Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	11009
Gene name Gene Name - the full gene name approved by the HGNC.	Interleukin 24
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	IL24
Synonyms (NCBI Gene) Gene synonyms aliases	C49A, FISP, IL10B, MDA7, MOB5, ST16
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q32.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of

Show/Hide all(188)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005563	hsa-miR-205-5p	Luciferase reporter assay, qRT-PCR, Western blot	20737563
MIRT005563	hsa-miR-205-5p	Luciferase reporter assay, qRT-PCR, Western blot	20737563
MIRT006858	hsa-miR-203a-3p	Luciferase reporter assay	22917968
MIRT006858	hsa-miR-203a-3p	Luciferase reporter assay	22917968
MIRT005563	hsa-miR-205-5p	Luciferase reporter assay	23212344
MIRT1064659	hsa-miR-2054	CLIP-seq
MIRT1064660	hsa-miR-3121-3p	CLIP-seq
MIRT1064661	hsa-miR-1224-3p	CLIP-seq
MIRT1064662	hsa-miR-1260	CLIP-seq
MIRT1064663	hsa-miR-1260b	CLIP-seq
MIRT1064664	hsa-miR-1280	CLIP-seq
MIRT1064665	hsa-miR-154	CLIP-seq
MIRT1064666	hsa-miR-3689a-5p	CLIP-seq
MIRT1064667	hsa-miR-3689b	CLIP-seq
MIRT1064668	hsa-miR-3689e	CLIP-seq
MIRT1064669	hsa-miR-3689f	CLIP-seq
MIRT1064670	hsa-miR-4464	CLIP-seq
MIRT1064671	hsa-miR-4733-5p	CLIP-seq
MIRT1064672	hsa-miR-4748	CLIP-seq
MIRT1064673	hsa-miR-490-5p	CLIP-seq
MIRT1064674	hsa-miR-624	CLIP-seq
MIRT2015375	hsa-miR-203	CLIP-seq
MIRT2015376	hsa-miR-425	CLIP-seq
MIRT2015377	hsa-miR-495	CLIP-seq
MIRT2015378	hsa-miR-642b	CLIP-seq
MIRT2389369	hsa-miR-3183	CLIP-seq
MIRT2389370	hsa-miR-324-5p	CLIP-seq
MIRT2389371	hsa-miR-4723-3p	CLIP-seq
MIRT2389372	hsa-miR-642a	CLIP-seq
MIRT2551148	hsa-miR-1185	CLIP-seq
MIRT2551149	hsa-miR-1224-5p	CLIP-seq
MIRT2551150	hsa-miR-1268	CLIP-seq
MIRT2551151	hsa-miR-1268b	CLIP-seq
MIRT2551152	hsa-miR-1293	CLIP-seq
MIRT2551153	hsa-miR-1321	CLIP-seq
MIRT2551154	hsa-miR-1343	CLIP-seq
MIRT2551155	hsa-miR-1825	CLIP-seq
MIRT2551156	hsa-miR-186	CLIP-seq
MIRT2551157	hsa-miR-198	CLIP-seq
MIRT2551158	hsa-miR-199a-5p	CLIP-seq
MIRT2551159	hsa-miR-199b-5p	CLIP-seq
MIRT2015375	hsa-miR-203	CLIP-seq
MIRT1064659	hsa-miR-2054	CLIP-seq
MIRT2551160	hsa-miR-27a	CLIP-seq
MIRT2551161	hsa-miR-27b	CLIP-seq
MIRT2551162	hsa-miR-300	CLIP-seq
MIRT2551163	hsa-miR-3117-5p	CLIP-seq
MIRT1064660	hsa-miR-3121-3p	CLIP-seq
MIRT2551164	hsa-miR-3133	CLIP-seq
MIRT2551165	hsa-miR-3137	CLIP-seq
MIRT2551166	hsa-miR-3153	CLIP-seq
MIRT2551167	hsa-miR-3160-3p	CLIP-seq
MIRT2551168	hsa-miR-3162-5p	CLIP-seq
MIRT2551169	hsa-miR-3173-3p	CLIP-seq
MIRT2551170	hsa-miR-3190	CLIP-seq
MIRT2551171	hsa-miR-3202	CLIP-seq
MIRT2551172	hsa-miR-342-5p	CLIP-seq
MIRT2551173	hsa-miR-3605-5p	CLIP-seq
MIRT2551174	hsa-miR-3616-3p	CLIP-seq
MIRT2551175	hsa-miR-3616-5p	CLIP-seq
MIRT2551176	hsa-miR-3646	CLIP-seq
MIRT2551177	hsa-miR-3647-5p	CLIP-seq
MIRT2551178	hsa-miR-3649	CLIP-seq
MIRT2551179	hsa-miR-3663-5p	CLIP-seq
MIRT2551180	hsa-miR-3679-5p	CLIP-seq
MIRT2551181	hsa-miR-381	CLIP-seq
MIRT2551182	hsa-miR-3915	CLIP-seq
MIRT2551183	hsa-miR-3926	CLIP-seq
MIRT2551184	hsa-miR-412	CLIP-seq
MIRT2015376	hsa-miR-425	CLIP-seq
MIRT2551185	hsa-miR-4305	CLIP-seq
MIRT2551186	hsa-miR-4419a	CLIP-seq
MIRT2551187	hsa-miR-4461	CLIP-seq
MIRT2551188	hsa-miR-4476	CLIP-seq
MIRT2551189	hsa-miR-4483	CLIP-seq
MIRT2551190	hsa-miR-4487	CLIP-seq
MIRT2551191	hsa-miR-4510	CLIP-seq
MIRT2551192	hsa-miR-452	CLIP-seq
MIRT2551193	hsa-miR-4640-5p	CLIP-seq
MIRT2551194	hsa-miR-4651	CLIP-seq
MIRT2551195	hsa-miR-4664-5p	CLIP-seq
MIRT2551196	hsa-miR-4668-5p	CLIP-seq
MIRT2551197	hsa-miR-4676-3p	CLIP-seq
MIRT2551198	hsa-miR-4686	CLIP-seq
MIRT2551199	hsa-miR-4689	CLIP-seq
MIRT2551200	hsa-miR-4699-5p	CLIP-seq
MIRT2551201	hsa-miR-4716-3p	CLIP-seq
MIRT2551202	hsa-miR-4720-3p	CLIP-seq
MIRT2551203	hsa-miR-4723-5p	CLIP-seq
MIRT2551204	hsa-miR-4726-5p	CLIP-seq
MIRT2551205	hsa-miR-4728-5p	CLIP-seq
MIRT2551206	hsa-miR-4739	CLIP-seq
MIRT2551207	hsa-miR-4755-3p	CLIP-seq
MIRT2551208	hsa-miR-4756-5p	CLIP-seq
MIRT2551209	hsa-miR-4779	CLIP-seq
MIRT2551210	hsa-miR-4792	CLIP-seq
MIRT2551211	hsa-miR-4795-5p	CLIP-seq
MIRT2551212	hsa-miR-4804-3p	CLIP-seq
MIRT2015377	hsa-miR-495	CLIP-seq
MIRT2551213	hsa-miR-500a	CLIP-seq
MIRT2551214	hsa-miR-513a-5p	CLIP-seq
MIRT2551215	hsa-miR-514	CLIP-seq
MIRT2551216	hsa-miR-514b-3p	CLIP-seq
MIRT2551217	hsa-miR-520a-5p	CLIP-seq
MIRT2551218	hsa-miR-525-5p	CLIP-seq
MIRT2551219	hsa-miR-548s	CLIP-seq
MIRT2551220	hsa-miR-558	CLIP-seq
MIRT2551221	hsa-miR-573	CLIP-seq
MIRT2551222	hsa-miR-574-5p	CLIP-seq
MIRT2551223	hsa-miR-601	CLIP-seq
MIRT2551224	hsa-miR-608	CLIP-seq
MIRT2551225	hsa-miR-617	CLIP-seq
MIRT2015378	hsa-miR-642b	CLIP-seq
MIRT2551226	hsa-miR-668	CLIP-seq
MIRT2551227	hsa-miR-7	CLIP-seq
MIRT2551228	hsa-miR-711	CLIP-seq
MIRT2551229	hsa-miR-942	CLIP-seq
MIRT2551150	hsa-miR-1268	CLIP-seq
MIRT2551151	hsa-miR-1268b	CLIP-seq
MIRT2551153	hsa-miR-1321	CLIP-seq
MIRT2551154	hsa-miR-1343	CLIP-seq
MIRT2551155	hsa-miR-1825	CLIP-seq
MIRT2551156	hsa-miR-186	CLIP-seq
MIRT2551157	hsa-miR-198	CLIP-seq
MIRT2551158	hsa-miR-199a-5p	CLIP-seq
MIRT2551159	hsa-miR-199b-5p	CLIP-seq
MIRT2015375	hsa-miR-203	CLIP-seq
MIRT1064659	hsa-miR-2054	CLIP-seq
MIRT2551162	hsa-miR-300	CLIP-seq
MIRT2551163	hsa-miR-3117-5p	CLIP-seq
MIRT1064660	hsa-miR-3121-3p	CLIP-seq
MIRT2551164	hsa-miR-3133	CLIP-seq
MIRT2551165	hsa-miR-3137	CLIP-seq
MIRT2551166	hsa-miR-3153	CLIP-seq
MIRT2551167	hsa-miR-3160-3p	CLIP-seq
MIRT2551168	hsa-miR-3162-5p	CLIP-seq
MIRT2551169	hsa-miR-3173-3p	CLIP-seq
MIRT2551170	hsa-miR-3190	CLIP-seq
MIRT2551171	hsa-miR-3202	CLIP-seq
MIRT2551172	hsa-miR-342-5p	CLIP-seq
MIRT2551174	hsa-miR-3616-3p	CLIP-seq
MIRT2551175	hsa-miR-3616-5p	CLIP-seq
MIRT2551177	hsa-miR-3647-5p	CLIP-seq
MIRT2551178	hsa-miR-3649	CLIP-seq
MIRT2551179	hsa-miR-3663-5p	CLIP-seq
MIRT2551181	hsa-miR-381	CLIP-seq
MIRT2551183	hsa-miR-3926	CLIP-seq
MIRT2551184	hsa-miR-412	CLIP-seq
MIRT2015376	hsa-miR-425	CLIP-seq
MIRT2551185	hsa-miR-4305	CLIP-seq
MIRT2551186	hsa-miR-4419a	CLIP-seq
MIRT2551188	hsa-miR-4476	CLIP-seq
MIRT2551190	hsa-miR-4487	CLIP-seq
MIRT2551191	hsa-miR-4510	CLIP-seq
MIRT2551192	hsa-miR-452	CLIP-seq
MIRT2551193	hsa-miR-4640-5p	CLIP-seq
MIRT2551194	hsa-miR-4651	CLIP-seq
MIRT2551195	hsa-miR-4664-5p	CLIP-seq
MIRT2551197	hsa-miR-4676-3p	CLIP-seq
MIRT2551200	hsa-miR-4699-5p	CLIP-seq
MIRT2551201	hsa-miR-4716-3p	CLIP-seq
MIRT2551202	hsa-miR-4720-3p	CLIP-seq
MIRT2551203	hsa-miR-4723-5p	CLIP-seq
MIRT2551204	hsa-miR-4726-5p	CLIP-seq
MIRT2551205	hsa-miR-4728-5p	CLIP-seq
MIRT2551206	hsa-miR-4739	CLIP-seq
MIRT2551207	hsa-miR-4755-3p	CLIP-seq
MIRT2551208	hsa-miR-4756-5p	CLIP-seq
MIRT2551209	hsa-miR-4779	CLIP-seq
MIRT2551210	hsa-miR-4792	CLIP-seq
MIRT2551211	hsa-miR-4795-5p	CLIP-seq
MIRT2551212	hsa-miR-4804-3p	CLIP-seq
MIRT2015377	hsa-miR-495	CLIP-seq
MIRT2551213	hsa-miR-500a	CLIP-seq
MIRT2551215	hsa-miR-514	CLIP-seq
MIRT2551216	hsa-miR-514b-3p	CLIP-seq
MIRT2551219	hsa-miR-548s	CLIP-seq
MIRT2551220	hsa-miR-558	CLIP-seq
MIRT2551221	hsa-miR-573	CLIP-seq
MIRT2551222	hsa-miR-574-5p	CLIP-seq
MIRT2551223	hsa-miR-601	CLIP-seq
MIRT2551224	hsa-miR-608	CLIP-seq
MIRT2551225	hsa-miR-617	CLIP-seq
MIRT2015378	hsa-miR-642b	CLIP-seq
MIRT2551226	hsa-miR-668	CLIP-seq
MIRT2551227	hsa-miR-7	CLIP-seq
MIRT2551228	hsa-miR-711	CLIP-seq
MIRT2551229	hsa-miR-942	CLIP-seq

Transcription factors

Show/Hide all(2)

Transcription factor	Regulation	Reference
CEBPB	Unknown	10942517
JUN	Unknown	21357535

Show/Hide all(16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005125	Function	Cytokine activity	IBA
GO:0005125	Function	Cytokine activity	IEA
GO:0005515	Function	Protein binding	IPI	25640309
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0006915	Process	Apoptotic process	TAS	9826712
GO:0006955	Process	Immune response	IBA
GO:0007165	Process	Signal transduction	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IEA
GO:0030336	Process	Negative regulation of cell migration	IEA
GO:0071222	Process	Cellular response to lipopolysaccharide	IEA
GO:0071353	Process	Cellular response to interleukin-4	IEA

MIM	HGNC	e!Ensembl
604136	11346	ENSG00000162892

Protein

UniProt ID

Q13007

Protein name

Interleukin-24 (IL-24) (Melanoma differentiation-associated gene 7 protein) (MDA-7) (Suppression of tumorigenicity 16 protein)

Protein function

Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed:25168428, PubMed:27687232). Possesses antiviral functions and induces the type I inter

PDB

6DF3 , 6GG1

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Up-regulated in melanoma cells induced to terminally differentiate.

Sequence

MNFQQRLQSLWTLARPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPCQ
VKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKTV
FKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQL
DVEAALTKALGEVDILLTWMQKFYKL

Sequence length

206

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor JAK-STAT signaling pathway		Interleukin-20 family signaling

IL24 (interleukin 24)