Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10991
Gene name Gene Name - the full gene name approved by the HGNC.	Solute carrier family 38 member 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SLC38A3
Synonyms (NCBI Gene) Gene synonyms aliases	DEE102, G17, NAT1, SN1, SNAT3
Disease Acronyms (UniProt) Disease acronyms from UniProt database	DEE102
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3p21.31

Show/Hide all(21)

miRTarBase ID	miRNA	Experiments
MIRT1363005	hsa-miR-143	CLIP-seq
MIRT1363006	hsa-miR-1915	CLIP-seq
MIRT1363007	hsa-miR-4685-5p	CLIP-seq
MIRT1363008	hsa-miR-4770	CLIP-seq
MIRT2107651	hsa-miR-1275	CLIP-seq
MIRT1363005	hsa-miR-143	CLIP-seq
MIRT2107652	hsa-miR-3175	CLIP-seq
MIRT2107653	hsa-miR-4525	CLIP-seq
MIRT2107654	hsa-miR-4656	CLIP-seq
MIRT2107655	hsa-miR-4665-5p	CLIP-seq
MIRT2107656	hsa-miR-4723-5p	CLIP-seq
MIRT2107657	hsa-miR-4731-5p	CLIP-seq
MIRT1363008	hsa-miR-4770	CLIP-seq
MIRT2107658	hsa-miR-625	CLIP-seq
MIRT2107659	hsa-miR-637	CLIP-seq
MIRT2331487	hsa-miR-214	CLIP-seq
MIRT2331488	hsa-miR-3619-5p	CLIP-seq
MIRT2331489	hsa-miR-4291	CLIP-seq
MIRT2331490	hsa-miR-4758-3p	CLIP-seq
MIRT2331491	hsa-miR-761	CLIP-seq
MIRT2331492	hsa-miR-922	CLIP-seq

Show/Hide all(34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003333	Process	Amino acid transmembrane transport	IBA	21873635
GO:0005290	Function	L-histidine transmembrane transporter activity	IBA	21873635
GO:0005290	Function	L-histidine transmembrane transporter activity	IDA	10823827
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005887	Component	Integral component of plasma membrane	ISS
GO:0006814	Process	Sodium ion transport	IEA
GO:0006865	Process	Amino acid transport	TAS
GO:0006867	Process	Asparagine transport	IBA	21873635
GO:0006867	Process	Asparagine transport	IDA	10823827
GO:0006868	Process	Glutamine transport	IBA	21873635
GO:0006868	Process	Glutamine transport	IDA	10823827
GO:0007420	Process	Brain development	IEA
GO:0007565	Process	Female pregnancy	IEA
GO:0015171	Function	Amino acid transmembrane transporter activity	IBA	21873635
GO:0015171	Function	Amino acid transmembrane transporter activity	TAS
GO:0015180	Function	L-alanine transmembrane transporter activity	IDA	10823827
GO:0015182	Function	L-asparagine transmembrane transporter activity	IBA	21873635
GO:0015182	Function	L-asparagine transmembrane transporter activity	IDA	10823827
GO:0015186	Function	L-glutamine transmembrane transporter activity	IBA	21873635
GO:0015186	Function	L-glutamine transmembrane transporter activity	IDA	10823827
GO:0015293	Function	Symporter activity	IEA
GO:0015297	Function	Antiporter activity	IEA
GO:0015808	Process	L-alanine transport	IDA	10823827
GO:0015817	Process	Histidine transport	IBA	21873635
GO:0015817	Process	Histidine transport	IDA	10823827
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016324	Component	Apical plasma membrane	ISS
GO:0051365	Process	Cellular response to potassium ion starvation	IEA
GO:0061402	Process	Positive regulation of transcription from RNA polymerase II promoter in response to acidic pH	IEA
GO:0089709	Process	L-histidine transmembrane transport	IEA
GO:0150104	Process	Transport across blood-brain barrier	NAS	26590417, 30280653
GO:2000487	Process	Positive regulation of glutamine transport	IEA

MIM	HGNC	e!Ensembl
604437	18044	ENSG00000188338

Protein

UniProt ID

Q99624

Protein name

Sodium-coupled neutral amino acid transporter 3 (N-system amino acid transporter 1) (Na(+)-coupled neutral amino acid transporter 3) (Solute carrier family 38 member 3) (System N amino acid transporter 1)

Protein function

Symporter that cotransports specific neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:10823827). Mainly participates in the glutamate-GABA-glutamine cycle in brain where it transports L-glutamine from astrocyte

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01490	Aa_trans	64 → 491	Transmembrane amino acid transporter protein	Family

Sequence

MEAPLQTEMVELVPNGKHSEGLLPVITPMAGNQRVEDPARSCMEGKSFLQKSPSKEPHFT
DFEGKTSFGMSVFNLSNAIMGSGILGLAYAMANTGIILFLFLLTAVALLSSYSIHLLLKS
SGVVGIRAYEQLGYRAFGTPGKLAAALAITLQNIGAMSSYLYIIKSELPLVIQTFLNLEE
KTSDWYMNGNYLVILVSVTIILPLALMRQLGYLGYSSGFSLSCMVFFLIAVIYKKFHVPC
PLPPNFNNTTGNFSHVEIVKEKVQLQVEPEASAFCTPSYFTLNSQTAYTIPIMAFAFVCH
PEVLPIYTELKDPSKKKMQHISNLSIAVMYIMYFLAALFGYLTFYNGVESELLHTYSKVD
PFDVLILCVRVAVLTAVTLTVPIVLFPVRRAIQQMLFPNQEFSWLRHVLIAVGLLTCINL
LVIFAPNILGIFGVIGATSAPFLIFIFPAIFYFRIMPTEKEPARSTPKILALCFAMLGFL
LMTMSLSFIIIDWASGTSRHGGNH

Sequence length

504

Interactions

View interactions

	KEGG		Reactome
	Glutamatergic synapse GABAergic synapse Proximal tubule bicarbonate reclamation		Amino acid transport across the plasma membrane

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Conotruncal heart defect	CONOTRUNCAL HEART MALFORMATIONS (disorder)	rs267606914, rs587777422	28468790

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Source
Unknown
Epileptic encephalopathy	developmental and epileptic encephalopathy 102	GenCC
Schizophrenia	Schizophrenia	GWAS

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References
Associations from Text Mining
Brain Diseases	Associate	34605855
Carcinoma Hepatocellular	Associate	12381519
Diabetes Mellitus Type 2	Associate	36364703
Diabetic Angiopathies	Associate	36364703
Diabetic Retinopathy	Associate	36364703
Epilepsy	Associate	34605855
Epileptic Encephalopathy Early Infantile 3	Associate	34605855
Intellectual Disability	Associate	34605855
Neoplasms	Inhibit	23811327, 25804888
Renal Insufficiency Chronic	Associate	36364703
Schizophrenia	Associate	30285260
Speech Disorders	Associate	34605855
Vision Disorders	Associate	34605855

SLC38A3 (solute carrier family 38 member 3)