LILRB5 (leukocyte immunoglobulin like receptor B5)

Gene

• Entrez ID: 10990
• Gene name: Leukocyte immunoglobulin like receptor B5
• Gene symbol: LILRB5
• Synonyms (NCBI Gene): CD85C, LIR-8, LIR8
• Chromosome: 19
• Chromosome location: 19q13.42
• Summary: This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017799	hsa-miR-335-5p	Microarray	18185580
MIRT021930	hsa-miR-128-3p	Microarray	17612493
MIRT1109384	hsa-miR-1237	CLIP-seq
MIRT1109385	hsa-miR-1248	CLIP-seq
MIRT1109386	hsa-miR-1267	CLIP-seq
MIRT1109387	hsa-miR-1289	CLIP-seq
MIRT1109388	hsa-miR-3182	CLIP-seq
MIRT1109389	hsa-miR-3198	CLIP-seq
MIRT1109390	hsa-miR-3921	CLIP-seq
MIRT1109391	hsa-miR-4294	CLIP-seq
MIRT1109392	hsa-miR-4309	CLIP-seq
MIRT1109393	hsa-miR-4652-3p	CLIP-seq
MIRT1109394	hsa-miR-4653-5p	CLIP-seq
MIRT1109395	hsa-miR-4682	CLIP-seq
MIRT1109396	hsa-miR-593	CLIP-seq
MIRT1109397	hsa-miR-627	CLIP-seq
MIRT1109398	hsa-miR-924	CLIP-seq
MIRT1109384	hsa-miR-1237	CLIP-seq
MIRT1109387	hsa-miR-1289	CLIP-seq
MIRT2261127	hsa-miR-1299	CLIP-seq
MIRT1109389	hsa-miR-3198	CLIP-seq
MIRT1109390	hsa-miR-3921	CLIP-seq
MIRT1109391	hsa-miR-4294	CLIP-seq
MIRT2261128	hsa-miR-4297	CLIP-seq
MIRT1109392	hsa-miR-4309	CLIP-seq
MIRT1109394	hsa-miR-4653-5p	CLIP-seq
MIRT1109395	hsa-miR-4682	CLIP-seq
MIRT2261129	hsa-miR-4782-5p	CLIP-seq
MIRT2261130	hsa-miR-516b	CLIP-seq
MIRT2261131	hsa-miR-550a	CLIP-seq
MIRT1109396	hsa-miR-593	CLIP-seq
MIRT1109397	hsa-miR-627	CLIP-seq
MIRT1109398	hsa-miR-924	CLIP-seq
MIRT1109384	hsa-miR-1237	CLIP-seq
MIRT2561107	hsa-miR-1914	CLIP-seq
MIRT2261128	hsa-miR-4297	CLIP-seq
MIRT2561108	hsa-miR-4488	CLIP-seq
MIRT2561109	hsa-miR-4660	CLIP-seq
MIRT2561110	hsa-miR-4697-5p	CLIP-seq
MIRT2561111	hsa-miR-486-3p	CLIP-seq
MIRT2261131	hsa-miR-550a	CLIP-seq
MIRT2561112	hsa-miR-637	CLIP-seq
MIRT1109384	hsa-miR-1237	CLIP-seq
MIRT2561107	hsa-miR-1914	CLIP-seq
MIRT2261128	hsa-miR-4297	CLIP-seq
MIRT2561108	hsa-miR-4488	CLIP-seq
MIRT2561109	hsa-miR-4660	CLIP-seq
MIRT2561110	hsa-miR-4697-5p	CLIP-seq
MIRT2561111	hsa-miR-486-3p	CLIP-seq
MIRT2261131	hsa-miR-550a	CLIP-seq
MIRT2561112	hsa-miR-637	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002250	Process	Adaptive immune response	IEA
GO:0002376	Process	Immune system process	IEA
GO:0002764	Process	Immune response-regulating signaling pathway	IBA
GO:0004888	Function	Transmembrane signaling receptor activity	TAS	9548455
GO:0005886	Component	Plasma membrane	IBA
GO:0006952	Process	Defense response	TAS	9548455
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	9548455
GO:0016020	Component	Membrane	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	IBA
GO:0032396	Function	Inhibitory MHC class I receptor activity	IBA

Other IDs

• MIM: 604814
• HGNC: 6609
• e!Ensembl: ENSG00000105609

Protein

• UniProt ID: O75023
• Protein name: Leukocyte immunoglobulin-like receptor subfamily B member 5 (CD85 antigen-like family member C) (Leukocyte immunoglobulin-like receptor 8) (LIR-8) (CD antigen CD85c)
• Protein function: May act as receptor for class I MHC antigens.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13895	Ig_2	28 → 117	Immunoglobulin domain	Domain
  PF00047	ig	227 → 306	Immunoglobulin domain	Domain
  PF00047	ig	327 → 409	Immunoglobulin domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Detected in a natural killer (NK) cells. {ECO:0000269|PubMed:9548455}.
• Sequence:

  MTLTLSVLICLGLSVGPRTCVQAGTLPKPTLWAEPASVIARGKPVTLWCQGPLETEEYRL
  DKEGLPWARKRQNPLEPGAKAKFHIPSTVYDSAGRYRCYYETPAGWSEPSDPLELVATGF
  YAEPTLLALPSPVVASGGNVTLQCDTLDGLLTFVLVEEEQKLPRTLYSQKLPKGPSQALF
  PVGPVTPSCRWRFRCYYYYRKNPQVWSNPSDLLEILVPGVSRKPSLLIPQGSVVARGGSL
  TLQCRSDVGYDIFVLYKEGEHDLVQGSGQQPQAGLSQANFTLGPVSRSHGGQYRCYGAHN
  LSPRWSAPSDPLDILIAGLIPDIPALSVQPGPKVASGENVTLLCQSWHQIDTFFLTKEGA
  AHPPLCLKSKYQSYRHQAEFSMSPVTSAQGGTYRCYSAIRSYPYLLSSPSYPQELVVSGP
  SGDPSLSPTGSTPTPGPEDQPLTPTGLDPQSGLGRHLGVVTGVSVAFVLLLFLLLFLLLR
  HRHQSKHRTSAHFYRPAGAAGPEPKDQGLQKRASPVADIQEEILNAAVKDTQPKDGVEMD
  ARAAASEAPQDVTYAQLHSLTLRREATEPPPSQEREPPAEPSIYAPLAIH

• Sequence length: 590

Pathways

KEGG:

Osteoclast differentiation
B cell receptor signaling pathway

Reactome:

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell