Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene Gene ontology Other IDs Protein Pathways
Entrez ID	109703458
Gene name	Hydroxyacyl-thioester dehydratase type 2
Gene symbol	HTD2
Synonyms (NCBI Gene)	-
Chromosome	3
Chromosome location	3p14.3
Summary	This gene encodes a protein that localizes to the mitochondria and can function as a 3-hydroxyacyl thioester dehydratase. This gene is located just downstream of the gene for ribonuclease P/MRP subunit p14 (RPP14) in a genomic context that is conserved am

Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005730	Component	Nucleolus	IDA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0006633	Process	Fatty acid biosynthetic process	IBA
GO:0016829	Function	Lyase activity	IEA
GO:0016836	Function	Hydro-lyase activity	IEA
GO:0018812	Function	3-hydroxyacyl-CoA dehydratase activity	TAS
GO:0019171	Function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	IBA
GO:0019171	Function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	IEA
GO:0046949	Process	Fatty-acyl-CoA biosynthetic process	TAS

MIM	HGNC	e!Ensembl
620769	53111	ENSG00000255154

P86397

Protein name

Hydroxyacyl-thioester dehydratase type 2, mitochondrial (HsHTD2) (EC 4.2.1.59) (3-hydroxyacyl-[acyl-carrier-protein] dehydratase)

Protein function

Mitochondrial 3-hydroxyacyl-thioester dehydratase, which may be involved in fatty acid biosynthesis.

PDB

3IR3

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01575	MaoC_dehydratas	32 → 152	MaoC like domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in heart and liver. Expressed at lower levels in skeletal muscle, spleen, kidney and placenta. {ECO:0000269|PubMed:17898086}.

Sequence

MFPLISSHHLWWGGLRRTVCLNLPVLTLQHFQHMHIKVGDRAELRRAFTQTDVATFSELT
GDVNPLHLNEDFAKHTKFGNTIVHGVLINGLISALLGTKMPGPGCVFLSQEISFPAPLYI
GEVVLASAEVKKLKRFIAIIAVSCSVIESKKTVMEGWVKVMVPEASKS

Sequence length

168

Interactions

View interactions

	KEGG		Reactome
	Fatty acid biosynthesis Metabolic pathways Fatty acid metabolism		Fatty acyl-CoA biosynthesis

HTD2 (hydroxyacyl-thioester dehydratase type 2)