Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	11009
Gene name Gene Name - the full gene name approved by the HGNC.	Interleukin 24
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	IL24
Synonyms (NCBI Gene) Gene synonyms aliases	C49A, FISP, IL10B, MDA7, MOB5, ST16
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q32.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of

Show/Hide all(188)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005563	hsa-miR-205-5p	Luciferase reporter assay, qRT-PCR, Western blot	20737563
MIRT005563	hsa-miR-205-5p	Luciferase reporter assay, qRT-PCR, Western blot	20737563
MIRT006858	hsa-miR-203a-3p	Luciferase reporter assay	22917968
MIRT006858	hsa-miR-203a-3p	Luciferase reporter assay	22917968
MIRT005563	hsa-miR-205-5p	Luciferase reporter assay	23212344
MIRT1064659	hsa-miR-2054	CLIP-seq
MIRT1064660	hsa-miR-3121-3p	CLIP-seq
MIRT1064661	hsa-miR-1224-3p	CLIP-seq
MIRT1064662	hsa-miR-1260	CLIP-seq
MIRT1064663	hsa-miR-1260b	CLIP-seq
MIRT1064664	hsa-miR-1280	CLIP-seq
MIRT1064665	hsa-miR-154	CLIP-seq
MIRT1064666	hsa-miR-3689a-5p	CLIP-seq
MIRT1064667	hsa-miR-3689b	CLIP-seq
MIRT1064668	hsa-miR-3689e	CLIP-seq
MIRT1064669	hsa-miR-3689f	CLIP-seq
MIRT1064670	hsa-miR-4464	CLIP-seq
MIRT1064671	hsa-miR-4733-5p	CLIP-seq
MIRT1064672	hsa-miR-4748	CLIP-seq
MIRT1064673	hsa-miR-490-5p	CLIP-seq
MIRT1064674	hsa-miR-624	CLIP-seq
MIRT2015375	hsa-miR-203	CLIP-seq
MIRT2015376	hsa-miR-425	CLIP-seq
MIRT2015377	hsa-miR-495	CLIP-seq
MIRT2015378	hsa-miR-642b	CLIP-seq
MIRT2389369	hsa-miR-3183	CLIP-seq
MIRT2389370	hsa-miR-324-5p	CLIP-seq
MIRT2389371	hsa-miR-4723-3p	CLIP-seq
MIRT2389372	hsa-miR-642a	CLIP-seq
MIRT2551148	hsa-miR-1185	CLIP-seq
MIRT2551149	hsa-miR-1224-5p	CLIP-seq
MIRT2551150	hsa-miR-1268	CLIP-seq
MIRT2551151	hsa-miR-1268b	CLIP-seq
MIRT2551152	hsa-miR-1293	CLIP-seq
MIRT2551153	hsa-miR-1321	CLIP-seq
MIRT2551154	hsa-miR-1343	CLIP-seq
MIRT2551155	hsa-miR-1825	CLIP-seq
MIRT2551156	hsa-miR-186	CLIP-seq
MIRT2551157	hsa-miR-198	CLIP-seq
MIRT2551158	hsa-miR-199a-5p	CLIP-seq
MIRT2551159	hsa-miR-199b-5p	CLIP-seq
MIRT2015375	hsa-miR-203	CLIP-seq
MIRT1064659	hsa-miR-2054	CLIP-seq
MIRT2551160	hsa-miR-27a	CLIP-seq
MIRT2551161	hsa-miR-27b	CLIP-seq
MIRT2551162	hsa-miR-300	CLIP-seq
MIRT2551163	hsa-miR-3117-5p	CLIP-seq
MIRT1064660	hsa-miR-3121-3p	CLIP-seq
MIRT2551164	hsa-miR-3133	CLIP-seq
MIRT2551165	hsa-miR-3137	CLIP-seq
MIRT2551166	hsa-miR-3153	CLIP-seq
MIRT2551167	hsa-miR-3160-3p	CLIP-seq
MIRT2551168	hsa-miR-3162-5p	CLIP-seq
MIRT2551169	hsa-miR-3173-3p	CLIP-seq
MIRT2551170	hsa-miR-3190	CLIP-seq
MIRT2551171	hsa-miR-3202	CLIP-seq
MIRT2551172	hsa-miR-342-5p	CLIP-seq
MIRT2551173	hsa-miR-3605-5p	CLIP-seq
MIRT2551174	hsa-miR-3616-3p	CLIP-seq
MIRT2551175	hsa-miR-3616-5p	CLIP-seq
MIRT2551176	hsa-miR-3646	CLIP-seq
MIRT2551177	hsa-miR-3647-5p	CLIP-seq
MIRT2551178	hsa-miR-3649	CLIP-seq
MIRT2551179	hsa-miR-3663-5p	CLIP-seq
MIRT2551180	hsa-miR-3679-5p	CLIP-seq
MIRT2551181	hsa-miR-381	CLIP-seq
MIRT2551182	hsa-miR-3915	CLIP-seq
MIRT2551183	hsa-miR-3926	CLIP-seq
MIRT2551184	hsa-miR-412	CLIP-seq
MIRT2015376	hsa-miR-425	CLIP-seq
MIRT2551185	hsa-miR-4305	CLIP-seq
MIRT2551186	hsa-miR-4419a	CLIP-seq
MIRT2551187	hsa-miR-4461	CLIP-seq
MIRT2551188	hsa-miR-4476	CLIP-seq
MIRT2551189	hsa-miR-4483	CLIP-seq
MIRT2551190	hsa-miR-4487	CLIP-seq
MIRT2551191	hsa-miR-4510	CLIP-seq
MIRT2551192	hsa-miR-452	CLIP-seq
MIRT2551193	hsa-miR-4640-5p	CLIP-seq
MIRT2551194	hsa-miR-4651	CLIP-seq
MIRT2551195	hsa-miR-4664-5p	CLIP-seq
MIRT2551196	hsa-miR-4668-5p	CLIP-seq
MIRT2551197	hsa-miR-4676-3p	CLIP-seq
MIRT2551198	hsa-miR-4686	CLIP-seq
MIRT2551199	hsa-miR-4689	CLIP-seq
MIRT2551200	hsa-miR-4699-5p	CLIP-seq
MIRT2551201	hsa-miR-4716-3p	CLIP-seq
MIRT2551202	hsa-miR-4720-3p	CLIP-seq
MIRT2551203	hsa-miR-4723-5p	CLIP-seq
MIRT2551204	hsa-miR-4726-5p	CLIP-seq
MIRT2551205	hsa-miR-4728-5p	CLIP-seq
MIRT2551206	hsa-miR-4739	CLIP-seq
MIRT2551207	hsa-miR-4755-3p	CLIP-seq
MIRT2551208	hsa-miR-4756-5p	CLIP-seq
MIRT2551209	hsa-miR-4779	CLIP-seq
MIRT2551210	hsa-miR-4792	CLIP-seq
MIRT2551211	hsa-miR-4795-5p	CLIP-seq
MIRT2551212	hsa-miR-4804-3p	CLIP-seq
MIRT2015377	hsa-miR-495	CLIP-seq
MIRT2551213	hsa-miR-500a	CLIP-seq
MIRT2551214	hsa-miR-513a-5p	CLIP-seq
MIRT2551215	hsa-miR-514	CLIP-seq
MIRT2551216	hsa-miR-514b-3p	CLIP-seq
MIRT2551217	hsa-miR-520a-5p	CLIP-seq
MIRT2551218	hsa-miR-525-5p	CLIP-seq
MIRT2551219	hsa-miR-548s	CLIP-seq
MIRT2551220	hsa-miR-558	CLIP-seq
MIRT2551221	hsa-miR-573	CLIP-seq
MIRT2551222	hsa-miR-574-5p	CLIP-seq
MIRT2551223	hsa-miR-601	CLIP-seq
MIRT2551224	hsa-miR-608	CLIP-seq
MIRT2551225	hsa-miR-617	CLIP-seq
MIRT2015378	hsa-miR-642b	CLIP-seq
MIRT2551226	hsa-miR-668	CLIP-seq
MIRT2551227	hsa-miR-7	CLIP-seq
MIRT2551228	hsa-miR-711	CLIP-seq
MIRT2551229	hsa-miR-942	CLIP-seq
MIRT2551150	hsa-miR-1268	CLIP-seq
MIRT2551151	hsa-miR-1268b	CLIP-seq
MIRT2551153	hsa-miR-1321	CLIP-seq
MIRT2551154	hsa-miR-1343	CLIP-seq
MIRT2551155	hsa-miR-1825	CLIP-seq
MIRT2551156	hsa-miR-186	CLIP-seq
MIRT2551157	hsa-miR-198	CLIP-seq
MIRT2551158	hsa-miR-199a-5p	CLIP-seq
MIRT2551159	hsa-miR-199b-5p	CLIP-seq
MIRT2015375	hsa-miR-203	CLIP-seq
MIRT1064659	hsa-miR-2054	CLIP-seq
MIRT2551162	hsa-miR-300	CLIP-seq
MIRT2551163	hsa-miR-3117-5p	CLIP-seq
MIRT1064660	hsa-miR-3121-3p	CLIP-seq
MIRT2551164	hsa-miR-3133	CLIP-seq
MIRT2551165	hsa-miR-3137	CLIP-seq
MIRT2551166	hsa-miR-3153	CLIP-seq
MIRT2551167	hsa-miR-3160-3p	CLIP-seq
MIRT2551168	hsa-miR-3162-5p	CLIP-seq
MIRT2551169	hsa-miR-3173-3p	CLIP-seq
MIRT2551170	hsa-miR-3190	CLIP-seq
MIRT2551171	hsa-miR-3202	CLIP-seq
MIRT2551172	hsa-miR-342-5p	CLIP-seq
MIRT2551174	hsa-miR-3616-3p	CLIP-seq
MIRT2551175	hsa-miR-3616-5p	CLIP-seq
MIRT2551177	hsa-miR-3647-5p	CLIP-seq
MIRT2551178	hsa-miR-3649	CLIP-seq
MIRT2551179	hsa-miR-3663-5p	CLIP-seq
MIRT2551181	hsa-miR-381	CLIP-seq
MIRT2551183	hsa-miR-3926	CLIP-seq
MIRT2551184	hsa-miR-412	CLIP-seq
MIRT2015376	hsa-miR-425	CLIP-seq
MIRT2551185	hsa-miR-4305	CLIP-seq
MIRT2551186	hsa-miR-4419a	CLIP-seq
MIRT2551188	hsa-miR-4476	CLIP-seq
MIRT2551190	hsa-miR-4487	CLIP-seq
MIRT2551191	hsa-miR-4510	CLIP-seq
MIRT2551192	hsa-miR-452	CLIP-seq
MIRT2551193	hsa-miR-4640-5p	CLIP-seq
MIRT2551194	hsa-miR-4651	CLIP-seq
MIRT2551195	hsa-miR-4664-5p	CLIP-seq
MIRT2551197	hsa-miR-4676-3p	CLIP-seq
MIRT2551200	hsa-miR-4699-5p	CLIP-seq
MIRT2551201	hsa-miR-4716-3p	CLIP-seq
MIRT2551202	hsa-miR-4720-3p	CLIP-seq
MIRT2551203	hsa-miR-4723-5p	CLIP-seq
MIRT2551204	hsa-miR-4726-5p	CLIP-seq
MIRT2551205	hsa-miR-4728-5p	CLIP-seq
MIRT2551206	hsa-miR-4739	CLIP-seq
MIRT2551207	hsa-miR-4755-3p	CLIP-seq
MIRT2551208	hsa-miR-4756-5p	CLIP-seq
MIRT2551209	hsa-miR-4779	CLIP-seq
MIRT2551210	hsa-miR-4792	CLIP-seq
MIRT2551211	hsa-miR-4795-5p	CLIP-seq
MIRT2551212	hsa-miR-4804-3p	CLIP-seq
MIRT2015377	hsa-miR-495	CLIP-seq
MIRT2551213	hsa-miR-500a	CLIP-seq
MIRT2551215	hsa-miR-514	CLIP-seq
MIRT2551216	hsa-miR-514b-3p	CLIP-seq
MIRT2551219	hsa-miR-548s	CLIP-seq
MIRT2551220	hsa-miR-558	CLIP-seq
MIRT2551221	hsa-miR-573	CLIP-seq
MIRT2551222	hsa-miR-574-5p	CLIP-seq
MIRT2551223	hsa-miR-601	CLIP-seq
MIRT2551224	hsa-miR-608	CLIP-seq
MIRT2551225	hsa-miR-617	CLIP-seq
MIRT2015378	hsa-miR-642b	CLIP-seq
MIRT2551226	hsa-miR-668	CLIP-seq
MIRT2551227	hsa-miR-7	CLIP-seq
MIRT2551228	hsa-miR-711	CLIP-seq
MIRT2551229	hsa-miR-942	CLIP-seq

Transcription factors

Show/Hide all(2)

Transcription factor	Regulation	Reference
CEBPB	Unknown	10942517
JUN	Unknown	21357535

Show/Hide all(14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005125	Function	Cytokine activity	IEA
GO:0005515	Function	Protein binding	IPI	25640309
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0030336	Process	Negative regulation of cell migration	IEA
GO:0042060	Process	Wound healing	IEA
GO:0042501	Process	Serine phosphorylation of STAT protein	IEA
GO:0042531	Process	Positive regulation of tyrosine phosphorylation of STAT protein	IEA
GO:0071222	Process	Cellular response to lipopolysaccharide	IEA
GO:0071353	Process	Cellular response to interleukin-4	IEA

MIM	HGNC	e!Ensembl
604136	11346	ENSG00000162892

Protein

UniProt ID

Q13007

Protein name

Interleukin-24 (IL-24) (Melanoma differentiation-associated gene 7 protein) (MDA-7) (Suppression of tumorigenicity 16 protein)

Protein function

Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed:25168428, PubMed:27687232). Possesses antiviral functions and induces the type I inter

PDB

6DF3 , 6GG1

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Up-regulated in melanoma cells induced to terminally differentiate.

Sequence

MNFQQRLQSLWTLARPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPCQ
VKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKTV
FKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQL
DVEAALTKALGEVDILLTWMQKFYKL

Sequence length

206

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor JAK-STAT signaling pathway		Interleukin-20 family signaling

Show/Hide Causal Diseases (6)

Disease term	Disease name	dbSNP ID	References
Causal
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158 View all (309 more)	16298037, 21671747
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451 View all (71 more)	21671747, 16298037
Lung cancer	Malignant neoplasm of lung	rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135	12830052, 15713900
Marfan syndrome	Mammary Carcinoma, Human	rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465 View all (942 more)	16298037, 21671747
Pancreatic cancer	Malignant neoplasm of pancreas	rs118203998, rs180177143, rs587776417, rs587776527, rs864622498, rs876659571, rs587778587, rs886039619, rs745533713, rs1555460431	15580305
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	14678967, 21671747

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Mental depression	Unipolar Depression, Major Depressive Disorder		19087313	ClinVar

Show/Hide Text Mining Associations (80)

Disease Name	Relationship Type	References
Associations from Text Mining
Arthritis Juvenile	Associate	23094074
Arthritis Rheumatoid	Associate	26968800
Asthma	Associate	19710636
Atherosclerosis	Associate	24552169
Brain Neoplasms	Inhibit	25091574
Breast Neoplasms	Associate	12907143, 15851011, 16710719, 21546925, 28187446, 29749438, 30424508, 36766731
Burkitt Lymphoma	Associate	29415639
Calcinosis	Associate	29330517
Carcinoma Hepatocellular	Associate	16586551, 20872968, 22899557, 26320498, 26361419, 27528029
Carcinoma Hepatocellular	Inhibit	29484443
Carcinoma Non Small Cell Lung	Associate	12409262, 15093181, 27519412, 33562773
Carcinoma Renal Cell	Associate	19417161, 35915803
Carcinoma Squamous Cell	Associate	24270662
Carcinoma Squamous Cell	Inhibit	28461326
Colitis Ulcerative	Stimulate	24527982
Colorectal Neoplasms	Associate	18277093
Coronary Artery Disease	Associate	24552169
Crohn Disease	Stimulate	24527982
Cystic Fibrosis	Associate	19399182
Dermatitis Atopic	Associate	33321923
Diabetes Mellitus Type 2	Associate	24552169
Disease	Associate	27349517, 31973719
Drug Related Side Effects and Adverse Reactions	Associate	16710719, 18941194, 19910452, 20179672, 25452327, 27519412
Drug Related Side Effects and Adverse Reactions	Stimulate	23794295, 25990458, 27349517
Enterocolitis Necrotizing	Associate	36806964
Gingival Diseases	Associate	31743516
Glioblastoma	Associate	20107314, 20179672, 37280571
Glioma	Associate	15197348, 18281515, 23794295
Glioma	Inhibit	20179672, 26168134, 37280571
Glut1 Deficiency Syndrome	Associate	33321923
Hypertension	Associate	24552169
Hypoxia	Associate	37753073
Infections	Associate	20962773, 25404022, 27349517, 31145345
Inflammation	Associate	20072629, 20545760, 26577568, 29703138, 36806964, 40133606
Inflammatory Bowel Diseases	Stimulate	24527982
Leukemia	Associate	20858700
Leukemia Lymphocytic Chronic B Cell	Associate	18941194
Leukemia Lymphoma Adult T Cell	Associate	34334531
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	26097559
Leukemia Myeloid	Associate	20858700
Leukemia Myeloid Acute	Associate	20858700
Leukemia Promyelocytic Acute	Associate	31145345
Liposarcoma Myxoid	Associate	22588557
Lung Neoplasms	Associate	12830052, 12907143, 15006602, 15851011, 26009991, 27602961, 27931220, 29048638
Lung Neoplasms	Inhibit	15093181, 18059175, 25775124
Lymphoma	Associate	34334531
Melanoma	Associate	12114539, 15304100, 15851011, 18511292, 19056673, 20216471, 20383178, 22027907, 23430584, 29048638, 32246006
Melanoma	Inhibit	15564140, 18074024
Mesothelioma Malignant	Associate	20137089
Mitochondrial Diseases	Associate	20179672
Mouth Neoplasms	Associate	23212344
Myotonic Dystrophy	Inhibit	26354610
Mysophobia	Associate	24527982
Necrosis	Associate	19910452
Neoplasms	Associate	11471572, 12114539, 12351624, 15298707, 15564140, 15667561, 16054437, 16646087, 16710719, 17360670, 17551500, 18277093, 18511292, 18599461, 18768668 View all (14 more)
Neoplasms	Inhibit	12606823, 12907143, 15006602, 15093181, 15304100, 15585416, 15585417, 15851011, 16908595, 18074024, 19056673, 19417161, 19734147, 20072629, 20216471 View all (22 more)
Neoplasms Second Primary	Inhibit	25091574
Osteosarcoma	Associate	28942243
Ovarian Neoplasms	Associate	16646087
Ovarian Neoplasms	Inhibit	19910452
Pancreatic Neoplasms	Associate	15851011, 17360670, 25452327, 25990458
Pancreatic Neoplasms	Inhibit	18768668
Periodontitis	Associate	35154475
Prostatic Neoplasms	Associate	20406981, 20737563, 21524313, 21610321
Prostatic Neoplasms	Inhibit	26528857
Psoriasis	Associate	15667561, 20072629, 30301277
Rectal Neoplasms	Associate	21448421
Reperfusion Injury	Associate	40705804
Rhabdomyosarcoma	Associate	31462501
Rhinitis	Associate	26577568
Schizophrenia	Inhibit	39940697
Squamous Cell Carcinoma of Head and Neck	Associate	25091574, 34326893
Squamous Cell Carcinoma of Head and Neck	Stimulate	32623386
Tertiary Lymphoid Structures	Associate	21448421
Tuberculosis	Associate	18199488, 37460564
Tuberculosis Meningeal	Associate	18199488
Tuberculosis Multidrug Resistant	Associate	22899557
Tuberculosis Pulmonary	Associate	37460564
Uterine Cervical Neoplasms	Associate	18299662
Wrist Injuries	Associate	29364468

IL24 (interleukin 24)