Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	10989
Gene name	Inner membrane mitochondrial protein
Gene symbol	IMMT
Synonyms (NCBI Gene)	HMPMICOS60MINOS2Mic60P87P87/89P89PIG4PIG52
Chromosome	2
Chromosome location	2p11.2\|2

155

Show/Hide all (155)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025510	hsa-miR-34a-5p	Proteomics	21566225
MIRT025510	hsa-miR-34a-5p	Proteomics	21566225
MIRT050824	hsa-miR-17-5p	CLASH	23622248
MIRT040039	hsa-miR-615-3p	CLASH	23622248
MIRT039513	hsa-miR-652-3p	CLASH	23622248
MIRT1065614	hsa-miR-186	CLIP-seq
MIRT1065615	hsa-miR-199a-3p	CLIP-seq
MIRT1065616	hsa-miR-199b-3p	CLIP-seq
MIRT1065617	hsa-miR-205	CLIP-seq
MIRT1065618	hsa-miR-3121-5p	CLIP-seq
MIRT1065619	hsa-miR-3129-5p	CLIP-seq
MIRT1065620	hsa-miR-34c-3p	CLIP-seq
MIRT1065621	hsa-miR-3616-3p	CLIP-seq
MIRT1065622	hsa-miR-3688-3p	CLIP-seq
MIRT1065623	hsa-miR-3978	CLIP-seq
MIRT1065624	hsa-miR-411	CLIP-seq
MIRT1065625	hsa-miR-421	CLIP-seq
MIRT1065626	hsa-miR-4305	CLIP-seq
MIRT1065627	hsa-miR-4328	CLIP-seq
MIRT1065628	hsa-miR-4457	CLIP-seq
MIRT1065629	hsa-miR-4497	CLIP-seq
MIRT1065630	hsa-miR-4694-3p	CLIP-seq
MIRT1065631	hsa-miR-4709-5p	CLIP-seq
MIRT1065632	hsa-miR-4719	CLIP-seq
MIRT1065633	hsa-miR-4757-5p	CLIP-seq
MIRT1065634	hsa-miR-4777-5p	CLIP-seq
MIRT1065635	hsa-miR-509-3p	CLIP-seq
MIRT1065636	hsa-miR-513b	CLIP-seq
MIRT1065637	hsa-miR-518d-5p	CLIP-seq
MIRT1065638	hsa-miR-519b-5p	CLIP-seq
MIRT1065639	hsa-miR-519c-5p	CLIP-seq
MIRT1065640	hsa-miR-520c-5p	CLIP-seq
MIRT1065641	hsa-miR-526a	CLIP-seq
MIRT1065642	hsa-miR-548p	CLIP-seq
MIRT1065643	hsa-miR-639	CLIP-seq
MIRT1065644	hsa-miR-720	CLIP-seq
MIRT1065615	hsa-miR-199a-3p	CLIP-seq
MIRT1065616	hsa-miR-199b-3p	CLIP-seq
MIRT1065619	hsa-miR-3129-5p	CLIP-seq
MIRT1065621	hsa-miR-3616-3p	CLIP-seq
MIRT2015600	hsa-miR-3941	CLIP-seq
MIRT1065624	hsa-miR-411	CLIP-seq
MIRT1065625	hsa-miR-421	CLIP-seq
MIRT1065627	hsa-miR-4328	CLIP-seq
MIRT2015601	hsa-miR-466	CLIP-seq
MIRT2015602	hsa-miR-4672	CLIP-seq
MIRT2015603	hsa-miR-4684-3p	CLIP-seq
MIRT1065631	hsa-miR-4709-5p	CLIP-seq
MIRT2015604	hsa-miR-4731-3p	CLIP-seq
MIRT2015605	hsa-miR-4801	CLIP-seq
MIRT2015606	hsa-miR-518a-5p	CLIP-seq
MIRT2015607	hsa-miR-527	CLIP-seq
MIRT1065644	hsa-miR-720	CLIP-seq
MIRT2247951	hsa-miR-101	CLIP-seq
MIRT1065615	hsa-miR-199a-3p	CLIP-seq
MIRT1065616	hsa-miR-199b-3p	CLIP-seq
MIRT1065617	hsa-miR-205	CLIP-seq
MIRT2247952	hsa-miR-30a	CLIP-seq
MIRT2247953	hsa-miR-30b	CLIP-seq
MIRT2247954	hsa-miR-30c	CLIP-seq
MIRT2247955	hsa-miR-30d	CLIP-seq
MIRT2247956	hsa-miR-30e	CLIP-seq
MIRT1065619	hsa-miR-3129-5p	CLIP-seq
MIRT1065621	hsa-miR-3616-3p	CLIP-seq
MIRT1065624	hsa-miR-411	CLIP-seq
MIRT1065625	hsa-miR-421	CLIP-seq
MIRT1065626	hsa-miR-4305	CLIP-seq
MIRT1065627	hsa-miR-4328	CLIP-seq
MIRT1065629	hsa-miR-4497	CLIP-seq
MIRT1065631	hsa-miR-4709-5p	CLIP-seq
MIRT1065634	hsa-miR-4777-5p	CLIP-seq
MIRT1065637	hsa-miR-518d-5p	CLIP-seq
MIRT1065638	hsa-miR-519b-5p	CLIP-seq
MIRT1065639	hsa-miR-519c-5p	CLIP-seq
MIRT1065640	hsa-miR-520c-5p	CLIP-seq
MIRT1065641	hsa-miR-526a	CLIP-seq
MIRT1065643	hsa-miR-639	CLIP-seq
MIRT1065644	hsa-miR-720	CLIP-seq
MIRT2247957	hsa-miR-767-3p	CLIP-seq
MIRT1065626	hsa-miR-4305	CLIP-seq
MIRT1065629	hsa-miR-4497	CLIP-seq
MIRT1065634	hsa-miR-4777-5p	CLIP-seq
MIRT1065637	hsa-miR-518d-5p	CLIP-seq
MIRT1065638	hsa-miR-519b-5p	CLIP-seq
MIRT1065639	hsa-miR-519c-5p	CLIP-seq
MIRT1065640	hsa-miR-520c-5p	CLIP-seq
MIRT1065641	hsa-miR-526a	CLIP-seq
MIRT1065644	hsa-miR-720	CLIP-seq
MIRT2247951	hsa-miR-101	CLIP-seq
MIRT1065614	hsa-miR-186	CLIP-seq
MIRT1065617	hsa-miR-205	CLIP-seq
MIRT2247952	hsa-miR-30a	CLIP-seq
MIRT2247953	hsa-miR-30b	CLIP-seq
MIRT2247954	hsa-miR-30c	CLIP-seq
MIRT2247955	hsa-miR-30d	CLIP-seq
MIRT2247956	hsa-miR-30e	CLIP-seq
MIRT2551700	hsa-miR-3143	CLIP-seq
MIRT2551701	hsa-miR-3647-3p	CLIP-seq
MIRT1065622	hsa-miR-3688-3p	CLIP-seq
MIRT2551702	hsa-miR-3934	CLIP-seq
MIRT1065623	hsa-miR-3978	CLIP-seq
MIRT1065626	hsa-miR-4305	CLIP-seq
MIRT1065629	hsa-miR-4497	CLIP-seq
MIRT2551703	hsa-miR-4517	CLIP-seq
MIRT1065630	hsa-miR-4694-3p	CLIP-seq
MIRT2551704	hsa-miR-4694-5p	CLIP-seq
MIRT2551705	hsa-miR-4773	CLIP-seq
MIRT1065634	hsa-miR-4777-5p	CLIP-seq
MIRT1065637	hsa-miR-518d-5p	CLIP-seq
MIRT1065638	hsa-miR-519b-5p	CLIP-seq
MIRT1065639	hsa-miR-519c-5p	CLIP-seq
MIRT1065640	hsa-miR-520c-5p	CLIP-seq
MIRT1065641	hsa-miR-526a	CLIP-seq
MIRT2551706	hsa-miR-543	CLIP-seq
MIRT1065642	hsa-miR-548p	CLIP-seq
MIRT2551707	hsa-miR-552	CLIP-seq
MIRT1065643	hsa-miR-639	CLIP-seq
MIRT1065644	hsa-miR-720	CLIP-seq
MIRT2247957	hsa-miR-767-3p	CLIP-seq
MIRT2247951	hsa-miR-101	CLIP-seq
MIRT1065614	hsa-miR-186	CLIP-seq
MIRT1065617	hsa-miR-205	CLIP-seq
MIRT2247952	hsa-miR-30a	CLIP-seq
MIRT2247953	hsa-miR-30b	CLIP-seq
MIRT2247954	hsa-miR-30c	CLIP-seq
MIRT2247955	hsa-miR-30d	CLIP-seq
MIRT2247956	hsa-miR-30e	CLIP-seq
MIRT1065618	hsa-miR-3121-5p	CLIP-seq
MIRT2551700	hsa-miR-3143	CLIP-seq
MIRT1065620	hsa-miR-34c-3p	CLIP-seq
MIRT2551701	hsa-miR-3647-3p	CLIP-seq
MIRT1065622	hsa-miR-3688-3p	CLIP-seq
MIRT2551702	hsa-miR-3934	CLIP-seq
MIRT1065623	hsa-miR-3978	CLIP-seq
MIRT1065626	hsa-miR-4305	CLIP-seq
MIRT1065629	hsa-miR-4497	CLIP-seq
MIRT2551703	hsa-miR-4517	CLIP-seq
MIRT1065630	hsa-miR-4694-3p	CLIP-seq
MIRT2551704	hsa-miR-4694-5p	CLIP-seq
MIRT2551705	hsa-miR-4773	CLIP-seq
MIRT1065634	hsa-miR-4777-5p	CLIP-seq
MIRT2682820	hsa-miR-489	CLIP-seq
MIRT2682821	hsa-miR-514	CLIP-seq
MIRT2682822	hsa-miR-514b-3p	CLIP-seq
MIRT1065637	hsa-miR-518d-5p	CLIP-seq
MIRT1065638	hsa-miR-519b-5p	CLIP-seq
MIRT1065639	hsa-miR-519c-5p	CLIP-seq
MIRT1065640	hsa-miR-520c-5p	CLIP-seq
MIRT1065641	hsa-miR-526a	CLIP-seq
MIRT2551706	hsa-miR-543	CLIP-seq
MIRT1065642	hsa-miR-548p	CLIP-seq
MIRT2551707	hsa-miR-552	CLIP-seq
MIRT1065643	hsa-miR-639	CLIP-seq
MIRT1065644	hsa-miR-720	CLIP-seq
MIRT2247957	hsa-miR-767-3p	CLIP-seq

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001401	Component	SAM complex	HDA	26477565
GO:0003723	Function	RNA binding	HDA	22658674
GO:0005515	Function	Protein binding	IPI	16169070, 17043677, 20880836, 21081504, 21900206, 22228767, 25764979, 25959826, 26168012, 26666268, 29128334, 30021884, 31379806, 31413325, 31644573, 32814053, 36127429
GO:0005739	Component	Mitochondrion	HDA	20833797
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA	25781180, 25997101
GO:0005739	Component	Mitochondrion	IEA
GO:0005740	Component	Mitochondrial envelope	IEA
GO:0005743	Component	Mitochondrial inner membrane	IDA	9168817, 25997101
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	NAS	25997101
GO:0005758	Component	Mitochondrial intermembrane space	IEA
GO:0007007	Process	Inner mitochondrial membrane organization	IC	26477565
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0042407	Process	Cristae formation	IBA
GO:0042407	Process	Cristae formation	IMP	25781180, 32567732, 33130824
GO:0042407	Process	Cristae formation	NAS	25997101
GO:0044284	Component	Mitochondrial crista junction	NAS	25997101
GO:0051560	Process	Mitochondrial calcium ion homeostasis	IEA
GO:0061617	Component	MICOS complex	HDA	26477565
GO:0061617	Component	MICOS complex	IBA
GO:0061617	Component	MICOS complex	IDA	25781180, 25997101
GO:0061617	Component	MICOS complex	IMP	32567732
GO:0061617	Component	MICOS complex	NAS	25997101
GO:0070050	Process	Neuron cellular homeostasis	IEA
GO:0140275	Component	MIB complex	HDA	26477565

MIM	HGNC	e!Ensembl
600378	6047	ENSG00000132305

Q16891

Protein name

MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89)

Protein function

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMe

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09731	Mitofilin	41 → 746	Mitochondrial inner membrane protein	Family

Sequence

MLRACQLSGVTAAAQSCLCGKFVLRPLRPCRRYSTSGSSGLTTGKIAGAGLLFVGGGIGG
TILYAKWDSHFRESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKE
SKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPEIGEGK
PTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIA
AQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE
ELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHE
LVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELA
EQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMR
TQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDIN
TAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIK
ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFL
SYLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRV
AQDWLKEARMTLETKQIVEILTAYASAVGIGTTQVQPE

Sequence length

758

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
See cases	Uncertain significance	rs748333563	RCV001838850

Show/Hide Text Mining Associations (14)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	31583841
Adenocarcinoma of Lung	Associate	31583841
Adenoma	Associate	38139086
Breast Neoplasms	Associate	36899366
Carcinoma Pancreatic Ductal	Associate	36223343
Carcinoma Renal Cell	Associate	37240154
Colorectal Neoplasms	Associate	23594796
Inflammation	Associate	36223343
Neoplasms	Associate	19887603, 31583841
Neoplasms	Inhibit	36223343
Neoplastic Syndromes Hereditary	Associate	20208140
Parkinson Disease	Associate	34148545
Squamous Cell Carcinoma of Head and Neck	Associate	37356748
Xeroderma Pigmentosum	Associate	11027286, 20208140

IMMT (inner membrane mitochondrial protein)