Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	11017
Gene name	Small nuclear ribonucleoprotein U4/U6.U5 subunit 27
Gene symbol	SNRNP27
Synonyms (NCBI Gene)	27KRY1
Chromosome	2
Chromosome location	2p13.3
Summary	This gene encodes a serine/arginine-rich (SR) protein. SR proteins play important roles in pre-mRNA splicing by facilitating the recognition and selection of splice sites. The encoded protein associates with the 25S U4/U6.U5 tri-snRNP, a major component o

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miRTarBase ID	miRNA	Experiments	Reference
MIRT048472	hsa-miR-100-5p	CLASH	23622248
MIRT462015	hsa-miR-548n	PAR-CLIP	23592263
MIRT462014	hsa-miR-3133	PAR-CLIP	23592263
MIRT462013	hsa-miR-186-5p	PAR-CLIP	23592263
MIRT462012	hsa-miR-548av-5p	PAR-CLIP	23592263
MIRT462011	hsa-miR-548k	PAR-CLIP	23592263
MIRT462009	hsa-miR-8054	PAR-CLIP	23592263
MIRT462010	hsa-miR-4511	PAR-CLIP	23592263
MIRT303303	hsa-miR-101-3p	PAR-CLIP	23592263
MIRT462008	hsa-miR-376c-3p	PAR-CLIP	23592263
MIRT462007	hsa-miR-217	PAR-CLIP	23592263
MIRT462006	hsa-miR-6807-3p	PAR-CLIP	23592263
MIRT462005	hsa-miR-5003-3p	PAR-CLIP	23592263
MIRT462004	hsa-miR-6888-5p	PAR-CLIP	23592263
MIRT303305	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT303311	hsa-miR-5197-5p	PAR-CLIP	23592263
MIRT462003	hsa-miR-944	PAR-CLIP	23592263
MIRT462002	hsa-miR-1244	PAR-CLIP	23592263
MIRT303308	hsa-miR-128-3p	PAR-CLIP	23592263
MIRT303307	hsa-miR-216a-3p	PAR-CLIP	23592263
MIRT303310	hsa-miR-3681-3p	PAR-CLIP	23592263
MIRT303309	hsa-miR-4328	PAR-CLIP	23592263
MIRT462001	hsa-miR-4524a-3p	PAR-CLIP	23592263
MIRT462000	hsa-miR-139-3p	PAR-CLIP	23592263
MIRT303306	hsa-miR-31-5p	PAR-CLIP	23592263
MIRT303312	hsa-miR-6809-5p	PAR-CLIP	23592263
MIRT461999	hsa-miR-374a-5p	PAR-CLIP	23592263
MIRT461998	hsa-miR-374b-5p	PAR-CLIP	23592263
MIRT303302	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT303304	hsa-miR-27b-3p	PAR-CLIP	23592263
MIRT462015	hsa-miR-548n	PAR-CLIP	23592263
MIRT462014	hsa-miR-3133	PAR-CLIP	23592263
MIRT462013	hsa-miR-186-5p	PAR-CLIP	23592263
MIRT462012	hsa-miR-548av-5p	PAR-CLIP	23592263
MIRT462011	hsa-miR-548k	PAR-CLIP	23592263
MIRT462009	hsa-miR-8054	PAR-CLIP	23592263
MIRT462010	hsa-miR-4511	PAR-CLIP	23592263
MIRT303303	hsa-miR-101-3p	PAR-CLIP	23592263
MIRT462008	hsa-miR-376c-3p	PAR-CLIP	23592263
MIRT462007	hsa-miR-217	PAR-CLIP	23592263
MIRT462006	hsa-miR-6807-3p	PAR-CLIP	23592263
MIRT462005	hsa-miR-5003-3p	PAR-CLIP	23592263
MIRT462004	hsa-miR-6888-5p	PAR-CLIP	23592263
MIRT303305	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT303311	hsa-miR-5197-5p	PAR-CLIP	23592263
MIRT462003	hsa-miR-944	PAR-CLIP	23592263
MIRT462002	hsa-miR-1244	PAR-CLIP	23592263
MIRT303308	hsa-miR-128-3p	PAR-CLIP	23592263
MIRT303307	hsa-miR-216a-3p	PAR-CLIP	23592263
MIRT303310	hsa-miR-3681-3p	PAR-CLIP	23592263
MIRT303309	hsa-miR-4328	PAR-CLIP	23592263
MIRT462001	hsa-miR-4524a-3p	PAR-CLIP	23592263
MIRT462000	hsa-miR-139-3p	PAR-CLIP	23592263
MIRT303306	hsa-miR-31-5p	PAR-CLIP	23592263
MIRT303312	hsa-miR-6809-5p	PAR-CLIP	23592263
MIRT461999	hsa-miR-374a-5p	PAR-CLIP	23592263
MIRT461998	hsa-miR-374b-5p	PAR-CLIP	23592263
MIRT303302	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT303304	hsa-miR-27b-3p	PAR-CLIP	23592263
MIRT1375926	hsa-miR-101	CLIP-seq
MIRT1375927	hsa-miR-125a-3p	CLIP-seq
MIRT1375928	hsa-miR-1267	CLIP-seq
MIRT1375929	hsa-miR-1275	CLIP-seq
MIRT1375930	hsa-miR-128	CLIP-seq
MIRT1375931	hsa-miR-129-5p	CLIP-seq
MIRT1375932	hsa-miR-1304	CLIP-seq
MIRT1375933	hsa-miR-1827	CLIP-seq
MIRT1375934	hsa-miR-205	CLIP-seq
MIRT1375935	hsa-miR-2115	CLIP-seq
MIRT1375936	hsa-miR-27a	CLIP-seq
MIRT1375937	hsa-miR-27b	CLIP-seq
MIRT1375938	hsa-miR-3074-3p	CLIP-seq
MIRT1375939	hsa-miR-3148	CLIP-seq
MIRT1375940	hsa-miR-3180	CLIP-seq
MIRT1375941	hsa-miR-3180-3p	CLIP-seq
MIRT1375942	hsa-miR-3182	CLIP-seq
MIRT1375943	hsa-miR-3184	CLIP-seq
MIRT1375944	hsa-miR-3192	CLIP-seq
MIRT1375945	hsa-miR-3196	CLIP-seq
MIRT1375946	hsa-miR-3692	CLIP-seq
MIRT1375947	hsa-miR-376c	CLIP-seq
MIRT1375948	hsa-miR-3935	CLIP-seq
MIRT1375949	hsa-miR-423-5p	CLIP-seq
MIRT1375950	hsa-miR-4260	CLIP-seq
MIRT1375951	hsa-miR-4314	CLIP-seq
MIRT1375952	hsa-miR-448	CLIP-seq
MIRT1375953	hsa-miR-4488	CLIP-seq
MIRT1375954	hsa-miR-4646-5p	CLIP-seq
MIRT1375955	hsa-miR-4652-3p	CLIP-seq
MIRT1375956	hsa-miR-4659a-3p	CLIP-seq
MIRT1375957	hsa-miR-4659b-3p	CLIP-seq
MIRT1375958	hsa-miR-4665-5p	CLIP-seq
MIRT1375959	hsa-miR-4668-5p	CLIP-seq
MIRT1375960	hsa-miR-4697-5p	CLIP-seq
MIRT1375961	hsa-miR-4793-5p	CLIP-seq
MIRT1375962	hsa-miR-487a	CLIP-seq
MIRT1375963	hsa-miR-516a-3p	CLIP-seq
MIRT1375964	hsa-miR-522	CLIP-seq
MIRT1375965	hsa-miR-548ag	CLIP-seq
MIRT1375966	hsa-miR-548ai	CLIP-seq
MIRT1375967	hsa-miR-548c-3p	CLIP-seq
MIRT1375968	hsa-miR-548t	CLIP-seq
MIRT1375969	hsa-miR-552	CLIP-seq
MIRT1375970	hsa-miR-577	CLIP-seq
MIRT1553883	hsa-miR-186	CLIP-seq
MIRT2111769	hsa-miR-409-3p	CLIP-seq
MIRT2111770	hsa-miR-4698	CLIP-seq
MIRT2111771	hsa-miR-653	CLIP-seq
MIRT1375926	hsa-miR-101	CLIP-seq
MIRT1375930	hsa-miR-128	CLIP-seq
MIRT1553883	hsa-miR-186	CLIP-seq
MIRT1375936	hsa-miR-27a	CLIP-seq
MIRT1375937	hsa-miR-27b	CLIP-seq
MIRT2335048	hsa-miR-31	CLIP-seq
MIRT2335049	hsa-miR-374a	CLIP-seq
MIRT2335050	hsa-miR-374b	CLIP-seq
MIRT1375947	hsa-miR-376c	CLIP-seq
MIRT2335051	hsa-miR-4778-5p	CLIP-seq
MIRT2629087	hsa-miR-1231	CLIP-seq
MIRT1375928	hsa-miR-1267	CLIP-seq
MIRT1375931	hsa-miR-129-5p	CLIP-seq
MIRT1375932	hsa-miR-1304	CLIP-seq
MIRT2629088	hsa-miR-146a	CLIP-seq
MIRT2629089	hsa-miR-146b-5p	CLIP-seq
MIRT1375933	hsa-miR-1827	CLIP-seq
MIRT2629090	hsa-miR-2054	CLIP-seq
MIRT2629091	hsa-miR-3064-3p	CLIP-seq
MIRT1375938	hsa-miR-3074-3p	CLIP-seq
MIRT2629092	hsa-miR-3145-3p	CLIP-seq
MIRT2629093	hsa-miR-3150a-3p	CLIP-seq
MIRT2629094	hsa-miR-3175	CLIP-seq
MIRT1375942	hsa-miR-3182	CLIP-seq
MIRT2629095	hsa-miR-3685	CLIP-seq
MIRT2629096	hsa-miR-380	CLIP-seq
MIRT2629097	hsa-miR-384	CLIP-seq
MIRT2629098	hsa-miR-4428	CLIP-seq
MIRT1375952	hsa-miR-448	CLIP-seq
MIRT1375955	hsa-miR-4652-3p	CLIP-seq
MIRT1375956	hsa-miR-4659a-3p	CLIP-seq
MIRT1375957	hsa-miR-4659b-3p	CLIP-seq
MIRT2629099	hsa-miR-4667-5p	CLIP-seq
MIRT2629100	hsa-miR-4700-5p	CLIP-seq
MIRT2629101	hsa-miR-4719	CLIP-seq
MIRT2629102	hsa-miR-4762-5p	CLIP-seq
MIRT1375962	hsa-miR-487a	CLIP-seq
MIRT1375965	hsa-miR-548ag	CLIP-seq
MIRT1375966	hsa-miR-548ai	CLIP-seq
MIRT1375967	hsa-miR-548c-3p	CLIP-seq
MIRT2629103	hsa-miR-550b	CLIP-seq
MIRT2629104	hsa-miR-637	CLIP-seq
MIRT2629105	hsa-miR-654-3p	CLIP-seq
MIRT2629106	hsa-miR-939	CLIP-seq
MIRT2629087	hsa-miR-1231	CLIP-seq
MIRT1375928	hsa-miR-1267	CLIP-seq
MIRT1375931	hsa-miR-129-5p	CLIP-seq
MIRT1375932	hsa-miR-1304	CLIP-seq
MIRT2629088	hsa-miR-146a	CLIP-seq
MIRT2629089	hsa-miR-146b-5p	CLIP-seq
MIRT1375933	hsa-miR-1827	CLIP-seq
MIRT2629090	hsa-miR-2054	CLIP-seq
MIRT2629091	hsa-miR-3064-3p	CLIP-seq
MIRT1375938	hsa-miR-3074-3p	CLIP-seq
MIRT2629092	hsa-miR-3145-3p	CLIP-seq
MIRT2629093	hsa-miR-3150a-3p	CLIP-seq
MIRT2629094	hsa-miR-3175	CLIP-seq
MIRT1375942	hsa-miR-3182	CLIP-seq
MIRT2629095	hsa-miR-3685	CLIP-seq
MIRT2629096	hsa-miR-380	CLIP-seq
MIRT2629097	hsa-miR-384	CLIP-seq
MIRT2629098	hsa-miR-4428	CLIP-seq
MIRT1375952	hsa-miR-448	CLIP-seq
MIRT1375955	hsa-miR-4652-3p	CLIP-seq
MIRT1375956	hsa-miR-4659a-3p	CLIP-seq
MIRT1375957	hsa-miR-4659b-3p	CLIP-seq
MIRT2629099	hsa-miR-4667-5p	CLIP-seq
MIRT2629100	hsa-miR-4700-5p	CLIP-seq
MIRT2629101	hsa-miR-4719	CLIP-seq
MIRT2629102	hsa-miR-4762-5p	CLIP-seq
MIRT1375962	hsa-miR-487a	CLIP-seq
MIRT1375965	hsa-miR-548ag	CLIP-seq
MIRT1375966	hsa-miR-548ai	CLIP-seq
MIRT1375967	hsa-miR-548c-3p	CLIP-seq
MIRT2629103	hsa-miR-550b	CLIP-seq
MIRT2629104	hsa-miR-637	CLIP-seq
MIRT2629105	hsa-miR-654-3p	CLIP-seq
MIRT2629106	hsa-miR-939	CLIP-seq

Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000398	Process	MRNA splicing, via spliceosome	NAS	30975767
GO:0003676	Function	Nucleic acid binding	NAS	7931148
GO:0005515	Function	Protein binding	IPI	22365833, 23602568, 25416956
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	30975767
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IPI	30975767
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0046540	Component	U4/U6 x U5 tri-snRNP complex	IPI	30975767

MIM	HGNC	e!Ensembl
619629	30240	ENSG00000124380

Q8WVK2

Protein name

U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein (U4/U6.U5 snRNP 27 kDa protein) (U4/U6.U5-27K) (Nucleic acid-binding protein RY-1) (U4/U6.U5 tri-snRNP-associated 27 kDa protein) (27K) (U4/U6.U5 tri-snRNP-associated protein 3)

Protein function

May play a role in mRNA splicing.

PDB

6QW6 , 6QX9 , 8H6E , 8H6J , 8QP8 , 8QP9 , 8QPK , 8QXD , 8R08 , 8R0A

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08648	SNRNP27	98 → 154	U4/U6.U5 small nuclear ribonucleoproteins	Family

Sequence

MGRSRSRSPRRERRRSRSTSRERERRRRERSRSRERDRRRSRSRSPHRRRSRSPRRHRST
SPSPSRLKERRDEEKKETKETKSKERQITEEDLEGKTEEEIEMMKLMGFASFDSTKGKKV
DGSVNAYAINVSQKRKYRQYMNRKGGFNRPLDFIA

Sequence length

155

Interactions

View interactions

	KEGG		Reactome
	Spliceosome		mRNA Splicing - Major Pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATRIAL FIBRILLATION	—	CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Atrial Fibrillation	Associate	29545482	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

SNRNP27 (small nuclear ribonucleoprotein U4/U6.U5 subunit 27)