23592263
MIRT462007	hsa-miR-217	PAR-CLIP	23592263
MIRT462006	hsa-miR-6807-3p	PAR-CLIP	23592263
MIRT462005	hsa-miR-5003-3p	PAR-CLIP	23592263
MIRT462004	hsa-miR-6888-5p	PAR-CLIP	23592263
MIRT303305	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT303311	hsa-miR-5197-5p	PAR-CLIP	23592263
MIRT462003	hsa-miR-944	PAR-CLIP	23592263
MIRT462002	hsa-miR-1244	PAR-CLIP	23592263
MIRT303308	hsa-miR-128-3p	PAR-CLIP	23592263
MIRT303307	hsa-miR-216a-3p	PAR-CLIP	23592263
MIRT303310	hsa-miR-3681-3p	PAR-CLIP	23592263
MIRT303309	hsa-miR-4328	PAR-CLIP	23592263
MIRT462001	hsa-miR-4524a-3p	PAR-CLIP	23592263
MIRT462000	hsa-miR-139-3p	PAR-CLIP	23592263
MIRT303306	hsa-miR-31-5p	PAR-CLIP	23592263
MIRT303312	hsa-miR-6809-5p	PAR-CLIP	23592263
MIRT461999	hsa-miR-374a-5p	PAR-CLIP	23592263
MIRT461998	hsa-miR-374b-5p	PAR-CLIP	23592263
MIRT303302	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT303304	hsa-miR-27b-3p	PAR-CLIP	23592263
MIRT1375926	hsa-miR-101	CLIP-seq
MIRT1375927	hsa-miR-125a-3p	CLIP-seq
MIRT1375928	hsa-miR-1267	CLIP-seq
MIRT1375929	hsa-miR-1275	CLIP-seq
MIRT1375930	hsa-miR-128	CLIP-seq
MIRT1375931	hsa-miR-129-5p	CLIP-seq
MIRT1375932	hsa-miR-1304	CLIP-seq
MIRT1375933	hsa-miR-1827	CLIP-seq
MIRT1375934	hsa-miR-205	CLIP-seq
MIRT1375935	hsa-miR-2115	CLIP-seq
MIRT1375936	hsa-miR-27a	CLIP-seq
MIRT1375937	hsa-miR-27b	CLIP-seq
MIRT1375938	hsa-miR-3074-3p	CLIP-seq
MIRT1375939	hsa-miR-3148	CLIP-seq
MIRT1375940	hsa-miR-3180	CLIP-seq
MIRT1375941	hsa-miR-3180-3p	CLIP-seq
MIRT1375942	hsa-miR-3182	CLIP-seq
MIRT1375943	hsa-miR-3184	CLIP-seq
MIRT1375944	hsa-miR-3192	CLIP-seq
MIRT1375945	hsa-miR-3196	CLIP-seq
MIRT1375946	hsa-miR-3692	CLIP-seq
MIRT1375947	hsa-miR-376c	CLIP-seq
MIRT1375948	hsa-miR-3935	CLIP-seq
MIRT1375949	hsa-miR-423-5p	CLIP-seq
MIRT1375950	hsa-miR-4260	CLIP-seq
MIRT1375951	hsa-miR-4314	CLIP-seq
MIRT1375952	hsa-miR-448	CLIP-seq
MIRT1375953	hsa-miR-4488	CLIP-seq
MIRT1375954	hsa-miR-4646-5p	CLIP-seq
MIRT1375955	hsa-miR-4652-3p	CLIP-seq
MIRT1375956	hsa-miR-4659a-3p	CLIP-seq
MIRT1375957	hsa-miR-4659b-3p	CLIP-seq
MIRT1375958	hsa-miR-4665-5p	CLIP-seq
MIRT1375959	hsa-miR-4668-5p	CLIP-seq
MIRT1375960	hsa-miR-4697-5p	CLIP-seq
MIRT1375961	hsa-miR-4793-5p	CLIP-seq
MIRT1375962	hsa-miR-487a	CLIP-seq
MIRT1375963	hsa-miR-516a-3p	CLIP-seq
MIRT1375964	hsa-miR-522	CLIP-seq
MIRT1375965	hsa-miR-548ag	CLIP-seq
MIRT1375966	hsa-miR-548ai	CLIP-seq
MIRT1375967	hsa-miR-548c-3p	CLIP-seq
MIRT1375968	hsa-miR-548t	CLIP-seq
MIRT1375969	hsa-miR-552	CLIP-seq
MIRT1375970	hsa-miR-577	CLIP-seq
MIRT1553883	hsa-miR-186	CLIP-seq
MIRT2111769	hsa-miR-409-3p	CLIP-seq
MIRT2111770	hsa-miR-4698	CLIP-seq
MIRT2111771	hsa-miR-653	CLIP-seq
MIRT1375926	hsa-miR-101	CLIP-seq
MIRT1375930	hsa-miR-128	CLIP-seq
MIRT1553883	hsa-miR-186	CLIP-seq
MIRT1375936	hsa-miR-27a	CLIP-seq
MIRT1375937	hsa-miR-27b	CLIP-seq
MIRT2335048	hsa-miR-31	CLIP-seq
MIRT2335049	hsa-miR-374a	CLIP-seq
MIRT2335050	hsa-miR-374b	CLIP-seq
MIRT1375947	hsa-miR-376c	CLIP-seq
MIRT2335051	hsa-miR-4778-5p	CLIP-seq
MIRT2629087	hsa-miR-1231	CLIP-seq
MIRT1375928	hsa-miR-1267	CLIP-seq
MIRT1375931	hsa-miR-129-5p	CLIP-seq
MIRT1375932	hsa-miR-1304	CLIP-seq
MIRT2629088	hsa-miR-146a	CLIP-seq
MIRT2629089	hsa-miR-146b-5p	CLIP-seq
MIRT1375933	hsa-miR-1827	CLIP-seq
MIRT2629090	hsa-miR-2054	CLIP-seq
MIRT2629091	hsa-miR-3064-3p	CLIP-seq
MIRT1375938	hsa-miR-3074-3p	CLIP-seq
MIRT2629092	hsa-miR-3145-3p	CLIP-seq
MIRT2629093	hsa-miR-3150a-3p	CLIP-seq
MIRT2629094	hsa-miR-3175	CLIP-seq
MIRT1375942	hsa-miR-3182	CLIP-seq
MIRT2629095	hsa-miR-3685	CLIP-seq
MIRT2629096	hsa-miR-380	CLIP-seq
MIRT2629097	hsa-miR-384	CLIP-seq
MIRT2629098	hsa-miR-4428	CLIP-seq
MIRT1375952	hsa-miR-448	CLIP-seq
MIRT1375955	hsa-miR-4652-3p	CLIP-seq
MIRT1375956	hsa-miR-4659a-3p	CLIP-seq
MIRT1375957	hsa-miR-4659b-3p	CLIP-seq
MIRT2629099	hsa-miR-4667-5p	CLIP-seq
MIRT2629100	hsa-miR-4700-5p	CLIP-seq
MIRT2629101	hsa-miR-4719	CLIP-seq
MIRT2629102	hsa-miR-4762-5p	CLIP-seq
MIRT1375962	hsa-miR-487a	CLIP-seq
MIRT1375965	hsa-miR-548ag	CLIP-seq
MIRT1375966	hsa-miR-548ai	CLIP-seq
MIRT1375967	hsa-miR-548c-3p	CLIP-seq
MIRT2629103	hsa-miR-550b	CLIP-seq
MIRT2629104	hsa-miR-637	CLIP-seq
MIRT2629105	hsa-miR-654-3p	CLIP-seq
MIRT2629106	hsa-miR-939	CLIP-seq
MIRT2629087	hsa-miR-1231	CLIP-seq
MIRT1375928	hsa-miR-1267	CLIP-seq
MIRT1375931	hsa-miR-129-5p	CLIP-seq
MIRT1375932	hsa-miR-1304	CLIP-seq
MIRT2629088	hsa-miR-146a	CLIP-seq
MIRT2629089	hsa-miR-146b-5p	CLIP-seq
MIRT1375933	hsa-miR-1827	CLIP-seq
MIRT2629090	hsa-miR-2054	CLIP-seq
MIRT2629091	hsa-miR-3064-3p	CLIP-seq
MIRT1375938	hsa-miR-3074-3p	CLIP-seq
MIRT2629092	hsa-miR-3145-3p	CLIP-seq
MIRT2629093	hsa-miR-3150a-3p	CLIP-seq
MIRT2629094	hsa-miR-3175	CLIP-seq
MIRT1375942	hsa-miR-3182	CLIP-seq
MIRT2629095	hsa-miR-3685	CLIP-seq
MIRT2629096	hsa-miR-380	CLIP-seq
MIRT2629097	hsa-miR-384	CLIP-seq
MIRT2629098	hsa-miR-4428	CLIP-seq
MIRT1375952	hsa-miR-448	CLIP-seq
MIRT1375955	hsa-miR-4652-3p	CLIP-seq
MIRT1375956	hsa-miR-4659a-3p	CLIP-seq
MIRT1375957	hsa-miR-4659b-3p	CLIP-seq
MIRT2629099	hsa-miR-4667-5p	CLIP-seq
MIRT2629100	hsa-miR-4700-5p	CLIP-seq
MIRT2629101	hsa-miR-4719	CLIP-seq
MIRT2629102	hsa-miR-4762-5p	CLIP-seq
MIRT1375962	hsa-miR-487a	CLIP-seq
MIRT1375965	hsa-miR-548ag	CLIP-seq
MIRT1375966	hsa-miR-548ai	CLIP-seq
MIRT1375967	hsa-miR-548c-3p	CLIP-seq
MIRT2629103	hsa-miR-550b	CLIP-seq
MIRT2629104	hsa-miR-637	CLIP-seq
MIRT2629105	hsa-miR-654-3p	CLIP-seq
MIRT2629106	hsa-miR-939	CLIP-seq

Show/Hide all(6)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000398	Process	MRNA splicing, via spliceosome	TAS
GO:0003676	Function	Nucleic acid binding	NAS	7931148
GO:0005515	Function	Protein binding	IPI	22365833, 23602568, 25416956
GO:0005575	Component	Cellular_component	ND
GO:0005654	Component	Nucleoplasm	TAS
GO:0008150	Process	Biological_process	ND

MIM	HGNC	e!Ensembl
619629	30240	ENSG00000124380

Protein

UniProt ID

Q8WVK2

Protein name

U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein (U4/U6.U5 snRNP 27 kDa protein) (U4/U6.U5-27K) (Nucleic acid-binding protein RY-1) (U4/U6.U5 tri-snRNP-associated 27 kDa protein) (27K) (U4/U6.U5 tri-snRNP-associated protein 3)

Protein function

May play a role in mRNA splicing.

PDB

6QW6 , 6QX9 , 8H6E , 8H6J , 8QP8 , 8QP9 , 8QPK , 8QXD , 8R08 , 8R0A

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08648	SNRNP27	98 → 154	U4/U6.U5 small nuclear ribonucleoproteins	Family

Sequence

MGRSRSRSPRRERRRSRSTSRERERRRRERSRSRERDRRRSRSRSPHRRRSRSPRRHRST
SPSPSRLKERRDEEKKETKETKSKERQITEEDLEGKTEEEIEMMKLMGFASFDSTKGKKV
DGSVNAYAINVSQKRKYRQYMNRKGGFNRPLDFIA

Sequence length

155

Interactions

View interactions

	KEGG		Reactome
	Spliceosome		mRNA Splicing - Major Pathway

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Atrial fibrillation	Atrial Fibrillation	rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557 View all (6 more)	29892015

Show/Hide Unknown Diseases (3)

Disease term	Disease name	Evidence	References	Source
Unknown
Paroxysmal atrial fibrillation	Paroxysmal atrial fibrillation		29892015	ClinVar
Breast cancer	Breast cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients		GWAS, CBGDA
Atrial Fibrillation	Atrial Fibrillation			GWAS

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References
Associations from Text Mining
Atrial Fibrillation	Associate	29545482

SNRNP27 (small nuclear ribonucleoprotein U4/U6.U5 subunit 27)