Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10979
Gene name Gene Name - the full gene name approved by the HGNC.	FERM domain containing kindlin 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	FERMT2
Synonyms (NCBI Gene) Gene synonyms aliases	KIND2, MIG2, PLEKHC1, UNC112, UNC112B, mig-2
Chromosome Chromosome number	14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	14q22.1

Show/Hide all(300)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005281	hsa-miR-1-3p	pSILAC	18668040
MIRT005281	hsa-miR-1-3p	Proteomics	18668040
MIRT031065	hsa-miR-21-5p	Microarray	20371350
MIRT046125	hsa-miR-30b-5p	CLASH	23622248
MIRT054683	hsa-miR-200b-3p	KYSE150	24064224
MIRT054683	hsa-miR-200b-3p	KYSE150	24064224
MIRT054683	hsa-miR-200b-3p	KYSE150	24064224
MIRT054683	hsa-miR-200b-3p	KYSE150	24064224
MIRT507277	hsa-miR-138-5p	PAR-CLIP	23446348
MIRT507276	hsa-miR-8084	PAR-CLIP	23446348
MIRT507275	hsa-miR-1910-3p	PAR-CLIP	23446348
MIRT507274	hsa-miR-6511a-5p	PAR-CLIP	23446348
MIRT507273	hsa-miR-6808-5p	PAR-CLIP	23446348
MIRT507272	hsa-miR-6893-5p	PAR-CLIP	23446348
MIRT507271	hsa-miR-940	PAR-CLIP	23446348
MIRT507270	hsa-miR-2682-5p	PAR-CLIP	23446348
MIRT507269	hsa-miR-34b-5p	PAR-CLIP	23446348
MIRT507268	hsa-miR-449c-5p	PAR-CLIP	23446348
MIRT507267	hsa-miR-8062	PAR-CLIP	23446348
MIRT507266	hsa-miR-4728-3p	PAR-CLIP	23446348
MIRT507265	hsa-miR-1324	PAR-CLIP	23446348
MIRT507264	hsa-miR-4299	PAR-CLIP	23446348
MIRT507263	hsa-miR-3166	PAR-CLIP	23446348
MIRT507262	hsa-miR-133a-5p	PAR-CLIP	23446348
MIRT507261	hsa-miR-6131	PAR-CLIP	23446348
MIRT507260	hsa-miR-4423-3p	PAR-CLIP	23446348
MIRT440645	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440645	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT507277	hsa-miR-138-5p	Luciferase reporter assay, qRT-PCR, Western blot	26474967
MIRT507277	hsa-miR-138-5p	Luciferase reporter assay, qRT-PCR, Western blot	26474967
MIRT507277	hsa-miR-138-5p	Luciferase reporter assay, qRT-PCR, Western blot	26474967
MIRT507277	hsa-miR-138-5p	Luciferase reporter assay, qRT-PCR, Western blot	26474967
MIRT507277	hsa-miR-138-5p	Luciferase reporter assay, qRT-PCR, Western blot	26474967
MIRT507277	hsa-miR-138-5p	Luciferase reporter assay, qRT-PCR, Western blot	26474967
MIRT735914	hsa-miR-200c-3p	Luciferase reporter assay, Western blotting, Immunoprecipitaion (IP), Immunofluorescence, qRT-PCR	33125708
MIRT507277	hsa-miR-138-5p	PAR-CLIP	23446348
MIRT507276	hsa-miR-8084	PAR-CLIP	23446348
MIRT507275	hsa-miR-1910-3p	PAR-CLIP	23446348
MIRT507274	hsa-miR-6511a-5p	PAR-CLIP	23446348
MIRT507273	hsa-miR-6808-5p	PAR-CLIP	23446348
MIRT507272	hsa-miR-6893-5p	PAR-CLIP	23446348
MIRT507271	hsa-miR-940	PAR-CLIP	23446348
MIRT507270	hsa-miR-2682-5p	PAR-CLIP	23446348
MIRT507269	hsa-miR-34b-5p	PAR-CLIP	23446348
MIRT507268	hsa-miR-449c-5p	PAR-CLIP	23446348
MIRT507267	hsa-miR-8062	PAR-CLIP	23446348
MIRT507266	hsa-miR-4728-3p	PAR-CLIP	23446348
MIRT507265	hsa-miR-1324	PAR-CLIP	23446348
MIRT507264	hsa-miR-4299	PAR-CLIP	23446348
MIRT507263	hsa-miR-3166	PAR-CLIP	23446348
MIRT507262	hsa-miR-133a-5p	PAR-CLIP	23446348
MIRT507261	hsa-miR-6131	PAR-CLIP	23446348
MIRT507260	hsa-miR-4423-3p	PAR-CLIP	23446348
MIRT994774	hsa-miR-1	CLIP-seq
MIRT994775	hsa-miR-103a	CLIP-seq
MIRT994776	hsa-miR-107	CLIP-seq
MIRT994777	hsa-miR-1200	CLIP-seq
MIRT994778	hsa-miR-124	CLIP-seq
MIRT994779	hsa-miR-1246	CLIP-seq
MIRT994780	hsa-miR-1279	CLIP-seq
MIRT994781	hsa-miR-1291	CLIP-seq
MIRT994782	hsa-miR-1297	CLIP-seq
MIRT994783	hsa-miR-1305	CLIP-seq
MIRT994784	hsa-miR-130a	CLIP-seq
MIRT994785	hsa-miR-130b	CLIP-seq
MIRT994786	hsa-miR-1587	CLIP-seq
MIRT994787	hsa-miR-15a	CLIP-seq
MIRT994788	hsa-miR-15b	CLIP-seq
MIRT994789	hsa-miR-16	CLIP-seq
MIRT994790	hsa-miR-195	CLIP-seq
MIRT994791	hsa-miR-200b	CLIP-seq
MIRT994792	hsa-miR-200c	CLIP-seq
MIRT994793	hsa-miR-2054	CLIP-seq
MIRT994794	hsa-miR-206	CLIP-seq
MIRT994795	hsa-miR-221	CLIP-seq
MIRT994796	hsa-miR-222	CLIP-seq
MIRT994797	hsa-miR-26a	CLIP-seq
MIRT994798	hsa-miR-26b	CLIP-seq
MIRT994799	hsa-miR-301a	CLIP-seq
MIRT994800	hsa-miR-301b	CLIP-seq
MIRT994801	hsa-miR-3074-3p	CLIP-seq
MIRT994802	hsa-miR-328	CLIP-seq
MIRT994803	hsa-miR-3591-5p	CLIP-seq
MIRT994804	hsa-miR-3663-5p	CLIP-seq
MIRT994805	hsa-miR-3666	CLIP-seq
MIRT994806	hsa-miR-3675-3p	CLIP-seq
MIRT994807	hsa-miR-3682-5p	CLIP-seq
MIRT994808	hsa-miR-3688-5p	CLIP-seq
MIRT994809	hsa-miR-3714	CLIP-seq
MIRT994810	hsa-miR-376a	CLIP-seq
MIRT994811	hsa-miR-376b	CLIP-seq
MIRT994812	hsa-miR-3910	CLIP-seq
MIRT994813	hsa-miR-3912	CLIP-seq
MIRT994814	hsa-miR-3935	CLIP-seq
MIRT994815	hsa-miR-410	CLIP-seq
MIRT994816	hsa-miR-411	CLIP-seq
MIRT994817	hsa-miR-424	CLIP-seq
MIRT994818	hsa-miR-4287	CLIP-seq
MIRT994819	hsa-miR-4289	CLIP-seq
MIRT994820	hsa-miR-429	CLIP-seq
MIRT994821	hsa-miR-4295	CLIP-seq
MIRT994822	hsa-miR-4301	CLIP-seq
MIRT994823	hsa-miR-4326	CLIP-seq
MIRT994824	hsa-miR-4328	CLIP-seq
MIRT994825	hsa-miR-4424	CLIP-seq
MIRT994826	hsa-miR-4465	CLIP-seq
MIRT994827	hsa-miR-4469	CLIP-seq
MIRT994828	hsa-miR-4470	CLIP-seq
MIRT994829	hsa-miR-4473	CLIP-seq
MIRT994830	hsa-miR-4474-3p	CLIP-seq
MIRT994831	hsa-miR-4477a	CLIP-seq
MIRT994832	hsa-miR-4477b	CLIP-seq
MIRT994833	hsa-miR-4484	CLIP-seq
MIRT994834	hsa-miR-4490	CLIP-seq
MIRT994835	hsa-miR-4503	CLIP-seq
MIRT994836	hsa-miR-4504	CLIP-seq
MIRT994837	hsa-miR-4521	CLIP-seq
MIRT994838	hsa-miR-4527	CLIP-seq
MIRT994839	hsa-miR-454	CLIP-seq
MIRT994840	hsa-miR-4655-3p	CLIP-seq
MIRT994841	hsa-miR-4671-3p	CLIP-seq
MIRT994842	hsa-miR-4674	CLIP-seq
MIRT994843	hsa-miR-4685-3p	CLIP-seq
MIRT994844	hsa-miR-4686	CLIP-seq
MIRT994845	hsa-miR-4756-3p	CLIP-seq
MIRT994846	hsa-miR-4760-3p	CLIP-seq
MIRT994847	hsa-miR-4774-5p	CLIP-seq
MIRT994848	hsa-miR-4775	CLIP-seq
MIRT994849	hsa-miR-4795-3p	CLIP-seq
MIRT994850	hsa-miR-487a	CLIP-seq
MIRT994851	hsa-miR-490-5p	CLIP-seq
MIRT994852	hsa-miR-495	CLIP-seq
MIRT994853	hsa-miR-497	CLIP-seq
MIRT994854	hsa-miR-506	CLIP-seq
MIRT994855	hsa-miR-518a-5p	CLIP-seq
MIRT994856	hsa-miR-527	CLIP-seq
MIRT994857	hsa-miR-542-3p	CLIP-seq
MIRT994858	hsa-miR-548a-3p	CLIP-seq
MIRT994859	hsa-miR-548an	CLIP-seq
MIRT994860	hsa-miR-548e	CLIP-seq
MIRT994861	hsa-miR-548f	CLIP-seq
MIRT994862	hsa-miR-548v	CLIP-seq
MIRT994863	hsa-miR-582-3p	CLIP-seq
MIRT994864	hsa-miR-613	CLIP-seq
MIRT994865	hsa-miR-633	CLIP-seq
MIRT994866	hsa-miR-636	CLIP-seq
MIRT994867	hsa-miR-944	CLIP-seq
MIRT994774	hsa-miR-1	CLIP-seq
MIRT994780	hsa-miR-1279	CLIP-seq
MIRT994781	hsa-miR-1291	CLIP-seq
MIRT994782	hsa-miR-1297	CLIP-seq
MIRT994793	hsa-miR-2054	CLIP-seq
MIRT994794	hsa-miR-206	CLIP-seq
MIRT994797	hsa-miR-26a	CLIP-seq
MIRT994798	hsa-miR-26b	CLIP-seq
MIRT994868	hsa-miR-29a	CLIP-seq
MIRT994869	hsa-miR-29b	CLIP-seq
MIRT994870	hsa-miR-29c	CLIP-seq
MIRT994801	hsa-miR-3074-3p	CLIP-seq
MIRT994871	hsa-miR-323b-3p	CLIP-seq
MIRT994802	hsa-miR-328	CLIP-seq
MIRT994807	hsa-miR-3682-5p	CLIP-seq
MIRT994810	hsa-miR-376a	CLIP-seq
MIRT994811	hsa-miR-376b	CLIP-seq
MIRT994826	hsa-miR-4465	CLIP-seq
MIRT994836	hsa-miR-4504	CLIP-seq
MIRT994837	hsa-miR-4521	CLIP-seq
MIRT994872	hsa-miR-4698	CLIP-seq
MIRT994873	hsa-miR-4731-3p	CLIP-seq
MIRT994846	hsa-miR-4760-3p	CLIP-seq
MIRT994849	hsa-miR-4795-3p	CLIP-seq
MIRT994874	hsa-miR-4801	CLIP-seq
MIRT994875	hsa-miR-508-3p	CLIP-seq
MIRT994855	hsa-miR-518a-5p	CLIP-seq
MIRT994856	hsa-miR-527	CLIP-seq
MIRT994857	hsa-miR-542-3p	CLIP-seq
MIRT994864	hsa-miR-613	CLIP-seq
MIRT1556347	hsa-miR-338-5p	CLIP-seq
MIRT1556348	hsa-miR-433	CLIP-seq
MIRT994835	hsa-miR-4503	CLIP-seq
MIRT1995054	hsa-miR-2682	CLIP-seq
MIRT1995055	hsa-miR-449c	CLIP-seq
MIRT2229084	hsa-miR-1179	CLIP-seq
MIRT994825	hsa-miR-4424	CLIP-seq
MIRT994832	hsa-miR-4477b	CLIP-seq
MIRT994774	hsa-miR-1	CLIP-seq
MIRT2428875	hsa-miR-1244	CLIP-seq
MIRT994781	hsa-miR-1291	CLIP-seq
MIRT994783	hsa-miR-1305	CLIP-seq
MIRT2428876	hsa-miR-154	CLIP-seq
MIRT2428877	hsa-miR-194	CLIP-seq
MIRT994794	hsa-miR-206	CLIP-seq
MIRT994868	hsa-miR-29a	CLIP-seq
MIRT994869	hsa-miR-29b	CLIP-seq
MIRT994870	hsa-miR-29c	CLIP-seq
MIRT2428878	hsa-miR-3121-3p	CLIP-seq
MIRT2428879	hsa-miR-3163	CLIP-seq
MIRT2428880	hsa-miR-323-3p	CLIP-seq
MIRT994871	hsa-miR-323b-3p	CLIP-seq
MIRT994802	hsa-miR-328	CLIP-seq
MIRT1556347	hsa-miR-338-5p	CLIP-seq
MIRT2428881	hsa-miR-340	CLIP-seq
MIRT2428882	hsa-miR-4282	CLIP-seq
MIRT994822	hsa-miR-4301	CLIP-seq
MIRT994824	hsa-miR-4328	CLIP-seq
MIRT2428883	hsa-miR-4435	CLIP-seq
MIRT994837	hsa-miR-4521	CLIP-seq
MIRT2428884	hsa-miR-4717-3p	CLIP-seq
MIRT994846	hsa-miR-4760-3p	CLIP-seq
MIRT2428885	hsa-miR-4773	CLIP-seq
MIRT994875	hsa-miR-508-3p	CLIP-seq
MIRT994858	hsa-miR-548a-3p	CLIP-seq
MIRT2428886	hsa-miR-548ae	CLIP-seq
MIRT2428887	hsa-miR-548aj	CLIP-seq
MIRT2428888	hsa-miR-548am	CLIP-seq
MIRT994860	hsa-miR-548e	CLIP-seq
MIRT994861	hsa-miR-548f	CLIP-seq
MIRT2428889	hsa-miR-548g	CLIP-seq
MIRT2428890	hsa-miR-548x	CLIP-seq
MIRT2428891	hsa-miR-586	CLIP-seq
MIRT2428892	hsa-miR-590-3p	CLIP-seq
MIRT2428893	hsa-miR-599	CLIP-seq
MIRT994864	hsa-miR-613	CLIP-seq
MIRT2532744	hsa-miR-1275	CLIP-seq
MIRT2428877	hsa-miR-194	CLIP-seq
MIRT2532745	hsa-miR-1972	CLIP-seq
MIRT2532746	hsa-miR-1976	CLIP-seq
MIRT994868	hsa-miR-29a	CLIP-seq
MIRT994869	hsa-miR-29b	CLIP-seq
MIRT994870	hsa-miR-29c	CLIP-seq
MIRT994801	hsa-miR-3074-3p	CLIP-seq
MIRT2532747	hsa-miR-3145-3p	CLIP-seq
MIRT2428880	hsa-miR-323-3p	CLIP-seq
MIRT994871	hsa-miR-323b-3p	CLIP-seq
MIRT994808	hsa-miR-3688-5p	CLIP-seq
MIRT994814	hsa-miR-3935	CLIP-seq
MIRT994816	hsa-miR-411	CLIP-seq
MIRT2532748	hsa-miR-4260	CLIP-seq
MIRT2532749	hsa-miR-4278	CLIP-seq
MIRT994819	hsa-miR-4289	CLIP-seq
MIRT1556348	hsa-miR-433	CLIP-seq
MIRT994825	hsa-miR-4424	CLIP-seq
MIRT2428883	hsa-miR-4435	CLIP-seq
MIRT994828	hsa-miR-4470	CLIP-seq
MIRT994830	hsa-miR-4474-3p	CLIP-seq
MIRT994832	hsa-miR-4477b	CLIP-seq
MIRT2532750	hsa-miR-455-3p	CLIP-seq
MIRT2532751	hsa-miR-4645-5p	CLIP-seq
MIRT2532752	hsa-miR-4650-5p	CLIP-seq
MIRT2532753	hsa-miR-4665-5p	CLIP-seq
MIRT2532754	hsa-miR-4673	CLIP-seq
MIRT2532755	hsa-miR-4694-3p	CLIP-seq
MIRT2532756	hsa-miR-4716-3p	CLIP-seq
MIRT2532757	hsa-miR-4723-5p	CLIP-seq
MIRT2428885	hsa-miR-4773	CLIP-seq
MIRT994848	hsa-miR-4775	CLIP-seq
MIRT994875	hsa-miR-508-3p	CLIP-seq
MIRT2532758	hsa-miR-522	CLIP-seq
MIRT994858	hsa-miR-548a-3p	CLIP-seq
MIRT994860	hsa-miR-548e	CLIP-seq
MIRT994861	hsa-miR-548f	CLIP-seq
MIRT2532744	hsa-miR-1275	CLIP-seq
MIRT2428877	hsa-miR-194	CLIP-seq
MIRT2532745	hsa-miR-1972	CLIP-seq
MIRT2532746	hsa-miR-1976	CLIP-seq
MIRT994868	hsa-miR-29a	CLIP-seq
MIRT994869	hsa-miR-29b	CLIP-seq
MIRT994870	hsa-miR-29c	CLIP-seq
MIRT994801	hsa-miR-3074-3p	CLIP-seq
MIRT2532747	hsa-miR-3145-3p	CLIP-seq
MIRT2428880	hsa-miR-323-3p	CLIP-seq
MIRT994871	hsa-miR-323b-3p	CLIP-seq
MIRT994808	hsa-miR-3688-5p	CLIP-seq
MIRT994814	hsa-miR-3935	CLIP-seq
MIRT994816	hsa-miR-411	CLIP-seq
MIRT2532748	hsa-miR-4260	CLIP-seq
MIRT2532749	hsa-miR-4278	CLIP-seq
MIRT994819	hsa-miR-4289	CLIP-seq
MIRT1556348	hsa-miR-433	CLIP-seq
MIRT994825	hsa-miR-4424	CLIP-seq
MIRT2428883	hsa-miR-4435	CLIP-seq
MIRT994828	hsa-miR-4470	CLIP-seq
MIRT994830	hsa-miR-4474-3p	CLIP-seq
MIRT994832	hsa-miR-4477b	CLIP-seq
MIRT2532750	hsa-miR-455-3p	CLIP-seq
MIRT2532751	hsa-miR-4645-5p	CLIP-seq
MIRT2532752	hsa-miR-4650-5p	CLIP-seq
MIRT2532753	hsa-miR-4665-5p	CLIP-seq
MIRT2532754	hsa-miR-4673	CLIP-seq
MIRT2532755	hsa-miR-4694-3p	CLIP-seq
MIRT2532756	hsa-miR-4716-3p	CLIP-seq
MIRT2428884	hsa-miR-4717-3p	CLIP-seq
MIRT2532757	hsa-miR-4723-5p	CLIP-seq
MIRT2428885	hsa-miR-4773	CLIP-seq
MIRT994848	hsa-miR-4775	CLIP-seq
MIRT994875	hsa-miR-508-3p	CLIP-seq
MIRT2532758	hsa-miR-522	CLIP-seq
MIRT994858	hsa-miR-548a-3p	CLIP-seq
MIRT994860	hsa-miR-548e	CLIP-seq
MIRT994861	hsa-miR-548f	CLIP-seq

Show/Hide all(63)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001725	Component	Stress fiber	IEA
GO:0003779	Function	Actin binding	IMP	29496737
GO:0005178	Function	Integrin binding	IBA	21873635
GO:0005515	Function	Protein binding	IPI	22699938
GO:0005547	Function	Phosphatidylinositol-3,4,5-trisphosphate binding	IDA	21325030, 22030399
GO:0005634	Component	Nucleus	IDA	22699938
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	18528435, 22699938, 28799653
GO:0005829	Component	Cytosol	IDA	23723426
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	23723426, 30382829
GO:0005912	Component	Adherens junction	IDA	28799653
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0005925	Component	Focal adhesion	IBA	21873635
GO:0005925	Component	Focal adhesion	IDA	18528435, 21325030, 29162887, 29496737
GO:0005938	Component	Cell cortex	IEA
GO:0007155	Process	Cell adhesion	IGI	21356350
GO:0007155	Process	Cell adhesion	IMP	30382829
GO:0007160	Process	Cell-matrix adhesion	IBA	21873635
GO:0007160	Process	Cell-matrix adhesion	IMP	21325030
GO:0007160	Process	Cell-matrix adhesion	ISS
GO:0007179	Process	Transforming growth factor beta receptor signaling pathway	IMP	21325030
GO:0007229	Process	Integrin-mediated signaling pathway	IMP	21325030
GO:0008360	Process	Regulation of cell shape	IEA
GO:0009986	Component	Cell surface	IEA
GO:0010718	Process	Positive regulation of epithelial to mesenchymal transition	IDA	24226523
GO:0016055	Process	Wnt signaling pathway	IMP	22699938
GO:0019901	Function	Protein kinase binding	IPI	30254023
GO:0022604	Process	Regulation of cell morphogenesis	IMP	30254023
GO:0030054	Component	Cell junction	IDA	30382829
GO:0030055	Component	Cell-substrate junction	IBA	21873635
GO:0030335	Process	Positive regulation of cell migration	IMP	30382829
GO:0031234	Component	Extrinsic component of cytoplasmic side of plasma membrane	IBA	21873635
GO:0031234	Component	Extrinsic component of cytoplasmic side of plasma membrane	IDA	21325030
GO:0031258	Component	Lamellipodium membrane	IEA
GO:0031674	Component	I band	IEA
GO:0033622	Process	Integrin activation	IMP	22030399
GO:0033625	Process	Positive regulation of integrin activation	IGI	21356350
GO:0034329	Process	Cell junction assembly	TAS
GO:0034334	Process	Adherens junction maintenance	IMP	28799653
GO:0034446	Process	Substrate adhesion-dependent cell spreading	ISS
GO:0034713	Function	Type I transforming growth factor beta receptor binding	IPI	23723426
GO:0035505	Process	Positive regulation of myosin light chain kinase activity	IMP	29496737
GO:0043116	Process	Negative regulation of vascular permeability	IMP	28799653
GO:0043547	Process	Positive regulation of GTPase activity	IMP	29496737
GO:0045599	Process	Negative regulation of fat cell differentiation	IMP	29496737
GO:0045669	Process	Positive regulation of osteoblast differentiation	IMP	29496737
GO:0046332	Function	SMAD binding	IPI	23723426
GO:0048041	Process	Focal adhesion assembly	IMP	21356350
GO:0048041	Process	Focal adhesion assembly	ISS
GO:0051015	Function	Actin filament binding	IEA
GO:0051496	Process	Positive regulation of stress fiber assembly	IMP	29496737
GO:0051894	Process	Positive regulation of focal adhesion assembly	IMP	29496737
GO:0051897	Process	Positive regulation of protein kinase B signaling	IDA	24226523
GO:0060173	Process	Limb development	IEA
GO:0060548	Process	Negative regulation of cell death	IMP	29496737
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IDA	24226523
GO:0072657	Process	Protein localization to membrane	ISS
GO:1900026	Process	Positive regulation of substrate adhesion-dependent cell spreading	IGI	30254023
GO:1900182	Process	Positive regulation of protein localization to nucleus	IDA	23723426
GO:1902414	Process	Protein localization to cell junction	IMP	30254023
GO:1902462	Process	Positive regulation of mesenchymal stem cell proliferation	IMP	29496737
GO:1903691	Process	Positive regulation of wound healing, spreading of epidermal cells	IMP	21356350

MIM	HGNC	e!Ensembl
607746	15767	ENSG00000073712

Protein

UniProt ID

Q96AC1

Protein name

Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1)

Protein function

Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular

PDB

2LGX , 2LKO , 2MSU , 4F7H , 6U4N , 6XTJ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF18124	Kindlin_2_N	13 → 97	Kindlin-2 N-terminal domain	Domain
PF00373	FERM_M	281 → 573	FERM central domain	Domain
PF00169	PH	375 → 476	PH domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. Found in numerous tumor tissues.

Sequence

MALDGIRMPDGCYADGTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSD
HALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVF
KAVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYS
SPGLYSKTMTPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQ
ALLDKAKINQGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKW
AILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGG
KTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQ
MNLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTM
ADSSYNLEVQNILSFLKMQHLNPDPQLIPEQITTDITPECLVSPRYLKKYKNKQITARIL
EAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAYNRLIRMDAST
GDAIKTWRFSNMKQWNVNWEIKMVTVEFADEVRLSFICTEVDCKVVHEFIGGYIFLSTRA
KDQNESLDEEMFYKLTSGWV

Sequence length

680

Interactions

View interactions

	Reactome
			Cell-extracellular matrix interactions

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Alzheimer disease	Alzheimer`s Disease	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039 View all (65 more)	24162737, 29777097
Prostate cancer	Malignant neoplasm of prostate, Prostate carcinoma	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	23535732, 29892016

Show/Hide Unknown Diseases (3)

Disease term	Disease name	Source
Unknown
Hypertension	Hypertension	GWAS
Dementia	Dementia	GWAS
Hypertrophic cardiomyopathy	Hypertrophic cardiomyopathy	GWAS

Show/Hide Text Mining Associations (39)

Disease Name	Relationship Type	References
Associations from Text Mining
AA amyloidosis	Associate	29340569
Adenocarcinoma of Lung	Associate	33648465, 40179422
Alzheimer Disease	Associate	25114068, 26543236, 27215977, 28199971, 30286791, 30371777, 31561366, 33144711, 33213512, 34092785, 37101235, 38511601
Alzheimer Disease	Inhibit	36480537
Amyloidosis	Associate	29340569
Breast Neoplasms	Associate	17189381, 28755003, 30236106, 30477537, 32436609, 40643553
Carcinogenesis	Associate	21821115, 25152024, 27713156
Carcinoma	Inhibit	32169902
Carcinoma Hepatocellular	Associate	28969700
Carcinoma Intraductal Noninfiltrating	Associate	30236106
Carcinoma Non Small Cell Lung	Associate	33934696
Carcinoma Renal Cell	Associate	33850477
Carcinoma Squamous Cell	Associate	40179422
Cognition Disorders	Associate	28199971, 29340569
Colorectal Neoplasms	Stimulate	36480537
Diabetic Retinopathy	Associate	37480504
Esophageal Squamous Cell Carcinoma	Associate	25605255
Fibrosarcoma	Inhibit	18505917
Glaucoma Angle Closure	Associate	30399154
Glioma	Associate	25152024, 27713156
Hemorrhage	Associate	37480504
Hereditary Breast and Ovarian Cancer Syndrome	Associate	28755003
Hypoxia	Inhibit	32169902
Leiomyosarcoma	Associate	18505917
Lymphatic Metastasis	Stimulate	28755003
Menorrhagia	Associate	34807970
Mouth Neoplasms	Associate	36849997
Neoplasm Metastasis	Stimulate	28755003
Neoplasm Metastasis	Associate	28969700, 32436609, 37142218
Neoplasms	Associate	18505917, 22699938, 23337877, 25152024, 30477537, 32169902, 33850477, 34638957, 38431242
Neoplasms	Inhibit	32377753
Neuroblastoma	Associate	32169902
Neuroendocrine Tumors	Associate	37453564
Pancreatic Neoplasms	Associate	34638957, 38431242
Parkinson Disease	Associate	37142218
Plaque Amyloid	Associate	29340569
Prostatic Neoplasms	Associate	23337877
Prostatic Neoplasms Castration Resistant	Associate	26474967
Uterine Cervical Neoplasms	Inhibit	32377753

FERMT2 (FERM domain containing kindlin 2)