IL24 (interleukin 24)

Gene

• Entrez ID: 11009
• Gene name: Interleukin 24
• Gene symbol: IL24
• Synonyms (NCBI Gene): C49A, FISP, IL10B, MDA7, MOB5, ST16
• Chromosome: 1
• Chromosome location: 1q32.1
• Summary: This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT005563	hsa-miR-205-5p	Luciferase reporter assay, qRT-PCR, Western blot	20737563
MIRT005563	hsa-miR-205-5p	Luciferase reporter assay, qRT-PCR, Western blot	20737563
MIRT006858	hsa-miR-203a-3p	Luciferase reporter assay	22917968
MIRT006858	hsa-miR-203a-3p	Luciferase reporter assay	22917968
MIRT005563	hsa-miR-205-5p	Luciferase reporter assay	23212344
MIRT1064659	hsa-miR-2054	CLIP-seq
MIRT1064660	hsa-miR-3121-3p	CLIP-seq
MIRT1064661	hsa-miR-1224-3p	CLIP-seq
MIRT1064662	hsa-miR-1260	CLIP-seq
MIRT1064663	hsa-miR-1260b	CLIP-seq
MIRT1064664	hsa-miR-1280	CLIP-seq
MIRT1064665	hsa-miR-154	CLIP-seq
MIRT1064666	hsa-miR-3689a-5p	CLIP-seq
MIRT1064667	hsa-miR-3689b	CLIP-seq
MIRT1064668	hsa-miR-3689e	CLIP-seq
MIRT1064669	hsa-miR-3689f	CLIP-seq
MIRT1064670	hsa-miR-4464	CLIP-seq
MIRT1064671	hsa-miR-4733-5p	CLIP-seq
MIRT1064672	hsa-miR-4748	CLIP-seq
MIRT1064673	hsa-miR-490-5p	CLIP-seq
MIRT1064674	hsa-miR-624	CLIP-seq
MIRT2015375	hsa-miR-203	CLIP-seq
MIRT2015376	hsa-miR-425	CLIP-seq
MIRT2015377	hsa-miR-495	CLIP-seq
MIRT2015378	hsa-miR-642b	CLIP-seq
MIRT2389369	hsa-miR-3183	CLIP-seq
MIRT2389370	hsa-miR-324-5p	CLIP-seq
MIRT2389371	hsa-miR-4723-3p	CLIP-seq
MIRT2389372	hsa-miR-642a	CLIP-seq
MIRT2551148	hsa-miR-1185	CLIP-seq
MIRT2551149	hsa-miR-1224-5p	CLIP-seq
MIRT2551150	hsa-miR-1268	CLIP-seq
MIRT2551151	hsa-miR-1268b	CLIP-seq
MIRT2551152	hsa-miR-1293	CLIP-seq
MIRT2551153	hsa-miR-1321	CLIP-seq
MIRT2551154	hsa-miR-1343	CLIP-seq
MIRT2551155	hsa-miR-1825	CLIP-seq
MIRT2551156	hsa-miR-186	CLIP-seq
MIRT2551157	hsa-miR-198	CLIP-seq
MIRT2551158	hsa-miR-199a-5p	CLIP-seq
MIRT2551159	hsa-miR-199b-5p	CLIP-seq
MIRT2015375	hsa-miR-203	CLIP-seq
MIRT1064659	hsa-miR-2054	CLIP-seq
MIRT2551160	hsa-miR-27a	CLIP-seq
MIRT2551161	hsa-miR-27b	CLIP-seq
MIRT2551162	hsa-miR-300	CLIP-seq
MIRT2551163	hsa-miR-3117-5p	CLIP-seq
MIRT1064660	hsa-miR-3121-3p	CLIP-seq
MIRT2551164	hsa-miR-3133	CLIP-seq
MIRT2551165	hsa-miR-3137	CLIP-seq
MIRT2551166	hsa-miR-3153	CLIP-seq
MIRT2551167	hsa-miR-3160-3p	CLIP-seq
MIRT2551168	hsa-miR-3162-5p	CLIP-seq
MIRT2551169	hsa-miR-3173-3p	CLIP-seq
MIRT2551170	hsa-miR-3190	CLIP-seq
MIRT2551171	hsa-miR-3202	CLIP-seq
MIRT2551172	hsa-miR-342-5p	CLIP-seq
MIRT2551173	hsa-miR-3605-5p	CLIP-seq
MIRT2551174	hsa-miR-3616-3p	CLIP-seq
MIRT2551175	hsa-miR-3616-5p	CLIP-seq
MIRT2551176	hsa-miR-3646	CLIP-seq
MIRT2551177	hsa-miR-3647-5p	CLIP-seq
MIRT2551178	hsa-miR-3649	CLIP-seq
MIRT2551179	hsa-miR-3663-5p	CLIP-seq
MIRT2551180	hsa-miR-3679-5p	CLIP-seq
MIRT2551181	hsa-miR-381	CLIP-seq
MIRT2551182	hsa-miR-3915	CLIP-seq
MIRT2551183	hsa-miR-3926	CLIP-seq
MIRT2551184	hsa-miR-412	CLIP-seq
MIRT2015376	hsa-miR-425	CLIP-seq
MIRT2551185	hsa-miR-4305	CLIP-seq
MIRT2551186	hsa-miR-4419a	CLIP-seq
MIRT2551187	hsa-miR-4461	CLIP-seq
MIRT2551188	hsa-miR-4476	CLIP-seq
MIRT2551189	hsa-miR-4483	CLIP-seq
MIRT2551190	hsa-miR-4487	CLIP-seq
MIRT2551191	hsa-miR-4510	CLIP-seq
MIRT2551192	hsa-miR-452	CLIP-seq
MIRT2551193	hsa-miR-4640-5p	CLIP-seq
MIRT2551194	hsa-miR-4651	CLIP-seq
MIRT2551195	hsa-miR-4664-5p	CLIP-seq
MIRT2551196	hsa-miR-4668-5p	CLIP-seq
MIRT2551197	hsa-miR-4676-3p	CLIP-seq
MIRT2551198	hsa-miR-4686	CLIP-seq
MIRT2551199	hsa-miR-4689	CLIP-seq
MIRT2551200	hsa-miR-4699-5p	CLIP-seq
MIRT2551201	hsa-miR-4716-3p	CLIP-seq
MIRT2551202	hsa-miR-4720-3p	CLIP-seq
MIRT2551203	hsa-miR-4723-5p	CLIP-seq
MIRT2551204	hsa-miR-4726-5p	CLIP-seq
MIRT2551205	hsa-miR-4728-5p	CLIP-seq
MIRT2551206	hsa-miR-4739	CLIP-seq
MIRT2551207	hsa-miR-4755-3p	CLIP-seq
MIRT2551208	hsa-miR-4756-5p	CLIP-seq
MIRT2551209	hsa-miR-4779	CLIP-seq
MIRT2551210	hsa-miR-4792	CLIP-seq
MIRT2551211	hsa-miR-4795-5p	CLIP-seq
MIRT2551212	hsa-miR-4804-3p	CLIP-seq
MIRT2015377	hsa-miR-495	CLIP-seq
MIRT2551213	hsa-miR-500a	CLIP-seq
MIRT2551214	hsa-miR-513a-5p	CLIP-seq
MIRT2551215	hsa-miR-514	CLIP-seq
MIRT2551216	hsa-miR-514b-3p	CLIP-seq
MIRT2551217	hsa-miR-520a-5p	CLIP-seq
MIRT2551218	hsa-miR-525-5p	CLIP-seq
MIRT2551219	hsa-miR-548s	CLIP-seq
MIRT2551220	hsa-miR-558	CLIP-seq
MIRT2551221	hsa-miR-573	CLIP-seq
MIRT2551222	hsa-miR-574-5p	CLIP-seq
MIRT2551223	hsa-miR-601	CLIP-seq
MIRT2551224	hsa-miR-608	CLIP-seq
MIRT2551225	hsa-miR-617	CLIP-seq
MIRT2015378	hsa-miR-642b	CLIP-seq
MIRT2551226	hsa-miR-668	CLIP-seq
MIRT2551227	hsa-miR-7	CLIP-seq
MIRT2551228	hsa-miR-711	CLIP-seq
MIRT2551229	hsa-miR-942	CLIP-seq
MIRT2551150	hsa-miR-1268	CLIP-seq
MIRT2551151	hsa-miR-1268b	CLIP-seq
MIRT2551153	hsa-miR-1321	CLIP-seq
MIRT2551154	hsa-miR-1343	CLIP-seq
MIRT2551155	hsa-miR-1825	CLIP-seq
MIRT2551156	hsa-miR-186	CLIP-seq
MIRT2551157	hsa-miR-198	CLIP-seq
MIRT2551158	hsa-miR-199a-5p	CLIP-seq
MIRT2551159	hsa-miR-199b-5p	CLIP-seq
MIRT2015375	hsa-miR-203	CLIP-seq
MIRT1064659	hsa-miR-2054	CLIP-seq
MIRT2551162	hsa-miR-300	CLIP-seq
MIRT2551163	hsa-miR-3117-5p	CLIP-seq
MIRT1064660	hsa-miR-3121-3p	CLIP-seq
MIRT2551164	hsa-miR-3133	CLIP-seq
MIRT2551165	hsa-miR-3137	CLIP-seq
MIRT2551166	hsa-miR-3153	CLIP-seq
MIRT2551167	hsa-miR-3160-3p	CLIP-seq
MIRT2551168	hsa-miR-3162-5p	CLIP-seq
MIRT2551169	hsa-miR-3173-3p	CLIP-seq
MIRT2551170	hsa-miR-3190	CLIP-seq
MIRT2551171	hsa-miR-3202	CLIP-seq
MIRT2551172	hsa-miR-342-5p	CLIP-seq
MIRT2551174	hsa-miR-3616-3p	CLIP-seq
MIRT2551175	hsa-miR-3616-5p	CLIP-seq
MIRT2551177	hsa-miR-3647-5p	CLIP-seq
MIRT2551178	hsa-miR-3649	CLIP-seq
MIRT2551179	hsa-miR-3663-5p	CLIP-seq
MIRT2551181	hsa-miR-381	CLIP-seq
MIRT2551183	hsa-miR-3926	CLIP-seq
MIRT2551184	hsa-miR-412	CLIP-seq
MIRT2015376	hsa-miR-425	CLIP-seq
MIRT2551185	hsa-miR-4305	CLIP-seq
MIRT2551186	hsa-miR-4419a	CLIP-seq
MIRT2551188	hsa-miR-4476	CLIP-seq
MIRT2551190	hsa-miR-4487	CLIP-seq
MIRT2551191	hsa-miR-4510	CLIP-seq
MIRT2551192	hsa-miR-452	CLIP-seq
MIRT2551193	hsa-miR-4640-5p	CLIP-seq
MIRT2551194	hsa-miR-4651	CLIP-seq
MIRT2551195	hsa-miR-4664-5p	CLIP-seq
MIRT2551197	hsa-miR-4676-3p	CLIP-seq
MIRT2551200	hsa-miR-4699-5p	CLIP-seq
MIRT2551201	hsa-miR-4716-3p	CLIP-seq
MIRT2551202	hsa-miR-4720-3p	CLIP-seq
MIRT2551203	hsa-miR-4723-5p	CLIP-seq
MIRT2551204	hsa-miR-4726-5p	CLIP-seq
MIRT2551205	hsa-miR-4728-5p	CLIP-seq
MIRT2551206	hsa-miR-4739	CLIP-seq
MIRT2551207	hsa-miR-4755-3p	CLIP-seq
MIRT2551208	hsa-miR-4756-5p	CLIP-seq
MIRT2551209	hsa-miR-4779	CLIP-seq
MIRT2551210	hsa-miR-4792	CLIP-seq
MIRT2551211	hsa-miR-4795-5p	CLIP-seq
MIRT2551212	hsa-miR-4804-3p	CLIP-seq
MIRT2015377	hsa-miR-495	CLIP-seq
MIRT2551213	hsa-miR-500a	CLIP-seq
MIRT2551215	hsa-miR-514	CLIP-seq
MIRT2551216	hsa-miR-514b-3p	CLIP-seq
MIRT2551219	hsa-miR-548s	CLIP-seq
MIRT2551220	hsa-miR-558	CLIP-seq
MIRT2551221	hsa-miR-573	CLIP-seq
MIRT2551222	hsa-miR-574-5p	CLIP-seq
MIRT2551223	hsa-miR-601	CLIP-seq
MIRT2551224	hsa-miR-608	CLIP-seq
MIRT2551225	hsa-miR-617	CLIP-seq
MIRT2015378	hsa-miR-642b	CLIP-seq
MIRT2551226	hsa-miR-668	CLIP-seq
MIRT2551227	hsa-miR-7	CLIP-seq
MIRT2551228	hsa-miR-711	CLIP-seq
MIRT2551229	hsa-miR-942	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CEBPB	Unknown	10942517
JUN	Unknown	21357535

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005125	Function	Cytokine activity	IBA
GO:0005125	Function	Cytokine activity	IEA
GO:0005515	Function	Protein binding	IPI	25640309
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0006915	Process	Apoptotic process	TAS	9826712
GO:0006955	Process	Immune response	IBA
GO:0007165	Process	Signal transduction	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IEA
GO:0030336	Process	Negative regulation of cell migration	IEA
GO:0071222	Process	Cellular response to lipopolysaccharide	IEA
GO:0071353	Process	Cellular response to interleukin-4	IEA

Other IDs

• MIM: 604136
• HGNC: 11346
• e!Ensembl: ENSG00000162892

Protein

• UniProt ID: Q13007
• Protein name: Interleukin-24 (IL-24) (Melanoma differentiation-associated gene 7 protein) (MDA-7) (Suppression of tumorigenicity 16 protein)
• Protein function: Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed:25168428, PubMed:27687232). Possesses antiviral functions and induces the type I inter
• PDB: 6DF3, 6GG1
• Tissue specificity: TISSUE SPECIFICITY: Up-regulated in melanoma cells induced to terminally differentiate.
• Sequence:

  MNFQQRLQSLWTLARPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPCQ
  VKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKTV
  FKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQL
  DVEAALTKALGEVDILLTWMQKFYKL

• Sequence length: 206

Pathways

KEGG:

Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
JAK-STAT signaling pathway

Reactome:

Interleukin-20 family signaling